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1. 发明专利

AU2002358602B2 Pharmaceutical composition comprising a 5HT1 receptor agonist 未知
公开(公告)号：AU2002358602B2
公开(公告)日：2005-05-26
申请号：AU2002358602
申请日：2002-12-04
申请人： ASPEN GLOBAL INCOPORATED
发明人： BAKER ROBERT WILLIAM , DOW ALAN DAVID , SUMMERS SIMON JOHN , WESTRUP JULIAN
IPC分类号： A61K9/20 , A61K9/22 , A61K9/28 , A61K9/46 , A61K31/00 , A61K31/40 , A61K31/404 , A61K31/4045 , A61K31/4172 , A61K47/04 , A61K47/38 , A61P25/04 , A61P25/06 , A61P43/00 , A61K009/22 , A61K009/46 , A61K031/00
摘要： The present invention relates to a pharmaceutical composition for oral administration capable of rapid disintegration and dispersion within the gastrointestinal tract comprising sumatriptan or a pharmaceutically acceptable salt or solvate thereof as active ingredient, in particular a composition in solid-dosage form that is intended to be swallowed, and methods of treatment of cephalic pain, especially migraine, using such composition.

2. 发明申请

US20040265380A1 Orodispersible effervescent tablets 审中-公开
标题翻译：分散泡腾片
公开(公告)号：US20040265380A1
公开(公告)日：2004-12-30
申请号：US10475208
申请日：2004-08-30
发明人： Pascal Delmas , Jean-Marc Zuccarelli , Claire Mallard , James W. McGinity
IPC分类号： A61K009/46
CPC分类号： A61K9/0056 , A61K9/0007 , A61K9/1694
摘要： The invention relates to an orodispersible effervescent tablet comprising at least one active ingredient, a mixture of excipients comprising at least one disintegrating agent, a diluting soluble agent, a luficating agent and, optionally, an internal dehydrating agent, a swelling agent, a permeabilizing agent, sweetening agents, flavouring agents and colorants, and effervescent granules based on a mixture which is essentially composed of an acidic agent, a heat extrudable binding agent and an alkaline agent and, optionally, a dehydrating agent and a lubricant, said granules being prepared by means of heat extrusion in the absence of of water and solvents, and said tablet disintegrating in the pharynx when it comes into contact with saliva in at least 60 seconds and preferentially in less than 40 seconds.

3. 发明申请

US20020071809A1 Effervescent drug delivery system for oral administration 有权
公开(公告)号：US20020071809A1
公开(公告)日：2002-06-13
申请号：US10021486
申请日：2001-10-29
发明人： S. Indiran Pather , Joseph R. Robinson , Jonathan D. Eichman , Rajendra K. Khankari , John Hontz , Sangeeta V. Gupte
IPC分类号： A61K009/46
CPC分类号： A61K9/2886 , A61K9/0007 , A61K9/2072 , A61K9/2866 , A61K9/5084 , Y10S514/96
摘要： The pharmaceutical compositions of the present invention comprise orally administerable dosage forms that use effervescence as a penetration enhancer for drugs known, or suspected, of having poor bioavailability. Effervescence can occur in the stomach, once the tablet or other dosage form is ingested. In addition to effervescence in the stomach, or as alternative technique, by the use of appropriate coatings and other techniques, the effervescence can occur in other parts of the gastrointestinal tract, including, but not limited to, the esophagus, duodenum, and colon. The site of effervescence and drug release is chosen to correspond with the segment of the gastrointestinal tract displaying maximal absorption of the formulated drug, or to gain some other therapeutic advantage.

4. 发明申请

US20040180086A1 Gastro-retentive levodopa delivery form 审中-公开
标题翻译：保持性左旋多巴的交付形式
公开(公告)号：US20040180086A1
公开(公告)日：2004-09-16
申请号：US10684058
申请日：2003-10-10
发明人： Zebunnissa Ramtoola , Kenneth I. Cumming , Mary L. Martin
IPC分类号： A61K009/46
CPC分类号： A61K9/0065 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/284 , A61K31/198
摘要： Gastro-retentive dosage forms for prolonged delivery of levodopa and carbidopalevodopa combinations are described. The dosage forms comprise a tablet containing the active ingredient and a gas-generating agent sealed within an expandable, hydrophilic, water-permeable and substantially gas-impermeable membrane. Upon contact with gastric fluid, the membrane expands as a result of the release of gas from the gas-generating agent in the tablet. The expanded membrane is retained in the stomach for a prolonged period of time up to 24 hours or more during which period the active ingredient is released from the tablet providing delivery of levodopa to the site of optimum absorption in the upper small intestine.
摘要翻译：描述了用于延长递送左旋多巴和卡比多巴多组胺的保持性剂型。剂型包含含有活性成分的片剂和密封在可膨胀的，亲水的，水可渗透的和基本上不透气的膜内的气体发生剂。与胃液接触时，由于片剂中气体发生剂的气体释放，膜膨胀。膨胀的膜在胃中保持长达24小时或更长的时间段，在此期间，活性成分从片剂中释放出来，从而提供左旋多巴的输送到上部小肠中最佳吸收的部位。

