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1. 发明申请

WO2021097353A2 VARIABLE DOSING SYRINGE 审中-公开
公开(公告)号：WO2021097353A2
公开(公告)日：2021-05-20
申请号：PCT/US2020/060589
申请日：2020-11-13
申请人： CONGRUENCE MEDICAL SOLUTIONS, LLC
发明人： SHETTY, Gautam Nithyanand , CASTAGNA, Lou
IPC分类号： A61M5/315 , A61M5/32 , A61M5/31 , A61M2005/31508 , A61M2005/3217 , A61M2005/3247 , A61M2005/3267 , A61M2205/581 , A61M5/3146 , A61M5/31511 , A61M5/3153 , A61M5/3155 , A61M5/31551 , A61M5/31556 , A61M5/3156 , A61M5/3157 , A61M5/31573 , A61M5/3158 , A61M5/31591 , A61M5/3216 , A61M5/3234
摘要： A syringe includes a dosage setter operatively coupled to a plunger rod and comprising a rotatable body that comprises a set of one or more stops for engaging the set of one or more protrusions of the plunger rod depending on at least a rotational position of the set of one or more stops relative to the set of one or more protrusions, wherein a first rotational adjustment associated with the dosage setter is configured to set a first dosage increment by adjusting a relative axial position between the rotatable body and the plunger rod, and a second rotational adjustment associated with the dosage setting assembly is configured to set a second dosage increment that is larger than the first dosage increment by adjusting a relative rotational alignment between the set of one or more stops and the set of one or more protrusions.

2. 发明申请

WO2023059577A1 STABILIZER FOR MEDICATION DELIVERY DEVICE 审中-公开
公开(公告)号：WO2023059577A1
公开(公告)日：2023-04-13
申请号：PCT/US2022/045594
申请日：2022-10-04
申请人： ELI LILLY AND COMPANY
发明人： ARNETT, Jaime Ray
IPC分类号： A61M5/315 , A61M2005/2407 , A61M2005/2488 , A61M5/31535 , A61M5/31551 , A61M5/31585
摘要： The present disclosure relates to a medication delivery device including a stabilizing apparatus for effective delivery of a dose of medication without interference with various device components or misapplication of pressure to the device by a user. The stabilizing apparatus couples to the medication delivery device and facilitates proper force delivery to the underlaying medication delivery device.

3. 发明申请

WO2021191326A1 DRUG DELIVERY DEVICE WITH ELECTRONIC SYSTEM 审中-公开
公开(公告)号：WO2021191326A1
公开(公告)日：2021-09-30
申请号：PCT/EP2021/057669
申请日：2021-03-25
申请人： SANOFI
发明人： MORRIS, Anthony, Paul , EARDLEY, Zoë, Georgina , MARSH, William, Geoffrey, Arthur , VEASEY, Robert
IPC分类号： A61M5/315 , A61M5/24 , A61M2205/3561 , A61M5/31551
摘要： The present invention refers to an electronic system (100) for a drug delivery device (1). The electronic system (100) may comprise a dose setting and drive mechanism which is configured to perform a dose setting operation for setting a dose to be delivered by the drug delivery device and a dose delivery operation for delivering the set dose. The dose setting and drive mechanism may comprise a first member (20) and a button module (11), wherein the dose setting and drive mechanism is configured such that, at least in the dose delivery operation and/or in the dose setting operation, the first member moves relative to the button module (11). The electronic system (100) may have at least a first low power consumption state and a second high power consumption state, wherein rotatation and/or axial movement of the button module (11) relative to the first member (20) generates a, preferably axial, movement component of the at least one switch member relative to the button module (11) and the first member (20), which triggers switching between the first low power consumption state and the second high power consumption state.

4. 发明申请

WO2021260161A2 IMPROVEMENTS OF AN OPTICAL SENSING SYSTEM OF A DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：WO2021260161A2
公开(公告)日：2021-12-30
申请号：PCT/EP2021/067443
申请日：2021-06-25
申请人： SANOFI
发明人： MASON, Craig, Ashley , GAZELEY, Oliver, Charles , O'HARE, Aidan, Michael , HOBSON, Matthew, Francis , ALLERDINGS, Alexander
IPC分类号： G01D5/347 , A61M2205/3306 , A61M2205/3317 , A61M2205/3561 , A61M2205/50 , A61M5/24 , A61M5/31551 , G01D5/34723
摘要： Optical guiding means (10) configured for application with a drug delivery device having a movable dosage programming component (12) comprising a rotary encoder system and a sensor arrangement (14) comprising at least one optical sensor (16, 16') configured to detect movement of the movable dosage programming component (12) relative to the sensor arrangement (14) during dosing of a drug by emitting radiation (18, 18') and detecting reflections (20, 20') of the emitted radiation from the rotary encoder system, wherein the optical guiding means (10) are configured for guiding the radiation (18, 18') and reflections (20, 20') of the emitted radiation and comprise at least one light pipe (100, 100') having the shape of a frustum with a sensor-side surface (102, 102') and a encoder-side surface (104,104'). The at least one light pipe comprises one or more of the following features: the ratio of the sensor-side surface (102) and the encoder-side surface (104) being equal to or larger than about 1.0; the ratio of the surface (24) of a discreet encoding target (22) of the rotary encoder system and the encoder-side surface (104) being equal to or larger than 1.0; the encoder-side surface (104) having a roughness with an average feature size in the range of the wavelength of the radiation emitted by the at least one optical sensor (16, 16'); the sensor-side surface forms a single lens face (26) being moulded as part of the optical guiding means (10), wherein the single lens face (26) is formed as collimating optics.

