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1. 发明授权

EP0366060B1 Glykosidase-Inhibitor Salbostatin, Verfahren zu seiner Herstellung und seine Verwendung 失效
标题翻译：糖苷酶抑制剂salbostatin，其制备方法及其使用方法。
公开(公告)号：EP0366060B1
公开(公告)日：1994-03-02
申请号：EP89119704.8
申请日：1989-10-24
申请人： HOECHST AKTIENGESELLSCHAFT
发明人： Vértesy, Lászlo, Dr. , Fehlhaber, Hans-Wolfram, Dr. , Schulz, Arno, Dr.
IPC分类号： C07D309/14 , C12P17/06 , C12P1/06 , A61K31/35 , C12N9/99 , A01N43/16
CPC分类号： A01N43/16 , C07D309/14 , Y10S435/887 , Y10S514/866 , Y10S514/884 , Y10S514/909

2. 发明授权

US4009074A Preparation of levulose from granular starch 失效
标题翻译：从颗粒淀粉制备左旋糖
公开(公告)号：US4009074A
公开(公告)日：1977-02-22
申请号：US558184
申请日：1975-03-13
申请人： Raoul Guillaume Philippe Walon
发明人： Raoul Guillaume Philippe Walon
IPC分类号： C13K11/00 , C12D13/02
CPC分类号： C13K11/00 , Y10S435/836 , Y10S435/887
摘要： A process for the direct conversion of granular starch to levulose comprising mixing a granular starch with water, bacterial alpha-amylase, glucoamylase and a glucose isomerase derived from Streptomyces albus at a temperature of from about 40.degree. to about 70.degree. C. and a pH of from about 5.0 to about 7.0 and maintaining the starch in essentially granular form until a soluble hydrolysate containing levulose is produced, wherein any residual insoluble starch is in essentially granular, ungelatinized form.
摘要翻译：一种将粒状淀粉直接转化成左旋糖的方法，其包括将粒状淀粉与水，细菌α-淀粉酶，葡糖淀粉酶和源自阿斯巴斯芽孢杆菌的葡萄糖异构酶在约40℃至约70℃的温度和pH 为约5.0至约7.0，并将淀粉保持为基本颗粒形式，直到产生含有左旋糖的可溶性水解产物，其中任何残留的不溶性淀粉基本上呈颗粒状，未凝胶化形式。

3. 发明授权

US3804717A Production of new amylases by cultivation of streptomyces and uses of these new amylases 失效
标题翻译：通过培养结构形式生产新的淀粉和使用这些新的淀粉
公开(公告)号：US3804717A
公开(公告)日：1974-04-16
申请号：US19096271
申请日：1971-10-20
申请人： MEIJI SEIKA KAISHA
发明人： KOAZE Y , NAKAJIMA Y , HIDAKA H , YOSHIDA K , ITO J , NIWA T , ADACHI T , UEDA M , NIIDA T , SHOMURA T
IPC分类号： C12N9/28 , C12N9/26 , C12P19/14 , C12D13/10
CPC分类号： C12P19/14 , Y10S435/886 , Y10S435/887 , Y10S435/889 , Y10S435/898
摘要： THIS INVENTION RELATES TO PRODUCING A NEW AMYLASE BY CULTIVATING A STRAIN OF THE PARTICULAR SEVEN SPECIES OF STREPTOMYCES; STREPTOMUCES ALUBUS, STREPTOMYCES AUREOFACIENS, STREPTOMYCES HYDROSCOPICUS, STREPTOMYCES HYDROSCOPCUS VAR. ANGUSTOMYCETICUS, STREPTOMYCES VIRIDOCHROMOGENES, STREPTOMYCES FLAVUS AND STREPTOMYCES TOSAENSIS. THESE NEW AMYLASES PRODUCED BY THE ABOVE PARTICULAR SPECIES, RESPECTIVELY HAVE SOME ENZYMATIC ACTIVITIES AND CHARACTERISTICS WHICH ARE MUCH MORE USEFUL AND ADVANTAGEOUS IN PRODUCING A HIGHER YEILD OF MALTOSE FROM STARCH AND AMYLOSE, AS COMPARED TO THE USE OF THE KNOWN AMYLASES. THE STARCH HYDROLYZATE WHICH IS OBTAINED BY REACTING THE NEW AMYLASE WITH STARCH IN AQUEOUS DISPERSION CONTAINS A PREDOMINANT PROTORTION OF MALTOSE AND IS USEFUL AS A NATURAL SWEETENING MATERIAL, FURTHER, THIS STARCH HYDROLYZATE MAINLY COMPOSED OF MALTOSE IS CONVERTED INTO A MIXTURE OF SUGAR ALCOHOLS MAINLY COMPOSED OF MALTITOL BY HYDROGENATING IN THE PRESENCE OF A NICKEL CATALYST.

