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1. 发明公开

CN1284168A 固相吸头及其相关应用无效
公开(公告)号：CN1284168A
公开(公告)日：2001-02-14
申请号：CN98813351.2
申请日：1998-12-30
申请人：佳根基因组学公司
发明人： L·K·加里森 , J·C·塔伯恩 , J·范尼斯
IPC分类号： G01N33/543 , G01N33/53 , C12Q1/68 , B01J19/00
CPC分类号： C12Q1/6834 , B01J19/0046 , B01J2219/00315 , B01J2219/00387 , B01J2219/0047 , B01J2219/00472 , B01J2219/00504 , B01J2219/00506 , B01J2219/00585 , B01J2219/00596 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/5302 , G01N33/54386
摘要：固相试验为医学诊断和基础研究中生物分子的分析提供了十分有效的方法。例如,固相核酸杂交方法已应用于遗传多态性分析、遗传性疾病的诊断、癌症诊断、病毒性或微生物性病原体的检测、克隆的筛选、和基因组片段的排序。一种新的固相样品保留吸头使生物分子的合成或检测过程得到改进。这些吸头可用来设计样品保存装置,而这样的装置又可与吸头组合,形成可用于自动过程的固相样品保存装置阵列。吸头可与受弹簧压紧的支持钉相连,还包含包被该吸头并可与生物分子结合的化学层。

2. 发明申请

US20030134432A1 Methods for pre-determined mass sorting of positional-encoded solid phase synthesis supports 审中-公开
标题翻译：用于定位编码的固相合成载体的预定质量分选的方法
公开(公告)号：US20030134432A1
公开(公告)日：2003-07-17
申请号：US10283825
申请日：2002-10-29
申请人： Ontogen Corporation
发明人： Romaine R. Maiefski , John F. Cargill , Thomas J. Baiga
IPC分类号： G01N033/53 , G01N033/543
CPC分类号： C07K1/047 , B01J19/0046 , B01J2219/00279 , B01J2219/00306 , B01J2219/00308 , B01J2219/00315 , B01J2219/00454 , B01J2219/00468 , B01J2219/00472 , B01J2219/00497 , B01J2219/0054 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00659 , B01J2219/00691 , B01J2219/0072 , B01J2219/00725 , C40B40/10 , C40B50/14 , C40B60/14 , C40B70/00 , G01N35/028 , G01N35/1074 , G01N2001/288 , G01N2035/0425
摘要： A system for producing a library of oligomer comprising at least two monomers in a positionally determined array comprise a plurality of synthesis supports, a first plurality of support carriers wherein each carrier has a uniform array of distinct support holding positions for the synthesis supports; means for contacting each array of synthesis supports with a different monomer to provide a first chemical transformation of the synthesis supports; a second plurality of support carriers wherein each carrier has a uniform array of distinct support holding positions for receiving the chemically transformed synthesis supports contained in the first plurality of support carriers; transfer apparatus for transferring a selected row or column of synthesis supports from each of the first plurality of carriers to each of the second plurality of carriers to enable the supports in the second to undergo at least a second chemical transformation; and whereby each support position in each carrier identifies the chemical compound thereon.
摘要翻译：用于制备包含位置确定阵列中的至少两种单体的寡聚物文库的系统包括多个合成载体，第一多个载体载体，其中每个载体具有用于合成载体的不同载体保持位置的均匀阵列; 用于使每个合成载体阵列与不同单体接触以提供合成载体的第一化学转化的装置; 第二多个支撑载体，其中每个载体具有用于接收包含在第一多个载体载体中的化学转化的合成载体的不同支撑保持位置的均匀阵列; 传送装置，用于将所选择的一行或多列合成载体从所述第一多个载体中的每一个传送到所述第二多个载体中的每一个，以使得所述第二载体中的载体能够进行至少第二化学转化; 并且由此每个载体中的每个支撑位置识别其上的化合物。

