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1. 发明公开

EP0191427A3 Hair prosthesis 失效
标题翻译：头发预防
公开(公告)号：EP0191427A3
公开(公告)日：1988-09-21
申请号：EP86101585
申请日：1986-02-07
申请人： SALC di Pellegrino & C. SDF
发明人： Santi, Claudio
IPC分类号： A61F02/10
CPC分类号： A61F2/10

2. 发明申请

WO1994007433A1 DEVICE FOR TRANSPLANTING SMALL DIAMETER HAIR GRAFTS 审中-公开
标题翻译：用于移动小直径头发的装置
公开(公告)号：WO1994007433A1
公开(公告)日：1994-04-14
申请号：PCT/FR1993000955
申请日：1993-09-30
申请人： BOUDJEMA, J., Pascal
IPC分类号： A61F02/10
CPC分类号： A61B10/0283 , A61B17/3417 , A61B17/3468 , A61B2017/00544 , A61B2017/00752 , A61F2/10
摘要： A device for transplanting small diameter hair grafts comprises a hand-held cutting instrument consisting of a body (1) holding the tool, a rotary cylindrical tool (2) and a drive assembly (3) capable of driving the tool in rotation with respect to said body, said tool having a hollow end (6) for cutting a graft. The cylindrical tool is a hollow needle with an axial through bore of the same diameter as the hollow cutting end to which it forms an extension. The device comprises means (8, 14, 38, 39) for taking the graft by sucking it up through the axial bore of the needle.
摘要翻译：用于移植小直径头发移植物的装置包括手持式切割仪器，其由保持工具的主体（1），旋转圆柱形工具（2）和驱动组件（3）组成，该驱动组件能够相对于所述工具具有用于切割移植物的中空端（6）。圆柱形工具是具有与其形成延伸部的中空切割端的直径相同的轴向通孔的中空针。该装置包括用于通过将其从针的轴向孔吸入而将移植物取出的装置（8,14,38,39）。

3. 发明申请

WO1988008286A1 ARTIFICIAL HAIR FILAMENT AND METHOD FOR IMPLANTING SAME 审中-公开
标题翻译：人造毛发及其相关的方法
公开(公告)号：WO1988008286A1
公开(公告)日：1988-11-03
申请号：PCT/US1988001362
申请日：1988-04-25
申请人： KIRSHBAUM, Bernard, A.
IPC分类号： A61F02/10
CPC分类号： A61F2/10
摘要： An artificial hair filament (10) for implanting in living tissue as a replacement for natural hair includes a stem section consisting essentilly of expanded polytetrafluoroethylene having an open microstructure formed of nodes with interconnecting fibrils having a length of from about 50 to about 500 microns, and wherein the filaments (10) include at least one radially extending anchoring member (e.g. 34, 36, 44, 54, 56) adjacent a downstream end thereof. An apparatus (70) in accordance with this invention includes an outer needle and guide member (72) having a lower piercing end (74) for piercing tissue (e.g., 14) as part of a filament implantation procedure, and an inner, stepped driving member (76) movable relative to the needle and guide member (72) for engaging the anchoring member of the filament at different locations for forcing the filament out of the needle and guide member (72). A method of implanting the artificial filament (10) of this invention also forms a part of the present invention.
摘要翻译：用于植入作为天然毛发的替代物的生物组织中的人造毛发细丝（10）包括：茎部，其包含膨胀的聚四氟乙烯，其具有由具有约50至约500微米的长度的互连原纤维的节点形成的开放微结构，以及其中所述细丝（10）包括邻近其下游端的至少一个径向延伸的固定构件（例如34,36,44,54,56）。根据本发明的装置（70）包括外针和引导构件（72），其具有用于刺穿组织（例如14）的下穿刺端（74），作为灯丝注入程序的一部分，以及内部阶梯式驱动构件（76）相对于针和引导构件（72）可移动，用于在不同位置处接合细丝的固定构件，以迫使细丝离开针和引导构件（72）。植入本发明的人造丝（10）的方法也构成本发明的一部分。

