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1. 发明专利

AU2003215474B2 Use of methylene blue and related compounds to prevent or reverse an exaggerated hemodynamic reation 未知
公开(公告)号：AU2003215474B2
公开(公告)日：2005-10-20
申请号：AU2003215474
申请日：2003-03-28
申请人： INST DE CARDIOLOGIE DE MONTREAL / MONTREAL HEART INSTE
发明人： TANGUAY JEAN-FRANCOIS , JUNEAU MARTIN , BROUILLETTE DENIS
IPC分类号： A61K31/00 , A61K31/519 , A61K31/5415 , A61K45/06 , A61P9/02 , A61P39/02 , A61K031/5415 , A61P039/02 , A61P009/02
摘要： The present invention relates to the use of the dye methylene blue (MB) or a related compound to prevent or reverse an exaggerated hemodynamic reaction in animals in need thereof, including humans. More specifically, the present invention concerns the use of MB or a related compound to prevent or reverse hypotension, unstable angina, myocardial infarction or shock caused by the concomitant ingestion of a phosphodiesterase inhibitor, such as sildenafil citrate, and a NO-donor, such as L-arginine, or an organic nitrate, such as nitroglycerin.

2. 发明专利

AU2002253181B2 Use of selective COX-2 inhibitors for the treatment of urinary incontinence 未知
公开(公告)号：AU2002253181B2
公开(公告)日：2005-02-17
申请号：AU2002253181
申请日：2002-04-05
申请人： RECORDATI CHEM PHARM
发明人： TESTA RODOLFO , GUARNERI LUCIANO , LEONARDI AMEDEO
IPC分类号： C07D231/12 , A61K31/00 , A61K31/18 , A61K31/365 , A61K31/415 , A61K31/4162 , A61K31/42 , A61K31/427 , A61K31/4439 , A61K31/444 , A61K31/5415 , A61P13/00 , A61P13/02 , A61P13/08 , A61P21/00 , C07D261/08 , C07D307/58 , C07D417/12 , C07D495/04 , C12Q1/26 , A61K031/5415 , A61K031/415 , A61K031/365 , A61K031/42 , A61P013/00 , A61K031/444 , A61K031/4439 , A61K031/427 , A61K031/18
摘要： The treatment of neuromuscular dysfunction of the lower urinary tract by compounds which selectively inhibit the COX-2 isozyme is described. The compounds concerned inhibit the COX-2 isozyme with a potency at least 10-fold, and preferably at least 100-fold, greater than their potency on the COX-1 isozyme.

3. 发明专利

AU2001247540B2 Novel benzosultam oxazolidinone antibacterial agents 未知
公开(公告)号：AU2001247540B2
公开(公告)日：2004-08-19
申请号：AU2001247540
申请日：2001-03-27
申请人： UPJOHN CO
发明人： GENIN MICHAEL J , CISKE FRED L
IPC分类号： A61K31/427 , A61K31/428 , A61K31/5415 , A61P17/00 , A61P27/02 , A61P31/00 , A61P31/04 , C07D417/04 , A61P031/04 , A61K031/5415 , A61K031/428
摘要： The present invention provides a compound of formula Iwhich have potent antibacterial activities.

4. 发明申请

US20040248885A1 Use of thiazole derivatives for preparing a medicine for protecting mitochondria 有权
标题翻译：噻唑衍生物用于制备线粒体保护药物的应用
公开(公告)号：US20040248885A1
公开(公告)日：2004-12-09
申请号：US10483823
申请日：2004-01-13
发明人： Michel Auguet , Pierre-Etienne Chabrier De Lassauniere , Jeremiah Harnett
IPC分类号： A61K031/5415 , A61K031/426 , C07D417/02
CPC分类号： A61K31/425 , A61K31/426 , A61K31/427 , A61K31/497 , A61K31/54 , Y10S514/838
摘要： The invention concerns compounds of general formula (I), wherein: A represents one of the radicals in which R5 represents independently a hydrogen atom, or alkyl; R6, R7 and R8 independently represent a hydrogen atom, alkyl, cycloalkyl, hydroxy or alkoxy; R11 represents a hydrogen atom of alkyl; and R9, R10 and R12 independently represent a hydrogen atom, alkyl, hydroxy or alkoxy: B represents a hydrogen atom or alkyl; n represents an integer from 0 to 5; R1 and R2 independently represent a hydrogen atom, alkyl or cycloalkyl; R3 and R4 independently represent a hydrogen atom or an alkyl radical, or R3 and R4 together form with the nitrogen atom which bears them a heterocycle optionally substituted comprising in all 1 to 2 heteroatoms and 5 to 7 members. Said compounds can be used for preparing a medicine for protecting mitochondria, and in particular a medicine for preventing or treating cirrhosis. 1
摘要翻译：本发明涉及通式（I）的化合物，其中：A表示其中R 5独立地表示氢原子或烷基的基团之一; R 6，R 7和R 8独立地表示氢原子，烷基，环烷基，羟基或烷氧基; R 11表示烷基的氢原子; R 9，R 10和R 12独立地表示氢原子，烷基，羟基或烷氧基：B表示氢原子或烷基; n表示0〜5的整数， R 1和R 2独立地表示氢原子，烷基或环烷基; R 3和R 4独立地表示氢原子或烷基，或者R 3和R 4与氮原子一起形成，它们带有任选被取代的杂环，所述杂环任选地被包含在所有1至2个杂原子中， 5至7名成员。所述化合物可用于制备用于保护线粒体的药物，特别是用于预防或治疗肝硬化的药物。

