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1. 发明公开

CN106795530A 用于生物合成化合物的方法、试剂和细胞无效转让
公开(公告)号：CN106795530A
公开(公告)日：2017-05-31
申请号：CN201580043006.X
申请日：2015-06-16
申请人：英威达技术有限责任公司
发明人： A.L.博特斯 , A.V.E.康拉迪
IPC分类号： C12P7/18 , C12P7/44 , C12P7/24 , C12P7/62 , C12P13/00 , C12P17/10 , C12N1/21 , C12R1/19
CPC分类号： C12P7/62 , C07C69/533 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/18 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P11/00 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/99006 , C12Y203/01016 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/01085 , C12Y301/02
摘要：本文件描述了使用脂肪酸O‑甲基转移酶，硫酯酶，CoA转移酶，CoA连接酶中的一种或多种从前体，诸如2‑酮戊二酸，乙酰CoA，或琥珀酰‑CoA产生2(E)‑庚烯二酰基‑CoA甲酯的生物化学途径，以及表达一种或多种此类酶的重组宿主。可以使用反式‑2‑烯酰基‑CoA还原酶，和甲酯酶将2(E)‑庚烯二酰基‑CoA甲酯酶促转化为庚二酰‑CoA。可以将庚二酰‑CoA酶促转化为庚二酸，7‑氨基庚酸，7‑羟基庚酸，七亚甲基二胺，或1,7‑庚二醇。

2. 发明公开

CN106795519A 用于生成戊二酸和戊二酸甲酯的方法无效转让
公开(公告)号：CN106795519A
公开(公告)日：2017-05-31
申请号：CN201580038453.6
申请日：2015-06-16
申请人：英威达技术有限责任公司
发明人： A.L.博特斯 , A.V.E.康拉迪
IPC分类号： C12N15/52 , C12P7/42 , C12P7/44 , C12P7/62 , C12P13/00
CPC分类号： C12P7/62 , C07C69/42 , C07C229/08 , C12N9/0008 , C12N9/1007 , C12N9/1096 , C12N9/16 , C12N9/18 , C12N15/52 , C12P7/42 , C12P7/44 , C12P13/001 , C12Y102/99006 , C12Y201/01197 , C12Y206/01018 , C12Y206/01038 , C12Y301/01085
摘要：本文件描述了用于生成戊二酸、5‑氨基戊酸、5‑羟基戊酸、尸胺或1,5‑戊二醇的生物化学途径，其通过在C5主链底物，诸如丙二酰基‑CoA或丙二酰基‑[acp]中形成一个或两个由羧基、胺或羟基基团构成的末端官能团进行。

3. 发明申请

US20150361463A1 METHODS, REAGENTS AND CELLS FOR BIOSYNTHESIZING COMPOUNDS 有权
标题翻译：生物化学化合物的方法，试剂和细胞
公开(公告)号：US20150361463A1
公开(公告)日：2015-12-17
申请号：US14740749
申请日：2015-06-16
申请人： INVISTA North America S.á r.l.
发明人： Adriana Leonora Botes , Alex Van Eck Conradie
IPC分类号： C12P13/00 , C12P7/40 , C12P7/24 , C07C69/533 , C12N9/16 , C12N9/10 , C12N9/02 , C12N9/18 , C12P7/44 , C12P11/00
CPC分类号： C12P7/62 , C07C69/533 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/18 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P11/00 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/99006 , C12Y203/01016 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/01085 , C12Y301/02
摘要： This document describes biochemical pathways for producing 2,3-dehydroadipyl-CoA methyl ester from precursors such as 2-oxoglutarate using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase and a CoA ligase, as well as recombinant hosts expressing one or more of such enzymes. 2,3-dehydroadipyl-CoA methyl ester can be enzymatically converted to adipyl-CoA using a trans-2-enoyl-CoA reductase, and a methylesterase, which in turn can be enzymatically converted to adipic acid, 6-aminohexanoate, 6-hydroxyhexanoate, caprolactam, hexamethylenediamine, or 1,6-hexanediol.
摘要翻译：该文献描述了使用一种或多种脂肪酸O-甲基转移酶，硫酯酶，辅酶A转移酶和辅酶A连接酶从前体如2-氧戊二酸生产2,3-脱氢阿迪普基-CoA甲酯的生化途径，以及表达一种或多种此类酶的重组宿主。可以使用反式-2-烯酰辅酶A还原酶将2,3-脱氢脱苄基-CoA甲酯酶促转化为己二酰CoA，甲酯酶又可以酶促转化为己二酸，6-氨基己酸6-羟基己酸酯，己内酰胺，六亚甲基二胺或1,6-己二醇。