3. 发明申请

US20030198999A1 Apparatus and method for synthesizing combinatorial libraries 有权
标题翻译：用于合成组合库的装置和方法
公开(公告)号：US20030198999A1
公开(公告)日：2003-10-23
申请号：US10316353
申请日：2002-12-11
申请人： Selecticide Corporation
发明人： Marcel Patek , Safar Pavel , Martin Smrcina , Eric Wegrzyniak , Peter Strop , Gary A. Flynn , Stephen A. Baum
IPC分类号： G01N033/53 , B32B005/02 , G01N021/00 , B32B027/04 , B32B027/12 , C12M001/34
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00286 , B01J2219/0031 , B01J2219/00313 , B01J2219/00315 , B01J2219/00317 , B01J2219/00319 , B01J2219/00322 , B01J2219/00328 , B01J2219/00459 , B01J2219/00461 , B01J2219/00468 , B01J2219/00472 , B01J2219/00475 , B01J2219/00497 , B01J2219/005 , B01J2219/00502 , B01J2219/00522 , B01J2219/00527 , B01J2219/00565 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00659 , B01J2219/00664 , B01J2219/00668 , B01J2219/00675 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L2300/0819 , B01L2300/0829 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , C40B70/00 , G01N33/543 , Y10T436/24 , Y10T436/25 , Y10T436/255
摘要： An apparatus and method for synthesizing a combinatorial library comprising a plurality of chemical compounds such that the chemical composition of each compound is easily tracked. The library compounds are synthesized on solid-phase supports, which are spatially arranged in frames during synthesis according to a predetermined protocol, such that each solid-phase support passes through a series of unique spatial 2D or 3D addresses by which the chemical composition of each compound may be determined at any point during synthesis. Solid-phase supports include hollow tubular-shaped lanterns and gears.
摘要翻译：一种用于合成包含多种化学化合物的组合文库的装置和方法，使得容易追踪每种化合物的化学组成。文库化合物在固相载体上合成，根据预定的方案在合成过程中在空间上排列成帧，使得每个固相载体通过一系列独特的空间2D或3D地址，通过这些独特的空间2D或3D地址，化合物可以在合成过程中的任何时间点确定。固相支架包括中空的管状灯笼和齿轮。

4. 发明授权

US06528324B1 Apparatus for pre-determined mass sorting of positional-encoded solid phase synthesis supports 失效
标题翻译：用于对位置编码的固相合成载体进行预定质量分选的装置
公开(公告)号：US06528324B1
公开(公告)日：2003-03-04
申请号：US09500249
申请日：2000-02-08
申请人： Romaine R. Maiefski , Edmund J. Moran , Thomas J. Baiga
发明人： Romaine R. Maiefski , Edmund J. Moran , Thomas J. Baiga
IPC分类号： G01N33543
CPC分类号： C07K1/047 , B01J19/0046 , B01J2219/00279 , B01J2219/00306 , B01J2219/00308 , B01J2219/00315 , B01J2219/00454 , B01J2219/00468 , B01J2219/00472 , B01J2219/00497 , B01J2219/0054 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00659 , B01J2219/00691 , B01J2219/0072 , B01J2219/00725 , C40B40/10 , C40B50/14 , C40B60/14 , C40B70/00 , G01N35/028 , G01N35/1074 , G01N2001/288 , G01N2035/0425
摘要： A system for producing a library of oligomer comprising at least two monomers in a positionally determined array comprise a plurality of synthesis supports, a first plurality of support carriers wherein each carrier has a uniform array of distinct support holding positions for the synthesis supports; means for contacting each array of synthesis supports with a different monomer to provide a first chemical transformation of the synthesis supports; a second plurality of support carriers wherein each carrier has a uniform array of distinct support holding positions for receiving the chemically transformed synthesis supports contained in the first plurality of support carriers; transfer apparatus for transferring a selected row or column of synthesis supports from each of the first plurality of carriers to each of the second plurality of carriers to enable the supports in the second to undergo at least a second chemical transformation; and whereby each support position in each carrier identifies the chemical compound thereon.
摘要翻译：用于制备包含位置确定阵列中的至少两种单体的寡聚物文库的系统包括多个合成载体，第一多个载体载体，其中每个载体具有用于合成载体的不同载体保持位置的均匀阵列; 用于使每个合成载体阵列与不同单体接触以提供合成载体的第一化学转化的装置; 第二多个支撑载体，其中每个载体具有用于接收包含在第一多个载体载体中的化学转化的合成载体的不同支撑保持位置的均匀阵列; 传送装置，用于将所选择的一行或多列合成载体从所述第一多个载体中的每一个传送到所述第二多个载体中的每一个，以使得所述第二载体中的载体能够进行至少第二化学转化; 并且由此每个载体中的每个支撑位置识别其上的化合物。

