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1. 发明授权

US06784168B1 Biocidal compositions and treatments 有权
标题翻译：杀菌组合物和处理
公开(公告)号：US06784168B1
公开(公告)日：2004-08-31
申请号：US09582152
申请日：2000-09-05
申请人： Christopher Raymond Jones , Robert Eric Talbot
发明人： Christopher Raymond Jones , Robert Eric Talbot
IPC分类号： A01N5726
CPC分类号： C02F1/50 , A01N57/34 , C02F2103/023 , A01N61/00 , A01N47/28 , A01N33/12 , A01N25/30 , A01N2300/00
摘要： A synergistic biocide comprises a tris(hydroxymethyl)phosphine or a tetrakis (hydroxymethyl)phosphonium salt and at least one non-surfactant biopenetrant, such as a polymer or copolymer having a plurality of quaternary ammonium groups, a hydrotrope or a syntan, together optionally with a surfactant.
摘要翻译：协同杀生物剂包括三（羟甲基）膦或四（羟甲基）鏻盐和至少一种非表面活性剂生物渗透剂，例如具有多个季铵基团的聚合物或共聚物，水溶助长剂或合成鞣剂，表面活性剂。

2. 发明授权

US06747017B2 Method of inhibiting hair growth 有权
标题翻译：抑制毛发生长的方法
公开(公告)号：US06747017B2
公开(公告)日：2004-06-08
申请号：US09220691
申请日：1998-12-28
申请人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yoshinori Takema , Yasuto Suzuki , Genji Imokawa
发明人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yoshinori Takema , Yasuto Suzuki , Genji Imokawa
IPC分类号： A01N5726
CPC分类号： A61K8/46 , A61K8/447 , A61K8/55 , A61K2800/782 , A61Q7/02
摘要： Disclosed herein are a method of inhibiting hair growth, which comprises administering an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor, and use of an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor for the preparation of a hair-growth inhibitor.
摘要翻译：本文公开了一种抑制毛发生长的方法，其包括施用弹性蛋白酶样酶或中性内肽酶抑制剂的抑制剂，以及使用弹性蛋白酶样酶抑制剂或中性肽链内切酶抑制剂来制备毛发生长抑制剂。

3. 发明授权

US06613717B1 Phosphoric benzoyl derivatives and their use as herbicides 失效
标题翻译：磷酰苯甲酰衍生物及其作为除草剂的用途
公开(公告)号：US06613717B1
公开(公告)日：2003-09-02
申请号：US09959510
申请日：2001-10-29
申请人： Klaus Langemann , Thorsten Volk , Ernst Baumann , Wolfgang von Deyn , Steffen Kudis , Guido Mayer , Ulf Misslitz , Ulf Neidlein , Matthias Witschel , Martina Otten , Karl-Otto Westphalen , Helmut Walter
发明人： Klaus Langemann , Thorsten Volk , Ernst Baumann , Wolfgang von Deyn , Steffen Kudis , Guido Mayer , Ulf Misslitz , Ulf Neidlein , Matthias Witschel , Martina Otten , Karl-Otto Westphalen , Helmut Walter
IPC分类号： A01N5726
CPC分类号： C07F9/65685 , A01N57/22 , A01N57/24 , C07F9/4021 , C07F9/4025 , C07F9/4419 , C07F9/5325 , C07F9/5329 , C07F9/572 , C07F9/65031 , C07F9/653 , C07F9/657181 , C07F9/65785
摘要： Phosphorus-containing benzoyl derivatives of the formula I where: P(═X)R1R2X is an organic phosphorus radical; R3 is hydrogen, nitro, cyano, halogen, unsub. or sub. alkyl, alkylcarbonyl, alkoxycarbonyl, unsub. or sub. alkoxy, unsub. or sub. alkylthio, unsub. or sub. alkylsulfinyl, unsub. or sub. alkylsulfonyl, unsub. or sub. aminosulfonyl, unsub. or sub. amino, P(═X)R1R2, unsub. or sub. phenyl or unsub. or sub. heterocyclyl; R4 is nitro, cyano, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl or alkylsulfonyl; l is 0, 1 or 2; Q is unsub. or sub. 1-hydroxy-3-oxocyclohex-1-en-2-yl, unsub. or sub. 5-hydroxypyrazol-4-yl, unsub. or sub. isoxazol-4-yl or unsub. or sub. 2-cyano-1-oxoeth-2-yl; and their agriculturally useful salts; processes and intermediates for preparing the phosphorus-containing benzoyl derivatives; compositions comprising them and the use of these derivatives or the compositions comprising them for controlling undesirable plants are described.
摘要翻译：含有式I的苯甲酰基衍生物其中：P（= X）R 1 R 2 X是有机磷基; R 3是氢，硝基，氰基，卤素，未取代的。或子。烷基，烷基羰基，烷氧基羰基，未取代的。或子。烷氧基或子。烷硫基或子。烷基亚磺酰基或子。烷基磺酰基或子氨基磺酰基或子。氨基，P（= X）R 1 R 2，未取代。或子。苯基或未取代的。或子。杂环基; R 4是硝基，氰基，卤素，烷基，烷氧基，烷硫基，烷基亚磺酰基或烷基磺酰基; l是0,1或2; Q是未取代的。或子。 1-羟基-3-氧代环己-1-烯-2-基，或子。 5-羟基吡唑-4-基，或子。异恶唑-4-基或未取代的。或子。 2-氰基-1-氧代乙基-2-基;及其农业上可用的盐;制备含磷苯甲酰基衍生物的方法和中间体; 描述了包含它们的组合物以及这些衍生物或包含它们的组合物用于防治不期望的植物的用途。