4. 发明授权

US2763642A Puromycin and preparation of same 失效
标题翻译：嘌呤霉素及其制备方法
公开(公告)号：US2763642A
公开(公告)日：1956-09-18
申请号：US25435451
申请日：1951-11-01
申请人： AMERICAN CYANAMID CO
发明人： NORMAN PORTER JOHN , CHARLES KRUPKA GEORGE , NESTOR BOHONOS
IPC分类号： C07H19/16
CPC分类号： C07H19/16 , Y10S435/886 , Y10S435/887

5. 发明申请

WO02034938A1 DIAGNOSTICS AND EXAMINATION METHOD FOR CANCER OF THE COLON USING TANNASE AS INDICATION 审中-公开
标题翻译：使用TANNASE作为指标的血清癌症的诊断和检查方法
公开(公告)号：WO02034938A1
公开(公告)日：2002-05-02
申请号：PCT/JP2001/009449
申请日：2001-10-26
IPC分类号： C12Q1/14 , C12Q1/44 , G01N33/569 , G01N33/573 , G01N33/574
CPC分类号： C12Q1/44 , C12Q1/14 , G01N33/56911 , G01N33/56938 , G01N33/573 , G01N33/57419 , Y10S435/882 , Y10S435/887
摘要： Diagnostics for cancer of the colon containing a reagent for detecting a bacterium capable of producing much tannase or quantifying tannase in an intestinal flora sample; and a method of examining cancer of the colon involving the step of detecting a bacterium capable of producing much tannase or quantifying tannase in an intestinal flora sample.
摘要翻译：含有用于检测肠道菌群样品中能够产生大量鞣酸酶或定量鞣酸酶的细菌的试剂的结肠癌诊断; 以及检查结肠癌症的方法，其涉及检测肠道菌群样品中能够产生大量鞣酸酶或定量鞣酸酶的细菌的步骤。

6. 发明公开

EP1335025A1 DIAGNOSTICS AND EXAMINATION METHOD FOR CANCER OF THE COLON USING TANNASE AS INDICATION 审中-公开
标题翻译：诊断：UNTERSUCHUNGSVERFAHRENFÜRDICKDARMKREBS MIT TANNASE ALSINDIKATORMOLEKÜL
公开(公告)号：EP1335025A1
公开(公告)日：2003-08-13
申请号：EP01976851.4
申请日：2001-10-26
申请人： Eisai Co., Ltd
发明人： SASATSU, Masanori , NOGUCHI, Masahisa , SHIRATORI, Taisei
IPC分类号： C12Q1/44 , C12Q1/14 , G01N33/569 , G01N33/573 , G01N33/574
CPC分类号： C12Q1/44 , C12Q1/14 , G01N33/56911 , G01N33/56938 , G01N33/573 , G01N33/57419 , Y10S435/882 , Y10S435/887
摘要： A diagnostic agent for colon cancer, which comprises a reagent for detecting a tannase high-producing bacterium or measuring an amount of tannase contained in an intracolonic microflora sample, and a test method for colon cancer, which comprises the step of detecting a tannase high-producing bacterium or measuring an amount of tannase contained in an intracolonic microflora sample.
摘要翻译：一种结肠癌诊断剂，其特征在于，含有检测鞣酸酶高产细菌的检测剂或测定所述胶原内微生物菌样品中所含的鞣酸酶的量，以及结肠癌检测方法，其特征在于，产生细菌或测量包含在体内微生物群落样品中的鞣酸酶的量。

7. 发明授权

EP0035125B1 Feststoff der Salinomycin-Kulturbrühe und Verfahren zu seiner Gewinnung 失效
标题翻译：沙门氏菌发酵液的固体质量及其过程
公开(公告)号：EP0035125B1
公开(公告)日：1984-03-28
申请号：EP81100801.0
申请日：1981-02-05
申请人： HOECHST AKTIENGESELLSCHAFT
发明人： Höhl, Rolf, Dr. , Heine, Helmut
IPC分类号： C12P1/00 , A23K1/17
CPC分类号： C12P17/181 , C12R1/00 , Y10S435/887

