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1. 发明授权

US06559223B2 Hydrogels and methods for their production 失效
标题翻译：水凝胶及其生产方法
公开(公告)号：US06559223B2
公开(公告)日：2003-05-06
申请号：US09790739
申请日：2001-02-22
申请人： Mark M. Green , Sung Yun Yang
发明人： Mark M. Green , Sung Yun Yang
IPC分类号： B01J1300
CPC分类号： C08F2/10 , Y10S522/904 , Y10S522/905 , Y10S524/916 , Y10S525/936
摘要： Forming graft copolymers in water using labeling of water soluble polymers with photoinitiators. Water soluble polymers can form environmentally responsive hydrophobically stimulated cages. The cages, which contain initiating radicals after irradiation, may be “opened” or “closed” by changes in environmental conditions. When the cage is closed, the radicals are trapped inside and thus do not cause substantial polymerization of water soluble monomers in the same solution. When the cage is closed, the radicals escape and cause polymerization. In another variation, hydrogels and graft copolymers are formed by covalently linking phototoinitiator groups to water soluble polymers that do not form cages. Thus, monomers may form grafts to the polymer, allowing formation of physical hydrogels. The physical hydrogels formed in either case show properties responsive to pH, salt and/or solvent composition, so that the hydrogels may be rendered to a powder by addition of non-solvents and these powders can reform the gels.
摘要翻译：通过用光引发剂标记水溶性聚合物在水中形成接枝共聚物。水溶性聚合物可以形成环境响应性疏水刺激的笼。笼罩在辐射后含有起始自由基，可能会因环境条件的变化“开启”或“封闭”。当笼闭合时，自由基被捕获在内部，因此不会在同一溶液中引起水溶性单体的显着聚合。当笼子闭合时，自由基逸出并引起聚合。在另一个实施方案中，水凝胶和接枝共聚物通过将光引发剂基团与不形成笼子的水溶性聚合物共价连接而形成。因此，单体可以形成接枝到聚合物上，从而形成物理水凝胶。在任一种情况下形成的物理水凝胶都显示出对pH，盐和/或溶剂组成有响应的性质，使得可以通过加入非溶剂使水凝胶变成粉末，并且这些粉末可以改性凝胶。

2. 发明授权

US06368658B1 Coating medical devices using air suspension 有权
标题翻译：使用空气悬浮的涂层医疗设备
公开(公告)号：US06368658B1
公开(公告)日：2002-04-09
申请号：US09551614
申请日：2000-04-17
申请人： Marlene Schwarz , Kathleen Miller , Kalpana Kamath
发明人： Marlene Schwarz , Kathleen Miller , Kalpana Kamath
IPC分类号： B01J1300
CPC分类号： A61L27/28 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/252 , A61L2300/258 , A61L2300/606 , A61L2300/608 , A61L2420/02 , B05B13/02 , B05B13/0221 , B05B13/025 , B05B13/0257 , B05C13/00 , B05D1/22 , C23C14/50 , C23C16/458
摘要： Methods and apparatuses for coating medical devices and the devices thereby produced are disclosed. In one embodiment, the invention includes a method comprising the steps of suspending the medical device in an air stream and introducing a coating material into the air stream such that the coating material is dispersed therein and coats at least a portion of the medical device. In another embodiment, the medical devices are suspended in an air stream and a coating apparatus coats at least a portion of the medical device with a coating material. The coating apparatus may include a device that utilizes any number of alternative coating techniques for coating the medical devices. This process is used to apply one or more coating materials, simultaneously or in sequence. In certain embodiments of the invention, the coating materials include therapeutic agents, polymers, sugars, waxes, or fats. By using air suspensions to coat medical devices, the methods of the present invention result in coatings having minimal defects and uniform thicknesses and mechanical properties. Further, the methods of the present invention are time efficient and cost effective because they facilitate the coating of numerous medical devices in a single batch, resulting in numerous medical device units containing substantially the same coating.
摘要翻译：公开了用于涂覆医疗装置的方法和装置以及由此制造的装置。在一个实施方案中，本发明包括一种方法，其包括以下步骤：将医疗装置悬浮在空气流中并将涂料引入空气流中，使得涂层材料分散在其中并涂覆医疗装置的至少一部分。在另一个实施方案中，医疗装置悬浮在空气流中，并且涂覆装置用涂料涂覆医疗装置的至少一部分。涂覆设备可以包括利用任何数量的替代涂覆技术来涂覆医疗装置的装置。该方法用于同时或按顺序施用一种或多种涂料。在本发明的某些实施方案中，涂层材料包括治疗剂，聚合物，糖，蜡或脂肪。通过使用空气悬浮液来涂覆医疗装置，本发明的方法产生具有最小缺陷和均匀厚度和机械性能的涂层。此外，本发明的方法是时间有效和成本有效的，因为它们有助于单批次涂覆许多医疗装置，导致许多医疗装置单元含有基本上相同的涂层。

