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    • 8. 发明授权
    • Antidote including activated carbon particles
    • 解毒剂包括活性炭颗粒
    • US4761284A
    • 1988-08-02
    • US759933
    • 1985-07-29
    • Yasushi Nishimura
    • Yasushi Nishimura
    • A61K33/44C01B31/08C01B31/14
    • A61K33/44C01B31/082C01B31/083C01B31/14
    • Disclosed is a pharmaceutical composition having an antidotal activity, which in dosage unit form is capable of adsorbing exogenous or endogenous toxins in the gastrointestinal tract of a patient without disintegration of said pharmaceutical composition and without causing the patient to become constipated. The active ingredient comprises spherical particles of an activated carbon wherein at least 85% in number of said spherical particles of activated carbon are microscopically spherical particles which have smooth and convex-curved surfaces without sharp edges. Specific physical parameters of the carbon particles include, maximum to minimum diameter ratios of 1.0 to 1.3, diameters of 0.05 to 2.0 mm and pore cavity volume of not more than 0.5 cc/g determined in the range of pore-radius of 5000 to 75,000 .ANG.. Dosage unit forms included, capsules, tablets, and aqueous slurries.
    • 公开了具有解毒活性的药物组合物,其剂量单位形式能够吸收患者的胃肠道中的外源性或内源性毒素,而不会使所述药物组合物分解并且不导致患者便秘。 活性成分包括活性炭的球形颗粒,其中至少85%的所述活性炭球形颗粒是显微球形颗粒,其具有没有锐边的平滑和凸曲面。 碳颗粒的具体物理参数包括最大至最小直径比为1.0至1.3,直径为0.05至2.0mm,孔隙体积不大于0.5cc / g,孔径半径范围为5000至75,000安培 。 包括剂量单位,胶囊,片剂和水性浆液。