8. 发明专利

JPS5754151A Physiologically active substance b-52653 and its preparation 失效
标题翻译：空值
公开(公告)号：JPS5754151A
公开(公告)日：1982-03-31
申请号：JP13029880
申请日：1980-09-18
申请人： Takeda Chem Ind Ltd
发明人： HIGASHIDE EIJI , HORII SATOSHI
IPC分类号： C12P21/02 , A61K38/00 , A61P31/04 , A61P43/00 , C07K5/06 , C07K14/195 , C07K14/41 , C12R1/47
CPC分类号： C12R1/465 , A61K38/00 , C07K5/06026 , Y10S435/886 , Y10S435/887
摘要： NEW MATERIAL:A physiologically active substance B-52653, and L-alanyl-L-[(3R)-5-hydroxyl-2-oxopyrrolidine-3-yl]glycine. Color and shape of substance, white powder Elemental analysis, C
9 H
15 N
3 O
5 .2H
2 O. Specific rotatory power, [α]D
25 +50°± 5°(C=1.0, H
2 O). Color reaction, positive in ninhydrin reaction, etc.
USE: Useful as a physiologically active substance. Exhibiting antibacterial power against the growth of Gram-positive and Gram-negative bacteria by inhibiting action on cell wall synthesis. Exhibiting inhibiting actions on collagen proline hydroy enzyme.
PROCESS: "Streptomyces" No.B-52653 strain (FERM-P5677) is cultivated in a proper culture, and a single means or any combination of means to be used to collect a substance of metabolism from the filtrate is effected to give B-52653.
COPYRIGHT: (C)1982,JPO&Japio
摘要翻译：目的：生理活性物质B-52653和L-丙氨酰-L- [（3R）-5-羟基-2-氧代吡咯烷-3-基]甘氨酸。物质的颜色和形状，白色粉末元素分析，C9H15N3O5.2H2O。特定旋光度，αD 25 + 50度+或-5℃（C = 1.0，H 2 O）。色素反应，茚三酮反应中呈阳性等。用途：可用作生理活性物质。通过抑制细胞壁合成的作用，展现抗革兰氏阳性和革兰氏阴性细菌生长的抗菌力。展示胶原脯氨酸水解酶的抑制作用。方法：将“Streptomyces”号B-52653菌株（FERM-P5677）在合适的培养物中培养，并且实现用于从滤液中收集代谢物质的单一方法或任何组合的方法，以得到 B-52653。

9. 发明公开

EP1335025A4 DIAGNOSTICS AND EXAMINATION METHOD FOR CANCER OF THE COLON USING TANNASE AS INDICATION 审中-公开
标题翻译：诊断和分析迪克·科隆单宁酶作为指示剂分子的方法
公开(公告)号：EP1335025A4
公开(公告)日：2006-07-05
申请号：EP01976851
申请日：2001-10-26
申请人： EISAI CO LTD
发明人： SASATSU MASANORI , NOGUCHI MASAHISA , SHIRATORI TAISEI
IPC分类号： C12Q1/14 , C12Q1/44 , G01N33/569 , G01N33/573 , G01N33/574
CPC分类号： C12Q1/44 , C12Q1/14 , G01N33/56911 , G01N33/56938 , G01N33/573 , G01N33/57419 , Y10S435/882 , Y10S435/887
摘要： Diagnostics for cancer of the colon containing a reagent for detecting a bacterium capable of producing much tannase or quantifying tannase in an intestinal flora sample; and a method of examining cancer of the colon involving the step of detecting a bacterium capable of producing much tannase or quantifying tannase in an intestinal flora sample.

10. 发明公开

EP0366060A1 Glykosidase-Inhibitor Salbostatin, Verfahren zu seiner Herstellung und seine Verwendung 失效
标题翻译：糖苷酶抑制剂salbostatin，其制备方法及其使用方法。
公开(公告)号：EP0366060A1
公开(公告)日：1990-05-02
申请号：EP89119704.8
申请日：1989-10-24
申请人： HOECHST AKTIENGESELLSCHAFT
发明人： Vértesy, Lászlo, Dr. , Fehlhaber, Hans-Wolfram, Dr. , Schulz, Arno, Dr.
IPC分类号： C07D309/14 , C12P17/06 , C12P1/06 , A61K31/35 , C12N9/99 , A01N43/16
CPC分类号： A01N43/16 , C07D309/14 , Y10S435/887 , Y10S514/866 , Y10S514/884 , Y10S514/909
摘要： Salbostatin, eine Verbindung der Formel I
wirkt als Glycosidase-Inhibitor und eignet sich zur Anwendung in der Pharmazie sowie im Pflanzenschutz.
摘要翻译： Salbostatin，式I 的化合物用作糖苷酶抑制剂，并且适用于在药房使用和植物保护。

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