专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20170253650A1 ANTI-PARASITIC COMPLEXES 审中-公开
公开(公告)号：US20170253650A1
公开(公告)日：2017-09-07
申请号：US15507173
申请日：2015-08-21
申请人： Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.
发明人： Rolf Fendel , Stephanie Kapelski , Stefan Barth , Rainer Fischer , Andreas Reimann
IPC分类号： C07K16/20 , C12N9/64
CPC分类号： C07K16/205 , A61K47/6815 , A61K47/6835 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C12N9/6467 , C12Y304/21079
摘要： The technology provided herein relates to novel anti-parasitic complexes, in particular recombinant fusion proteins suitable as human and/or animal drugs against a parasite of the phylum Apicomplexa, in particular against Plasmodium falciparum (P. falciparum) comprising at least one component A and at least one component B, characterized in that component A has a binding activity for cellular surface structures presented on the surface of a parasite of the phylum Apicomplexa or for parasitic antigens presented on a parasitized host cell, and component B is a compound having anti-parasitic activity.

2. 发明申请

US20150352047A1 DRUG DELIVERY MEANS 审中-公开
标题翻译：药物递送手段
公开(公告)号：US20150352047A1
公开(公告)日：2015-12-10
申请号：US14741915
申请日：2015-06-17
申请人： Mary P. McCourt
发明人： Mary P. McCourt
IPC分类号： A61K9/127 , A61K38/48 , A61K38/17 , A61K38/45 , A61K47/10 , A61K47/28
CPC分类号： A61K9/1272 , A61K9/127 , A61K9/1277 , A61K38/1709 , A61K38/1761 , A61K38/45 , A61K38/482 , A61K47/10 , A61K47/28 , C12Y207/11001 , C12Y304/21078 , C12Y304/21079
摘要： The invention broadly comprises a chemical composition including a plurality of cholesteryl esters arranged to form a vesicle. In several embodiments, all of the plurality of cholesteryl esters have a same molecular length, which in some embodiments provides a vesicle having a generally smooth outer surface, while in other embodiments, a portion of the plurality of cholesteryl esters have different molecular lengths, which in some embodiments provides a vesicle having a generally irregular outer surface. In yet further embodiments, a shape of the vesicle is selected from the group consisting of spherical, oval, disc-like, tubular and polyhedral shapes, and in yet other embodiments, a wall of the vesicle is selected from the group consisting of a monolayer and a bilayer. In still further embodiments, the chemical composition further includes a polyethylene glycol coat of mixed polymer size. In some embodiments, the plurality of cholesteryl esters include at least two different cholesteryl esters, and in some of these embodiments, the at least two different cholesteryl esters are selected from the group consisting of: cholesteryl myristate, cholesteryl laurate, cholesteryl dodeconate, cholesteryl palmitate, cholesteryl arachidonate, cholesteryl behenate, cholesteryl linoleate, cholesteryl linolenate, cholesteryl oleate and cholesteryl stearate.
摘要翻译：本发明广泛地包括一种化学组合物，其包括布置成形成囊泡的多个胆固醇酯。在几个实施方案中，所有多个胆固醇酯具有相同的分子长度，其在一些实施方案中提供具有大致光滑的外表面的囊泡，而在其它实施方案中，多个胆固醇酯的一部分具有不同的分子长度，在一些实施例中提供了具有大致不规则的外表面的囊泡。在另外的实施方案中，泡囊的形状选自球形，椭圆形，盘状，管状和多面体形状，并且在其它实施方案中，泡囊的壁选自单层和双层。在另外的实施方案中，化学组合物还包括混合聚合物尺寸的聚乙二醇涂层。在一些实施方案中，多种胆固醇酯包括至少两种不同的胆固醇酯，并且在这些实施方案的一些实施方案中，所述至少两种不同的胆固醇酯选自：肉豆蔻酸胆固醇酯，月桂酸胆固醇酯，胆固醇十二酸胆固醇酯，棕榈酸胆固醇酯胆固醇基花生四烯酸，胆固醇基山嵛酸酯，胆固醇基亚油酸酯，胆固醇亚油酸酯，胆固醇油酸酯和胆固醇基硬脂酸酯。

3. 发明公开

EP4396211A2 PRO-APOPTOTIC CONSTRUCT AND USE THEREOF 审中-公开
公开(公告)号：EP4396211A2
公开(公告)日：2024-07-10
申请号：EP22772477.0
申请日：2022-08-30
申请人： UMC Utrecht Holding B.V.
发明人： PEPERZAK, Victor , SEBESTYEN, Zsolt , KIMMAN, Thomas
IPC分类号： C07K14/47 , A61K35/17
CPC分类号： C07K14/4747 , C12N9/6467 , C07K2319/05520130101 , C12Y304/21079 , A61K38/00

4. 发明公开

EP2990059A1 Anti-parasitic complexes 审中-公开
标题翻译： AntiparasitäreKomplexe
公开(公告)号：EP2990059A1
公开(公告)日：2016-03-02
申请号：EP14182195.9
申请日：2014-08-26
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
发明人： Fendel, Rolf , Kapelski, Stephanie , Barth, Stefan , Fischer, Rainer , Reimann, Andreas
IPC分类号： A61K47/48 , C07K16/20
CPC分类号： C07K16/205 , A61K47/6815 , A61K47/6835 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C12N9/6467 , C12Y304/21079
摘要： The technology provided herein relates to novel anti-parasitic complexes, in particular recombinant fusion proteins suitable as human and/or animal drugs against a parasite of the phylum Apicomplexa, in particular against Plasmodium falciparum ( P. falciparum ) comprising at least one component A and at least one component B, characterized in that component A has a binding activity for cellular surface structures presented on the surface of a parasite of the phylum Apicomplexa or for parasitic antigens presented on a parasitized host cell, and component B is a compound having anti-parasitic activity.
摘要翻译：本文提供的技术涉及新型抗寄生虫复合物，特别是适合作为人和/或动物药物的重组融合蛋白，其针对门复合物的寄生虫，特别是抗恶性疟原虫（恶性疟原虫），其包含至少一种组分A和至少一种组分B，其特征在于组分A具有在Apicomplexa门寄生虫的表面上呈现的细胞表面结构的结合活性或存在于寄生的宿主细胞上的寄生抗原，组分B是具有抗 - 寄生活动。

5. 发明授权

US11913043B2 Cell-targeted cytotoxic constructs 有权
公开(公告)号：US11913043B2
公开(公告)日：2024-02-27
申请号：US17519545
申请日：2021-11-04
申请人： Research Development Foundation
发明人： Xinjian Lin , Xiying Shang , Stephen B. Howell
IPC分类号： C12N9/64 , C12N9/52 , A61K47/68 , A61K47/65 , C07K14/435 , C07K14/59 , C12N9/96 , A61K48/00
CPC分类号： C12N9/6467 , A61K47/65 , A61K47/6889 , C07K14/43504 , C07K14/59 , C12N9/52 , C12N9/6424 , C12N9/96 , C12Y304/21079 , C12Y304/2207 , C12Y304/22007 , A61K48/00 , C07K2319/00 , C07K2319/21 , C07K2319/33 , C07K2319/40 , C07K2319/55 , C07K2319/70 , C07K2319/74 , C07K2319/90
摘要： The invention is directed to cell-targeted cytotoxic agents, including sortase serine protease constructs. Methods for targeted cell killing for treatment of proliferative diseases, for example, cancer, are provided. Exemplary embodiments comprise an R-spondin ligand for targeting the cytotoxic agents to effect the cell killing.

6. 发明授权

US09539307B2 Compositions and methods for treating amyotrophic lateral sclerosis 有权
标题翻译：用于治疗肌萎缩性侧索硬化的组合物和方法
公开(公告)号：US09539307B2
公开(公告)日：2017-01-10
申请号：US14428765
申请日：2013-09-17
申请人： THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
发明人： Brian Kaspar
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04 , C12N15/11 , A61K38/17 , A61K31/7105
CPC分类号： A61K38/1774 , A61K31/7105 , A61K38/10 , A61K38/17 , A61K48/00 , A61K48/005 , C07K14/70539 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12Y304/21079
摘要： The invention relates to pharmaceutical compositions, kits, methods, and uses for the treatment of amyotrophic lateral sclerosis. In particular, the invention relates to pharmaceutical compositions, kits, methods, and uses for the treatment of amyotrophic lateral sclerosis by decreasing the expression of a cytoplasmic granule toxin in astrocytes of a patient, or by increasing the expression of MHC class I in motor neurons of the patient.
摘要翻译：本发明涉及用于治疗肌萎缩性侧索硬化的药物组合物，试剂盒，方法和用途。特别地，本发明涉及通过降低患者星形胶质细胞中细胞质颗粒毒素的表达或通过增加运动神经元中MHC I类的表达来治疗肌萎缩性侧索硬化的药物组合物，试剂盒，方法和用途的病人。

7. 发明申请

US20150231207A1 COMPOSITIONS AND METHODS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS 有权
标题翻译：组合物和方法治疗左心室狭窄
公开(公告)号：US20150231207A1
公开(公告)日：2015-08-20
申请号：US14428765
申请日：2013-09-17
申请人： THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
发明人： Brian Kaspar
IPC分类号： A61K38/17 , A61K31/7105
CPC分类号： A61K38/1774 , A61K31/7105 , A61K38/10 , A61K38/17 , A61K48/00 , A61K48/005 , C07K14/70539 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12Y304/21079
摘要： The invention relates to pharmaceutical compositions, kits, methods, and uses for the treatment of amyotrophic lateral sclerosis. In particular, the invention relates to pharmaceutical compositions, kits, methods, and uses for the treatment of amyotrophic lateral sclerosis by decreasing the expression of a cytoplasmic granule toxin in astrocytes of a patient, or by increasing the expression of MHC class I in motor neurons of the patient.
摘要翻译：本发明涉及用于治疗肌萎缩性侧索硬化的药物组合物，试剂盒，方法和用途。特别地，本发明涉及通过降低患者星形胶质细胞中细胞质颗粒毒素的表达或通过增加运动神经元中MHC I类的表达来治疗肌萎缩性侧索硬化的药物组合物，试剂盒，方法和用途的病人。

8. 发明申请

US20140356347A1 NOVEL SERINE PROTEASE VARIANTS 有权
标题翻译：新型丝氨酸蛋白酶变体
公开(公告)号：US20140356347A1
公开(公告)日：2014-12-04
申请号：US14346600
申请日：2012-09-21
申请人： PHARMEDARTIS GMBH
发明人： Stefan Barth , Sonja Schiffer , Grit Hehmann-Titt
IPC分类号： C12N9/64 , A61K47/48
CPC分类号： C12N9/6467 , A61K38/482 , A61K47/6849 , C12N9/6421 , C12Y304/21079
摘要： The present disclosure provides novel variants of enzymes exhibiting serine protease activity; nucleic acid molecules encoding said proteases, vectors, host cells containing the nucleic acids and methods for preparation and producing such enzymes; compositions and complexes comprising at least one of the proteases; and methods for using such enzymes as a part of an immunoprotease, in particular for the treatment of cancer.
摘要翻译：本公开提供了显示丝氨酸蛋白酶活性的酶的新型变体; 编码所述蛋白酶，载体，含有核酸的宿主细胞的核酸分子以及制备和产生此类酶的方法; 包含至少一种蛋白酶的组合物和复合物; 以及使用这些酶作为免疫蛋白酶的一部分的方法，特别是用于治疗癌症的方法。

9. 发明公开

US20240229003A1 CELL-TARGETED CYTOTOXIC CONSTRUCTS 审中-公开
公开(公告)号：US20240229003A1
公开(公告)日：2024-07-11
申请号：US18425681
申请日：2024-01-29
申请人： RESEARCH DEVELOPMENT FOUNDATION
发明人： Xinjian LIN , Xiying SHANG , Stephen B. HOWELL
IPC分类号： C12N9/64 , A61K47/65 , A61K47/68 , A61K48/00 , C07K14/435 , C07K14/59 , C12N9/52 , C12N9/96
CPC分类号： C12N9/6467 , A61K47/65 , A61K47/6889 , C07K14/43504 , C07K14/59 , C12N9/52 , C12N9/6424 , C12N9/96 , C12Y304/21079 , C12Y304/22007 , C12Y304/2207 , A61K48/00 , C07K2319/00 , C07K2319/21 , C07K2319/33 , C07K2319/40 , C07K2319/55 , C07K2319/70 , C07K2319/74 , C07K2319/90
摘要： The invention is directed to cell-targeted cytotoxic agents, including sortase serine protease constructs. Methods for targeted cell killing for treatment of proliferative diseases, for example, cancer, are provided. Exemplary embodiments comprise an R-spondin ligand for targeting the cytotoxic agents to effect the cell killing.

10. 发明申请

US20170362582A1 CYTOTOXIC MOLECULES RESPONSIVE TO INTRACELLULAR LIGANDS FOR SELECTIVE T CELL MEDIATED KILLING 审中-公开
公开(公告)号：US20170362582A1
公开(公告)日：2017-12-21
申请号：US15536009
申请日：2015-12-14
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Yvonne Y. CHEN , Patrick HO
IPC分类号： C12N9/64 , C07K16/40 , C12N5/0783 , A61K35/17 , A61K38/48 , C07K14/47
CPC分类号： C12N9/6467 , A61K35/17 , A61K38/482 , C07K14/47 , C07K14/4702 , C07K16/40 , C07K2317/622 , C07K2319/00 , C07K2319/95 , C12N5/0636 , C12N15/85 , C12N2510/00 , C12Y304/21079
摘要： Compositions and methods are provided for the cell-mediated targeted killing of diseased cells based on the presence of an intracellular antigen, rather than a surface-bound marker. The targeting cells are modified to express a cytotoxic protein that is delivered into a targeted cell, and after delivery is selectively activated by the presence of a cytoplasmic protein of interest. In one embodiment of the invention, the cytotoxic molecule is a Granzyme B (GrB) polypeptide. In the compositions of the invention, GrB is modified to render its cytotoxic enzymatic functions inactive, until the presence of an intracellular antigen unlocks the GrB molecule to enable enzymatic activities.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式