5. 发明申请

US20030170301A1 Effervescent composition including stevia 有权
标题翻译：泡腾成分包括甜叶菊
公开(公告)号：US20030170301A1
公开(公告)日：2003-09-11
申请号：US10096417
申请日：2002-03-11
发明人： Fred Wehling
IPC分类号： A61K009/46
CPC分类号： A61K9/2068 , A23L2/40 , A23L33/15 , A23L33/175 , A23V2002/00 , A61K9/0007 , Y10S514/96 , A23V2250/262 , A23V2250/642 , A23V2200/222 , A23V2250/032 , A23V2250/708 , A23V2250/0652
摘要： A tablet that includes stevia, water soluble binder, water soluble lubricant, active agent, and effervescent agent.
摘要翻译：包含甜叶菊，水溶性粘合剂，水溶性润滑剂，活性剂和泡腾剂的片剂。

6. 发明申请

US20030138486A1 Methods and dosage forms for improving the bioavailability of therapeutic agents 审中-公开
标题翻译：提高治疗剂生物利用度的方法和剂型
公开(公告)号：US20030138486A1
公开(公告)日：2003-07-24
申请号：US10283520
申请日：2002-10-29
申请人： King Pharmaceuticals Research
发明人： Laure Patricia Njiki Ouadji
IPC分类号： A61K009/46 , A61K009/22 , A61K009/14
CPC分类号： A61K9/0065 , A61K9/485 , A61K9/4858 , A61K9/4866
摘要： The present invention relates to methods and dosage forms for improving the bioavailability of therapeutic agents that are metabolized in the upper gastrointestinal (GI) tract. The present invention improves the bioavailability of by administering such therapeutic agents in a floating dosage form. The floating dosage forms are kept in the stomach for extended periods of time and the therapeutic agents are not immediately released after ingestion. Controlled release of such therapeutic agents from the dosage forms prevents enzyme saturation thereby improving the bioavailability of such therapeutic agents.
摘要翻译：本发明涉及用于改善在上胃肠道（GI）区代谢的治疗剂的生物利用度的方法和剂型。本发明通过以漂浮剂型施用这种治疗剂来改善生物利用度。漂浮剂型在胃中长时间保存，摄取后治疗剂不会立即释放。这些治疗剂从剂型的控制释放防止酶饱和，从而提高这些治疗剂的生物利用度。

7. 发明申请

US20030059435A1 Vaccine composition and method of using the same 有权
标题翻译：疫苗组合物及其使用方法
公开(公告)号：US20030059435A1
公开(公告)日：2003-03-27
申请号：US10167329
申请日：2002-06-10
申请人： Teva Pharmaceutical Industries, Ltd.
发明人： Gilad Gallili , Norbert Frydman
IPC分类号： A61K039/00 , A61K039/12 , A61K009/46
CPC分类号： A61K39/02 , A61K9/0007 , A61K2039/52 , A61K2039/525
摘要： The present invention relates to a stable compacted, compressed or hard tableted injectable composition, including a vaccine composition comprising at least one freeze dried antigenic component and a dissolution aid. A package containing the above injectable composition and method to facilitate immunizing a subject against a disease comprising the steps of first dissolving the compacted, compressed or hard tableted vaccine composition in a package with a diluent to form a vaccine solution, and administering the resulting vaccine solution in an amount effective for immunizing is also provided.
摘要翻译：本发明涉及一种稳定压实，压制或硬片的可注射组合物，其包括含有至少一种冷冻干燥抗原组分和溶解助剂的疫苗组合物。一种包含以上可注射组合物和方法的包装，其包括以下步骤：首先将经压实的，压制的或硬的经压片的或压制的或者经过压片的或者硬的压片的疫苗组合物与稀释剂一起溶解以形成疫苗溶液，并将所得的疫苗溶液还提供了有效免疫的量。