5. 发明申请

US20040247695A1 Light-stabilized $I(in vivo) stain composition and method of manufacture 有权
标题翻译：光稳定的I I（体内）染色组合物和制造方法
公开(公告)号：US20040247695A1
公开(公告)日：2004-12-09
申请号：US10487329
申请日：2004-02-17
发明人： Douglas D Burkett
IPC分类号： A61K031/5415 , A61K033/00
CPC分类号： A61K49/003 , A61K41/0057 , A61K47/02
摘要： Photochemical demethylation reactions in solutions of thiazine dyes, in which the dye molecules act as both sensitizer and substrate, are reduced by quenching triple-state dye molecules, returning them to the unreactive around state.
摘要翻译：染料分子作为敏化剂和底物的噻嗪染料溶液中的光化学去甲基化反应可以通过淬灭三态染料分子而降低，使其回到非反应性状态。

6. 发明申请

US20040191338A1 Administration of capsaicinoids 审中-公开
标题翻译：管理辣椒素
公开(公告)号：US20040191338A1
公开(公告)日：2004-09-30
申请号：US10741194
申请日：2003-12-18
申请人： AlgoRx
发明人： Ronald M. Burch , Richard B. Carter , Jeff Lazar
IPC分类号： A61K035/78 , A61K031/551 , A61K031/5415
CPC分类号： A61K31/165 , A61K31/05 , A61K31/16 , A61K31/167 , A61K31/5415 , A61K31/551 , A61K36/81 , A61K45/06 , C07C231/02 , A61K2300/00 , C07C233/20
摘要： Disclosed in certain embodiments is a method for relieving pain at a site in a human or animal in need thereof, comprising administering by injection or infiltration, a dose of a capsaicinoid and coadministering a tricyclic antidepressant.
摘要翻译：在某些实施方案中公开了一种在有需要的人或动物的部位缓解疼痛的方法，包括通过注射或渗入给予一种剂量的辣椒素并共同施用三环类抗抑郁药。

7. 发明申请

US20040167125A1 Combination of cyamemazine and an atypical neuroleptic 有权
标题翻译： cyamemazine与非典型精神安定药联合使用
公开(公告)号：US20040167125A1
公开(公告)日：2004-08-26
申请号：US10783451
申请日：2004-02-20
申请人： Aventis Pharma S.A.
发明人： Michel Dib , Cyrille Leperlier
IPC分类号： A61K031/5415 , A61K031/519 , A61K031/405
CPC分类号： A61K31/54 , A61K31/55 , A61K31/505 , A61K31/495 , A61K31/445 , A61K2300/00
摘要： The present invention relates to the combination of cyamemazine and an atypical neuroleptic, or a pharmaceutically acceptable salt thereof, and to the use thereof in the treatment of schizophrenia, and in particular of acute episodes of schizophrenia.
摘要翻译：本发明涉及胞嘧啶和非典型精神抑制药物或其药学上可接受的盐的组合，以及其在治疗精神分裂症，特别是精神分裂症急性发作中的用途。

