专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20040091459A1 Bone graft material incorporating demineralized bone matrix and lipids 有权
标题翻译：骨移植材料包含脱钙骨基质和脂质
公开(公告)号：US20040091459A1
公开(公告)日：2004-05-13
申请号：US10413171
申请日：2003-04-11
发明人： Marcel E. Nimni
IPC分类号： A61K035/32
CPC分类号： A61K35/32
摘要： One embodiment of the invention is demineralized bone putty composition comprises: (1) demineralized bone matrix (DBM); and (2) a lipid fraction selected from the group consisting of lecithin and a mixture of lecithin and triglycerides containing unsaturated fatty acids. The putty composition is moldable, biocompatible, slowly resorbable, insoluble in tissue fluids, and non-extrudable. The composition delivers a biologically active product to animals and humans that will enhance bone formation at sites where bone is lost, deficient, or present in suboptimal amounts. The composition can further comprise calcium, an antioxidant such as Vitamin E or Vitamin C, or a hydrophilic polymer such as methylcellulose, a methylcellulose derivative, carboxymethyl cellulose, or hydroxypropyl methylcellulose. A second embodiment of the invention is a demineralized bone paste composition comprising: (1) about 15% to about 75% of an emulsion carrier, such as an aqueous phase; and (2) a bone-material-containing phase comprising: (a) demineralized bone matrix (DBM); and (b) an emulsifier component that is compatible with lipids. This bone paste composition is moldable, biocompatible, slowly resorbable, miscible with bone graft materials, soluble or partially soluble in tissue fluids, and extrudable.
摘要翻译：本发明的一个实施方案是软化骨灰质组合物，包括：（1）软化骨基质（DBM）; 和（2）选自卵磷脂和含有不饱和脂肪酸的卵磷脂和甘油三酯的混合物的脂质部分。腻子组合物是可模塑的，生物相容的，缓慢吸收的，不溶于组织液，不可挤出。该组合物向动物和人类递送生物活性产品，其将在骨丢失，缺陷或以不理想的量存在的部位增强骨形成。该组合物可进一步包含钙，抗氧化剂如维生素E或维生素C，或亲水性聚合物如甲基纤维素，甲基纤维素衍生物，羧甲基纤维素或羟丙基甲基纤维素。本发明的第二个实施方案是一种软化骨糊组合物，其包含：（1）约15％至约75％的乳液载体，例如水相; 和（2）含骨材料的相，包含：（a）软化骨基质（DBM）; 和（b）与脂质相容的乳化剂组分。该骨糊组合物是可模塑的，生物相容的，缓慢吸收的，与骨移植材料混溶，可溶或部分可溶于组织液，并可挤出。

2. 发明申请

US20030228372A1 Antler composition and its manufacturing process 失效
标题翻译：鹿茸成分及其制造工艺
公开(公告)号：US20030228372A1
公开(公告)日：2003-12-11
申请号：US10325746
申请日：2002-12-23
申请人：
发明人： David H. Hsu , Eve Sze-Ju Chen
IPC分类号： A61K035/32 , A61K031/70 , A61K031/198
CPC分类号： A61K35/32 , A61K9/1652 , A61K31/198 , A61K31/70 , A61K2300/00
摘要： An antler composition and its manufacturing process are disclosed, which comprises an antler extract mixture and a matrix which comprises null-cyclodextrin, a higher ester compound, a proteinase inhibitor, and an organic solvent; wherein the weight ratio of the matrix to the antler extract mixture is between 1:1.5 and 1:2.7. The antler composition poses excellent activities and stable properties to be released steadily in human body. The present invention also relates to the antler extract mixture and the process for preparing the antler composition and the antler extract mixture.
摘要翻译：公开了鹿茸组合物及其制造方法，其包括鹿茸提取物混合物和包含β-环糊精，高级酯化合物，蛋白酶抑制剂和有机溶剂的基质; 其中所述基质与鹿茸提取物混合物的重量比在1:1.5至1:2.7之间。鹿角组合物具有优异的活性和稳定的性质，可以在人体内稳定释放。本发明还涉及鹿茸提取物混合物和制备鹿茸组合物和鹿茸提取物混合物的方法。

