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1. 发明授权

US06683206B2 Preparation of (R -2-alkyl-3-phenylpropionic acids 失效
标题翻译：（R -2-烷基-3-苯基丙酸的制备）
公开(公告)号：US06683206B2
公开(公告)日：2004-01-27
申请号：US10312855
申请日：2003-01-02
申请人： Stefan Stutz , Peter Herold , Felix Spindler , Walter Weissensteiner , Thomas Sturm
发明人： Stefan Stutz , Peter Herold , Felix Spindler , Walter Weissensteiner , Thomas Sturm
IPC分类号： C07C6364
CPC分类号： C07C59/66 , C07C51/36
摘要： Compounds of formula (I), wherein R1 and R2 are, independently of one another, H, C1-C6alkyl, C1-C6halogenalkyl, C1-C6alkoxy, C1-C6alkoxy-C1-C6alkyl, or C1-C6alkoxy-C1l-C6alkyloxy, and R3 is C1-C6alkyl, are obtainable in high yields by stereoselective addition of R3-substituted propionic acid esters to R1- and R2-substituted benzaldehydes of formula R—CHO to form corresponding 3-R-3-hydroxy-2-R3-propionic acid esters, conversion of the OH group to a leavaing group, subsequent regioselective elimination to form 3-R-2-R3-propenic acid esters, and their hydrolysis to form corresponding propenic carboxylic acids and their enantioselective hydrogenation, wherein R is (a).
摘要翻译：式（I）化合物，其中R 1和R 2彼此独立地为H，C 1 -C 6烷基，C 1 -C 6卤代烷基，C 1 -C 6烷氧基，C 1 -C 6烷氧基-C 1 -C 6烷基或C 1 -C 6烷氧基-C 1 -C 6烷氧基， R 3是C 1 -C 6烷基，可以通过立体选择性地将R 3取代的丙酸酯加成到式R-CHO的R 1和R 2取代的苯甲醛以高产率获得，形成相应的3-R-3-羟基-2-R3-丙酸酸酯，OH基转化为脱氯基团，随后进行区域选择性消除以形成3-R-2-R3-丙烯酸酯，并且它们的水解形成相应的丙烯羧酸及其对映选择性氢化，其中R为（a）。

2. 发明授权

US06278019B1 Process for acyloxylating side chains of alkyl-substituted aromatic compounds and catalysts used therefor 失效
标题翻译：用于烷基取代的芳族化合物的侧链酰氧基化方法和用于其的催化剂的方法
公开(公告)号：US06278019B1
公开(公告)日：2001-08-21
申请号：US09284815
申请日：1999-05-27
申请人： Jiro Nakatani , Eiichi Minomiya , Tetsuya Kato , Satoru Miyata
发明人： Jiro Nakatani , Eiichi Minomiya , Tetsuya Kato , Satoru Miyata
IPC分类号： C07C6364
CPC分类号： C07C67/00 , B01J21/18 , B01J23/002 , B01J23/80 , B01J27/128 , B01J29/106 , B01J29/46 , B01J29/7215 , B01J37/03 , B01J37/088 , C07C67/035 , C07C67/39 , C07C253/30 , C07C69/007 , C07C69/16 , C07C69/157 , C07C69/63 , C07C255/55
摘要： The present invention is a method for acyloxylating an alkyl group substituted aromatic compound at the side chain, by letting the alkyl group substituted aromatic compound and a carboxylic acid and/or a carboxylic anhydride react with each other in the presence of an oxygen containing gas. In this case, if (1) a solid catalyst in which at least one selected from cobalt, cerium and manganese is supported on a solid material or (2) a catalyst containing at least one selected from cobalt oxides, cerium oxides and manganese oxides is used, an alkali group substituted aromatic compound and a carboxylic acid and/or a carboxylic anhydride can be caused to react with each other efficiently in the presence of an oxygen containing gas, and in addition the catalyst can be easily separated from the reaction solution. Furthermore, (3) a compound diacyloxylated at the side chains can be highly selectively produced if a cerium compound is used as a catalyst in the absence of a cobalt compound and a manganese compound. Moreover, the present invention relates to a method for producing a cinnamic acid by letting a benzylidene diacetate react in the presence of a basic catalyst. The alkyl group substituted aromatic compounds acyloxylated and diacyloxylated at the side chain obtained in the present invention are useful for perfumes, and the benzyl alcohols and benzaldehydes obtained by hydrolyzing them are useful for intermediate products of agricultural chemicals, drugs and perfumes and also for resin additives. The cinnamic acids produced according to the present invention are useful for intermediate products of agricultural chemicals, drugs and perfumes.
摘要翻译：本发明是通过在含氧气体的存在下使烷基取代的芳香族化合物和羧酸和/或羧酸酐反应而使侧链上的烷基取代芳香族化合物酰化而成的方法。在这种情况下，如果（1）其中选自钴，铈和锰中的至少一种负载在固体材料上的固体催化剂或（2）含有选自氧化钴，氧化铈和氧化锰中的至少一种的催化剂是使用时，可以在含氧气体的存在下使碱基取代的芳香族化合物和羧酸和/或羧酸酐有效反应，另外，催化剂也容易与反应溶液分离。此外，如果在没有钴化合物和锰化合物的情况下使用铈化合物作为催化剂，则可以高选择性地制备（3）侧链二酰氧基化的化合物。此外，本发明涉及一种制备通过使亚苄基二乙酸酯在碱性催化剂存在下反应，得到肉桂酸。在pr中获得的侧链上被酰氧基化和二酰氧基化的烷基取代的芳族化合物本发明可用于香料，通过水解获得的苄醇和苯甲醛可用于农药，药物和香料以及树脂添加剂的中间产物。根据本发明生产的肉桂酸可用于农药，药物和香料的中间产物。

3. 发明授权

US06187950B1 Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological 失效
标题翻译：取代的二芳基或二杂芳基甲烷，具有类视黄醇激动剂，拮抗剂或反向激动剂型生物的醚和胺
公开(公告)号：US06187950B1
公开(公告)日：2001-02-13
申请号：US09267992
申请日：1999-03-12
申请人： Tae K. Song , Min Teng , Roshantha A. Chandraratna
发明人： Tae K. Song , Min Teng , Roshantha A. Chandraratna
IPC分类号： C07C6364
CPC分类号： C07D213/80 , C07C65/28 , C07C69/94 , C07C205/38 , C07C235/56 , C07C247/16
摘要： Compounds of the formula Y3(R4)—X—Y1(R1R2)—Z—Y2(R2)—A—B where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist or retinoid inverse agonist type biological activity.
摘要翻译：符号具有本说明书中定义的含义的化合物具有类视黄醇，维生素A拮抗剂或类视黄醇反向激动剂型生物活性。

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