4. 发明授权

US09920339B2 Methods, reagents and cells for biosynthesizing compounds 有权
公开(公告)号：US09920339B2
公开(公告)日：2018-03-20
申请号：US14741392
申请日：2015-06-16
申请人： INVISTA North America S.á r.l.
发明人： Nadia Fatma Kadi , Mariusz Kamionka , Alexander Brett Foster , Alex Van Eck Conradie , Adriana Leonora Botes
IPC分类号： C12P7/62 , C12P7/40 , C12P7/42 , C12P7/44 , C12N1/20 , C12N1/00 , C07H21/04 , C12P13/00 , C07C229/08 , C12N9/10 , C07C69/42 , C12N9/02 , C12N9/18 , C12N9/16 , C12N15/52
CPC分类号： C12P7/62 , C07C69/42 , C07C229/08 , C12N9/0008 , C12N9/1007 , C12N9/1096 , C12N9/16 , C12N9/18 , C12N15/52 , C12P7/42 , C12P7/44 , C12P13/001 , C12Y102/99006 , C12Y201/01197 , C12Y206/01018 , C12Y206/01038 , C12Y301/01085
摘要： This document describes biochemical pathways for producing glutaric acid, 5-aminopentanoic acid, 5-hydroxypentanoic acid, cadaverine or 1,5-pentanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C5 backbone substrate such as malonyl-CoA or malonyl-[acp].

5. 发明申请

US20170152531A1 PROCESS FOR PRODUCING GLUTARATE AND GLUTARIC ACID METHYL ESTER 审中-公开
公开(公告)号：US20170152531A1
公开(公告)日：2017-06-01
申请号：US15318403
申请日：2015-06-16
申请人： NORTH AMERICA S.A.R.L.
发明人： Adriana Leonora Botes , Alex Van Eck Conradie
IPC分类号： C12P7/62 , C12N9/02 , C12N9/16 , C12P7/44 , C12N9/10
CPC分类号： C12P7/62 , C07C69/42 , C07C229/08 , C12N9/0008 , C12N9/1007 , C12N9/1096 , C12N9/16 , C12N9/18 , C12N15/52 , C12P7/42 , C12P7/44 , C12P13/001 , C12Y102/99006 , C12Y201/01197 , C12Y206/01018 , C12Y206/01038 , C12Y301/01085
摘要： This document describes biochemical pathways for producing 2,4-pentadienoyl-CoA by forming one or two terminal functional groups, comprised of carboxyl or hydroxyl group, in a C5 backbone substrate such as glutaryl-CoA, glutaryl-[acp] or glutarate methyl ester. 2,4-pentadienoyl-CoA can be enzymatically converted to 1,3-butadiene.

6. 发明公开

EP3155105A1 METHODS, REAGENTS AND CELLS FOR BIOSYNTHESIZING COMPOUNDS 审中-公开
标题翻译：生物合成化合物的方法，试剂和细胞
公开(公告)号：EP3155105A1
公开(公告)日：2017-04-19
申请号：EP15731802.3
申请日：2015-06-16
申请人： Invista Technologies S.A R.L.
发明人： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck
IPC分类号： C12P7/18 , C12N15/63 , C12P7/44 , C12P7/62 , C12P13/00 , C12P17/10
CPC分类号： C12P7/62 , C07C69/533 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/18 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P11/00 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/99006 , C12Y203/01016 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/01085 , C12Y301/02
摘要： This document describes biochemical pathways for producing 2(E)-heptenedioyl-CoA methyl ester from precursors such as 2-oxo-glutarate, acetyl-CoA, or succinyl-CoA using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase, a CoA ligase, as well as recombinant hosts expressing one or more of such enzymes. 2(E)-heptenedioyl-CoA methyl ester can be enzymatically converted to pimeloyl-CoA using a trans-2-enoyl-CoA reductase, and a methylesterase. Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol.
摘要翻译：该文献描述了使用脂肪酸O-甲基转移酶，硫酯酶，CoA-转移酶和CoA连接酶中的一种或多种从前体如2-酮戊二酸产生2,3-脱氢戊酰-CoA甲酯的生物化学途径，以及表达一种或多种此类酶的重组宿主。可以使用反式-2-烯酰-CoA还原酶和甲基酯酶将2,3-脱氢戊酰-CoA甲酯酶促转化为己二酰-CoA，所述甲酯酶进而可以酶促转化为己二酸6-氨基己酸酯，6-羟基己酸酯，己内酰胺，六亚甲基二胺或1,6-己二醇。

