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1. 发明授权

US06441034B1 Insect repellent 失效
标题翻译：驱虫剂
公开(公告)号：US06441034B1
公开(公告)日：2002-08-27
申请号：US09361188
申请日：1999-07-29
申请人： Reynald Roy
发明人： Reynald Roy
IPC分类号： A01N3710
CPC分类号： A01N37/18 , A01N25/24 , A01N25/04 , A01N2300/00
摘要： A crystal clear, transparent insect repellent in gel form contains N,N-diethyl-m-toluamide (DEET), water, a lower alcohol, preferably ethanol, carboxypolymethylene as a gelling agent, triethanolamine for neutralizing the gelling agent, methyl and propyl paraben, a perfume for masking the odor of the DEET, and a polysorbate, preferably polyoxyethylene (20) sorbitan monolaurate for improving the texture of the gel.
摘要翻译：透明的透明驱虫剂，其凝胶形式含有N，N-二乙基 - 间甲苯甲酰胺（DEET），水，低级醇，优选乙醇，羧基聚亚甲基作为胶凝剂，用于中和胶凝剂的三乙醇胺，对羟基苯甲酸甲酯和丙酯，用于掩蔽DEET的气味的香料，以及聚山梨醇酯，优选聚氧乙烯（20）脱水山梨糖醇单月桂酸酯，用于改善凝胶的质地。

2. 发明授权

US06342525B1 Benzenoid derivatives of 15-hydroxyeicosatetraenoic acid and methods of their use in treating dry eye disorders 失效
标题翻译： 15-羟基二十碳四烯酸的苯并衍生物及其用于治疗干眼症的方法
公开(公告)号：US06342525B1
公开(公告)日：2002-01-29
申请号：US09694614
申请日：2000-10-23
申请人： Peter G. Klimko , David R. Pierce
发明人： Peter G. Klimko , David R. Pierce
IPC分类号： A01N3710
CPC分类号： C07C59/48 , C07C51/09 , C07C51/367
摘要： Benzenoid HETE derivatives and methods of their use for treating dry eye are disclosed.
摘要翻译：公开了苯乙烯HETE衍生物及其用于治疗干眼症的方法

3. 发明授权

US06316500B1 Aliphatically unsaturated hydroxy benzoates and preservative compositions thereof 失效
标题翻译：脂肪族不饱和羟基苯甲酸酯及其防腐剂组合物
公开(公告)号：US06316500B1
公开(公告)日：2001-11-13
申请号：US09225629
申请日：1999-01-05
申请人： Todd Elder , John J. Merianos
发明人： Todd Elder , John J. Merianos
IPC分类号： A01N3710
CPC分类号： A01N37/40 , C07C69/88
摘要： The hydroxybenzoate compounds of this invention are defined by the formula: wherein Y is hydrogen, hydroxy, halo, a C1 to C6 alkyl or a C2 to C6 alkyl ether; R is a C4 to C6 mono- or di-olefinically unsaturated hydrocarbon radical, a C4 to C7 mono- or di-acetylenically unsaturated hydrocarbon radical or a C2 to C3 acetylenically unsaturated hydrocarbon radical when at least one of X and Y is other than hydrogen and X is hydrogen, hydroxy, halo, a C1 to C6 alkyl, a C2 to C6 alkyl ether or in which A is selected from the group of X, B is selected from the group of Y and R1 is hydrogen, hydroxy, C1 to C6 alkyl, C1 to C6 alkoxy or —COOR2 in which R2 is C1 to C6 alkyl, a C2 to C6 olefinically unsaturated hydrocarbon radical or a C2 to C7 acetylenically unsaturated hydrocarbon radical. The invention also pertains to food, beverage, cosmetic, agrichemical and topically applied pharmaceutical compositions containing an effective preservative amount of the hydroxy aliphatically unsaturated benzoate having the formula: wherein X′ is selected from the group of X; Y′ is selected from the group of Y and R4 is a C2 to C6 mono- or di-olefinically unsaturated hydrocarbon radical or a C2 to C7 mono- or di-acetylenically unsaturated hydrocarbon radical.
摘要翻译：本发明的羟基苯甲酸酯化合物由下式定义：其中Y为氢，羟基，卤素，C 1至C 6烷基或C 2至C 6烷基醚; R为C 4至C 6单或二烯属不饱和烃基，当X和Y中的至少一个不是氢而X是氢，羟基，卤素，C 1至C 6烷基，C 2至C 6烷基时，C 4至C 7单 - 或二 - 炔属不饱和烃基或C 2至C 3炔基不饱和烃基至C 6烷基醚或其中A选自X，B选自Y和R 1是氢，羟基，C 1至C 6烷基，C 1至C 6烷氧基或-COOR 2，其中R 2是C 1至C 6烷基 C2至C6烯属不饱和烃基或C2至C7炔属不饱和烃基。本发明还涉及含有有效防腐剂量的羟基不饱和苯甲酸酯的食品，饮料，化妆品，农药和局部应用的药物组合物具有下式：其中X'选自X; Y'选自Y和R4是C2-C6单或二烯属不饱和烃基或C2-C7单或二炔属不饱和烃基。