8. 发明申请

US20040157834A1 Somatostatin antagonists and agonists that act at the SST subtype 2 receptor 审中-公开
标题翻译：作用于SST亚型2受体的生长抑素拮抗剂和激动剂
公开(公告)号：US20040157834A1
公开(公告)日：2004-08-12
申请号：US10774668
申请日：2004-02-09
申请人： Pfizer Inc
发明人： Bruce A. Hay , Bridget M. Cole , Anthony P. Ricketts
IPC分类号： A61K031/5415 , A61K031/538 , A61K031/53 , A61K031/495 , A61K031/525 , A61K031/52
CPC分类号： C07K5/06139 , A61K38/00 , C07K5/06191
摘要： Compounds according to the formula A-Z-W as herein described, wherein A is selected from the groups consisting of: Anull-(CH2)nnull, Anull-(CH2)nSO2null, and Anull-(CH2)nCOnull, where n is 0 to 4; and Anull is selected from (a) (C6-C10)aryl-, or (b) (C1-C9)heteroaryl-; which groups may be optionally substituted; and pharmaceutically acceptable salts, solvates or hydrates thereof; pharmaceutical compositions thereof; and methods useful to facilitate secretion of growth hormone(GH) in mammals.
摘要翻译：根据本文所述的式AZW的化合物，其中A选自：A' - （CH 2）n - ，A' - （CH 2）n SO 2 - 和A' - （CH 2）n CO-，其中n 为0〜4; 并且A =选自（a）（C 6 -C 10）芳基 - 或（b）（C 1 -C 9）杂芳基 - ; 哪些基团可以任选被取代; 及其药学上可接受的盐，溶剂合物或水合物; 其药物组合物; 以及有助于哺乳动物分泌生长激素（GH）的方法。

9. 发明申请

US20040152696A1 2-substituted bicyclic benzoheterocyclic compounds and their use as sodium channel blockers 审中-公开
标题翻译： 2-取代的双环苯并杂环化合物及其作为钠通道阻断剂的用途
公开(公告)号：US20040152696A1
公开(公告)日：2004-08-05
申请号：US10628487
申请日：2003-07-29
申请人： Euro-Celtique S.A.
发明人： Qun Sun , Donald J. Kyle , Samuel F. Victory
IPC分类号： A61K031/5415 , A61K031/517 , C07D279/16 , C07D239/72
CPC分类号： C07D239/91 , C07D279/08
摘要： This invention relates to a method of treating disorders responsive to the blockade of sodium ion channels using novel 2-substituted bicyclic benzoheterocyclic compounds of Formula I: 1 or a pharmaceutically-acceptable salt or solvate thereof, wherein X is nullNHnull, nullNnull or nullSnull, Y is oxygen or sulfur, and n, p, R1, R2, R3 and R4 are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global or focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of acute or chronic pain, neuropathic pain or surgical pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
摘要翻译：本发明涉及一种使用新的式I的2-取代双环苯并杂环化合物或其药学上可接受的盐或溶剂合物来治疗对钠离子通道阻断有反应的病症的方法，其中X是-NH-，-N =或 -S-，Y是氧或硫，n，p，R1，R2，R3和R4在说明书中定义。本发明还涉及式I化合物用于治疗全身或局部缺血后神经元损伤，用于治疗或预防神经变性疾病如肌萎缩性侧索硬化（ALS）以及治疗，预防或改善的用途急性或慢性疼痛，神经性疼痛或外科手术疼痛，作为抗惊厥药，抗惊厥药，抗抑郁药，作为局部麻醉剂，作为抗心律失常药物和用于治疗或预防糖尿病性神经病变。

10. 发明申请

US20040126414A1 Methods and compositions for treating and preventing ear infections 审中-公开
标题翻译：治疗和预防耳部感染的方法和组合物
公开(公告)号：US20040126414A1
公开(公告)日：2004-07-01
申请号：US10734338
申请日：2003-12-11
发明人： Arthur F. Michaelis
IPC分类号： A61K031/5415 , A61L015/16
CPC分类号： A61K31/335 , A61K31/33 , A61K31/495 , A61K31/50
摘要： The present invention relates to methods of treating, reducing, or preventing ear infections by topically administering a rifamycin of the invention to the ear of a patient. Infections amenable to treatment according to this invention include, for example, otitis media, otitis externa, or infections arising from surgery.
摘要翻译：本发明涉及通过将本发明的利福霉素局部给予患者的耳朵来治疗，减少或预防耳朵感染的方法。根据本发明治疗的感染包括例如中耳炎，外耳炎或由手术引起的感染。

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