3. 发明授权

US06344489B1 Stabilized gas-enriched and gas-supersaturated liquids 失效
标题翻译：稳定的气体富集和气体过饱和液体
公开(公告)号：US06344489B1
公开(公告)日：2002-02-05
申请号：US08581019
申请日：1996-01-03
申请人： J. Richard Spears
发明人： J. Richard Spears
IPC分类号： B01J1300
CPC分类号： A23L2/54 , A61K9/5089 , A61M1/1678 , A61M1/1698 , A61M1/32 , A61M25/0026 , A61M25/007 , A61M25/09 , A61M2025/0057 , A61M2202/0476 , B01F3/04439 , B01F3/04985 , B01F3/0876 , B01F5/02 , B01F2003/04879 , B01F2003/04893 , B01F2215/0034 , B01F2215/0052 , B01F2215/0075 , B01F2215/0078 , B01J13/04 , C01B5/00 , C01B13/00 , C01B13/02 , D21C9/147 , A61M2202/0007
摘要： A gas-enriched liquid delivered at a site of interest that is substantially bubble free after delivery into a lower pressure liquid or gas environment. The delivered gas-enriched liquid is produced by a process comprising the steps of: a) preparing a mixture of gas and liquid; b) compressing the mixture to a pressure such that the gas completely dissolves in the liquid to form a gas-enriched liquid; c) enclosing the gas-enriched liquid within a confined space while retaining substantially the same pressure. The confined space has at least one dimension less than about 0.2 mm, and has at least one opening to a liquid or gas environment site of interest having a lower pressure than that of the pressure of the confined space; and d) delivering the gas-enriched liquid from the confined space out through the at least one exit opening to the lower pressure environment without formation of bubbles.
摘要翻译：在感兴趣的部位输送的富含气体的液体在输送到较低压力的液体或气体环境中之后基本上无气泡。输送的富含气体的液体通过包括以下步骤的方法生产：a）制备气体和液体的混合物; b）将混合物压缩至使得气体完全溶解在液体中以形成富气液体的压力 ; c）将气体富集液体封闭在密闭空间内，同时保持基本相同的压力。密闭空间具有小于约0.2mm的至少一个尺寸，并且具有至少一个开口，其具有比密闭空间的压力低的压力的感兴趣的液体或气体环境位置; 并且将来自密闭空间的气体富集液体通过至少一个出口开口输送到较低压力环境而不形成气泡。

4. 发明授权

US06521678B1 Process for the preparation of organoclays 失效
标题翻译：制备有机粘土的方法
公开(公告)号：US06521678B1
公开(公告)日：2003-02-18
申请号：US09717590
申请日：2000-11-21
申请人： David J. Chaiko
发明人： David J. Chaiko
IPC分类号： B01J1300
CPC分类号： C04B33/13 , Y10S507/901
摘要： A method for preparing organoclays from smectites for use as rheological control agents and in the preparation of nanocomposites. Typically, the clay is dispersed in water, and a substantially monomolecular layer of a water soluble polymer is applied to the surfaces of the clay. A surfactant is also applied to the clay to modify the surface hydrophilic/hydrophobic balance of the clay, and the organoclay is separated out for subsequent use.
摘要翻译：用于从蒙脱石制备有机粘土用作流变控制剂和制备纳米复合材料的方法。通常，将粘土分散在水中，将基本上单分子层的水溶性聚合物施加到粘土的表面。还将粘土上的表面活性剂用于粘土的表面亲水/疏水平衡，并将有机粘土分离出来用于随后的使用。