4. 发明公开

EP0243132A3 Artificial skin and its production 失效
标题翻译：人造皮及其生产
公开(公告)号：EP0243132A3
公开(公告)日：1987-12-23
申请号：EP87303441
申请日：1987-04-16
申请人： KOKEN CO. LTD.
发明人： Katsutoshi, Yoshizato , Toshio Taira , Teruo, Miyata
IPC分类号： A61F02/10
CPC分类号： A61L27/24 , A61F2/10 , A61F2/105 , A61F2310/00365 , A61L27/36 , A61L27/60 , Y10S623/901
摘要： An artificial skin comprising an insoluble atelocollagen sheet and an epidermal cell layer cultured only on one surface of the sheet, and a method of producing the same are disclosed, which method includes the steps of: forming an insoluble atelocollagen sheet; inoculating epidermal cells only on one surface of the atelocollagen sheet; and suspending the atelocollagen sheet in a liquid culture medium to culture the epidermal cells, thereby forming an epidermal cell layer.

5. 发明公开

EP0186632A3 An artificial implantological hair and a needle for its insertion into the subcutaneous 失效
标题翻译：人造革发型及其插入物的指针
公开(公告)号：EP0186632A3
公开(公告)日：1987-06-24
申请号：EP85830309
申请日：1985-12-18
申请人： C.IT.I.C. S.r.l. Centro Italiano di Implantologia di Capelli Artificiali
发明人： Onorati, Giuseppe , Forte, Mauro
IPC分类号： A61F02/10
CPC分类号： A61B17/3468 , A61F2/10
摘要： The present invention relates to an artificial implantological hair which comprises in a portion thereof a knot self-tying during its sliding movement along the fiber of the artificial hair. The cited knot once tied on the artificial hair fiber has a bulk dimension substantially equal to the diameter dimension of the artificial hair itself, and a lug defining with the end portion of the artificial hair a hooked configuration which cooperates with the knot to retain the artificial hair within the subcutaneous. For inserting the artificial hair into the subcutaneous, a device is provided which cooperates with a body wherein a needle is slidable which has sufficient hardness to penetrate the subcutaneous and high elasticity effective to enable it to move back through the same path opened in the subcutaneous during the introduction of the artificial hair.
摘要翻译：本发明涉及一种人造植入毛发，其在其一部分中包括在沿着人造毛发的纤维的滑动运动期间的结自粘。引用的结一旦被束缚在人造毛发上具有基本上等于人造毛发本身的直径尺寸的体积尺寸，并且具有与人造毛发的端部一起形成的钩状结构，其与结合配合以保持人造毛发本身皮下发。为了将人造毛发插入皮下，提供了与身体相配合的装置，其中针可滑动，其具有足够的硬度以穿透皮下和高弹性，以有效地使其能够通过在皮下开放的相同路径移回引进人造头发。

6. 发明申请

WO1995028896A1 APPARATUS FOR IMPLANTING HAIR ROOTS, AND MEANS FOR PLACING HAIR ROOTS ON AN ASSEMBLING STRIP FOR USE IN THE APPARATUS 审中-公开
标题翻译：用于植入头发的装置，以及用于在装置上使用的组装条上放置头发的装置
公开(公告)号：WO1995028896A1
公开(公告)日：1995-11-02
申请号：PCT/NO1995000067
申请日：1995-04-25
申请人： AASBERG, Olav, L.
IPC分类号： A61F02/10
CPC分类号： A61F2/10 , A61B17/3468 , A61B2017/00752 , A61B2017/00969
摘要： A system for hair transplantation comprises a pistol (13) for rapid shooting of hair grafts (6) into skin from an assembling strip (22) with receptacles (3) which have been loaded beforehand with such hair grafts. The system also comprises a means for placing such grafts (6) in receptacles (3) on the assembling strip (22), and said means includes a frame (32; 36) for a piece of skin (16) which has been surgically cut out, a videocamera (17) for detailed viewing of the skin piece (16) as well as a computer for analysis of the video picture and control of a number of motors (27, 28, 29) for moving and adjusting the assembling strip (22) and drill rod (26) for cutting out grafts (6) from the skin piece (16). The frame (32; 36) also comprises a cooling device for cooling the skin piece (16).
摘要翻译：一种用于毛发移植的系统包括用于从已经预先装载有这种头发移植物的容器（3）的组装带（22）快速地将头发移植物（6）快速射入皮肤的手枪（13）。该系统还包括用于将这种移植物（6）放置在组装条（22）上的容器（3）中的装置，并且所述装置包括用于一片皮肤（16）的框架（32; 36），该框架已被手术切割出来，用于皮肤片（16）的详细观看的视频摄像机（17）以及用于分析视频图像的计算机和用于移动和调整组合条的多个电机（27,28,29）的控制（ 22）和用于从皮肤片（16）切割移植物（6）的钻杆（26）。框架（32; 36）还包括用于冷却皮肤片（16）的冷却装置。