4. 发明授权

US06677319B1 Phosphatidylcholine as medication with protective effect large intestinal mucosa 有权
标题翻译：磷脂酰胆碱作为药物具有保护作用的大肠粘膜
公开(公告)号：US06677319B1
公开(公告)日：2004-01-13
申请号：US09762195
申请日：2001-02-05
申请人： Wolfgang Stremmel
发明人： Wolfgang Stremmel
IPC分类号： A01N5726
CPC分类号： A61K31/685
摘要： The presented invention relates to a medication containing a therapeutically effective amount of phosphatidylcholine as active substrate for treatment of disease where phosphatidylcholine has an advantageous, protective effect on the mucosa of large intestine. The invention also relates to the use and application form of phosphatidylcholine for local treatment of inflammation of the large intestine and prophylaxis against cancer of the colon. Phosphatidylcholine can be administered as a rectal installation for local treatment of inflammation (in rectum or pouch) as well as in orally administered delayed-release form. The orally administered, delayed-release form of phosphatidylcholine prevents absorption in upper intestine and thus provides targeted release in the lower sections of the small intestine or colon.
摘要翻译：本发明涉及含有治疗有效量的磷脂酰胆碱作为活性底物的药物，其用于治疗其中磷脂酰胆碱对大肠粘膜具有有利的保护作用的疾病。本发明还涉及用于局部治疗大肠炎症和预防结肠癌的磷脂酰胆碱的用途和应用形式。磷脂酰胆碱可以作为直肠装置施用，用于局部治疗炎症（直肠或小袋）以及口服延迟释放形式。经口给药的延迟释放形式的磷脂酰胆碱可防止上肠吸收，从而在小肠或结肠的下段提供靶向释放。

5. 发明授权

US06541462B1 Sphingomyelin enhancement of tumor therapy 有权
公开(公告)号：US06541462B1
公开(公告)日：2003-04-01
申请号：US09533799
申请日：2000-03-24
申请人： David Modrak
发明人： David Modrak
IPC分类号： A01N5726
CPC分类号： A61K31/704 , A61K31/513 , A61K31/688 , A61K45/06 , A61K2300/00
摘要： Cytotoxic tumor therapy in a patient is enhanced by co-administration of sphingomyelin. The invention most likely enhances a tumor cell's ability to undergo ceramide-induced apoptosis by increasing the levels of sphingomyelin in all cellular compartments, thereby providing sufficient substrate for activated sphingomyelinase. A method of treating rheumatoid arthritis also is provided.

