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1. 发明公开

CN108025054A 用于治疗和/或预防肿瘤的沙粒病毒和用于制备具有（改善的）肿瘤消退性能的沙粒病毒的方法有权转让
公开(公告)号：CN108025054A
公开(公告)日：2018-05-11
申请号：CN201680030624.5
申请日：2016-04-15
申请人：卡尔·塞班斯坦·兰
发明人：卡尔·塞班斯坦·兰 , H.卡尔卡万
IPC分类号： A61K39/12 , A61K39/00 , A61K35/76 , A61K35/768 , A61P35/00
CPC分类号： A61K39/12 , A61K35/76 , A61K35/768 , A61K2039/5254 , A61K2039/585 , A61P35/00 , C12N7/00 , C12N2760/10021 , C12N2760/10032 , C12N2760/10033
摘要：本发明涉及用于治疗和/或预防肿瘤的沙粒病毒以及用于制备具有（改善的）肿瘤消退性能的沙粒病毒的方法。

2. 发明申请

US20140243256A1 ARENAVIRUS INHIBITING PEPTIDES AND USES THEREFOR 有权
标题翻译： ARENAVIRUS抑制肽及其用途
公开(公告)号：US20140243256A1
公开(公告)日：2014-08-28
申请号：US13828581
申请日：2013-03-14
申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： Jennifer S. SPENCE , Robert F. GARRY
IPC分类号： C07K14/08 , C07K7/08 , C07K7/06
CPC分类号： C07K14/08 , C12N2760/10033 , Y10S530/826
摘要： The present invention describes peptides which inhibit fusion of an arenavirus (e.g., Pichinde virus; PICV) with a host cell membrane. The arenavirus inhibiting (AVI) peptides described herein comprise a segment of the GP2 protein of an arenavirus. The AVI peptides are useful for inhibiting arenavirus-to-host cell membrane fusion and for treating arenavirus infections. In a particular embodiment, the arenavirus inhibiting peptide comprises a segment of PICV glycoprotein 2 (PICV GP2; SEQ ID NO: 1), Tamiami virus (TAMV) GP2 (SEQ ID NO: 14), or Lassa virus (LASV) GP2 (SEQ ID NO: 15). In particular, the segment is selected from a region of an arenavirus GP2 extending from the N-terminus into the first half of the FIR (i.e., from residues 1 through 105 of SEQ ID NO: 1, SEQ ID NO: 14, or SEQ ID NO: 15).
摘要翻译：本发明描述了抑制斑马鱼病毒（例如，Pichinde病毒; PICV）与宿主细胞膜融合的肽。本文所述的异烟肼病毒抑制（AVI）肽包含斑马鱼病毒的GP2蛋白的片段。 AVI肽可用于抑制斑马鱼病毒与宿主细胞膜融合和治疗斑马疹病毒感染。在一个具体实施方案中，所述病毒毒素抑制肽包含PICV糖蛋白2（PICV GP2; SEQ ID NO：1），Tamiami病毒（TAMV）GP2（SEQ ID NO：14）或Lassv病毒（LASV）GP2（SEQ 编号：15）。特别地，该片段选自从N末端延伸到FIR前半部分（即，SEQ ID NO：1，SEQ ID NO：14或SEQ ID NO：14的残基1至105）的斑马鱼病毒GP2的区域编号：15）。

3. 发明授权

US11801294B2 Method of enhancing innate immune responses against a tumor comprising administering lymphocytic choriomeningitis virus (LCMV) 有权
公开(公告)号：US11801294B2
公开(公告)日：2023-10-31
申请号：US16267095
申请日：2019-02-04
申请人： ABALOS THERAPEUTICS GMBH
发明人： Karl Sebastian Lang , Halime Kalkavan
IPC分类号： A61K39/12 , A61K35/76 , A61K35/768 , C12N7/00 , A61K39/00 , A61P35/00
CPC分类号： A61K39/12 , A61K35/76 , A61K35/768 , C12N7/00 , A61K2039/5254 , A61K2039/585 , A61P35/00 , C12N2760/10011 , C12N2760/10021 , C12N2760/10032 , C12N2760/10033
摘要： The invention relates to arenaviruses for use in the treatment and/or prevention of tumors and also a method for preparing arenaviruses with (improved) tumor-regressive properties.

4. 发明授权

EP2597154B1 LCMV-GP-VSV-Pseudotypvektoren und tumorinfiltrierende Virusproduzentenzellen zur Therapie von Tumoren 有权转让
标题翻译： LCMV-GP假VSV载体和肿瘤浸润性病毒产生细胞为肿瘤的治疗
公开(公告)号：EP2597154B1
公开(公告)日：2014-09-03
申请号：EP13153949.6
申请日：2009-10-08
申请人： ViraTherapeutics GmbH
发明人： Von Laer, Dorothee , Heimann, Tsanan
IPC分类号： C12N15/86 , A61K35/76 , C12N5/10 , C12N5/074
CPC分类号： C12N15/86 , A61K48/005 , C07K14/005 , C07K14/52 , C07K14/5434 , C12N9/1211 , C12N2760/10022 , C12N2760/10023 , C12N2760/10032 , C12N2760/10033 , C12N2760/10044 , C12N2760/10045 , C12N2760/10122 , C12N2760/20222 , C12N2760/20223 , C12N2760/20241 , C12N2760/20243 , C12N2760/20245 , C12N2760/20252 , C12N2810/6072 , C12Y207/01021

5. 发明公开

EP2597154A1 LCMV-GP-VSV-Pseudotypvektoren und tumorinfiltrierende Virusproduzentenzellen zur Therapie von Tumoren 有权转让
公开(公告)号：EP2597154A1
公开(公告)日：2013-05-29
申请号：EP13153949.6
申请日：2009-10-08
申请人： Von Laer, Dorothee
发明人： Von Laer, Dorothee , Heimann, Tsanan
IPC分类号： C12N15/86 , A61K35/76 , C12N5/10 , C12N5/074
CPC分类号： C12N15/86 , A61K48/005 , C07K14/005 , C07K14/52 , C07K14/5434 , C12N9/1211 , C12N2760/10022 , C12N2760/10023 , C12N2760/10032 , C12N2760/10033 , C12N2760/10044 , C12N2760/10045 , C12N2760/10122 , C12N2760/20222 , C12N2760/20223 , C12N2760/20241 , C12N2760/20243 , C12N2760/20245 , C12N2760/20252 , C12N2810/6072 , C12Y207/01021
摘要： Die Erfindung betrifft rekombinante VSV-Viren und virale Vektoren, welche ein Glykoprotein GP des lymphozytären Choriomeningitisvirus (LCMV) anstelle des G-Proteins des VSV enthalten, Virusproduzentenzellen, welche mit LCMV-GP pseudotypisierte VSV-Virionen produzieren, sowie die Verwendung genannter Vektoren und Zellen zur Therapie solider Tumore, insbesondere Hirntumore.
摘要翻译：包含编码LCMV的GP的基因并且没有VSV的包膜蛋白G的功能基因的水泡性口炎病毒 - 淋巴细胞性脉络丛脑膜炎病毒 - 糖蛋白（VSV-LCMV-GP）假型载体是新的。包括以下的独立权利要求：（1）包含至少两个补体的复制VSV载体的VSV-LCMV-GP假型载体系统，其含有n，l，p和m编码N，L，P- 和VSV的基质（M）蛋白，编码LCMV-GP的基因gp和没有编码VSV的G蛋白的功能基因，其中在系统的每个载体中，n，l，p的基因之一，m和gp缺失，缺失的基因存在于载体系统的另一个载体中; （2）包含作为包膜蛋白的LCMV的GP-蛋白质的假型VSV病毒体; （3）产生假型VSV病毒粒子的病毒生产细胞; （4）在体外转移细胞中的转基因，包括用假型VSV病毒体转导细胞，其中病毒粒子含有转基因，或使细胞与病毒生产细胞接触。活动：细胞抑制。行动机制：无给予。

6. 发明公开

EP2155777A2 SOLUBLE AND MEMBRANE-ANCHORED FORMS OF LASSA VIRUS SUBUNIT PROTEINS 审中-公开
标题翻译：可溶性蛋白和膜蛋白停泊形式的病毒拉沙单位
公开(公告)号：EP2155777A2
公开(公告)日：2010-02-24
申请号：EP08742716.7
申请日：2008-04-10
申请人： The Administrators of the Tulane Educational Fund
发明人： BRANCO, Luis, M. , MATSCHINER, Alexander , ILLICK, Megan, M. , SAMPEY, Darryl, B. , GARRY, Robert, F. , BAUSCH, Daniel, G. , FAIR, Joseph, N. , GUTTIERI, Mary, C. , CASHMAN, Kathleen, A. , WILSON, Russell, B. , KULAKOSKY, Peter, C. , GESKE, F., Jon
IPC分类号： C07K14/08 , A61K38/16 , A61K39/12
CPC分类号： C07K14/005 , A61K39/00 , C07K16/10 , C07K2319/24 , C07K2319/30 , C12N2760/10022 , C12N2760/10033 , G01N33/56983 , G01N2333/08
摘要： The invention discloses compositions comprising soluble and membrane-anchored forms of Lassa virus (LASV) glycoprotein 1 (GP1), glycoprotein 2 (GP2), the glycoprotein precursor (GPC), the nucleocapsid protein (NP), and the nucleic acids encoding these proteins. This invention further relates to diagnostic and preventative methods using these compositions. Preventative methods include preparation of vaccines, as well as factors (e.g. small molecules) that inhibit LASV infectivity. Further, the invention relates to diagnostic and therapeutic antibodies including neutralizing antibodies for the prevention and treatment of infection by LASV and other arenaviruses.

