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    • 10. 发明申请
    • ATTENUATED RABIES VIRUS WITH NUCLEOPROTEIN MUTATION AT THE PHOSPHORYLATION SITE FOR VACCINATION AGAINST RABIES AND GENE THERAPY IN THE CNS
    • 在中枢神经系统的抗病毒和基因治疗用于疫苗接种的细胞培养基中具有核糖体突变的衰减的病毒性病毒
    • WO2003046506A2
    • 2003-06-05
    • PCT/US2002/023108
    • 2002-07-22
    • THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    • FU, Zhen, Fang
    • G01N
    • C12N7/00A61K39/12A61K39/205A61K48/00A61K2039/5254C07K14/005C12N15/86C12N2760/20122C12N2760/20134C12N2760/20143C12N2760/20161
    • A mutant virus is provided which contains a mutation at a phosphorylation site in one or more of the proteins of the virus, which mutation causes the virus to be attenuated, and therefore, an improved vaccine composition can be produced therewith. The invention also relates to vaccine compositions which contain the mutant virus, as well as to methods of inducing an immune response, and of protecting mammals from infection by rabies virus. Also included in the invention are methods of producing the mutant virus and mutant viral proteins, including producing the mutant virus in a host cell which produces or even overproduces a wild-type counterpart of the mutant viral protein, which complements the other viral proteins such that production of the mutant viral particle is optimized. The invention also includes those host cells in which viral production is optimized, as well as vaccine compositions including the viral proteins, either alone or in combination with the intact virus, and to methods of inducing an immune response or protecting a mammal from infection, using the same. Also included in the invention are vectors suitable for delivering a gene to a cell of a human or animal, as well methods of delivery thereof.
    • 提供了突变病毒,其在病毒的一种或多种蛋白质中的磷酸化位点处含有突变,该突变导致病毒减毒,因此可以用其产生改进的疫苗组合物。 本发明还涉及含有突变病毒的疫苗组合物,以及诱导免疫应答的方法,以及保护哺乳动物不被狂犬病病毒感染。 本发明还包括产生突变病毒和突变病毒蛋白质的方法,包括在宿主细胞中产生突变病毒,所述宿主细胞产生甚至过度产生突变病毒蛋白质的野生型对应物,其补充其他病毒蛋白质,使得 优化突变病毒颗粒的生产。 本发明还包括其中优化病毒生产的那些宿主细胞以及包含病毒蛋白的疫苗组合物,其单独或与完整病毒组合,以及诱导免疫应答或保护哺乳动物感染的方法,使用 一样。 本发明还包括适合将基因递送至人或动物的细胞的载体,以及其递送方法。