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1. 发明授权

US08452417B2 System and method for treating pain with peripheral and spinal neuromodulation 有权
标题翻译：用于治疗周围和脊髓神经调节疼痛的系统和方法
公开(公告)号：US08452417B2
公开(公告)日：2013-05-28
申请号：US12799113
申请日：2010-04-19
申请人： Rosa M. Navarro
发明人： Rosa M. Navarro
IPC分类号： A61N1/0551
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/36071 , A61N1/37235
摘要： A system for treating pain uses spinal cord stimulation and peripheral subcutaneous field stimulation separately or in combination. The system includes an implantable device that is configured to deliver several electrical signals. Several electrical leads are connected to the implantable device. The electrical leads are implanted in the patient such that an electrical signal induces a current to flow between a subcutaneous lumbar region of the patient and a spinal cord region of the patient. The system can also include electrical leads that are implanted in the patient such that an electrical signal induces a current to flow across a lumbar region of the patient. A method for treating leg and back pain is also disclosed.
摘要翻译：用于治疗疼痛的系统分别或组合地使用脊髓刺激和外周皮下场刺激。该系统包括被配置为传送多个电信号的可植入装置。几个电引线连接到可植入装置。将电引线植入患者体内，使得电信号引起电流在患者的皮下腰部区域和患者的脊髓区域之间流动。该系统还可以包括植入患者体内的电引线，使得电信号引起电流流过患者的腰部区域。还公开了一种治疗腿部和背部疼痛的方法。

2. 发明申请

WO2022240580A1 REMOTE TITRATION OF NEUROSTIMULATION THERAPY 审中-公开
公开(公告)号：WO2022240580A1
公开(公告)日：2022-11-17
申请号：PCT/US2022/026311
申请日：2022-04-26
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： MOORE, Lisa Denise , MUSTAKOS, Richard
IPC分类号： A61N1/36 , A61N1/0551 , A61N1/36003 , A61N1/36132 , A61N1/36135 , A61N1/36139 , A61N1/36185 , A61N1/37223 , A61N1/37247
摘要： Systems and methods for creating, maintaining, and remotely modifying stimulation settings for a neuromodulation therapy are discussed. An exemplary system includes an implantable stimulator to provide electrostimulation via a lead comprising a plurality of electrodes, and a programming device. The programing device identifies a search space of electrode configurations and parameter values for the lead, and determines, based on a clinical response indicator under a first patient state, at least one base stimulation setting including an optimal electrode configuration and an optimal stimulation parameter value from the identified search space. The system includes a remotely controlled therapy titration device that can modify the base stimulation setting under a second patient state based on an evaluation of a modified clinical response indicator. The modified base stimulation setting may be stored in the memory, or used by the implantable stimulator to deliver electrostimulation.

3. 发明申请

WO2021127379A1 IMPLANTABLE MEDICAL SYSTEM WITH EXTERNAL POWER CHARGER 审中-公开
公开(公告)号：WO2021127379A1
公开(公告)日：2021-06-24
申请号：PCT/US2020/065920
申请日：2020-12-18
申请人： MEDTRONIC, INC.
发明人： SCHULZETENBERG, Robert M. , GADDAM, Venkat R. , HARPER, Jason H. , OTTESON, Brett
IPC分类号： A61N1/378 , A61N1/372 , A61B5/0015 , A61B5/0031 , A61N1/0551 , A61N1/37223 , A61N1/37235 , A61N1/3787 , H02J50/12 , H02J50/50 , H02J50/80 , H02J7/00032 , H02J7/02 , H04B5/0037 , H04B5/0075
摘要： An implantable medical system includes an implantable medical device and a external charger. The implantable medical device includes a rechargeable power source, electronic components coupled to the rechargeable power source to deliver a therapy to or monitor a parameter of a patient, and a recharge system operably coupled to the rechargeable power source including a secondary coil to receive power via an inductive power transfer. The external charger includes a housing forming an internal compartment, recharger electronic components disposed on a printed circuit board assembly in the internal compartment, and a recharge coil assembly disposed within the internal compartment, the recharge coil assembly including a recharge coil to provide power to the secondary coil via the inductive power transfer and a flux guide having a ferrite sheet disposed between the recharge coil and the printed circuit board assembly.

