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1. 发明授权

US5766579A Composition and method for treatment of dermatitis on the scalp 失效
公开(公告)号：US5766579A
公开(公告)日：1998-06-16
申请号：US778964
申请日：1997-01-06
申请人： R. Martin Earles
发明人： R. Martin Earles
IPC分类号： A61K8/23 , A61K8/31 , A61K8/34 , A61K8/63 , A61K8/81 , A61Q5/00 , A61Q19/00 , A61K7/06
CPC分类号： A61Q19/00 , A61K31/573 , A61K33/04 , A61K47/32 , A61K8/23 , A61K8/31 , A61K8/345 , A61K8/63 , A61K8/8147 , A61K9/0014 , A61Q5/00 , Y10S514/804 , Y10S514/864 , Y10S514/88 , Y10S514/944
摘要： The invention provides a composition for treating seborrheic dermatitis on the scalp, a method for treating seborrheic dermatitis and a method for making the composition of the invention. The composition of the invention, which is not a shampoo and does not contain any soap or detergent for cleaning hair, is a unique scalp medicament blend of ingredients. The composition comprises from about 0.5 to about 2.5 weight percent, based upon the weight of the composition, hydrocortisone; from about 2.5 to about 7.5 weight percent elemental sulfur; and from about 90 to about 97 weight percent of an active vehicle comprising a generally neutral hydrocarbon jelly, such as petrolatum or petroleum jelly, and gelled aqueous carboxypolymethylene.

2. 发明授权

US06180120B2 Cosmetic skin care compositions containing alpha hydroxy acids linoleates 失效
标题翻译：含有α-羟基酸亚油酸酯的美容护肤组合物
公开(公告)号：US06180120B2
公开(公告)日：2001-01-30
申请号：US09206881
申请日：1998-12-08
申请人： Joseph Michael Corey , Victor DeFlorio , Anthony Vargas , Stewart Paton Granger
发明人： Joseph Michael Corey , Victor DeFlorio , Anthony Vargas , Stewart Paton Granger
IPC分类号： A61K600
CPC分类号： A61Q19/00 , A61K8/37 , A61K8/67 , A61Q19/008 , A61Q19/08 , Y10S514/804
摘要： Cosmetic skin care compositions containing alpha hydroxy acid linoleates. The inventive compositions provide, improved oil control and improved skin feel, and/or anti-aging benefits.
摘要翻译：含有α-羟基酸亚油酸酯的美容护肤组合物。本发明的组合物提供改善的油控制和改善的皮肤感觉和/或抗衰老的益处。

3. 发明授权

US4327081A Method of enhancing absorption of antitumor agent into gastro-intestinal tumor site and orally administrable antitumor compositions therefor 失效
标题翻译：增强胃肠道肿瘤部位抗肿瘤剂吸收的方法及口服抗肿瘤药物组合物
公开(公告)号：US4327081A
公开(公告)日：1982-04-27
申请号：US88527
申请日：1979-10-26
申请人： Akira Matsuda , Osamu Yoshioka , Katsutoshi Takahashi , Kooichi Yoshida , Hiroshi Ninomiya
发明人： Akira Matsuda , Osamu Yoshioka , Katsutoshi Takahashi , Kooichi Yoshida , Hiroshi Ninomiya
IPC分类号： A61K31/505 , A61K38/14 , A61K47/32 , A61K31/78
CPC分类号： A61K31/505 , A61K38/14 , A61K47/32 , Y10S514/804
摘要： This invention relates to a method for selectively enhancing absorption of 5-fluorouracil, bleomycins or bleomycin derivatives into the gastrointestinal tumor site by orally administering such substance together with an alkali metal salt of polyacrylic acid, and an orally administrable antitumor composition used for such method.
摘要翻译：本发明涉及通过将这种物质与聚丙烯酸的碱金属盐一起口服给药，以及用于该方法的口服给药的抗肿瘤剂组合物，选择性地增强5-氟尿嘧啶，博来霉素或博来霉素衍生物对胃肠道肿瘤部位的吸收的方法。