8. 发明申请

US20020090343A1 Expanded perborate salt, use, and method of production 有权
标题翻译：膨胀过硼酸盐，用途和生产方法
公开(公告)号：US20020090343A1
公开(公告)日：2002-07-11
申请号：US09932766
申请日：2001-08-17
申请人： Chemlink Laboratories, LLC
发明人： Ryan Giffin Moore , Hilton G. Dawson , Richard A. DeSenna , Kenneth Scott Wiley
IPC分类号： A61K009/46 , A61L009/04
CPC分类号： A01N25/14 , A01N25/12 , A01N25/34 , A01N59/14 , A61K9/0007 , C11D3/0052 , C11D3/3942 , A01N2300/00
摘要： An effervescent compound is disclosed which includes a liquid ingredient, an effervescent system and optionally a solvent. The solvent may be either hydrophilic or hydrophilic, and may have low solubility with effervescent ingredients. The solvent may include an alcohol, a glycol or a glycol ether, for example, but not limited to, 2-butoxyethanol. The effervescent system used in the effervescent compound may be, for example, but not limited to, an expanded perborate salt, anhydrous, or a mixture of an expanded perborate salt, anhydrous, and oxoborate or an acid and one or more of sodium bicarbonate, sodium carbonate, potassium bicarbonate and potassium carbonate. The effervescent compound may further include any one, or all, or any combination of the following ingredients: surfactants, bleaching compositions, anti-redeposition agents, binders, lubricants, colors, fragrances, corrosion inhibitors, disinfectants, pesticides, fertilizers and/or optical brighteners. Further disclosed is a method of producing the expanded perborate salt, anhydrous. Also disclosed is a method for making an effervescent compound, including the steps of providing a solvent, providing an effervescent system in powder form, and mixing the solvent with the effervescent system, thereby producing a free-flowing effervescent compound. The method disclosed may also include the steps of compressing the effervescent compound, and then forming either granules or a tablet.
摘要翻译：公开了一种泡腾化合物，其包括液体成分，泡腾系统和任选的溶剂。溶剂可以是亲水的或亲水的，并且可以与泡腾成分具有低溶解度。溶剂可以包括醇，二醇或二醇醚，例如但不限于2-丁氧基乙醇。泡腾化合物中使用的泡腾体系可以是例如但不限于膨胀的过硼酸盐，无水或膨胀的过硼酸盐，无水和氧代硼酸盐或酸与碳酸氢钠的一种或多种的混合物，碳酸钠，碳酸氢钾和碳酸钾。泡腾化合物还可包括以下成分中的任何一种或全部或任何组合：表面活性剂，漂白组合物，抗再沉积剂，粘合剂，润滑剂，颜料，香料，腐蚀抑制剂，消毒剂，农药，肥料和/或光学增白剂进一步公开的是制备无水膨胀过的过硼酸盐的方法。还公开了一种制备泡腾化合物的方法，包括以下步骤：提供溶剂，提供粉末形式的泡腾体系，并将溶剂与泡腾体系混合，从而产生自由流动的泡腾化合物。所公开的方法还可以包括压缩泡腾化合物，然后形成颗粒或片剂的步骤。

9. 发明申请

US20020076439A1 Effervescent drug delivery system for oral administration 有权
公开(公告)号：US20020076439A1
公开(公告)日：2002-06-20
申请号：US10021109
申请日：2001-10-29
发明人： S. Indiran Pather , Joseph R. Robinson , Jonathan D. Eichman , Rajendra K. Khankari , John Hontz , Sangeeta V. Gupte
IPC分类号： A61K009/46 , A61K009/28
CPC分类号： A61K9/2886 , A61K9/0007 , A61K9/2072 , A61K9/2866 , A61K9/5084 , Y10S514/96
摘要： The pharmaceutical compositions of the present invention comprise orally administerable dosage forms that use effervescence as a penetration enhancer for drugs known, or suspected, of having poor bioavailability. Effervescence can occur in the stomach, once the tablet or other dosage form is ingested. In addition to effervescence in the stomach, or as alternative technique, by the use of appropriate coatings and other techniques, the effervescence can occur in other parts of the gastrointestinal tract, including, but not limited to, the esophagus, duodenum, and colon. The site of effervescence and drug release is chosen to correspond with the segment of the gastrointestinal tract displaying maximal absorption of the formulated drug, or to gain some other therapeutic advantage.

10. 发明申请

US20010041165A1 Effervescent bisphosphonate formulation 审中-公开
标题翻译：泡腾双膦酸盐配方
公开(公告)号：US20010041165A1
公开(公告)日：2001-11-15
申请号：US09878557
申请日：2001-06-11
申请人： MERCK & CO., Inc.
发明人： Ashok V. Katdare , Colin R. Gardner , Kenneth A. Kramer
IPC分类号： A61K009/46 , A61K031/663
CPC分类号： A61K9/0007 , A61K31/663 , A61K31/675
摘要： An effervescent formulation of alendronate contains an acid source, a carbonate source, a binder, a lubricant and optionally, flavoring agents, colorants and sweeteners.
摘要翻译：阿仑膦酸盐的泡腾制剂含有酸源，碳酸盐源，粘合剂，润滑剂和任选的调味剂，着色剂和甜味剂。

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