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1. 发明授权

US08048630B2 Methods and agents for detecting Parechovirus 有权
标题翻译：检测鱼腥草病的方法和试剂
公开(公告)号：US08048630B2
公开(公告)日：2011-11-01
申请号：US12299097
申请日：2006-05-01
申请人： William Allan Nix , M. Steven Oberste
发明人： William Allan Nix , M. Steven Oberste
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/701 , C12N2770/32511
摘要： The present disclosure provides methods that permit detection of all known species of Parechovirus, including Human parechovirus and Ljungan virus (LV). In particular examples the method includes amplifying at least a portion of the 5′NTR of parechovirus nucleic acid molecules obtained from a sample, and detecting the resulting amplicons, but does not require culturing of the virus. The present disclosure also provides methods for determining which particular species or serotype of parechovirus is present in a biological sample. Also provided are oligonucleotide primers and probes that can be used in the disclosed methods.
摘要翻译：本公开提供了允许检测所有已知种类的Parechovirus，包括人类parechovirus和Ljungan病毒（LV）的方法。在具体实例中，该方法包括扩增从样品获得的鹦鹉病毒核酸分子的5NTR的至少一部分，并检测所得扩增子，但不需要培养病毒。本公开还提供了用于确定生物样品中存在有哪些特定种类或血清型的parechovirus的方法。还提供了可用于所公开的方法中的寡核苷酸引物和探针。

2. 发明申请

US20100035230A1 METHODS AND AGENTS FOR DETECTING PARECHOVIRUS 有权
标题翻译：检测PARECHOVIRUS的方法和试剂
公开(公告)号：US20100035230A1
公开(公告)日：2010-02-11
申请号：US12299097
申请日：2006-05-01
申请人： William Allan Nix , M. Steven Oberste
发明人： William Allan Nix , M. Steven Oberste
IPC分类号： C12Q1/70 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/701 , C12N2770/32511
摘要： The present disclosure provides methods that permit detection of all known species of Parechovirus, including Human parechovirus and Ljungan virus (LV). In particular examples the method includes amplifying at least a portion of the 5′NTR of parechovirus nucleic acid molecules obtained from a sample, and detecting the resulting amplicons, but does not require culturing of the virus. The present disclosure also provides methods for determining which particular species or serotype of parechovirus is present in a biological sample. Also provided are oligonucleotide primers and probes that can be used in the disclosed methods.
摘要翻译：本公开提供了允许检测所有已知种类的Parechovirus，包括人类parechovirus和Ljungan病毒（LV）的方法。在具体实例中，该方法包括扩增从样品获得的鹦鹉病毒核酸分子的5NTR的至少一部分，并检测所得扩增子，但不需要培养病毒。本公开还提供了用于确定生物样品中存在有哪些特定种类或血清型的parechovirus的方法。还提供了可用于所公开的方法中的寡核苷酸引物和探针。

3. 发明公开

EP1907414A2 PARECHOVIRUS, VACCINES, MEDICAMENTS AND DIAGNOSTIC KITS 审中-公开
标题翻译： PARECHOVIRUS，疫苗，诊断试剂盒及药物
公开(公告)号：EP1907414A2
公开(公告)日：2008-04-09
申请号：EP06783845.8
申请日：2006-07-14
申请人： PrimaGen Holding B.V.
发明人： BENSCHOP, Kimberly Samantha Meriaha , SCHINKEL, Cornelia Johanna , LUKEN, Manon Elisabeth Maria , VAN DEN BROEK, Petrus Johannes Maria
IPC分类号： C07K14/085 , C12N15/41 , C12N7/00 , A61K39/125 , C12N15/15 , G01N33/53
CPC分类号： C12N7/00 , A61K2039/525 , C12N2770/32511 , C12N2770/32521
摘要： The invention provides a new parechoviral serotype called HPEV 251176, and functional parts, derivatives and analogues of said virus. Compounds capable of specifically binding HPEV 251176, such as isolated or recombinant antibodies and T cells, are also herewith provided. Immunogenic compositions, vaccines, pharmaceutical compositions and diagnostic kits comprising said virus, amino acid sequence or compound are also provided, as well as methods for producing same. A diagnostic kit of the invention may as well comprise a primer/probe capable of amplifying and/or hybridising at least part of the genome of HPEV 251176.

4. 发明公开

EP1746102A1 Parechovirus, vaccines, medicaments and diagnostic kits 审中-公开
标题翻译： Parechovirus，Impfstoffe，Medikamente und diagnische Kits
公开(公告)号：EP1746102A1
公开(公告)日：2007-01-24
申请号：EP05076632.8
申请日：2005-07-15
申请人： PrimaGen Holding B.V.
发明人： Benschop, Kimberley, Samantha, Meriaha , Schinkel, Cornelia Johanna , Luken, Manon Elisabeth Maria , Van den Broek, Petrus Johannes Maria
IPC分类号： C07K14/085 , C12N15/41 , C12N7/00 , A61K39/125 , C12N15/11 , G01N33/53
CPC分类号： C12N7/00 , A61K2039/525 , C12N2770/32511 , C12N2770/32521
摘要： The invention provides a new parechoviral serotype called HPEV 251176, and functional parts, derivatives and analogues of said virus. Compounds capable of specifically binding HPEV 251176, such as isolated or recombinant antibodies and T cells, are also herewith provided. Immunogenic compositions, vaccines, pharmaceutical compositions and diagnostic kits comprising said virus, amino acid sequence or compound are also provided, as well as methods for producing same. A diagnostic kit of the invention may as well comprise a primer/probe capable of amplifying and/or hybridising at least part of the genome of HPEV 251176.
摘要翻译：本发明提供了一种称为HPEV 251176的新型parechoviral血清型，以及所述病毒的功能部分，衍生物和类似物。还可以提供能够特异性结合HPEV 251176的化合物，例如分离或重组抗体和T细胞。还提供了包含所述病毒，氨基酸序列或化合物的免疫原性组合物，疫苗，药物组合物和诊断试剂盒，以及其制备方法。本发明的诊断试剂盒还可以包含能够扩增和/或杂交HPEV 251176的至少部分基因组的引物/探针。