5. 发明申请

US20030143630A1 Apparatus and method for synthesizing 审中-公开
标题翻译：用于合成的装置和方法
公开(公告)号：US20030143630A1
公开(公告)日：2003-07-31
申请号：US10317178
申请日：2002-12-11
申请人： Selecticide Corporation
发明人： Marcel Patek , Safar Pavel , Martin Smrcina , Eric Wegrzyniak , Peter Strop , Gary A. Flynn , Stephen A. Baum
IPC分类号： G01N033/53 , B32B005/02 , G01N033/543
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00286 , B01J2219/0031 , B01J2219/00313 , B01J2219/00315 , B01J2219/00317 , B01J2219/00319 , B01J2219/00322 , B01J2219/00328 , B01J2219/00459 , B01J2219/00461 , B01J2219/00468 , B01J2219/00472 , B01J2219/00475 , B01J2219/00497 , B01J2219/005 , B01J2219/00502 , B01J2219/00522 , B01J2219/00527 , B01J2219/00565 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00659 , B01J2219/00664 , B01J2219/00668 , B01J2219/00675 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L2300/0819 , B01L2300/0829 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , C40B70/00 , G01N33/543 , Y10T436/24 , Y10T436/25 , Y10T436/255
摘要： An apparatus and method for synthesizing a combinatorial library comprising a plurality of chemical compounds such that the chemical composition of each compound is easily tracked. The library compounds are synthesized on solid-phase supports, which are spatially arranged in frames during synthesis according to a predetermined protocol, such that each solid-phase support passes through a series of unique spatial 2D or 3D addresses by which the chemical composition of each compound may be determined at any point during synthesis. Solid-phase supports include hollow tubular-shaped lanterns and gears.
摘要翻译：一种用于合成包含多种化学化合物的组合文库的装置和方法，使得容易追踪每种化合物的化学组成。文库化合物在固相载体上合成，根据预定的方案在合成过程中在空间上排列成帧，使得每个固相载体通过一系列独特的空间2D或3D地址，通过这些独特的空间2D或3D地址，化合物可以在合成过程中的任何时间点确定。固相支架包括中空的管状灯笼和齿轮。