6. 发明授权

US06476006B2 Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates 失效
标题翻译：用于延迟胃释放阿仑膦酸盐和/或其它双膦酸盐的组合物和剂型
公开(公告)号：US06476006B2
公开(公告)日：2002-11-05
申请号：US09770898
申请日：2001-01-26
申请人： Moshe Flashner-Barak , Vered Rosenberger , Mazal Dahan , Yitzhak Lerner
发明人： Moshe Flashner-Barak , Vered Rosenberger , Mazal Dahan , Yitzhak Lerner
IPC分类号： A01N5726
CPC分类号： A61K31/663 , A61K9/2027 , A61K9/205 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/284 , A61K9/286 , A61K9/2866
摘要： The present invention provides compacted pharmaceutical composition for oral administration to a patient which expands upon contact with gastric fluid to retain a dosage form in the patient's stomach for an extended period of time, the formulation comprising a non-hydrated hydrogel, a superdisintegrant and tannic acid. The present invention further provides a pharmaceutical dosage form containing an active ingredient, and the compacted pharmaceutical composition. The invention further provides a dosage form suitable for delivering a therapeutic bis-phosphonate such as alendronate to the stomach of a patient over and extended period.
摘要翻译：本发明提供了一种用于口服给予患者的压制药物组合物，所述药物组合物在与胃液接触时膨胀，以将剂型在患者的胃中长时间保持，该制剂包含非水合水凝胶，超级崩解剂和丹宁酸。本发明还提供含有活性成分和压实的药物组合物的药物剂型。本发明进一步提供了适合于将治疗性双膦酸盐例如阿仑膦酸盐递送至患者胃部并持续延长的剂型。

7. 发明授权

US06337323B2 Chemically stable, insecticidally active phosphoromidothioate pellet compositions and methods for their manufacture 有权
标题翻译：化学稳定的杀虫活性硫代磷酸钠颗粒组合物及其制备方法
公开(公告)号：US06337323B2
公开(公告)日：2002-01-08
申请号：US09259300
申请日：1999-03-01
申请人： Gary L. Cummings , Young-Jin Lee , James L. Platt, Jr. , Matthew Hikade , Vernell Stornes
发明人： Gary L. Cummings , Young-Jin Lee , James L. Platt, Jr. , Matthew Hikade , Vernell Stornes
IPC分类号： A01N5726
CPC分类号： A01N57/28 , A01N25/12 , A01N2300/00
摘要： Chemically stable, insecticidally active pellets having a low moisture content and at least about 95% active ingredient are described, as well as a method for manufacturing them. The active ingredient is selected from a class of N-hydrocarboyl phosphoroamidothioate and phosphoroamidodithioate compounds as described in the specification. The pellets generally have a moisture content of about 0.5% by weight or less, preferably less than about 0.3% by weight. The pellets can be produced by one of two types of processes as described in detail, including a high pressure axial extrusion process and a low pressure basket extrusion process.
摘要翻译：描述了具有低水分含量和至少约95％活性成分的化学稳定的杀虫活性颗粒，以及其制备方法。活性成分选自如说明书中所述的一类N-巯基氨基硫代磷酸酯和氨基二硫代磷酸酯化合物。颗粒通常具有约0.5重量％以下的水分含量，优选小于约0.3重量％。颗粒可以通过如详细描述的两种类型的工艺之一制造，包括高压轴向挤出工艺和低压篮挤出工艺。

8. 发明授权

US06300324B1 Composition for repelling ticks 失效
标题翻译：组合排斥蜱
公开(公告)号：US06300324B1
公开(公告)日：2001-10-09
申请号：US09224794
申请日：1999-01-04
申请人： Scott E. Partelow
发明人： Scott E. Partelow
IPC分类号： A01N5726
CPC分类号： A61K8/97 , A01N57/12 , A01N65/00 , A01N65/20 , A01N65/22 , A01N65/28 , A01N65/44 , A61K8/67 , A61Q17/02 , Y02A50/322 , Y10S424/10 , Y10S514/918 , Y10S514/919 , A01N65/42 , A01N57/20 , A01N49/00
摘要： A composition (10) for repelling ticks and other insects contains a combination of plant extracts (14) in a topical liquid carrier (12). The plant extracts (14) include lavender (26), rosemary (30), thyme (32), aloe vera (28) and eucalyptus (34). The composition can further include one or more vitamins (18) such as Vitamin B1 (36), Vitamin B6 (38), Vitamin B12 (40) and Vitamin C (42). Lecithin (16) may be included as an additional insect repelling component and also to assist dispersion of the various active components in the liquid carrier (12).
摘要翻译：用于排斥蜱和其他昆虫的组合物（10）在局部液体载体（12）中含有植物提取物（14）的组合。植物提取物（14）包括薰衣草（26），迷迭香（30），百里香（32），芦荟（28）和桉树（34）。该组合物还可包含一种或多种维生素（18），例如维生素B1（36），维生素B6（38），维生素B12（40）和维生素C（42）。可以包括卵磷脂（16）作为额外的驱虫组分，并且还有助于各种活性成分在液体载体（12）中的分散。

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