3. 发明申请

US20030039678A1 Xenograft bone matrix for orthopedic applications 审中-公开
标题翻译：用于骨科应用的异种移植骨基质
公开(公告)号：US20030039678A1
公开(公告)日：2003-02-27
申请号：US10103613
申请日：2002-03-21
发明人： Kevin R. Stone , Thomas J. Turek
IPC分类号： A61K035/32 , C12N005/08
CPC分类号： A61L27/3695 , A01N1/00 , A61F2/2412 , A61F2/28 , A61F2/3094 , A61F2002/2835 , A61F2002/4649 , A61K35/34 , A61L27/3608 , A61L27/365 , A61L27/54 , A61L2300/254
摘要： The invention provides for the use of an improved xenograft bone particulate with respect to osteo-integration and bone remodeling, while diminishing the primate-to-pig immunological response using established bone-processing technique. Work was carried out using undecalcified bone to determine immunocompatibilty and bone remodeling potential of processed porcine bone struts following onlay graft implantation. New bone formation was evident, including the infiltration of cellular materials responsible for fusion and bone reconstruction.
摘要翻译：本发明提供了关于骨整合和骨重建的改进的异种移植骨颗粒的使用，同时使用已建立的骨加工技术减少灵长类动物对猪的免疫应答。使用未硬化的骨进行工作，以确定在植入植入后加工的猪骨支柱的免疫兼容性和骨重塑潜力。新骨形成是明显的，包括负责融合和骨重建的细胞材料的渗透。

4. 发明申请

US20020197242A1 Composition for filling bone defects 有权
标题翻译：用于填充骨缺损的组合物
公开(公告)号：US20020197242A1
公开(公告)日：2002-12-26
申请号：US10222807
申请日：2002-08-19
发明人： Arthur A. Gertzman , Moon Hae Sunwoo
IPC分类号： A61K035/32
CPC分类号： A61L24/0005 , A61F2/28 , A61F2002/30059 , A61F2310/00359 , A61K35/32 , A61K38/1875 , A61L24/0031 , A61L24/0094 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/3847 , A61L27/48 , A61L27/52 , A61L2430/02 , C08L5/08 , A61K2300/00
摘要： The invention is directed toward a formable bone composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of demineralized lyophilized allograft bone particles. The particle size ranges from about 0.1 mm to about 1.0 cm and is mixed in a hydrogel carrier containing a sodium phosphate saline buffer, the hydrogel component of the carrier ranging from about 1.0 to 5.0% of the composition and a pH between 6.8-7.4 with one or more additives of a cellular material, growth factor, demineralized bone chips or mineralized bone chips.
摘要翻译：本发明涉及一种用于骨缺损部位的可成形骨组合物，用于促进在包含新的骨生长诱导的脱矿质冻干同种异体移植骨颗粒化合物的位点处的新骨生长。粒度范围为约0.1mm至约1.0cm，并在含有磷酸钠盐水缓冲液的水凝胶载体中混合，载体的水凝胶组分范围为组合物的约1.0至5.0％，pH为6.8-7.4，pH为6.8-7.4，一种或多种细胞材料，生长因子，软化骨碎片或矿化骨碎屑的添加剂。