4. 发明授权

US06274626B1 Pheniramine-containing compositions and method for treating allergic responses 失效
标题翻译：含苯胺的组合物和治疗过敏反应的方法
公开(公告)号：US06274626B1
公开(公告)日：2001-08-14
申请号：US09219165
申请日：1998-12-22
申请人： Matthew S. Jonasse , Richard V. Smerbeck
发明人： Matthew S. Jonasse , Richard V. Smerbeck
IPC分类号： A01N3710
CPC分类号： A61K31/137 , A61K9/0048 , A61K31/79 , A61K47/32 , A61K31/44 , A61K2300/00
摘要： This invention relates to compositions comprising pheniramine. In particular, it has been found that pheniramine in combination with n effective amount of a povidone provides improved comfort and reduces the symptoms of dryness compared to compositions with pheniramine alone.
摘要翻译：本发明涉及包含苯吡胺的组合物。特别地，已经发现，与单独使用苯胺的组合物相比，苯胺与n有效量的聚维酮组合提供了改进的舒适性并且减少了干燥症状。

5. 发明授权

US06495596B1 Compounds and methods for inhibition of phospholipase A2 and cyclooxygenase-2 失效
标题翻译：抑制磷脂酶A2和环氧合酶-2的化合物和方法
公开(公告)号：US06495596B1
公开(公告)日：2002-12-17
申请号：US09877334
申请日：2001-06-07
申请人： Brian Keller
发明人： Brian Keller
IPC分类号： A01N3710
CPC分类号： C08G65/3322 , A23L33/115 , A61K31/23 , C07C69/30 , Y10S514/825 , Y10S514/886 , Y10S514/944 , Y10S514/962 , Y10S977/926
摘要： The present invention comprises a group of related lipid molecules, and methods for their use, that maybe used to treat inflammation and certain inflammation related diseases. The group of related lipid molecules are capable of inhibiting certain enzyme systems including phospholipase A2, and cyclooxygenase-2. The group of related lipid molecules of the invention may be characterized by specific structural characteristics, or by specific biological activity, including inhibition of the previously listed enzymes.
摘要翻译：本发明包括一组相关的脂质分子及其使用的方法，其可用于治疗炎症和某些炎症相关疾病。该组相关脂质分子能够抑制某些酶系统，包括磷脂酶A2和环氧合酶-2。本发明的相关脂质分子组可以通过特定的结构特征或特定的生物学活性来表征，包括先前列出的酶的抑制。

6. 发明授权

US06482855B2 Diamine alkylene diacetic or triacetic acid derivatives, preparation method, use in cosmetic and pharmaceutical compositions and compositions containing them 失效
标题翻译：二亚烷基二乙酸或三乙酸衍生物，制备方法，用于化妆品和药物组合物以及含有它们的组合物
公开(公告)号：US06482855B2
公开(公告)日：2002-11-19
申请号：US09779737
申请日：2001-02-09
申请人： Jean-Baptiste Galey , Jacqueline Dumats
发明人： Jean-Baptiste Galey , Jacqueline Dumats
IPC分类号： A01N3710
CPC分类号： A61K8/44 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C07C229/16 , C07C235/06
摘要： Novel alkylenediaminediacetic acid or alkylenediaminetriacetic derivatives of formula (I): or an organic or inorganic salt thereof, their process of preparation, and their use in cosmetic and pharmaceutical compositions, such as for protecting the body against oxidative stress are discussed.
摘要翻译：讨论式（I）的新型亚烷基二胺二乙酸或亚烷基二胺三乙酸衍生物：或其有机或无机盐，其制备方法及其在化妆品和药物组合物中的用途，例如用于保护身体免受氧化应激。

