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    • 10. 发明授权
    • Process for the production of poly-n-oxides
    • 生产聚-N-氧化物的方法
    • US3557140A
    • 1971-01-19
    • US3557140D
    • 1968-03-07
    • BAYER AG
    • PIEPER GUSTAVBONIN WULF VONGRUNDMANN EKKEHARD
    • C08F8/00C07D27/10
    • C08F222/08C08F8/06C08F8/32C08F8/48C08F222/40C08F2222/402C08F2222/404C08F2222/406C08F2800/10C08F212/08C08F222/06
    • POLY-N-OXIDES USEFUL IN THE TREATING OF SILICOSIS AND A PROCEDURE FOR MAKING THE SAME AND ADMINISTERING THEM ARE PROVIDED. THE POLY-N-OXIDES HAVE THE FORMULA:

      -(Z-(1-(O
      -(Z-(1-B,2,5-DI(O=)PYRROLIDIN-3,4-YLENE))M-

      IN WHICH Z IS THE MONOMER UNIT OF A VINYL COMPOUND OF THE FORMULA:

      -CH2-C(-R1)(-R2)-

      WHEREIN R3 IS ALKYLENE, PHENYLENE OR ALKYLPHENYLENE WITH UP TO 7 CARBON ATOMS OF WHICH ONE CH2 GROUP MAY BE REPLACED BY AN OXYGEN ATOM; R4 AND R5 ARE LOWER ALKYL WITH 1 TO 4 CARBON ATOMS WHICH, WHEN LINKED WITH THE NITROGEN ATOM, FORM A 5 TO 7-MEMBERED CYCLIC RING SYSTEM WHICH, IN THE CASE OF A 6-MEMBERED RING, MAY CONTAIN, AS FURTHER HETERO ATOM, OXYGEN, OR A NITROGEN ATOM WHICH IS SUBSTITUTED BY A LOWER ALKYL GROUPF AND THE HETEROCYCLIC RING SYSTEM BEING AROMATIC WHEN NO FURTHER HETERO ATOMS ARE PRESENT; B STANDS FOR AN ALKPIHATIC, CYCLOALIPHATIC, AROMATIC OR HETEROCYCLIC RADICAL OF A PRIMARY MONOAMINE OF UP TO 12 CARBON ATOMS, AND WHICH ARE UNSUBSTITUTED OR SUBSTITUTED BY OH OR LOWER ALKYL; N AND M ARE INTERGERS, WHEREBY THE RATION OF N:M IS 90:10 TO 60:40, THE SUM N+M SIGNIFYING THE POLYMERIZATION DEGREE OF THE M ALEIC ACID ANHYDRIDE COPOLYMER RANGING BETWEEN 50 AND 500.

      -R3-N(-R4)-R5

      WHICH IS COPOLYMERIZED WITH MALEIC ACID ANHYDRIDE AND WHEREIN R1 AND R2 STAND FOR THE SAME OR DIFFERENT RADICALS SUCH AS HYDROGEN, ALKYL WITH 1-4 CARBON ATOMS, CYCLOALKYL WITH 3 TO 6 CARBON ATOMS, PHENYL OR PHENYL SUBSTITUTED BY LOWER ALKYL, AND WHEREIN ONE OF R1 AND R2 MAY BE ONE OF CN, CONH2, COOH, COOR, OR, OR OCOR IN WHICH R IS ALKYL WITH 1 TO 4 CARBON ATOMS. THE MONOMER UNIT WHICH IS POLYMERIZED WITH MALEIC ANHYDRIDE MAY ALSO BE STYRENE OR ISOBUTYLENE OR ETHYLENE; A-->O STANDS FOR THE RADICAL A OF A PRIMARY-TERTIARY POLYAMINE WHEREIN AT LEAST ONE TERTIARY AMINO GROUP HAS BEEN OXIDIZED TO N-OXIDIZED, AND WHEREIN A HAS THE FORMULA: