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1. 发明公开

CN108025054A 用于治疗和/或预防肿瘤的沙粒病毒和用于制备具有（改善的）肿瘤消退性能的沙粒病毒的方法有权转让
公开(公告)号：CN108025054A
公开(公告)日：2018-05-11
申请号：CN201680030624.5
申请日：2016-04-15
申请人：卡尔·塞班斯坦·兰
发明人：卡尔·塞班斯坦·兰 , H.卡尔卡万
IPC分类号： A61K39/12 , A61K39/00 , A61K35/76 , A61K35/768 , A61P35/00
CPC分类号： A61K39/12 , A61K35/76 , A61K35/768 , A61K2039/5254 , A61K2039/585 , A61P35/00 , C12N7/00 , C12N2760/10021 , C12N2760/10032 , C12N2760/10033
摘要：本发明涉及用于治疗和/或预防肿瘤的沙粒病毒以及用于制备具有（改善的）肿瘤消退性能的沙粒病毒的方法。

2. 发明申请

US20140243256A1 ARENAVIRUS INHIBITING PEPTIDES AND USES THEREFOR 有权
标题翻译： ARENAVIRUS抑制肽及其用途
公开(公告)号：US20140243256A1
公开(公告)日：2014-08-28
申请号：US13828581
申请日：2013-03-14
申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： Jennifer S. SPENCE , Robert F. GARRY
IPC分类号： C07K14/08 , C07K7/08 , C07K7/06
CPC分类号： C07K14/08 , C12N2760/10033 , Y10S530/826
摘要： The present invention describes peptides which inhibit fusion of an arenavirus (e.g., Pichinde virus; PICV) with a host cell membrane. The arenavirus inhibiting (AVI) peptides described herein comprise a segment of the GP2 protein of an arenavirus. The AVI peptides are useful for inhibiting arenavirus-to-host cell membrane fusion and for treating arenavirus infections. In a particular embodiment, the arenavirus inhibiting peptide comprises a segment of PICV glycoprotein 2 (PICV GP2; SEQ ID NO: 1), Tamiami virus (TAMV) GP2 (SEQ ID NO: 14), or Lassa virus (LASV) GP2 (SEQ ID NO: 15). In particular, the segment is selected from a region of an arenavirus GP2 extending from the N-terminus into the first half of the FIR (i.e., from residues 1 through 105 of SEQ ID NO: 1, SEQ ID NO: 14, or SEQ ID NO: 15).
摘要翻译：本发明描述了抑制斑马鱼病毒（例如，Pichinde病毒; PICV）与宿主细胞膜融合的肽。本文所述的异烟肼病毒抑制（AVI）肽包含斑马鱼病毒的GP2蛋白的片段。 AVI肽可用于抑制斑马鱼病毒与宿主细胞膜融合和治疗斑马疹病毒感染。在一个具体实施方案中，所述病毒毒素抑制肽包含PICV糖蛋白2（PICV GP2; SEQ ID NO：1），Tamiami病毒（TAMV）GP2（SEQ ID NO：14）或Lassv病毒（LASV）GP2（SEQ 编号：15）。特别地，该片段选自从N末端延伸到FIR前半部分（即，SEQ ID NO：1，SEQ ID NO：14或SEQ ID NO：14的残基1至105）的斑马鱼病毒GP2的区域编号：15）。

3. 发明授权

US11801294B2 Method of enhancing innate immune responses against a tumor comprising administering lymphocytic choriomeningitis virus (LCMV) 有权
公开(公告)号：US11801294B2
公开(公告)日：2023-10-31
申请号：US16267095
申请日：2019-02-04
申请人： ABALOS THERAPEUTICS GMBH
发明人： Karl Sebastian Lang , Halime Kalkavan
IPC分类号： A61K39/12 , A61K35/76 , A61K35/768 , C12N7/00 , A61K39/00 , A61P35/00
CPC分类号： A61K39/12 , A61K35/76 , A61K35/768 , C12N7/00 , A61K2039/5254 , A61K2039/585 , A61P35/00 , C12N2760/10011 , C12N2760/10021 , C12N2760/10032 , C12N2760/10033
摘要： The invention relates to arenaviruses for use in the treatment and/or prevention of tumors and also a method for preparing arenaviruses with (improved) tumor-regressive properties.

4. 发明公开

EP2155777A2 SOLUBLE AND MEMBRANE-ANCHORED FORMS OF LASSA VIRUS SUBUNIT PROTEINS 审中-公开
标题翻译：可溶性蛋白和膜蛋白停泊形式的病毒拉沙单位
公开(公告)号：EP2155777A2
公开(公告)日：2010-02-24
申请号：EP08742716.7
申请日：2008-04-10
申请人： The Administrators of the Tulane Educational Fund
发明人： BRANCO, Luis, M. , MATSCHINER, Alexander , ILLICK, Megan, M. , SAMPEY, Darryl, B. , GARRY, Robert, F. , BAUSCH, Daniel, G. , FAIR, Joseph, N. , GUTTIERI, Mary, C. , CASHMAN, Kathleen, A. , WILSON, Russell, B. , KULAKOSKY, Peter, C. , GESKE, F., Jon
IPC分类号： C07K14/08 , A61K38/16 , A61K39/12
CPC分类号： C07K14/005 , A61K39/00 , C07K16/10 , C07K2319/24 , C07K2319/30 , C12N2760/10022 , C12N2760/10033 , G01N33/56983 , G01N2333/08
摘要： The invention discloses compositions comprising soluble and membrane-anchored forms of Lassa virus (LASV) glycoprotein 1 (GP1), glycoprotein 2 (GP2), the glycoprotein precursor (GPC), the nucleocapsid protein (NP), and the nucleic acids encoding these proteins. This invention further relates to diagnostic and preventative methods using these compositions. Preventative methods include preparation of vaccines, as well as factors (e.g. small molecules) that inhibit LASV infectivity. Further, the invention relates to diagnostic and therapeutic antibodies including neutralizing antibodies for the prevention and treatment of infection by LASV and other arenaviruses.

5. 发明公开

US20240252611A1 ARENAVIRUSES FOR USE IN THE TREATMENT AND/OR PREVENTION OF TUMORS AND METHOD FOR PRODUCING ARENAVIRUSES WITH (IM-PROVED) TUMOR-REGRESSION PROPERTIES 审中-公开
公开(公告)号：US20240252611A1
公开(公告)日：2024-08-01
申请号：US18385250
申请日：2023-10-30
申请人： ABALOS THERAPEUTICS GMBH
发明人： Karl Sebastian Lang , Halime Kalkavan
IPC分类号： A61K39/12 , A61K35/76 , A61K35/768 , A61K39/00 , A61P35/00 , C12N7/00
CPC分类号： A61K39/12 , A61K35/76 , A61K35/768 , C12N7/00 , A61K2039/5254 , A61K2039/585 , A61P35/00 , C12N2760/10011 , C12N2760/10021 , C12N2760/10032 , C12N2760/10033
摘要： The invention relates to arenaviruses for use in the treatment and/or prevention of tumors and also a method for preparing arenaviruses with (improved) tumor-regressive properties.

6. 发明授权

US09963718B2 LCMV-GP-VSV-pseudotyped vectors and tumor-infiltrating virus-producing cells for the therapy of tumors 有权
公开(公告)号：US09963718B2
公开(公告)日：2018-05-08
申请号：US15482430
申请日：2017-04-07
申请人： VIRATHERAPEUTICS GMBH
发明人： Dorothee Von Laer , Tsanan Heimann
IPC分类号： C12N15/86 , C07K14/005 , A61K48/00 , C07K14/54 , C07K14/52 , C12N9/12
CPC分类号： C12N15/86 , A61K48/005 , C07K14/005 , C07K14/52 , C07K14/5434 , C12N9/1211 , C12N2760/10022 , C12N2760/10023 , C12N2760/10032 , C12N2760/10033 , C12N2760/10044 , C12N2760/10045 , C12N2760/10122 , C12N2760/20222 , C12N2760/20223 , C12N2760/20241 , C12N2760/20243 , C12N2760/20245 , C12N2760/20252 , C12N2810/6072 , C12Y207/01021
摘要： The invention relates to recombinant VSV viruses and viral vectors which produce a glycoprotein GP of the lymphocyte choriomeningitis virus (LCMV) instead of the G protein of the VSV, to virus producing cells which produce LCMV-GP-pseudotyped VSV virions, and to the use of said vectors and cells in the therapy of solid tumors, especially brain tumors.

7. 发明授权

US09650649B2 LCMV-GP-VSV-pseudotyped vectors and tumor-infiltrating virus-producing cells for the therapy of tumors 有权
公开(公告)号：US09650649B2
公开(公告)日：2017-05-16
申请号：US13123175
申请日：2009-10-08
申请人： Dorothee Von Laer , Tsanan Heimann
发明人： Dorothee Von Laer , Tsanan Heimann
IPC分类号： A01N63/00 , C12N15/86 , C12N13/00 , A61K48/00
CPC分类号： C12N15/86 , A61K48/005 , C07K14/005 , C07K14/52 , C07K14/5434 , C12N9/1211 , C12N2760/10022 , C12N2760/10023 , C12N2760/10032 , C12N2760/10033 , C12N2760/10044 , C12N2760/10045 , C12N2760/10122 , C12N2760/20222 , C12N2760/20223 , C12N2760/20241 , C12N2760/20243 , C12N2760/20245 , C12N2760/20252 , C12N2810/6072 , C12Y207/01021
摘要： The invention relates to recombinant VSV viruses and viral vectors which produce a glycoprotein GP of the lymphocyte choriomeningitis virus (LCMV) instead of the G protein of the VSV, to virus producing cells which produce LCMV-GP-pseudotyped VSV virions, and to the use of said vectors and cells in the therapy of solid tumors, especially brain tumors.

8. 发明申请

US20170211096A1 LCMV-GP-VSV-Pseudotyped Vectors and Tumor-Infiltrating Virus-Producing Cells for the Therapy of Tumors 有权
公开(公告)号：US20170211096A1
公开(公告)日：2017-07-27
申请号：US15482430
申请日：2017-04-07
申请人： VIRATHERAPEUTICS GMBH
发明人： Dorothee Von Laer , Tsanan Heimann
IPC分类号： C12N15/86 , C12N9/12 , C07K14/54 , C07K14/52 , C07K14/005 , A61K48/00
CPC分类号： C12N15/86 , A61K48/005 , C07K14/005 , C07K14/52 , C07K14/5434 , C12N9/1211 , C12N2760/10022 , C12N2760/10023 , C12N2760/10032 , C12N2760/10033 , C12N2760/10044 , C12N2760/10045 , C12N2760/10122 , C12N2760/20222 , C12N2760/20223 , C12N2760/20241 , C12N2760/20243 , C12N2760/20245 , C12N2760/20252 , C12N2810/6072 , C12Y207/01021
摘要： The invention relates to recombinant VSV viruses and viral vectors which produce a glycoprotein GP of the lymphocyte choriomeningitis virus (LCMV) instead of the G protein of the VSV, to virus producing cells which produce LCMV-GP-pseudotyped VSV virions, and to the use of said vectors and cells in the therapy of solid tumors, especially brain tumors.

9. 发明申请

US20110250188A1 LCMV-GP-VSV-Pseudotyped Vectors and Tumor-Infiltrating Virus-Producing Cells for the Therapy of Tumors 有权
标题翻译：用于肿瘤治疗的LCMV-GP-VSV-假型载体和肿瘤浸润病毒产生细胞
公开(公告)号：US20110250188A1
公开(公告)日：2011-10-13
申请号：US13123175
申请日：2009-10-08
申请人： Dorothee Von Laer , Tsanan Heimann
发明人： Dorothee Von Laer , Tsanan Heimann
IPC分类号： A61K35/12 , C12N7/00 , A61P35/00 , A61K48/00 , A61K35/76 , C12N15/86 , C12N5/10
CPC分类号： C12N15/86 , A61K48/005 , C07K14/005 , C07K14/52 , C07K14/5434 , C12N9/1211 , C12N2760/10022 , C12N2760/10023 , C12N2760/10032 , C12N2760/10033 , C12N2760/10044 , C12N2760/10045 , C12N2760/10122 , C12N2760/20222 , C12N2760/20223 , C12N2760/20241 , C12N2760/20243 , C12N2760/20245 , C12N2760/20252 , C12N2810/6072 , C12Y207/01021
摘要： The invention relates to recombinant VSV viruses and viral vectors which produce a glycoprotein GP of the lymphocyte choriomeningitis virus (LCMV) instead of the G protein of the VSV, to virus producing cells which produce LCMV-GP-pseudotyped VSV virions, and to the use of said vectors and cells in the therapy of solid tumors, especially brain tumors.
摘要翻译：本发明涉及产生淋巴细胞性脉络丛脑膜炎病毒（LCMV）而不是VSV的G蛋白的糖蛋白GP的重组VSV病毒和产生LCMV-GP假型VSV病毒粒子的病毒产生细胞的病毒载体，以及使用的所述载体和细胞在治疗实体瘤，特别是脑肿瘤中。

10. 发明申请

US20100261640A1 SOLUBLE AND MEMBRANE ANCHORED FORMS OF LASSA VIRUS SUBUNIT PROTEINS 审中-公开
标题翻译： LASSA病毒亚型蛋白质的可溶性和膜型锚定形式
公开(公告)号：US20100261640A1
公开(公告)日：2010-10-14
申请号：US12450756
申请日：2008-04-10
申请人： Luis M. Branco , Alexander Matschiner , Megan M. Illick , Darryl B. Sampey , Robert F. Garry , Daniel G. Bausch , Joseph N. Fair , Mary C. Guttieri , Kathleen A. Cashman , Russell B. Wilson , Peter C. Kulakosky , F. Jon Geske
发明人： Luis M. Branco , Alexander Matschiner , Megan M. Illick , Darryl B. Sampey , Robert F. Garry , Daniel G. Bausch , Joseph N. Fair , Mary C. Guttieri , Kathleen A. Cashman , Russell B. Wilson , Peter C. Kulakosky , F. Jon Geske
IPC分类号： A61K38/16 , C07K14/08 , C07H21/04 , C12N15/63 , C07K16/10 , C12Q1/70 , C12P21/02 , A61P31/14
CPC分类号： C07K14/005 , A61K39/00 , C07K16/10 , C07K2319/24 , C07K2319/30 , C12N2760/10022 , C12N2760/10033 , G01N33/56983 , G01N2333/08
摘要： The invention discloses compositions comprising soluble and membrane-anchored forms of Lassa virus (LASV) glycoprotein 1 (GP1), glycoprotein 2 (GP2), the glycoprotein precursor (GPC), the nucleocapsid protein (NP), and the nucleic acids encoding these proteins. This invention further relates to diagnostic and preventative methods using these compositions. Preventative methods include preparation of vaccines, as well as factors (e.g. small molecules) that inhibit LASV infectivity. Further, the invention relates to diagnostic and therapeutic antibodies including neutralizing antibodies for the prevention and treatment of infection by LASV and other arenaviruses.
摘要翻译：本发明公开了包含Lassa病毒（LASV）糖蛋白1（GP1），糖蛋白2（GP2），糖蛋白前体（GPC），核衣壳蛋白（NP）和编码这些蛋白质的核酸的可溶性和膜锚定形式的组合物。本发明还涉及使用这些组合物的诊断和预防方法。预防方法包括疫苗的制备以及抑制LASV感染性的因子（例如小分子）。此外，本发明涉及诊断和治疗性抗体，包括用于预防和治疗LASV和其他微卫星型病毒感染的中和抗体。

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