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1. 发明公开

EP4450162A2 MICRODROPLET MANIPULATION DEVICE 审中-公开
公开(公告)号：EP4450162A2
公开(公告)日：2024-10-23
申请号：EP24195868.5
申请日：2018-06-21
申请人： Lightcast Discovery Ltd
发明人： ISAAC, Thomas Henry , CUNHA, Pedro , SHERIDAN, Eoin , LOVE, David , PALMER, Rebecca , KELLY, Douglas J. , PODD, Gareth
IPC分类号： B01L3/00
CPC分类号： B01L3/502792 , B01L2200/067320130101 , B01L2300/086420130101 , B01L2300/088720130101 , B01L2300/08920130101 , B01L2300/16120130101 , B01L2300/16520130101 , B01L2300/16820130101 , B01L2400/042720130101 , B01L3/50273
摘要： A device for fast manipulation of many thousands of microdroplets simultaneously using optically-mediated electrowetting is provided. The device comprising: a first composite wall comprising: a first substrate (2b); a first transparent conductor layer (3) on the first substrate (2b) having a thickness in the range 70 to 250 nm; a photoactive layer (5) activated by electromagnetic radiation in the wavelength range 400-1000 nm on the first transparent conductor layer having a thickness in the range 300-1000 nm and a first dielectric layer (6) on the photoactive layer having a thickness in the range of 120 to 160nm; and a first anti-fouling layer (7) on the first dielectric layer; a second composite wall comprising: a second substrate (2a); a second conductor layer (3) on the second substrate having a thickness in the range 70 to 250 nm; and a second dielectric layer (6) on the second conductor layer; and a second anti-fouling layer (7) on the second dielectric layer the device further comprising: one or more spacers for holding the first and second walls apart by a pre-determined amount to define a microfluidic space adapted to contain microdroplets, wherein the spacer comprises a bead, a pillar or a ridge; an A/C source (4) to provide a voltage of between 10V and 50V across the first and second composite walls connecting the first and second conductor layers so as to be below the dielectric breakdown voltage of the first and second dielectric layers (6); at least one source of electromagnetic radiation (8) having an energy higher than the bandgap of a photoexcitable layer adapted to impinge on the photoactive layer (5) to induce corresponding ephemeral electrowetting locations (11) on the surface of the first dielectric layer (6); and a microprocessor (12) for manipulating points of impingement of the electromagnetic radiation on the photoactive layer so as to vary the disposition of the ephemeral electrowetting locations (11) thereby creating at least one electrowetting pathway along which microdroplets may be caused to move; wherein the device is configured to performing chemical analyses carried out on multiple analytes simultaneously.

2. 发明公开

EP4436716A1 MATERIALS FOR HANDLING AND LONG-TERM STORAGE OF EXTRACELLULAR VESICLES 审中-实审
公开(公告)号：EP4436716A1
公开(公告)日：2024-10-02
申请号：EP22826732.4
申请日：2022-11-08
申请人： Corning Incorporated
发明人： KAUFFMAN, Amy Claire , PARDO, Ana Maria del Pilar
IPC分类号： B01L3/00
CPC分类号： B01L3/505 , B01L3/50825 , B01L2300/12320130101 , B01L2300/04220130101 , B01L2300/16120130101 , B01L3/5021 , B01L2200/068920130101 , A61K35/12

3. 发明公开

EP4420783A1 BIOMATERIAL DETECTION SENSOR AND METHOD OF MANUFACTURING THE SAME 审中-公开
公开(公告)号：EP4420783A1
公开(公告)日：2024-08-28
申请号：EP23188931.2
申请日：2023-08-01
申请人： Samsung Electronics Co., Ltd. , Seoul National University R & DB Foundation
发明人： Lee, Jae Hong , Park, Jungwon , Kang, Min-Ho , Lee, Minyoung , Jang, Hyeong Seok , Jung, Won Jong , Kim, Jin Ha , Namkoong, Kak , Youn, Hyung Jun
IPC分类号： B01L3/00 , B81C1/00 , G01N21/00 , G01N23/00
CPC分类号： B01L3/502707 , B01L2200/1220130101 , B01L2300/063620130101 , B01L2300/081920130101 , B01L2300/089320130101 , B01L2300/089620130101 , B01L2300/16120130101 , B01L2400/040620130101 , B81C1/00015 , G01N23/00 , G01N21/6458
摘要： The present disclosure provides methods and apparatuses for biomaterial detection sensors. In some embodiments, a biomaterial detection sensor includes a membrane including a plurality of wells. Each of the plurality of wells is configured to encapsulate a biomaterial contained in a sample solution. A surface of the membrane is selectively modified into at least one of a hydrophilic surface and a hydrophobic surface. In some embodiments, a method of manufacturing a biomaterial detection sensor includes depositing a first membrane and a second membrane on respective surfaces of a wafer, forming a window by etching the first membrane and the first surface of the wafer, forming a plurality of wells on the second membrane, modifying a surface of the second membrane into at least one of a hydrophilic surface and a hydrophobic surface; and transferring a two-dimensional graphene oxide material onto a bottom of each of the plurality of wells.

6. 发明公开

EP4363110A1 MICROFLUIDIC DEVICES 审中-实审
公开(公告)号：EP4363110A1
公开(公告)日：2024-05-08
申请号：EP22738084.7
申请日：2022-06-28
申请人： Capitainer AB
发明人： LENK, Gabriel , OHLANDER, Anna
IPC分类号： B01L3/00 , G01N33/49
CPC分类号： B01L3/502723 , B01L3/502753 , B01L2200/060520130101 , B01L3/50273 , B01L2300/068120130101 , B01L2300/16120130101 , B01L2400/068820130101 , B01L2400/08620130101 , B01L2400/08820130101 , B01L2200/064220130101 , B01L2200/068420130101 , B01L2200/063120130101

9. 发明授权

EP3855891B1 METHOD OF PRODUCING A REAGENT TAPE FOR USE IN A MILK SAMPLING DEVICE THEREWITH 有权
公开(公告)号：EP3855891B1
公开(公告)日：2024-10-23
申请号：EP19756437.0
申请日：2019-08-13
IPC分类号： A01J5/013 , G01N33/04 , G01N35/00 , G01N33/487 , B01L3/00 , G01N1/10 , G01N21/84
CPC分类号： G01N35/00009 , A01J5/0131 , G01N1/10 , G01N2035/0011820130101 , G01N2035/0003920130101 , G01N35/00029 , G01N21/8483 , B01L3/527 , B01L2200/1220130101 , B01L2300/082520130101 , B01L2300/16120130101

10. 发明公开

EP4433796A1 SURFACE-PATTERNED, OMNIPHOBIC TILES (SPOTS), FABRICATION, LOADING, AND USE THEREOF 审中-实审
公开(公告)号：EP4433796A1
公开(公告)日：2024-09-25
申请号：EP22896575.2
申请日：2022-11-21
申请人： Cornell University
发明人： CIRA, Nathaniel James , TAN, Shenghao , SHIRI, Samira , QAZI, Mohsin Jahan , ALBO, Jon , CHEN, Arnold
IPC分类号： G01N1/31 , G01N1/00 , G01N35/10 , B01L3/00
CPC分类号： B01L2200/064220130101 , B01L2300/16120130101 , B01L3/5088 , B01L3/5085 , B01L2200/02520130101 , B01L3/0262 , B01L2400/02220130101

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