4. 发明申请

WO2022240579A1 CONFIGURATION OF NEUROSTIMULATION ELECTRODES AND PARAMETERS 审中-公开
公开(公告)号：WO2022240579A1
公开(公告)日：2022-11-17
申请号：PCT/US2022/026306
申请日：2022-04-26
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： MOORE, Lisa Denise , MALEKMOHAMMADI, Mahsa
IPC分类号： A61N1/36 , A61N1/025 , A61N1/0551 , A61N1/36135 , A61N1/36185
摘要： Systems and methods for reducing neurostimulation electrode configuration and parameter search space and controlling electrostimulation are discussed. An exemplary system includes an implantable stimulator to provide electrostimulation via a lead comprising a plurality of electrodes, and a programming device. The programing device receives electrode position information relative to an anatomical region of interest or physiological signals respectively sensed by the plurality of electrodes, and identifies a search space of electrode configurations and parameter values for the lead with respect to the neural target. The programing device can determine a target stimulation setting based on a clinical response to electrostimulation delivered using electrodes and stimulation parameter values from the identified search space, and generate a control signal to the control the implantable stimulator to deliver electrostimulation in accordance with the target stimulation setting.

5. 发明申请

WO2021260435A1 SYSTEMS AND METHODS FOR TARGETED TISSUE TREATMENT 审中-公开
公开(公告)号：WO2021260435A1
公开(公告)日：2021-12-30
申请号：PCT/IB2021/000441
申请日：2021-06-25
申请人： NEURENT MEDICAL LIMITED
发明人： TOWNLEY, David
IPC分类号： A61B18/12 , A61B18/14 , A61B34/35 , A61N1/00 , G06N20/00 , A61B18/1206 , A61B18/1485 , A61B18/1492 , A61B2018/0016 , A61B2018/00267 , A61B2018/00327 , A61B2018/00351 , A61B2018/00434 , A61B2018/00577 , A61B2018/00642 , A61B2018/00648 , A61B2018/00672 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00732 , A61B2018/00755 , A61B2018/00791 , A61B2018/00839 , A61B2018/00875 , A61B2018/00886 , A61B2018/00904 , A61B5/053 , A61N1/0551 , A61N1/36017 , G06N3/02
摘要： The invention generally relates to systems and methods for providing detection, identification, and precision targeting of specific tissue of interest to undergo a therapeutic treatment while minimizing or avoiding collateral damage to surrounding or adjacent non- targeted tissue.

6. 发明申请

WO2021248895A1 一种动物迷走神经刺激系统及其制作方法审中-公开
公开(公告)号：WO2021248895A1
公开(公告)日：2021-12-16
申请号：PCT/CN2020/141951
申请日：2020-12-31
申请人：北京品驰医疗设备有限公司
发明人：许扶 , 郭剑
IPC分类号： A61N1/36 , A61D1/00 , A61N1/0551 , A61N1/0558 , A61N1/36064 , A61N1/36125 , A61N1/375 , A61N1/37518
摘要：一种动物迷走神经刺激系统及其制作方法，该系统包括有轴向开口（113）的柔性圆柱形塑胶管形成的保护管（110），其轴向开口（113）两侧各有一根外科手术缝线（111），向两侧拉拽外科手术缝线（111）可将保护管（110）轴向开口（113）拽开，松开后，保护管（110）轴向开口（113）恢复至原状；两个中空的半环形状金属件的刺激触点（120），内环与迷走神经（200）接触，外环贴合并固定于保护管（110）的内壁上；两根涂层导线（130），其一端穿入刺激触点（120）中空位置并且与刺激触点（120）连接，另一端从保护管（110）轴向中间位置内壁沿径向穿出，穿出的一端与插接件（140）连接。

7. 发明申请

WO2021195958A1 一种重建步态运动功能的双电极电子系统审中-公开
公开(公告)号：WO2021195958A1
公开(公告)日：2021-10-07
申请号：PCT/CN2020/082421
申请日：2020-03-31
申请人：南通大学
发明人：沈晓燕 , 李智玲 , 马磊
IPC分类号： A61N1/36 , A61N1/0551 , A61N1/36062 , A61N1/36067 , A61N1/36125 , A61N1/36128 , A61N1/36132 , A61N1/36139
摘要：一种重建步态运动功能的双电极电子系统，包括指令采集系统、脉冲信号产生系统和两个生物刺激电极及一个参考电极。指令采集系统根据该指令信息生成控制指令并发送给脉冲信号产生系统。脉冲信号产生系统根据控制指令产生脉冲信号发送给生物刺激电极。生物刺激电极对脊髓内诱发步态运动的两个关键位点进行交替地电脉冲激励，激活脊髓神经中产生下肢节律运动的固有中间神经元网络产生协调动作的关键位点。本系统以更接近生理状况的方式有效地进行下肢步态运动功能的重建，并且可应用于动物实验或康复训练。

