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    • 8. 发明专利
    • CH555314A
    • 1974-10-31
    • CH1696573
    • 1970-12-17
    • CIBA GEIGY AG
    • C07B61/00B01J23/00C01B7/09C07C17/087C07C67/00C07C209/00C07C209/08C07C209/22C07C209/26C07C209/48C07C209/52C07C211/17C07C211/25C07C85/14C07C87/34
    • 1338216 Cyclopropylmethyl - N - alkylamines ESSO RESEARCH & ENG CO 3 Dec 1970 [28 Aug 1970] 15446/73 Divided out of 1336860 Heading C2C Cyclopropylmethyl - N - alkylamines of the formula wherein R 1 is H or C 1 to C 4 alkyl and each of R 2 and R 3 is H or alkyl, are obtained by reacting a cyclopropylmethylamine of the formula with a compound of the formula in the presence of H 2 and a catalyst. Preferred catalysts are Rh supported on carbon, unsupported copper chromite containing from 1 to 50% of barium chromite, or Cu supported on either an alumina or a siliceous support. Examples are given which illustrate the process. The cyclopropylmethylamine of Formula II may be obtained by reacting an allylic chloride with HBr in the presence of a free radical catalyst to form the anti-Markownikoff product 1-bromo- 3-chloro-propane which may be substituted with a C 1 to C 4 alkyl group, contacting this product with a metal cyanide to form a gamma-chloronitrile, reacting this gamma-chloronitrile with an alkali metal hydroxide to give cyclopropylcyanide or a C 1 to C 4 alkyl cyclopropylcyanide, and reacting the cyclopropylcyanide with H 2 to give the required primary amine.