7. 发明公开

EP3155111A1 PROCESS FOR PRODUCING GLUTARATE AND GLUTARIC ACID METHYL ESTER 审中-公开
标题翻译：生产戊二酸酯和戊二酸甲酯的方法
公开(公告)号：EP3155111A1
公开(公告)日：2017-04-19
申请号：EP15731479.0
申请日：2015-06-16
申请人： Invista Technologies S.à r.l.
发明人： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck
IPC分类号： C12P7/44 , C12N9/10 , C12N9/16 , C12N9/18 , C12N15/52 , C12P7/62
CPC分类号： C12P7/62 , C07C69/42 , C07C229/08 , C12N9/0008 , C12N9/1007 , C12N9/1096 , C12N9/16 , C12N9/18 , C12N15/52 , C12P7/42 , C12P7/44 , C12P13/001 , C12Y102/99006 , C12Y201/01197 , C12Y206/01018 , C12Y206/01038 , C12Y301/01085
摘要： This document describes biochemical pathways for producing glutaric acid, 5-aminopentanoic acid, 5-hydroxypentanoic acid, cadaverine or 1,5-pentanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C5 backbone substrate such as malonyl-CoA or malonyl-[acp].
摘要翻译：该文件描述了通过在C5主链底物如戊二酰基-CoA，戊二酰基 - [acp]或戊二酸甲酯中形成包含羧基或羟基的一个或两个末端官能团来生产2,4-戊二烯酰-CoA的生物化学途径。 2,4-戊二烯酰-CoA可以酶促转化为1,3-丁二烯。

8. 发明公开

EP3155106A2 METHODS, REAGENTS AND CELLS FOR BIOSYNTHESIZING COMPOUND 审中-公开
标题翻译： VERFAHREN，REENENZIEN UND ZELLEN ZUR BIOSYNEESE EINER VERBINDUNG
公开(公告)号：EP3155106A2
公开(公告)日：2017-04-19
申请号：EP15795047.8
申请日：2015-06-16
申请人： Invista Technologies S.à.r.l.
发明人： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck
IPC分类号： C12P7/18 , C12N15/63 , C12P7/44 , C12P7/62 , C12P13/00 , C12P17/10
CPC分类号： C12P7/62 , C07C69/533 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/18 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P11/00 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/99006 , C12Y203/01016 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/01085 , C12Y301/02
摘要： This document describes biochemical pathways for producing 2(E)-heptenedioyl-CoA methyl ester from precursors such as 2-oxo-glutarate, acetyl-CoA, or succinyl-CoA using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase, a CoA ligase, as well as recombinant hosts expressing one or more of such enzymes. 2(E)-heptenedioyl-CoA methyl ester can be enzymatically converted to pimeloyl-CoA using a trans-2-enoyl-CoA reductase, and a methylesterase. Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol.
摘要翻译：本文件描述了使用一种或多种脂肪酸O-甲基转移酶，硫酯酶，辅酶A转移酶和辅酶A连接酶从前体例如2-氧戊二酸生产2,3-脱氢腺苷酰辅酶A甲酯的生物化学途径，以及表达一种或多种此类酶的重组宿主。 2,3-脱氢腺苷酰辅酶A甲酯可以使用反式-2-烯酰辅酶A还原酶酶促转化成己二酰辅酶A，甲酯酶又可以酶促转化为己二酸，6-氨基己酸6-羟基己酸酯，己内酰胺，六亚甲基二胺或1,6-己二醇。