5. 发明申请

WO2007133189A2 METHODS AND AGENTS FOR DETECTING PARECHOVIRUS 审中-公开
标题翻译：检测PARECHOVIRUS的方法和试剂
公开(公告)号：WO2007133189A2
公开(公告)日：2007-11-22
申请号：PCT/US2006/016624
申请日：2006-05-01
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES,CENTERS FOR DISEASE CONTROL AND PREVENTION , NIX, William , OBERSTE, M., Steven
发明人： NIX, William , OBERSTE, M., Steven
IPC分类号： H04L27/28
CPC分类号： C12Q1/701 , C12N2770/32511
摘要： The present disclosure provides methods that permit detection of all known species of Parechovirus, including Human parechovirus and Ljungan virus (LV). In particular examples the method includes amplifying at least a portion of the 5 TSTTR of parechovirus nucleic acid molecules obtained from a sample, and detecting the resulting amplicons, but does not require culturing of the virus. The present disclosure also provides methods for determining which particular species or serotype of parechovirus is present in a biological sample. Also provided are oligonucleotide primers and probes that can be used in the disclosed methods.
摘要翻译：本公开提供了允许检测所有已知种类的Parechovirus，包括人类parechovirus和Ljungan病毒（LV）的方法。在具体实例中，该方法包括扩增从样品获得的Parechovirus核酸分子的TSTTR的至少一部分，并检测所得的扩增子，但不需要培养病毒。本公开还提供了用于确定生物样品中存在有哪些特定种类或血清型的parechovirus的方法。还提供了可用于所公开的方法中的寡核苷酸引物和探针。

6. 发明申请

WO2007133189A3 METHODS AND AGENTS FOR DETECTING PARECHOVIRUS 审中-公开
标题翻译：检测PARECHOVIRUS的方法和试剂
公开(公告)号：WO2007133189A3
公开(公告)日：2009-04-16
申请号：PCT/US2006016624
申请日：2006-05-01
申请人： US GOV HEALTH & HUMAN SERV , NIX WILLIAM , OBERSTE M STEVEN
发明人： NIX WILLIAM , OBERSTE M STEVEN
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/701 , C12N2770/32511
摘要： The present disclosure provides methods that permit detection of all known species of Parechovirus, including Human parechovirus and Ljungan virus (LV). In particular examples the method includes amplifying at least a portion of the 5 TSTTR of parechovirus nucleic acid molecules obtained from a sample, and detecting the resulting amplicons, but does not require culturing of the virus. The present disclosure also provides methods for determining which particular species or serotype of parechovirus is present in a biological sample. Also provided are oligonucleotide primers and probes that can be used in the disclosed methods.
摘要翻译：本公开提供了允许检测所有已知种类的Parechovirus，包括人类parechovirus和Ljungan病毒（LV）的方法。在具体实例中，该方法包括扩增从样品获得的Parechovirus核酸分子的TSTTR的至少一部分，并检测所得的扩增子，但不需要培养病毒。本公开还提供了用于确定生物样品中存在有哪些特定种类或血清型的parechovirus的方法。还提供了可用于所公开的方法中的寡核苷酸引物和探针。

7. 发明申请

WO2007011210A2 PARECHOVIRUS, VACCINES, MEDICAMENTS AND DIAGNOSTIC KITS 审中-公开
标题翻译：禽流感病毒，疫苗，药物和诊断试剂盒
公开(公告)号：WO2007011210A2
公开(公告)日：2007-01-25
申请号：PCT/NL2006000368
申请日：2006-07-14
申请人： PRIMAGEN HOLDING BV , BENSCHOP KIMBERLY SAMANTHA MER , SCHINKEL CORNELIA JOHANNA , LUKEN MANON ELISABETH MARIA , VAN DEN BROEK PETRUS JOHANNES
发明人： BENSCHOP KIMBERLY SAMANTHA MER , SCHINKEL CORNELIA JOHANNA , LUKEN MANON ELISABETH MARIA , VAN DEN BROEK PETRUS JOHANNES
IPC分类号： C07K14/085 , A61K39/125 , C12N7/00 , C12N15/15 , C12N15/41 , G01N33/53
CPC分类号： C12N7/00 , A61K2039/525 , C12N2770/32511 , C12N2770/32521
摘要： The invention provides a new parechoviral serotype called HPEV 251176, and functional parts, derivatives and analogues of said virus. Compounds capable of specifically binding HPEV 251176, such as isolated or recombinant antibodies and T cells, are also herewith provided. Immunogenic compositions, vaccines, pharmaceutical compositions and diagnostic kits comprising said virus, amino acid sequence or compound are also provided, as well as methods for producing same. A diagnostic kit of the invention may as well comprise a primer/probe capable of amplifying and/or hybridising at least part of the genome of HPEV 251176.
摘要翻译：本发明提供了称为HPEV 251176的新型Parechoviral血清型，以及所述病毒的功能部分，衍生物和类似物。还提供了能够特异性结合HPEV 251176的化合物，例如分离的或重组的抗体和T细胞。还提供了包含所述病毒，氨基酸序列或化合物的免疫原性组合物，疫苗，药物组合物和诊断试剂盒及其制备方法。本发明的诊断试剂盒还可以包含能够扩增和/或杂交HPEV 251176的至少部分基因组的引物/探针。

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