7. 发明申请

WO1992000706A1 TISSUE GRAFTING 审中-公开
标题翻译：组织招
公开(公告)号：WO1992000706A1
公开(公告)日：1992-01-23
申请号：PCT/AU1991000286
申请日：1991-07-03
申请人： BENNETT, David, Mervyn, Pennington
IPC分类号： A61F02/10
CPC分类号： A61B17/3468 , A61F2/10
摘要： A cosmetic procedure for hair transplantation is carried out with an apparatus (50) comprising a magazine (52) with a plurality of compartments (53) each containing a sample of de-epithelialised tissue having at least one hair shaft attached to a hair bulb. The magazine (52) is loaded in an apparatus (50) having a tapered hollow lumen (57) aligned with a pusher rod (56). With the hollow lumen (57) penetrating a recipient graft site to a predetermined depth and the pusher rod (56), the hollow lumen (57) and a compartment (53) in axial alignment, pusher rod (56) moves through compartment (53) and into hollow lumen (57) to deposit a portion of donor tissue in the recipient graft site.
摘要翻译：一种用于毛发移植的美容方法是用包括具有多个隔室（53）的盒子（52）的装置（50）进行的，每个隔室包含附着到毛发上的至少一根毛发的去上皮组织样品。料仓（52）装载在具有与推杆（56）对准的锥形中空管腔（57）的装置（50）中。随着中空管腔（57）穿透接受者移植部位至预定深度，并且推杆（56），中空管腔（57）和轴向对齐的隔室（53）推动杆（56）移动通过隔室（53））并进入中空管腔（57）以将一部分供体组织沉积在接受者移植部位。

8. 发明申请

WO1991016010A1 COMPOSITE LIVING SKIN EQUIVALENTS 审中-公开
标题翻译：复合生活皮肤等效
公开(公告)号：WO1991016010A1
公开(公告)日：1991-10-31
申请号：PCT/AU1991000160
申请日：1991-04-24
申请人： EISENBERG, Mark
IPC分类号： A61F02/10
CPC分类号： A61L27/3804 , A61F2/105 , A61K35/12 , A61L27/24 , A61L27/3813 , A61L27/3891 , A61L27/56 , A61L27/60 , C12N5/0698 , C12N2502/094 , C12N2502/1323 , C12N2503/06 , C12N2533/54 , G01N33/5005 , G01N33/5014 , Y10S128/08
摘要： PCT No. PCT/AU91/00160 Sec. 371 Date Nov. 27, 1991 Sec. 102(e) Date Nov. 27, 1991 PCT Filed Apr. 24, 1991 PCT Pub. No. WO91/16010 PCT Pub. Date Oct. 31, 1991A composite living skin equivalent is described comprising an epidermal layer of cultured keratinocyte cells, a layer of non-porous collagen, and a dermal layer of cultured fibroblast cells in a porous cross-linked collagen sponge matrix. Preferably the non-porous collagen is Type 1, Type 3 or mixtures of Types 1 and 3 bovine collagen, which has been pepsin treated. A process for preparing the skin equivalent is described, as well as a test kit for in vitro testing of the skin equivalent. The skin equivalent has use for skin grafting as well as in vitro testing of the effects of various substances on skin. +RR The questions raised in reexamination request No. 90/003,418, filed Apr. 25, 1994, have been considered and the results thereof are reflected in this reissue patent which constitutes the reexamination certificate required by 35 U.S.C. 307 as provided in 37 CFR 1.570(e).
摘要翻译： PCT No.PCT / AU91 / 00160 Sec。 371日期1991年11月27日 102（e）日期1991年11月27日PCT 1991年4月24日PCT PCT。公开号WO91 / 16010PC 日期1991年10月31日描述了一种复合活体皮肤等效物，其包含培养的角质形成细胞的表皮层，无孔胶原层和培养的成纤维细胞的真皮层，多孔交联胶原海绵基质。优选地，无孔胶原蛋白是已被胃蛋白酶处理的1型，3型或1型和3型牛胶原蛋白的混合物。描述了制备皮肤等效物的方法，以及用于体外测试皮肤当量的测试试剂盒。皮肤等效物可用于皮肤移植以及体外测试各种物质对皮肤的影响。 + RR已经考虑了1994年4月25日提交的第90 / 003,418号复审请求中提出的问题，其结果反映在该重新颁发专利中，该专利构成了35U.S.C.所要求的复审证书。 307如第37 CFR 1.570（e）条所规定。