5. 发明申请

US20030035843A1 Method for processing and preserving collagen-based tissues for transplantation 失效
标题翻译：用于处理和保存用于移植的胶原基组织的方法
公开(公告)号：US20030035843A1
公开(公告)日：2003-02-20
申请号：US10165790
申请日：2002-06-07
申请人： LifeCell Corporation, a Delaware corporation
发明人： Stephen A. Livesey , Anthony A. del Campo , Abhijit Nag , Ken B. Nichols , Edward S. Griffey , Christopher Coleman
IPC分类号： C12N005/08 , A61K035/34 , A61K035/44 , A61K035/30 , A61K035/32
CPC分类号： A61L27/3683 , A01N1/00 , A01N1/02 , A01N1/0221 , A01N1/0231 , A61K35/18 , A61K39/12 , A61K39/13 , A61L27/3604 , A61L27/3808 , A61L27/3813 , A61L2430/40 , C12N1/04 , C12N2770/32634 , F25C1/142 , F26B5/065
摘要： A method for processing and preserving an acellular collagen-based tissue matrix for transplantation is disclosed. The method includes the steps of processing biological tissues with a stabilizing solution to reduce procurement damage, treatment with a processing solution to remove cells, treatment with a cryoprotectant solution followed by freezing, drying, storage and rehydration under conditions that preclude functionally significant damage and reconstitution with viable cells.
摘要翻译：公开了一种用于处理和保存用于移植的基于无细胞胶原的组织基质的方法。该方法包括用稳定溶液处理生物组织以减少采购损害，用处理溶液处理以除去细胞的处理，用冷冻保护剂溶液处理，然后冷冻，干燥，储存和补液的步骤，在排除功能重大损伤和重建的条件下与活细胞。

6. 发明申请

US20020192263A1 Allograft bone composition having a gelatin binder 有权
标题翻译：具有明胶粘合剂的同种异体移植骨组合物
公开(公告)号：US20020192263A1
公开(公告)日：2002-12-19
申请号：US10150097
申请日：2002-05-20
发明人： Barbara L. Merboth , Moon Hae Sunwoo , Arthur A. Gertzman
IPC分类号： A61K035/32
CPC分类号： A61K35/32 , A61F2002/30059 , A61K6/08 , A61K38/1875 , A61L24/0005 , A61L24/0031 , A61L24/0094 , A61L27/20 , A61L27/222 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L27/3695 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/52 , A61L27/54 , A61L2300/404 , A61L2300/406 , A61L2300/414 , A61L2300/428 , A61L2430/02 , C08L5/08 , A61K2300/00
摘要： The invention is directed toward an osteoimplant for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing composition of demineralized allograft bone material mixed with an aqueous phosphate buffered gelatin which when lyophilized to remove water from the composition cross links the gelatin to form a solid structure.
摘要翻译：本发明涉及一种用于骨缺损部位的骨植入物，以在该部位促进新骨生长，其包括与磷酸盐缓冲明胶水混合的脱矿质同种异体移植骨材料的新的骨生长诱导组合物，当将其冻干以从组合物将明胶交联形成固体结构。

7. 发明申请

US20020155162A1 Modeling viscoelastic torsional properties of osteons 有权
标题翻译：建模骨的粘弹性扭转性质
公开(公告)号：US20020155162A1
公开(公告)日：2002-10-24
申请号：US10066293
申请日：2002-01-31
发明人： Maria-Grazia Ascenzi , John Michael Kabo
IPC分类号： G06G007/48 , G06G007/58 , A61K035/32
CPC分类号： G09B23/30
摘要： The present invention provides a geometric/material computer model of hierarchical bone based upon the viscoelastic properties of longitudinal and alternate osteons. The viscoelastic properties of osteons include, for example, mechanical properties and osteon content of various components such as collagen, mucopolysacharides, hydroxyapatite, osteocytes and osteoblasts. The invention also provides a method for preparing such a model.
摘要翻译：本发明提供了基于纵向和交替骨的粘弹性质的分级骨骼的几何/物质计算机模型。骨的粘弹性质包括例如胶原，粘多糖，羟基磷灰石，骨细胞和成骨细胞等各种成分的机械性能和骨含量。本发明还提供了一种制备这种模型的方法。