5. 发明授权

US06506710B1 Viscoelastic surfactants and compositions containing same 有权
标题翻译：粘弹性表面活性剂和含有它们的组合物
公开(公告)号：US06506710B1
公开(公告)日：2003-01-14
申请号：US09553196
申请日：2000-04-20
申请人： Michael D. Hoey , Ralph Franklin , Douglas M. Lucas , Maurice Dery , Randy E. Dobson , Michael Engel , James F. Gadberry , Ramanair S. Premachandran , Glenda Del Carmen Vale
发明人： Michael D. Hoey , Ralph Franklin , Douglas M. Lucas , Maurice Dery , Randy E. Dobson , Michael Engel , James F. Gadberry , Ramanair S. Premachandran , Glenda Del Carmen Vale
IPC分类号： B01J1300
CPC分类号： C09K8/68 , C09K8/12 , C09K8/22 , C09K8/506 , C09K8/86 , C09K2208/30 , Y10S507/922 , Y10S507/925 , Y10S524/921
摘要： A method for controlling the rheology of aqueous systems, particularly for those intended for underground use, includes injecting an aqueous viscoelastic fluid containing a surfactant gelling agent into the system. The viscoelastic surfactant composition of the invention comprises, as a gelling agent, at least one fatty aliphatic amidoamine oxide in a glycol solvent. The composition also maintains the levels of free fatty acid and free amine within critical parameters in order to achieve superior performance. The additives may be incorporated in the viscoelastic fluid to tailor its use in stimulation fluids, drilling muds, fracture fluids, and in applications such as permeability modification, gravel packing, cementing, and the like.
摘要翻译：用于控制水性体系的流变学的方法，特别是用于地下使用的方法，包括将含有表面活性剂胶凝剂的含水粘弹性体注入体系中。作为胶凝剂，本发明的粘弹性表面活性剂组合物在二醇溶剂中含有至少一种脂肪族脂肪族酰氨基胺氧化物。该组合物还在关键参数内保持游离脂肪酸和游离胺的水平，以达到优异的性能。添加剂可以结合到粘弹性流体中以调整其在刺激流体，钻井泥浆，断裂流体中的应用，以及在渗透性改性，砾石填充，固井等的应用中。

6. 发明授权

US06420466B1 Process for preparing a thixotropic agent and its use 有权
标题翻译：制备触变剂及其用途的方法
公开(公告)号：US06420466B1
公开(公告)日：2002-07-16
申请号：US09557698
申请日：2000-04-25
申请人： Karlheinz Haubennestel , Ulrich Orth
发明人： Karlheinz Haubennestel , Ulrich Orth
IPC分类号： B01J1300
CPC分类号： C08G18/7621 , C08G18/225 , C08G18/282 , C08G18/2825 , C08G18/283 , C08G18/2835 , C08G18/284 , C08G18/3228 , C08G18/324 , Y10S528/903
摘要： The invention relates to a process for preparing a solution that is active as a thixotropic agent and contains urea urethanes, in which monohydroxyl compounds are reacted with an excess of toluene diisocyanate, the unreacted portion of the toluene diisocyanate is removed from the reaction mixture and the monosiocyanate adduct obtained is further reacted with diarines in the presence of a lithium salt to form urea urethanes. The invention also relates to the use of the solution for imparting thixotropic properties to coating compounds.
摘要翻译：本发明涉及一种制备作为触变剂有效的溶液并含有尿素氨基甲酸酯的方法，其中单羟基化合物与过量的甲苯二异氰酸酯反应，甲苯二异氰酸酯的未反应部分从反应混合物中除去，得到的单硫氰酸酯加成物在锂盐的存在下进一步与二元醇反应形成尿素氨基甲酸酯。本发明还涉及该溶液用于赋予涂料化合物触变性的用途。

7. 发明授权

US06174926B1 Method of preparing organically modified silica 有权
标题翻译：制备有机改性二氧化硅的方法
公开(公告)号：US06174926B1
公开(公告)日：2001-01-16
申请号：US09229179
申请日：1999-01-13
申请人： Vinayan C. Menon , Joanne Paul , Douglas M. Smith , Kenneth C. Koehlert
发明人： Vinayan C. Menon , Joanne Paul , Douglas M. Smith , Kenneth C. Koehlert
IPC分类号： B01J1300
CPC分类号： C01B33/159 , B01J13/006 , C01P2006/11 , C01P2006/12 , C01P2006/90 , C09C1/3081 , Y10T428/2995
摘要： The present invention provides a method of preparing lipophilic silica in an aqueous medium in the absence of added acids, bases, or organic solvents. In particular, the present inventive method of preparing lipophilic silica comprises (a) providing a mixture consisting essentially of (i) at least one organically modified silica precursor which is a trifunctional silane, (ii) water, and (iii) at least one tetrafunctional silane, (b) allowing the organically modified silica to form in the mixture, and (c) removing the organically modified silica from the mixture.
摘要翻译：本发明提供了在没有添加酸，碱或有机溶剂的情况下，在水性介质中制备亲油性二氧化硅的方法。特别地，本发明的制备亲油硅石的方法包括（a）提供基本上由（i）至少一种有机改性的二氧化硅前体，即三官能硅烷，（ii）水和（iii）至少一种四官能硅烷，（b）在混合物中形成有机改性的二氧化硅，和（c）从混合物中除去有机改性的二氧化硅。