7. 发明公开

US20240252611A1 ARENAVIRUSES FOR USE IN THE TREATMENT AND/OR PREVENTION OF TUMORS AND METHOD FOR PRODUCING ARENAVIRUSES WITH (IM-PROVED) TUMOR-REGRESSION PROPERTIES 审中-公开
公开(公告)号：US20240252611A1
公开(公告)日：2024-08-01
申请号：US18385250
申请日：2023-10-30
申请人： ABALOS THERAPEUTICS GMBH
发明人： Karl Sebastian Lang , Halime Kalkavan
IPC分类号： A61K39/12 , A61K35/76 , A61K35/768 , A61K39/00 , A61P35/00 , C12N7/00
CPC分类号： A61K39/12 , A61K35/76 , A61K35/768 , C12N7/00 , A61K2039/5254 , A61K2039/585 , A61P35/00 , C12N2760/10011 , C12N2760/10021 , C12N2760/10032 , C12N2760/10033
摘要： The invention relates to arenaviruses for use in the treatment and/or prevention of tumors and also a method for preparing arenaviruses with (improved) tumor-regressive properties.

8. 发明授权

US09963718B2 LCMV-GP-VSV-pseudotyped vectors and tumor-infiltrating virus-producing cells for the therapy of tumors 有权
公开(公告)号：US09963718B2
公开(公告)日：2018-05-08
申请号：US15482430
申请日：2017-04-07
申请人： VIRATHERAPEUTICS GMBH
发明人： Dorothee Von Laer , Tsanan Heimann
IPC分类号： C12N15/86 , C07K14/005 , A61K48/00 , C07K14/54 , C07K14/52 , C12N9/12
CPC分类号： C12N15/86 , A61K48/005 , C07K14/005 , C07K14/52 , C07K14/5434 , C12N9/1211 , C12N2760/10022 , C12N2760/10023 , C12N2760/10032 , C12N2760/10033 , C12N2760/10044 , C12N2760/10045 , C12N2760/10122 , C12N2760/20222 , C12N2760/20223 , C12N2760/20241 , C12N2760/20243 , C12N2760/20245 , C12N2760/20252 , C12N2810/6072 , C12Y207/01021
摘要： The invention relates to recombinant VSV viruses and viral vectors which produce a glycoprotein GP of the lymphocyte choriomeningitis virus (LCMV) instead of the G protein of the VSV, to virus producing cells which produce LCMV-GP-pseudotyped VSV virions, and to the use of said vectors and cells in the therapy of solid tumors, especially brain tumors.

9. 发明授权

US09650649B2 LCMV-GP-VSV-pseudotyped vectors and tumor-infiltrating virus-producing cells for the therapy of tumors 有权
公开(公告)号：US09650649B2
公开(公告)日：2017-05-16
申请号：US13123175
申请日：2009-10-08
申请人： Dorothee Von Laer , Tsanan Heimann
发明人： Dorothee Von Laer , Tsanan Heimann
IPC分类号： A01N63/00 , C12N15/86 , C12N13/00 , A61K48/00
CPC分类号： C12N15/86 , A61K48/005 , C07K14/005 , C07K14/52 , C07K14/5434 , C12N9/1211 , C12N2760/10022 , C12N2760/10023 , C12N2760/10032 , C12N2760/10033 , C12N2760/10044 , C12N2760/10045 , C12N2760/10122 , C12N2760/20222 , C12N2760/20223 , C12N2760/20241 , C12N2760/20243 , C12N2760/20245 , C12N2760/20252 , C12N2810/6072 , C12Y207/01021
摘要： The invention relates to recombinant VSV viruses and viral vectors which produce a glycoprotein GP of the lymphocyte choriomeningitis virus (LCMV) instead of the G protein of the VSV, to virus producing cells which produce LCMV-GP-pseudotyped VSV virions, and to the use of said vectors and cells in the therapy of solid tumors, especially brain tumors.

10. 发明申请

US20170211096A1 LCMV-GP-VSV-Pseudotyped Vectors and Tumor-Infiltrating Virus-Producing Cells for the Therapy of Tumors 有权
公开(公告)号：US20170211096A1
公开(公告)日：2017-07-27
申请号：US15482430
申请日：2017-04-07
申请人： VIRATHERAPEUTICS GMBH
发明人： Dorothee Von Laer , Tsanan Heimann
IPC分类号： C12N15/86 , C12N9/12 , C07K14/54 , C07K14/52 , C07K14/005 , A61K48/00
CPC分类号： C12N15/86 , A61K48/005 , C07K14/005 , C07K14/52 , C07K14/5434 , C12N9/1211 , C12N2760/10022 , C12N2760/10023 , C12N2760/10032 , C12N2760/10033 , C12N2760/10044 , C12N2760/10045 , C12N2760/10122 , C12N2760/20222 , C12N2760/20223 , C12N2760/20241 , C12N2760/20243 , C12N2760/20245 , C12N2760/20252 , C12N2810/6072 , C12Y207/01021
摘要： The invention relates to recombinant VSV viruses and viral vectors which produce a glycoprotein GP of the lymphocyte choriomeningitis virus (LCMV) instead of the G protein of the VSV, to virus producing cells which produce LCMV-GP-pseudotyped VSV virions, and to the use of said vectors and cells in the therapy of solid tumors, especially brain tumors.

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