9. 发明公开

EP2730655A1 Verfahren zur Umsetzung eines Carbonsäureesters unter Verwendung BioH-defizienter Zellen 审中-公开
标题翻译： Verfahren zur Umsetzung einesCarbonsäureestersunter Verwendung BioH-defizienter Zellen
公开(公告)号：EP2730655A1
公开(公告)日：2014-05-14
申请号：EP12007663.3
申请日：2012-11-12
申请人： Evonik Industries AG
发明人： Schaffer, Steffen, Dr. , Andrea, Heiko , Wessel, Mirja, Dr. , Hennemann, Hans-Georg, Dr. , Häger, Harald, Dr.
IPC分类号： C12N15/52 , C12N9/02 , C12N9/18 , C12P7/62 , C12P7/64
CPC分类号： C12P7/62 , C12N9/18 , C12P7/6436 , C12Y301/01085 , Y02P20/582
摘要： Die Erfindung betrifft ein Verfahren zur Umsetzung eines Carbonsäureesters der Formel (I)

R 1 -A-COOR 2 (I),

wobei R 1 aus der Gruppe ausgewählt ist, die Wasserstoff, -CH 2 OH, -CHO, -COOR 3 , -CH 2 SH, -CH 2 OR 3 und -CH 2 NH 2 umfasst,
wobei R 2 aus der Gruppe ausgewählt ist, die Alkyl, bevorzugt Methyl, Ethyl und Propyl, umfasst,
wobei R 3 aus der Gruppe ausgewählt ist, die Wasserstoff und Alkyl, bevorzugt Methyl, Ethyl und Propyl, umfasst,
und wobei es sich bei A um einen Alkylrest mit wenigstens vier Kohlenstoffatomen handelt,
mittels einer Zelle, umfassend den Schritt
a) Kontaktieren der Zelle mit dem Carbonsäureester in einer wässrigen Lösung,

wobei es sich bei der Zelle um eine rekombinante Zelle handelt, bei der die Aktivität eines Polypeptides umfassend SEQ ID NO 2 oder eine Variante davon gegenüber dem Wildtyp der Zelle verringert ist, sowie eine dazu geeignete Zelle und deren Verwendungen.
摘要翻译：通过电池转化羧酸酯（I）包括在水溶液中使细胞与羧酸酯（I）接触。细胞是重组细胞。包含与说明书或其变体中给出的256个氨基酸（SEQ ID NO：2）的肽序列的多肽的细胞活性相比，野生型的细胞减少。通过电池转化式（R1-A-COOR2）（I）的羧酸酯包括（使细胞与羧酸酯在水溶液中接触，细胞是重组细胞，细胞活性为包含与说明书或其变体中给出的256个氨基酸（SEQ ID NO：2）的肽序列的多肽相比，野生型的细胞R1：H，-CH 2 OH，-CHO，-COOR 3，-CH 2 SH， -CH 2 OR 3或-CH 2 NH 2; R 2：烷基，优选CH 3，C 2 H 5，C 3 H 8; R 3：H，烷基，优选CH 3，C 2 H 5，C 3 H 8;和A 4 C 4烷基独立还包括：（1）表达重组烷烃羟化酶的细胞;和（2）包含在水溶液中的细胞和式（R1-A1-COOR2）（II）的羧酸酯的反应混合物。 A1：任选取代的，任选支链和/或环状的4C，优选8C烷基，4C，优选8C芳基或4C，优选8C芳烷基。

10. 发明授权

US09896702B2 Methods, reagents and cells for biosynthesizing compounds 有权
公开(公告)号：US09896702B2
公开(公告)日：2018-02-20
申请号：US14740554
申请日：2015-06-16
申请人： INVISTA North America S.á r.l.
发明人： Alex Van Eck Conradie , Adriana Leonora Botes
IPC分类号： C12P7/62 , C12P13/00 , C12P7/42 , C12N9/18 , C12P7/44 , C12P7/18 , C12P11/00 , C12N9/16 , C12N9/10 , C12N9/02 , C07C69/533 , C12P7/24 , C12P7/40 , C12P17/10
CPC分类号： C12P7/62 , C07C69/533 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/18 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P11/00 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/99006 , C12Y203/01016 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/01085 , C12Y301/02
摘要： This document describes biochemical pathways for producing 2(E)-heptenedioyl-CoA methyl ester from precursors such as 2-oxo-glutarate, acetyl-CoA, or succinyl-CoA using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase, a CoA ligase, as well as recombinant hosts expressing one or more of such enzymes. 2(E)-heptenedioyl-CoA methyl ester can be enzymatically converted to pimeloyl-CoA using a trans-2-enoyl-CoA reductase, and a methylesterase. Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol.

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