6. 发明授权

US06420123B1 Spatially defined synthesis 失效
标题翻译：空间定义合成
公开(公告)号：US06420123B1
公开(公告)日：2002-07-16
申请号：US09544411
申请日：2000-04-06
申请人： Arpad Furka
发明人： Arpad Furka
IPC分类号： G01N3353
CPC分类号： C07K1/047 , B01J19/0046 , B01J2219/00286 , B01J2219/00295 , B01J2219/00297 , B01J2219/00299 , B01J2219/00457 , B01J2219/00459 , B01J2219/00463 , B01J2219/0047 , B01J2219/00472 , B01J2219/005 , B01J2219/00504 , B01J2219/00506 , B01J2219/00515 , B01J2219/0054 , B01J2219/00542 , B01J2219/00545 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00659 , B01J2219/00664 , B01J2219/0072 , B01J2219/00725 , C40B40/10 , C40B60/14 , C40B70/00
摘要： In accordance with the method of the invention and within the framework of the split synthesis technique, compounds are synthesized on macroscopic solid support units which are spatially organized in groups, referred to herein as strings, so that the location of each unit in a string is known and recorded. Each string is placed in a reaction vessel for contact with a suitable reagent or reagents to couple a first component on the support units. Each string is submitted to a different reaction and the sequential arrangement of the support units is maintained throughout the whole reaction step and any subsequent washing steps. At the completion of a reaction step the support units of the strings (referred to as source strings) are sorted in a different sequential arrangement to form new strings (referred to as destination strings) for the next reaction step. The reorganization of the support units into new destination strings is recorded for each reaction step in the synthesis. The destination strings may then be converted to source strings by subjecting each string to different second reaction steps to couple another component onto the solid support units. The reaction and sorting steps are repeated until the desired products are formed. The sequence history is reviewed and the composition of each product is predicted without the need for tags or labels. The sorting steps can be carried out manually or preferably by automated means.
摘要翻译：根据本发明的方法，并且在分裂合成技术的框架内，化合物在宏观固体支持单元上合成，其在空间上被组织成组，这里称为串，使得每个单元在串中的位置是已知和记录。将每个串放置在反应容器中以与合适的试剂或试剂接触以将第一组分偶联在载体单元上。每个串都进行不同的反应，并且在整个反应步骤和任何随后的洗涤步骤中保持支持单元的顺序排列。在反应步骤完成时，串的支持单元（称为源字符串）以不同的顺序排列排列以形成用于下一个反应步骤的新字符串（称为目的字符串）。在合成中记录每个反应步骤将支持单元重组成新的目的地字符串。然后可以通过使每个串进行不同的第二反应步骤将目的地字符串转换为源字符串，以将另一个组件耦合到固体支持单元上。重复反应和分选步骤，直到形成所需的产物。审查序列历史，并且预测每个产品的组成，而不需要标签或标签。分选步骤可以手动或优选通过自动化手段进行。

7. 发明公开

EP1040352A1 SOLID-PHASE TIPS AND USES RELATING THERETO 审中-公开
标题翻译： TIPS固相及其用途
公开(公告)号：EP1040352A1
公开(公告)日：2000-10-04
申请号：EP98965546.9
申请日：1998-12-30
申请人： Qiagen Genomics, Inc.
发明人： GARRISON, Lori, K. , TABONE, John, C. , VAN NESS, Jeffrey
IPC分类号： G01N33/543 , G01N33/53 , C12Q1/68 , B01J19/00
CPC分类号： C12Q1/6834 , B01J19/0046 , B01J2219/00315 , B01J2219/00387 , B01J2219/0047 , B01J2219/00472 , B01J2219/00504 , B01J2219/00506 , B01J2219/00585 , B01J2219/00596 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/5302 , G01N33/54386
摘要： Solid-phase assays have provided a powerful approach to the analysis of biomolecules in medical diagnosis and in basic research. Solid-phase nucleic acid hybridization methods, for example, have been applied to analysis of genetic polymorphisms, diagnosis of genetic disease, cancer diagnosis, detection of viral and microbial pathogens, screening of clones, and ordering of genomic fragments. A new solid-phase sample-retaining tip provides improved procedures for synthesizing or detecting a biomolecule. These tips can be used to devise sample-retaining assemblies, which in turn, can be combined to form arrays of solid-phase sample-retaining assemblies useful in automated processes. The tips may be connectable to a spring biased support pin and also contain a chemical layer coating said tip to which a biomolecule is bindable.

8. 发明公开

EP0904540A1 METHODS FOR SPATIALLY-DISPERSED POSITIONALLY-ENCODED COMBINATORIAL LIBRARY SYNTHESIS 失效
标题翻译：合成空间方法分布式组合文库的固定位置
公开(公告)号：EP0904540A1
公开(公告)日：1999-03-31
申请号：EP97916869.0
申请日：1997-03-21
申请人： ONTOGEN CORPORATION
发明人： MORAN, Edmund, J. , CARGILL, John, F. , MAIEFSKI, Romaine, R. , BAIGA, Thomas, J.
IPC分类号： C12N15 , B01J19 , C07B61 , C07D243 , C07K1 , C40B40 , C40B50 , C40B60 , C40B70
CPC分类号： C07K1/047 , B01J19/0046 , B01J2219/00306 , B01J2219/00315 , B01J2219/00454 , B01J2219/00472 , B01J2219/0054 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00659 , B01J2219/00725 , C40B40/10 , C40B50/14 , C40B60/14 , C40B70/00
摘要： The present invention relates to a method useful in combinatorial chemistry. More specifically, the present invention relates to methods for synthesizing spatially-dispersed positionally-encoded combinatorial chemistry libraries of oligomers whereby the synthesis is carried out on a plurality of solid supports which in turn are distributed in the form of a series of arrays. The position of each solid support in each array determines the exact identity of the oligomer.

