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1. 发明授权

US06331648B1 Ether amines and derivatives 失效
标题翻译：醚类胺及其衍生物
公开(公告)号：US06331648B1
公开(公告)日：2001-12-18
申请号：US09566505
申请日：2000-05-08
申请人： Thomas J. Daly , Michael Clumpner , Anthony J. O'Lenick, Jr.
发明人： Thomas J. Daly , Michael Clumpner , Anthony J. O'Lenick, Jr.
IPC分类号： C07C21728
CPC分类号： C07C217/08
摘要： The present invention relates to a series of derivatives of novel ether amine compounds prepared by the cyanobutylation reaction of an alcohol having 3 to 22 carbon atoms with 2-pentenenitrile to form a branched alkyl ether nitrile. The alkyl ether nitrites formed by the process are hydrogenated to form alkylether amines. The resulting product can be reacted with 2-pentenenitrile and or acrylonitrile and in a subsequent step, hydrogenated to yield a diamine. Specifically, the present invention deals with two types of tertiary amines one made by the reaction of novel ether amine compounds with ethylene oxide, propylene oxide or butylene oxide or mixtures thereof producing alkoxylated tertiary amines and the other made by the reaction of novel ether amine compounds with formaldehyde and hydrogen producing methylated tertiary amines. The invention also discloses novel amine oxides, and quaternary compounds made from said tertiary amines.
摘要翻译：本发明涉及通过具有3至22个碳原子的醇与2-戊烯腈的氰基丁基化反应制备的一系列新的醚胺化合物的衍生物，以形成支链烷基醚腈。通过该方法形成的烷基醚亚硝酸盐被氢化形成烷基醚胺。所得产物可与2-戊烯腈和/或丙烯腈反应，并在随后的步骤中氢化得到二胺。具体地，本发明涉及通过新型醚胺化合物与环氧乙烷，环氧丙烷或环氧丁烷或其混合物的反应制备烷氧基化叔胺而制备的两种叔胺，另一种由新的醚胺化合物与甲醛和氢气产生甲基化叔胺。本发明还公开了新的氧化胺和由所述叔胺制成的季铵化合物。

2. 发明授权

US06329409B1 Amine derivatives and skin preparations for external use containing the same 有权
标题翻译：胺衍生物和皮肤外用制剂含有相同的含量
公开(公告)号：US06329409B1
公开(公告)日：2001-12-11
申请号：US09786358
申请日：2001-03-14
申请人： Taketoshi Fujimori , Yukihiro Ohashi , Kazuhiko Higuchi , Junko Ishikawa , Takashi Kitahara
发明人： Taketoshi Fujimori , Yukihiro Ohashi , Kazuhiko Higuchi , Junko Ishikawa , Takashi Kitahara
IPC分类号： C07C21728
CPC分类号： C07D295/088 , A61K8/41 , A61K8/43 , A61K8/4913 , A61Q19/08 , C07C217/28 , C07C219/06 , C07C229/12 , C07C233/18 , C07C279/08 , C07C291/04 , C07D263/24 , C07F9/091
摘要： The invention relates to an amine derivative represented by the general formula (1): wherein R1 is a C1-C30 hydrocarbon group which may be interrupted by an ether linkage, with the proviso that phenyl and benzyl groups are excluded; one of A and B is and the other of them is —OR4; R2 and R3 are individually H, amidino group, alkanoyl group, C1-C20 hydrocarbon group, or the like; R4 and R5 are individually H, phosphoryl group, or the like, and an external skin care composition containing the same. The external skin care composition exhibits excellent preventing effects on aging of the skin, etc.
摘要翻译：本发明涉及由通式（1）表示的胺衍生物：其中R1是可被醚键中断的C1-C30烃基，条件是排除苯基和苄基; A和B之一是另一个是-OR4; R2和R3分别为H，脒基，烷酰基，C1-C20烃基等; R4和R5分别是H，磷酰基等，以及含有它们的外用护肤组合物。外用护肤组合物对皮肤老化等具有优异的防止作用。

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