8. 发明授权

US06767483B2 Sol-gel encapsulation of lipid vesicles, lipid membranes and proteins 失效
标题翻译：脂质囊泡，脂质膜和蛋白质的溶胶 - 凝胶包封
公开(公告)号：US06767483B2
公开(公告)日：2004-07-27
申请号：US09934989
申请日：2001-08-21
申请人： Michael H. B. Stowell , Guangyang Wang , Sunney I. Chan
发明人： Michael H. B. Stowell , Guangyang Wang , Sunney I. Chan
IPC分类号： B01J1300
CPC分类号： A61K9/1273
摘要： Inorganic-organic hybrid mixture sol-gel encapsulated lipid vesicles which are composed of silyl lipids or a mixture of silyl lipids and phospholipids are provided. The present invention also provides encapsulated Langmuir Blogget (LB) membranes and biological macromolecules. The sol-gel encapsulated lipid vesicles, LB membranes and proteins possess a higher stability than conventional vesicles. Inorganic-organic hybrid mixture sol-gels are provided as novel sol-gel materials possessing desirable mechanical and physicochemical properties. Also provided are methods of preparing encapsulated lipid vesicles, LB membranes and proteins. Methods of performing renal dialysis using compositions of the invention are also provided.
摘要翻译：提供由甲硅烷基脂质或甲硅烷基脂质和磷脂的混合物组成的无机 - 有机杂化混合物溶胶 - 凝胶包封的脂质囊泡。本发明还提供封装的Langmuir Blogget（LB）膜和生物大分子。溶胶 - 凝胶包封的脂质囊泡，LB膜和蛋白质具有比常规泡囊更高的稳定性。提供无机 - 有机杂化混合物溶胶，作为具有理想的机械和物理化学性质的新型溶胶 - 凝胶材料。还提供了制备包封的脂质囊泡，LB膜和蛋白质的方法。还提供了使用本发明组合物进行肾透析的方法。

9. 发明授权

US06737101B2 Particle formation 失效
标题翻译：颗粒形成
公开(公告)号：US06737101B2
公开(公告)日：2004-05-18
申请号：US10397329
申请日：2003-03-27
申请人： Yuh-Fun Maa
发明人： Yuh-Fun Maa
IPC分类号： B01J1300
CPC分类号： A61K9/1676 , A61K9/0021
摘要： Spray-coated pharmaceutical powder compositions for transdermal administration using a needleless syringe comprise seed particles coated with a pharmaceutical composition, the said coated seed particles having an average size of about 10 to 100 &mgr;m and having an envelope density ranging from about 0.1 to about 25 g/cm3.
摘要翻译：使用无针注射器进行透皮给药的喷涂药物粉末组合物包括用药物组合物涂覆的种子颗粒，所述涂覆的种子颗粒具有约10至100μm的平均尺寸并且具有约0.1至约25g的包络密度 / cm 3。

10. 发明授权

US06391927B1 Method for manufacturing ink follower for water base ballpoint pens 失效
标题翻译：水基圆珠笔墨水随动体的制造方法
公开(公告)号：US06391927B1
公开(公告)日：2002-05-21
申请号：US09463749
申请日：2000-04-07
申请人： Norio Ogura , Youji Takeuchi , Kiyoshi Iwamoto , Tadashi Kamagata , Katsuhiko Shiraishi
发明人： Norio Ogura , Youji Takeuchi , Kiyoshi Iwamoto , Tadashi Kamagata , Katsuhiko Shiraishi
IPC分类号： B01J1300
CPC分类号： B43K7/01 , Y10S516/924 , Y10S516/928 , Y10T137/3109
摘要： Dispersibility of thickener is constant for every lot and viscosity difference is little. Fine bubbles existing in the thicker in ink follower are removed. A step of homogenizing the thickener at any temperature within a range of 40° C. to 130° C. is included. Preferably, a step of homogenizing the thickener at any temperature within a range of 100° C. to 130° C. is included.
摘要翻译：增稠剂的分散性对于每一批都是不变的，粘度差很小。存在于较厚的墨水随动体中的微小气泡被去除。包括在40℃至130℃范围内的任何温度下均化增稠剂的步骤。优选地，包括在100℃至130℃的任何温度下使增稠剂均化的步骤。

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