4. 发明授权

US5958391A Composition and method for treatment of dermatitis on the scalp 失效
标题翻译：用于头皮治疗皮炎的组合物和方法
公开(公告)号：US5958391A
公开(公告)日：1999-09-28
申请号：US96768
申请日：1998-06-12
申请人： R. Martin Earles
发明人： R. Martin Earles
IPC分类号： A61K8/23 , A61K8/31 , A61K8/34 , A61K8/63 , A61K8/81 , A61Q5/00 , A61Q19/00 , A61K7/06
CPC分类号： A61Q19/00 , A61K31/573 , A61K33/04 , A61K47/32 , A61K8/23 , A61K8/31 , A61K8/345 , A61K8/63 , A61K8/8147 , A61K9/0014 , A61Q5/00 , Y10S514/804 , Y10S514/864 , Y10S514/88 , Y10S514/944
摘要： The invention provides a composition for treating seborrheic dermatitis on the scalp, a method for treating seborrheic dermatitis and a method for making the composition of the invention. The composition of the invention, which is not a shampoo and does not contain any soap or detergent for cleaning hair, is a unique scalp medicament blend of ingredients. The composition comprises from about 0.5 to about 2.5 weight percent, based upon the weight of the composition, hydrocortisone; from about 2.5 to about 7.5 weight percent elemental sulfur; and from about 90 to about 97 weight percent of an active vehicle comprising a generally neutral hydrocarbon jelly, such as petrolatum or petroleum jelly, and gelled aqueous carboxypolymethylene.
摘要翻译：本发明提供一种用于治疗头皮脂溢性皮炎的组合物，治疗脂溢性皮炎的方法和制备本发明组合物的方法。不是洗发剂并且不含任何用于清洁头发的肥皂或洗涤剂的本发明的组合物是成分的独特的头皮药物混合物。基于组合物的重量，组合物包含约0.5至约2.5重量％的氢化可的松; 约2.5至约7.5重量％的元素硫; 和约90-约97重量％的活性载体，其包含通常为中性的软体果冻，如凡士林或凡士林，以及凝胶化的羧基聚亚甲基水。

5. 发明授权

US5632975A Composition and method for treatment of dermatitis on the scalp 失效
标题翻译：用于头皮治疗皮炎的组合物和方法
公开(公告)号：US5632975A
公开(公告)日：1997-05-27
申请号：US401346
申请日：1995-03-09
申请人： R. Martin Earles
发明人： R. Martin Earles
IPC分类号： A61K8/23 , A61K8/31 , A61K8/34 , A61K8/63 , A61K8/81 , A61Q5/00 , A61Q19/00 , A61K7/06
CPC分类号： A61Q19/00 , A61K31/573 , A61K33/04 , A61K47/32 , A61K8/23 , A61K8/31 , A61K8/345 , A61K8/63 , A61K8/8147 , A61K9/0014 , A61Q5/00 , Y10S514/804 , Y10S514/864 , Y10S514/88 , Y10S514/944
摘要： The invention provides a composition for treating seborrheic dermatitis on the scalp, a method for treating seborrheic dermatitis and a method for making the composition of the invention. The composition of the invention, which is not a shampoo and does not contain any soap or detergent for cleaning hair, is a unique scalp medicament blend of ingredients. The composition comprises from about 0.5 to about 2.5 weight percent, based upon the weight of the composition, hydrocortisone; from about 2.5 to about 7.5 weight percent elemental sulfur; and from about 90 to about 97 weight percent of an active vehicle comprising a generally neutral hydrocarbon jelly, such as petrolatum or petroleum jelly, and gelled aqueous carboxypolymethylene.
摘要翻译：本发明提供一种用于治疗头皮脂溢性皮炎的组合物，治疗脂溢性皮炎的方法和制备本发明组合物的方法。不是洗发剂并且不含任何用于清洁头发的肥皂或洗涤剂的本发明的组合物是成分的独特的头皮药物混合物。基于组合物的重量，组合物包含约0.5至约2.5重量％的氢化可的松; 约2.5至约7.5重量％的元素硫; 和约90-约97重量％的活性载体，其包含通常为中性的软体果冻，如凡士林或凡士林，以及凝胶化的羧基聚亚甲基水。