8. 发明申请

US20020114845A1 Methods for processing animal tissues 有权
标题翻译：处理动物组织的方法
公开(公告)号：US20020114845A1
公开(公告)日：2002-08-22
申请号：US09941438
申请日：2001-08-28
发明人： Dale P. DeVore , Peter D. Ciarametaro
IPC分类号： A61K035/12 , A61K035/32 , A61K035/36 , A61F013/00
CPC分类号： A61K38/39 , A61K35/32 , A61K35/36
摘要： Described herein are methods for processing and dispersing animal tissues that involve exposing processed (e.g., decellularized) tissue to an acylating agent, wherein the ratio of acylating agent to wet tissue weight is about 0.003:1 or less. The disclosed methods result in a dispersed tissue matrix that has a high degree of resistance to digestion by non-collagenase proteases, such as trypsin. In order to produce sufficiently high yields of these trypsin-resistant compositions, the processed tissue is preferably cryomilled to increase its surface area prior to acylation.
摘要翻译：本文描述了用于处理和分散动物组织的方法，所述动物组织包括将加工（例如，脱细胞化）组织暴露于酰化剂，其中酰化剂与湿纸巾重量的比例为约0.003:1或更低。所公开的方法导致分散的组织基质，其具有高度抗非胶原酶蛋白酶如胰蛋白酶消化的抗性。为了产生足够高的这些胰蛋白酶抗性组合物的产量，处理过的组织优选被冷冻以在酰化之前增加其表面积。

9. 发明申请

US20040101570A1 Animal bone fiber and method of producing the same 审中-公开
标题翻译：动物骨纤维及其制造方法
公开(公告)号：US20040101570A1
公开(公告)日：2004-05-27
申请号：US10304714
申请日：2002-11-26
发明人： Sanai Fujita
IPC分类号： A61K035/32 , B32B005/02
CPC分类号： B01D39/1615 , B01D46/0028 , B01D46/0038 , D01F9/00 , Y10T442/2525
摘要： The bones of animals such as bovines and horses are, for example, boiled, dried sufficiently, melted under heating and made into a fibrous or filamentous form to produce animal bone fiber using animal bones as raw material. These animal bones have various effects such as an alkalinizing effect, antibacterial ability and adsorbing ability. The specific surface area of these animal bones can be increased if they are made into a fibrous or filamentous form and therefore, various effects can be produced more efficiently. Also, these bones can be used for a wider application by utilizing known fiber technologies.
摘要翻译：例如，牛，马等动物的骨头被煮沸，充分干燥，在加热下熔融并制成纤维状或丝状形式，以动物骨为原料生产动物骨纤维。这些动物骨骼具有碱化效果，抗菌能力和吸附能力等各种效果。这些动物骨骼的比表面积如果被制成纤维状或丝状形状则可以增加，因此可以更有效地产生各种效果。此外，这些骨骼可以通过利用已知的纤维技术用于更广泛的应用。

10. 发明申请

US20030190367A1 Oxygen enriched implant for orthopedic wounds and method of packaging and use 审中-公开
标题翻译：用于矫形伤口的富氧植入物以及包装和使用方法
公开(公告)号：US20030190367A1
公开(公告)日：2003-10-09
申请号：US10410418
申请日：2003-04-07
发明人： David Balding
IPC分类号： A61K035/32 , A61K031/685
CPC分类号： A61L27/3608 , A61K31/685 , A61L27/365 , A61L27/3654 , A61L27/3852 , A61L2430/02
摘要： For the repair of injured bone or cartilage, an oxygen enriched material is formed with a high-level (partial pressure) and amount (volume) of dissolved oxygen to support tissue healing. The oxygenated material can be placed in a container having an air valve and pressurized in the container with oxygen to supersaturate the material. The resulting container can be sterilized and transported for use. Immediately prior to use, the valve can be operated to vent the pressure in the container thereby facilitating access to the material. The material can then be applied directly to the hard tissue injury. Absorption of the oxygen to facilitate healing can be enhanced with the use of ultrasonic energy. An oxygen inhibiting film can be placed over the material to direct the oxygen toward the wound.
摘要翻译：对于损伤的骨或软骨的修复，形成富含氧的材料，其具有高水平（分压）和量（体积）的溶解氧以支持组织愈合。氧化材料可以放置在具有空气阀的容器中，并在容器中用氧气加压以使材料过饱和。所得容器可以被灭菌并运输使用。在使用之前，可以操作阀以排出容器中的压力，从而便于进入材料。该材料可以直接应用于硬组织损伤。通过使用超声波能量可以提高吸氧以促进愈合。可以将氧抑制膜放置在材料上以将氧引导到伤口。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式