5. 发明申请

WO2021228801A1 INJECTION DEVICE 审中-公开
公开(公告)号：WO2021228801A1
公开(公告)日：2021-11-18
申请号：PCT/EP2021/062401
申请日：2021-05-11
申请人： SANOFI
发明人： RIEDEL, Stephan , ALT, Stefan
IPC分类号： A61M5/315 , A61M5/20 , A61M2005/2006 , A61M2005/202 , A61M2205/33 , A61M2205/50 , A61M2205/581 , A61M2205/8212 , A61M5/31533 , A61M5/31548 , A61M5/31551 , A61M5/31553 , A61M5/31566 , A61M5/31585
摘要： An injection device comprises a housing; an actuation member movable between a first position relative to the housing and a second position relative to the housing, wherein the actuation member is arranged to inhibit a mechanical operation of the injection device when the actuation member is in the first position, but allow the mechanical operation of the injection device when the actuation member is in the second position; electronic circuitry; and an actuation sensing arrangement, wherein the actuation sensing arrangement is configured to detect movement of the actuation member from the first position relative to the housing to the second position relative to the housing, and wherein the electronic circuitry is configured to be activated in response to detection by the actuation sensing arrangement that the actuation member has moved from the first position relative to the housing to the second position relative to the housing.

6. 发明申请

WO2021249962A1 DRUG DELIVERY DEVICE AND METHOD FOR DETERMINING A DOSE 审中-公开
公开(公告)号：WO2021249962A1
公开(公告)日：2021-12-16
申请号：PCT/EP2021/065202
申请日：2021-06-08
申请人： SANOFI
发明人： JUGL, Michael , BLANCKE, Stefan
IPC分类号： A61M5/24 , A61M5/315 , A61M2205/3306 , A61M2205/50 , A61M5/2422 , A61M5/31551
摘要： The present invention refers to a drug delivery device comprising, a dose setting and/or drive mechanism (3) comprising a stationary housing (9) having at least one internal groove (10) on an inner surface; a driver (11) positioned within the housing (9) which is moveable relative to the housing (9) during dose dialing and which is moveable relative to the housing (9) during dose dispensing; and at least one flexible tab (14) that is biased to engage the at least one internal groove (10) such that the at least one flexible tab (14) repeatedly engages and disengages the at least one internal groove (10) during dose dialing or during dose dispensing, thereby performing an oscillating movement between two positions comprising a first position in which the at least one flexible tab (14) engages the at least one internal groove (10) and a second position in which the at least one flexible tab (14) is disengaged from the at least one internal groove (10). Further, the device comprises at least one micro-electro-mechanical system (16, 17, 18) comprising at least one sensor (16, 18) configured and arranged to detect the oscillating movement of the at least one flexible tab (14) during dose dialing or dose dispensing. In addition, the invention refers to a method for determining a dialed or dispensed dose in a drug delivery device.

7. 发明申请

WO2021130216A1 APPARATUS FOR DETECTING A MANIPULATION OF AN INJECTION DEVICE 审中-公开
公开(公告)号：WO2021130216A1
公开(公告)日：2021-07-01
申请号：PCT/EP2020/087610
申请日：2020-12-22
申请人： SANOFI
发明人： BOHLING, Stefan , JUGL, Michael , MUELLER-PATHLE, Stephan
IPC分类号： A61M5/315 , A61M5/24 , A61M2205/332 , A61M2205/50 , A61M2205/581 , A61M2205/8212 , A61M5/31551 , A61M5/31568
摘要： An apparatus configured to be arranged within a housing of an injection device and for detecting a manipulation of the injection device comprises: a cam part that is configured to be rotatable relative to a follower part; a resilient member arranged to urge the parts towards abutment with each other wherein rotation of the cam part relative to the follower part causes reciprocating motion of the follower part, wherein the follower part is configured to move reciprocally in an axial direction of the injection device; and a contact sensor provided between the cam part and the follower part and configured to detect the reciprocating motion of the follower part. The cam part comprises a profiled section comprising an axially varying profile arranged to be in abutment with the follower part and configured to cause reciprocating motion of the follower part, and the contact sensor is arranged on the cam part and is configured to separate from the follower part upon reciprocal movement of the follower part.