6. 发明授权

US4273761A Method of enhancing absorption of antitumor agent into gastrointestinal tumor site and orally administrable antitumor compositions therefor 失效
标题翻译：增强抗肿瘤剂吸收胃肠道肿瘤部位和口服给药抗肿瘤组合物的方法
公开(公告)号：US4273761A
公开(公告)日：1981-06-16
申请号：US894844
申请日：1978-04-10
申请人： Akira Matsuda , Osamu Yoshioka , Katsutoshi Takahashi , Kooichi Yoshida , Hiroshi Ninomiya
发明人： Akira Matsuda , Osamu Yoshioka , Katsutoshi Takahashi , Kooichi Yoshida , Hiroshi Ninomiya
IPC分类号： A61K31/505 , A61K38/14 , A61K47/32 , A61K31/78
CPC分类号： A61K31/505 , A61K38/14 , A61K47/32 , Y10S514/804
摘要： This invention relates to a method for selectively enhancing absorption of 5-fluorouracil, bleomycins or bleomycin derivatives into the gastrointestinal tumor site by orally administering such substance together with an alkali metal salt of polyacrylic acid, and an orally administable antitumor composition used for such method.
摘要翻译：本发明涉及通过将这种物质与聚丙烯酸的碱金属盐一起口服给药，选择性地增强5-氟尿嘧啶，博来霉素或博来霉素衍生物吸收到胃肠道肿瘤部位的方法，以及用于该方法的口服抗肿瘤药物。

7. 发明授权

US4180576A Purines useful for the potentiation of antibiotics 失效
标题翻译：用于增强抗生素的嘌呤
公开(公告)号：US4180576A
公开(公告)日：1979-12-25
申请号：US828875
申请日：1977-08-29
申请人： Geoffrey W. Grigg , Desmond J. Brown
发明人： Geoffrey W. Grigg , Desmond J. Brown
IPC分类号： C07D473/36 , A61K31/505 , A61K31/52
CPC分类号： C07D473/36 , Y10S514/804
摘要： Purines useful for the potentiation of antibiotics, particularly phleomycin and bleomycin, have the general formula: ##STR1## wherein W is selected from the group consisting of --SRCONR.sup.1 R.sup.2, --SRCN, and --SRCOR.sup.1, in which R is a --(CH.sub.2).sub.n -- group (n is an integer of 1 to 5) which may bear one or more side chain alkyl groups each having from 1 to 5 carbon atoms, and R.sup.1 and R.sup.2, which may be the same or different, are selected from hydrogen atoms and straight or branched chain alkyl groups having from 1 to 5 carbon atoms, or alternatively, R.sup.1 and R.sup.2 together comprise a polymethylene, oxapolymethylene or thiapolymethylene chain containing from 4 to 10 carbon atoms;R.sup.3, R.sup.4, R.sup.5 and R.sup.6, which may be the same or different, are selected from hydrogen atoms and straight or branched chain alkyl groups having from 1 to 5 carbon atoms; and R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 may be substituted by one or more non-toxic substituents.
摘要翻译：用于增强抗生素，特别是腐草霉素和博来霉素的嘌呤具有以下通式：其中W选自-SRCONR1R2，-SRCN和-SRCOR1，其中R是可以具有一个或多个各自具有1至5个碳原子的侧链烷基，和可以相同或不同的R 1和R 2的 - （CH 2）n - 基（n为1至5的整数）选自氢原子和具有1至5个碳原子的直链或支链烷基，或者，R 1和R 2一起包含含有4至10个碳原子的聚亚甲基，氧化聚亚甲基或硫代聚亚甲基; R 3，R 4，R 5和R 6可以相同或不同，选自氢原子和具有1至5个碳原子的直链或支链烷基; 并且R，R 1，R 2，R 3，R 4，R 5和R 6可以被一个或多个无毒取代基取代。

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