9. 发明授权

US07122323B2 Apparatus and method for synthesizing combinatorial libraries 有权
公开(公告)号：US07122323B2
公开(公告)日：2006-10-17
申请号：US10316353
申请日：2002-12-11
申请人： Marcel Patek , Safar Pavel , Martin Smrcina , Eric Wegrzyniak , Peter Strop , Gary A Flynn , Stephen A Baum
发明人： Marcel Patek , Safar Pavel , Martin Smrcina , Eric Wegrzyniak , Peter Strop , Gary A Flynn , Stephen A Baum
IPC分类号： G01N33/53 , C12M1/40 , G01N33/543 , G01N30/02
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00286 , B01J2219/0031 , B01J2219/00313 , B01J2219/00315 , B01J2219/00317 , B01J2219/00319 , B01J2219/00322 , B01J2219/00328 , B01J2219/00459 , B01J2219/00461 , B01J2219/00468 , B01J2219/00472 , B01J2219/00475 , B01J2219/00497 , B01J2219/005 , B01J2219/00502 , B01J2219/00522 , B01J2219/00527 , B01J2219/00565 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00659 , B01J2219/00664 , B01J2219/00668 , B01J2219/00675 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L2300/0819 , B01L2300/0829 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , C40B70/00 , G01N33/543 , Y10T436/24 , Y10T436/25 , Y10T436/255
摘要： An apparatus and method for synthesizing a combinatorial library comprising a plurality of chemical compounds such that the chemical composition of each compound is easily tracked. The library compounds are synthesized on solid-phase supports, which are spatially arranged in frames during synthesis according to a predetermined protocol, such that each solid-phase support passes through a series of unique spatial 2D or 3D addresses by which the chemical composition of each compound may be determined at any point during synthesis. Solid-phase supports include hollow tubular-shaped lanterns and gears.

10. 发明申请

US20030092064A1 System for the synthesis of spatially separated libraries of compounds and methods for the use thereof 审中-公开
标题翻译：用于合成空间分离的化合物文库的系统及其使用方法
公开(公告)号：US20030092064A1
公开(公告)日：2003-05-15
申请号：US10116860
申请日：2002-04-05
申请人： Millennium Pharmaceuticals, Inc.
发明人： John C. Reader
IPC分类号： G01N033/53 , G01N033/543
CPC分类号： B01J19/0046 , B01J2219/00299 , B01J2219/00308 , B01J2219/0031 , B01J2219/00313 , B01J2219/00319 , B01J2219/00461 , B01J2219/0047 , B01J2219/00472 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00664 , B01J2219/00666 , B01J2219/00671 , B01J2219/0072 , C40B60/14
摘要： Featured is an apparatus useful for preparing combinatorial libraries of compounds in a parallel fashion so that the individual compounds of the library are spatially separate and the position of each compound of the library in the apparatus is known. Moreover, the apparatus is useful for the preparation of combinatorial libraries of compounds where the library is constructed from three or more building blocks, e.g., three, four, five, six or seven building blocks, resulting in a three, four, five, six or seven dimensional combinatorial library. Also featured are related methods for the preparation of three, four, five, six or seven dimensional combinatorial libraries of compounds using the apparatus of the present invention.
摘要翻译：特征是用于以并行方式制备化合物的组合文库的装置，使得文库的各个化合物在空间上分离，并且文库中每种化合物在装置中的位置是已知的。此外，该装置对于制备化合物的组合文库是有用的，其中文库由三个或更多个构建块构成，例如三个，四个，五个，六个或六个或七个构建块，导致三，四，五，六或七维组合库。还特征在于使用本发明的装置制备化合物的三，四，五，六或七维组合文库的相关方法。

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