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    • 5. 发明公开
    • ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL
    • ORGANISMEN ZUR HERSTELLUNG VON 1,3-BUTANDIOL
    • EP3135760A1
    • 2017-03-01
    • EP16168278.6
    • 2010-04-30
    • Genomatica, Inc.
    • BURGARD, Anthony P.BURK, Mark J.OSTERHOUT, Robin E.PHARKYA, Priti
    • C12N1/21C12P7/18C12N9/04
    • C12P7/18C07C29/80C12N9/0006C12N9/0008C12N9/1029C12N9/1096C12N9/88C12N15/52C12Y101/01C12Y101/01157C12Y102/01C12Y203/01C12Y206/01C12Y401/01C12Y402/01C12Y403/01
    • A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate aminotransferase, a 2-amino-4-hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3-hydroxybutyraldehyde reductase, an AKP aminotransferase, an AKP oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an AKP decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2- one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an AKP ammonia-lyase, an acetylacrylate decarboxylase, an acetoacetyl-CoA reductase (CoA-dependent, aldehyde forming), an acetoacetyl-CoA reductase (CoA-dependent, alcohol forming), an acetoacetyl-CoA reductase (ketone reducing), a 3-hydroxybutyryl-CoA reductase (aldehyde forming), a 3-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl- CoA dehydratase, and a crotonase. A method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.
    • 非天然存在的微生物体包括具有1,3-丁二醇(1,3-BDO)途径的微生物生物,其具有至少一种编码1,3-BDO途径酶的外源核酸,其表达量足以产生1 ,3-BDO。 途径包括选自2-氨基-4-酮戊酸酯(AKP)硫解酶,AKP脱氢酶,2-氨基-4-羟基戊酸转氨酶,2-氨基-4-羟基戊酸酯氧化还原酶(脱氨基),2- 4-羟基戊酸脱羧酶,3-羟基丁醛还原酶,AKP氨基转移酶,AKP氧化还原酶(脱氨基),2,4-二氧代戊酸脱羧酶,3-氧代丁醛还原酶(还原酮),3-氧代丁醛还原酶 ),4-羟基-2-丁酮还原酶,AKP脱羧酶,4-氨基丁-2-酮氨基转移酶,4-氨基丁-2-酮氧化还原酶(脱氨基),4-氨基丁-2-酮氨裂解酶 乙酰乙酰辅酶A还原酶(CoA依赖性醛形成),乙酰乙酰辅酶A还原酶(CoA依赖性醇成型),乙酰乙酰辅酶A还原酶(酮 还原),3-羟基丁酰辅酶A还原酶(醛形成),3-羟基丁酸 yyl-CoA还原酶(醇形成),4-羟基丁酰辅酶A脱水酶和巴豆酸酶。 一种生产1,3-BDO的方法包括在条件和足够的时间内培养这些微生物生产1,3-BDO。
    • 7. 发明申请
    • ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL
    • 生产1,3-丁二醇的有机体
    • US20160053286A1
    • 2016-02-25
    • US14673600
    • 2015-03-30
    • Genomatica, Inc.
    • Anthony P. BurgardMark J. BurkRobin E. OsterhoutPriti Pharkya
    • C12P7/18C07C29/80C12N9/04C12N9/02C12N9/10C12N9/88
    • C12P7/18C07C29/80C12N9/0006C12N9/0008C12N9/1029C12N9/1096C12N9/88C12N15/52C12Y101/01C12Y101/01157C12Y102/01C12Y203/01C12Y206/01C12Y401/01C12Y402/01C12Y403/01
    • A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate aminotransferase, a 2-amino-4-hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3-hydroxybutyraldehyde reductase, an AKP aminotransferase, an AKP oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an AKP decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2-one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an AKP ammonia-lyase, an acetylacrylate decarboxylase, an acetoacetyl-CoA reductase (CoA-dependent, aldehyde forming), an acetoacetyl-CoA reductase (CoA-dependent, alcohol forming), an acetoacetyl-CoA reductase (ketone reducing), a 3-hydroxybutyryl-CoA reductase (aldehyde forming), a 3-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl-CoA dehydratase, and a crotonase. A method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.
    • 非天然存在的微生物生物体包括具有1,3-丁二醇(1,3-BDO)途径的微生物生物,其具有至少一种编码1,3-BDO途径酶的外源核酸,所述外源核酸以足够的量表达,以产生1 ,3-BDO。 该途径包括选自2-氨基-4-酮戊酸酯(AKP)硫解酶,AKP脱氢酶,2-氨基-4-羟基戊酸转氨酶,2-氨基-4-羟基戊酸酯氧化还原酶(脱氨基),2- 4-羟基戊酸脱羧酶,3-羟基丁醛还原酶,AKP氨基转移酶,AKP氧化还原酶(脱氨),2,4-二氧代戊酸脱羧酶,3-氧代丁醛还原酶(还原酮),3-氧代丁醛还原酶 ),4-羟基-2-丁酮还原酶,AKP脱羧酶,4-氨基丁-2-酮氨基转移酶,4-氨基丁-2-酮氧化还原酶(脱氨基),4-氨基丁-2-酮氨裂解酶 乙酰乙酰辅酶A还原酶(CoA依赖性醛形成),乙酰乙酰辅酶A还原酶(CoA依赖性醇形成),乙酰乙酰辅酶A还原酶(酮),乙酰乙酰辅酶A还原酶 还原),3-羟基丁酰辅酶A还原酶(醛形成),3-羟基 Ryl-CoA还原酶(醇形成),4-羟基丁酰辅酶A脱水酶和巴豆酸酶。 一种生产1,3-BDO的方法包括在条件和足够的时间内培养这些微生物生产1,3-BDO。