9. 发明申请

WO1997006750A1 HUMAN KERATINOCYTES SUPPORTED ON A HYDROPHILIC MEMBRANE AND METHODS OF USING SAME TO EFFECT WOUND CLOSURE 审中-公开
标题翻译：在人造膜上支持的人类杀虫剂及其使用方法来影响封闭
公开(公告)号：WO1997006750A1
公开(公告)日：1997-02-27
申请号：PCT/US1996012953
申请日：1996-08-09
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , HANSBROUGH, John, F. , RENNEKAMPFF, Hans, O.
IPC分类号： A61F02/10
CPC分类号： A61F2/105 , A61L27/60 , Y10S514/928
摘要： The present invention provides keratinocytes supported on an unperforated hydrophilic membrane, the composition being useful as a skin graft to effect closure of a wound. The invention further provides a composite skin replacement comprising a keratinocyte-containing hydrophilic membrane and a dermal analog. The invention also provides methods of preparing a keratinocyte-containing membrane and methods of preparing a composite skin replacement suitable for effecting wound closure. In addition, the invention provides methods of effecting closure of wound comprising contacting the wound with a keratinocyte-containing membrane or with a composite skin replacement.
摘要翻译：本发明提供了支撑在未穿孔的亲水膜上的角质形成细胞，该组合物可用作皮肤移植物以实现伤口闭合。本发明还提供了包含含角质细胞的亲水膜和真皮类似物的复合皮肤替代物。本发明还提供了制备含角质形成细胞的膜的方法以及制备适合于伤口闭合的复合皮肤替代物的方法。此外，本发明提供了实现伤口闭合的方法，包括将伤口与含角质形成细胞膜或复合皮肤替代物接触。

10. 发明申请

WO1996003094A1 MEMBRANE FOR REGENERATING BODY TISSUES AND USE OF SAID MEMBRANE AS A WOUND COVERING AND SUBSTITUTE SKIN 审中-公开
标题翻译： REED再生身体组织的芦苇用作伤口和皮肤支付更换
公开(公告)号：WO1996003094A1
公开(公告)日：1996-02-08
申请号：PCT/EP1995002869
申请日：1995-07-20
申请人： W.L. GORE & ASSOCIATES GMBH , BERTHOLDT, Günter
发明人： W.L. GORE & ASSOCIATES GMBH
IPC分类号： A61F02/10
CPC分类号： A61L27/60 , A61F2/105 , A61F13/023 , C12N5/0698 , C12N2502/094 , C12N2502/1323 , C12N2533/30 , C12N2533/40 , C12N2533/70
摘要： The invention concerns a membrane for regenerating body tissues which consists of a biocompatible material and is characterized by the combination of the following features: the membrane thickness ranges from 0.5 to 500 mu m; it is permeable to gases and macromolecules but impermeable to cells; and it has a microstructure in the form of peaks (16) and/or troughs (14).
摘要翻译：膜为生物相容材料的身体组织，其特征在于以下特征的组合的再生：厚度在0.5至500微米的范围内，透气的和大分子，不可渗透的细胞，与此相反，在突起的形式的微结构（16）和/或凹陷（14）。

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