8. 发明申请

WO2021255663A1 A DRIVE MECHANISM FOR AN APPLICATOR FOR DELIVERING A DOSE OF MEDICAMENT AND A CORRESPONDING APPLICATOR 审中-公开
公开(公告)号：WO2021255663A1
公开(公告)日：2021-12-23
申请号：PCT/IB2021/055308
申请日：2021-06-16
申请人： NEMERA SZCZECIN SPÓŁKA Z OGRANICZONĄ ODPOWIEDZIALNOŚCIĄ
发明人： WILCZEK, Mateusz , WOITAS, Arkadiusz Łukasz , LOZANO PLATONOFF, Alberto
IPC分类号： A61M5/315 , A61M2005/31518 , A61M5/31541 , A61M5/31551 , A61M5/31585
摘要： A drive mechanism for an applicator for delivering a dose of a medicament, comprising: a dose setting assembly (N), a knob (1), a rotatable and axially non-translatable clutch element (2) coupled in rotation with the knob (1) and cooperating with the dose setting assembly (N), a rotatable piston rod (3) having an external thread (3.2), the piston rod (3) being located inside the clutch element (2), a drive element (4) and a drive spring (5), wherein when a dose is being set (1) by means of the knob (1), the clutch element (2) is rotated so that the drive spring (5) is loaded, while the drive element (4) and the piston rod (3) are immobilized, and when the dose is being delivered, the drive spring (5) is being released causing the drive element (4) to rotate together with the piston rod (3), the piston rod (3) being moved axially in a distal direction, wherein the piston rod (3) is hollow and has an internal thread (3.3) and a shaft (21) having an external thread (21.2) is located within the piston rod (3), the shaft (21) being engaged in rotation with the clutch element (2) so that during the setting of each subsequent dose the shaft (21) is rotated in relation to the piston rod (3) and moved axially in a proximal direction, while during the delivery of the dose the shaft (21) is immobilized in relation to the piston rod (3), and wherein the total translation of the shaft (21) in relation to the piston rod (3) caused by the setting of a defined number of doses is limited by means of blocking elements (B) located respectively on the piston rod and the shaft. An applicator for delivering a dose of a medicament, the applicator comprising the disclosed drive mechanism.

9. 发明申请

WO2021195483A2 IMPROVED SYSTEMS, COMPONENTS, AND COMBINATIONS THEREOF FOR PEN-TYPE INJECTION DEVICES 审中-公开
公开(公告)号：WO2021195483A2
公开(公告)日：2021-09-30
申请号：PCT/US2021/024337
申请日：2021-03-26
申请人： BECTON, DICKINSON AND COMPANY
发明人： QUINN, Michael , CRONENBERG, Richard , BOYER, Robert , GORSHKOV, Alexander
IPC分类号： A61M5/00 , A61M5/20 , A61M5/315 , A61M5/2033 , A61M5/2422 , A61M5/31541 , A61M5/31551 , A61M5/31563 , A61M5/31585
摘要： The disclosure provides driver components, systems and drive methods that facilitate improved dose setting, correcting, and/or dispensing in a multiple use pen-type injection device. In particular, various novel braking systems are disclosed that can be implemented within pen-type injection devices to achieve such improvements.

10. 发明申请

WO2021191324A1 SWITCH ASSEMBLY FOR AN ELECTRONIC SYSTEM OF A DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：WO2021191324A1
公开(公告)日：2021-09-30
申请号：PCT/EP2021/057667
申请日：2021-03-25
申请人： SANOFI
发明人： BERNDORFER, Roman, Immo
IPC分类号： A61M5/24 , A61M5/315 , A61M2205/3317 , A61M2205/3561 , A61M2205/8212 , A61M5/31551 , A61M5/31568 , A61M5/3157
摘要： The present invention refers to a switch assembly (20, 30) for an electronic system of a drug delivery device (1). The switch assembly comprises a chassis (19) supporting a PC BA (110) comprising at least a first electrical contact (23a), a second electrical contact (23b), a third electrical contact (23c) and a fourth electrical contact (23d) and a ring (21) with a ratchet profile (22). The chassis (19) moves axially relative to the ring (21) from a first axial position to a second axial position during a first switch operation mode. The chassis (19) and the ring (21) are configured such that the ring (21) rotates relative to the chassis (19) during a second switch operation mode. The first electrical contact (23a) and the second electrical contact (23b) are arranged such that upon axial movement of the chassis (19) towards the ring (21) during the first switch operation mode an electrical connection between the first electrical contact (23a) and the second electrical contact (23b) is closed. Further, an elastically deformable arm (24) is radially interposed between ratchet profile (22) of the ring (21) and the chassis (19) and is guided on the ratchet profile (22) such that the arm (24) at least during the second switch operation mode elastically deforms in a radial direction towards the chassis (19) thereby alternately opening and closing an electrical connection between the third electrical contact (23c) and the fourth electrical contact (23d) via the arm (24).

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