8. 发明申请

WO2022265620A1 PARESTHESIA-FREE SPINAL CORD STIMULATION OCCURRING AT LOWER FREQUENCIES INVOLVING PERCEPTION THRESHOLD DETERMINATIONS 审中-公开
公开(公告)号：WO2022265620A1
公开(公告)日：2022-12-22
申请号：PCT/US2021/037272
申请日：2021-06-14
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： DOAN, Que, T. , ANNECCHINO, Luca, Antonello
IPC分类号： A61N1/36 , A61N1/05 , A61N1/372 , A61N1/0551 , A61N1/36062 , A61N1/36071 , A61N1/36185 , A61N1/37241 , A61N1/37247
摘要： Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during"sweet spot searching" during which a stimulation location in an electrode array is determined. Preferably, the supra-perception stimulation comprises a bipole formed using actively -driven symmetric biphasic waveforms at active ones of the electrodes in the array. After determining the location, a perception threshold for the bipole at the location is determined and stored, and an amplitude of the stimulation is reduced below the perception threshold to provide a sub-perception stimulation bipole. The determined perception threshold may be transmitted to the patient's remote controller, where it is used to limit amplitude adjustments to the sub-perception bipole by the patient.

9. 发明申请

WO2022031645A1 IMPLANTABLE LEAD MIGRATION MONITORING USING ECAP 审中-公开
公开(公告)号：WO2022031645A1
公开(公告)日：2022-02-10
申请号：PCT/US2021/044262
申请日：2021-08-03
申请人： MEDTRONIC, INC.
发明人： LI, Jiashu , DINSMOOR, David A. , BOURGET, Duane L. , HAGEMAN, Kristin N. , BINK, Hank , PULLIAM, Christopher L.
IPC分类号： A61B5/24 , A61B5/00 , A61N1/05 , A61N1/36 , A61N1/08 , G16H40/63 , A61B5/068 , A61B5/40 , A61B5/6877 , A61B5/6886 , A61B5/746 , A61N1/0551 , A61N1/36125 , A61N1/36135 , A61N1/36139 , A61N1/36142 , A61N1/36171 , A61N1/36175 , A61N1/37235
摘要： Systems, devices, methods, and techniques are described for using evoked compound action potential (ECAP) signals to monitor lead position and/or detect lead migration. An example system includes sensing circuitry configured to sense an ECAP signal, and processing circuitry. The processing circuity controls the sensing circuitry to detect, after delivery of an electrical stimulation pulse, a current ECAP signal, and determines one or more characteristics of the current ECAP signal. The processing circuitry also compares the one or more characteristics of the current ECAP signal to corresponding one or more characteristics of a baseline ECAP signal, and determines, based on the comparison, a migration state of the electrodes delivering the electrical stimulation pulse. Additionally, the processing circuitry outputs, based on the migration state, an alert indicative of migration of the electrodes.

10. 发明申请

WO2021194684A1 GRAPHICAL USER INTERFACE FOR ADJUSTING CURRENT MAGNITUDE IN A STIMULATOR DEVICE 审中-公开
公开(公告)号：WO2021194684A1
公开(公告)日：2021-09-30
申请号：PCT/US2021/019650
申请日：2021-02-25
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： MARNFELDT, Goran, N.
IPC分类号： A61N1/36 , A61N1/372 , A61N1/05 , A61N1/0534 , A61N1/0551 , A61N1/36062 , A61N1/36125 , A61N1/37247
摘要： A Graphical User Interface (GUI) for an external device used to program an implantable stimulator device is disclosed. The GUI includes aspects useful in adjusting the current magnitude provided at one or more of the stimulator device's electrodes. In particular, the GUI includes an amplitude slider, which allows the user to slide an indicator to increase or decrease the current magnitude at different rates depending on the length of the slide. The GUI further allows the user to prescribe drop back functionality, which reduces the current magnitude by a prescribed amount when the indicator is released. In one example, drop back functionality can be engaged in accordance with a rate threshold, and thus drop back functionality will only occur when the rate of increase equals or is above the threshold when the control button is released.

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