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    • 3. 发明授权
    • Method for encapsulating reactive dental agents
    • 包封活性牙科剂的方法
    • US06258343B1
    • 2001-07-10
    • US09639287
    • 2000-08-15
    • Alexander P. Kiczek, Sr.Mike Wong
    • Alexander P. Kiczek, Sr.Mike Wong
    • A61K718
    • A61Q11/00A61K8/11A61K2800/412B01J13/04
    • A method for encapsulating a water soluble reactive agent in an alkyl cellulosic polymer to provide an encapsulated product from which leaching of the reactive agent into an aqueous dentifrice containing another compound reactive with the agent is prevented or controlled, said method comprising the steps of (a) uniformly dispersing the reactive agent in the alkyl cellulose and a solvent for the polymer to form a paste; (b) casting the paste onto a sheet forming substrate; (c) grinding and subdividing the sheet having the reactive agent encased therein into particles of a predetermined size; (d) washing the particles with water to remove any encased agent exposed by the grinding; and, (e) drying the particles of encapsulated reactive agent.
    • 一种将水溶性反应剂包封在烷基纤维素聚合物中以提供包封产品的方法,所述方法包括以下步骤:(a)将所述活性剂浸出到含有与所述试剂反应的另一种化合物的水性洁齿剂中, )均匀地分散在烷基纤维素中的反应剂和用于聚合物的溶剂以形成糊状物;(b)将糊料浇铸到片材形成基材上;(c)将其中包含的反应剂的片材研磨和再分成 预定尺寸;(d)用水清洗颗粒以除去通过研磨暴露的任何包裹的试剂; 和(e)干燥包封的反应剂的颗粒。
    • 5. 发明授权
    • Composite toothpaste products
    • 复合牙膏产品
    • US06358494B1
    • 2002-03-19
    • US09381950
    • 1999-12-01
    • Hideki AokiMarehito AokiHidenao Aoki
    • Hideki AokiMarehito AokiHidenao Aoki
    • A61K718
    • A61Q11/00A61K8/21A61K8/24A61K2800/88
    • A composite toothpaste product comprising a toothpaste containing a hydroxyapatite as a main active ingredient and another toothpaste containing a fluorine compound as a main active ingredient, which are enclosed with a container made of, for instance, a flexible tube but separated from each other by a partition united to the container. In the composite toothpaste product, the toothpastes are separated from each other with no contact when it is out of use, and are squeezed out of the container, when in use, in such a manner that the latter toothpaste is enclosed with the former. It is far more effective in removing bacterial plaque, improving tooth whiteness, and preventing dental caries than the conventional toothpaste products containing only either a hydroxyapatite or a fluorine compound.
    • 一种复合牙膏产品,其包含含有羟基磷灰石作为主要活性成分的牙膏和另一种含有氟化合物作为主要活性成分的牙膏,其由例如柔性管制成的容器包围,但是通过 分区联合到容器。 在复合牙膏制品中,牙膏在不使用时彼此分离,无接触,并且在使用时以使后者牙膏与前者密封的方式从容器中挤出。 与仅含有羟基磷灰石或氟化合物的常规牙膏产品相比,除去细菌斑块,改善牙齿白度,防止龋齿更有效。