7. 发明授权

US06429173B1 Defloration agent for apple trees 失效
标题翻译：苹果树的脱色剂
公开(公告)号：US06429173B1
公开(公告)日：2002-08-06
申请号：US09721648
申请日：2000-11-27
申请人： Seigo Koura , Takashi Nakayama , Kiyoshi Yokota
发明人： Seigo Koura , Takashi Nakayama , Kiyoshi Yokota
IPC分类号： A01N3710
CPC分类号： A01N57/20 , A01N39/02 , A01N2300/00
摘要： The present invention relates to a defloration agent for apple trees. The present defloration agent comprises 3-(2-methyl-4-chlorophenoxy)butyric acid (MCPB) or an ester thereof and 2-chloroethylphosphonic acid (ethephon). The present invention provides an excellent defloration effect even when the temperature is low in the blossoming season.
摘要翻译：本发明涉及一种苹果树的脱色剂。本发明的脱色剂包括3-（2-甲基-4-氯苯氧基）丁酸（MCPB）或其酯和2-氯乙基膦酸（乙烯利）。即使在开花季节的温度低的情况下，本发明也提供了优异的脱色效果。

8. 发明授权

US06235782B1 Method for treating a patient with neoplasia by treatment with a platinum coordination complex 失效
标题翻译：用铂配位复合物治疗患有瘤形成的患者的方法
公开(公告)号：US06235782B1
公开(公告)日：2001-05-22
申请号：US09190830
申请日：1998-11-12
申请人： Rifat Pamukcu , Kerstin B. Menander
发明人： Rifat Pamukcu , Kerstin B. Menander
IPC分类号： A01N3710
CPC分类号： A61K31/28 , A61K33/24 , A61K45/06 , A61K31/19 , A61K2300/00
摘要： This invention provides a method for treating a patient with neoplasia by an adjuvant therapy that includes treatment with an antineoplastic platinum coordination complex.
摘要翻译：本发明提供了一种通过包括用抗肿瘤性铂配位复合物治疗的辅助治疗来治疗瘤形成患者的方法。

9. 发明授权

US06218432B1 Diamine alkylene diacetic or triacetic acid derivatives, preparation method, use in cosmetic and pharmaceutical compositions and compositions containing them 失效
标题翻译：二亚烷基二乙酸或三乙酸衍生物，制备方法，用于化妆品和药物组合物以及含有它们的组合物
公开(公告)号：US06218432B1
公开(公告)日：2001-04-17
申请号：US09297748
申请日：1999-07-14
申请人： Jean-Baptiste Galey , Jacqueline Dumats
发明人： Jean-Baptiste Galey , Jacqueline Dumats
IPC分类号： A01N3710
CPC分类号： A61K8/44 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C07C229/16 , C07C235/06
摘要： Novel alkylenediaminediacetic acid or alkylenediaminetriacetic derivatives of formula (I): or an organic or inorganic salt thereof, their process of preparation, and their use in cosmetic and pharmaceutical compositions, such as for protecting the body against oxidative stress are discussed.
摘要翻译：讨论式（I）的新型亚烷基二胺二乙酸或亚烷基二胺三乙酸衍生物：或其有机或无机盐，其制备方法及其在化妆品和药物组合物中的用途，例如用于保护身体免受氧化应激。

10. 发明授权

US06172115B2 Method for preventing onset of restenosis after angioplasty employing an RXR-specific retinoid 失效
标题翻译：在使用RXR特异性类视黄醇的血管成形术后预防再狭窄发作的方法
公开(公告)号：US06172115B2
公开(公告)日：2001-01-09
申请号：US09005897
申请日：1998-01-12
申请人： Roshantha A. Chandraratna
发明人： Roshantha A. Chandraratna
IPC分类号： A01N3710
CPC分类号： A61K31/34 , A61K31/19 , A61K31/38
摘要： A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering a retinoid, such as an RXR-selective retinoid, e.g. the compound of the formula: and pharmaceutically acceptable salts and esters and amides thereof.
摘要翻译：提供了一种通过施用类视黄醇（例如RXR-选择性类维生素A，例如紫杉醇）来预防或降低血管成形术后再狭窄的风险的方法。下式的化合物及其药学上可接受的盐和酯和酰胺。

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