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1. 发明授权

US6042610A Meniscal augmentation device 失效
标题翻译： Meniscal增加装置
公开(公告)号：US6042610A
公开(公告)日：2000-03-28
申请号：US28284
申请日：1998-02-24
申请人： Shu-Tung Li , Kevin R. Stone
发明人： Shu-Tung Li , Kevin R. Stone
IPC分类号： A61L27/00 , A01N1/02 , A61B17/04 , A61B19/00 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/38 , A61F2/42 , A61F2/44 , A61F2/46 , A61L27/20 , A61L27/22 , A61L27/24 , A61L27/26 , A61L27/36 , A61L27/46 , A61L27/48 , A61L27/54 , A61L27/56 , A61L27/58 , A61P19/02
CPC分类号： A61L27/58 , A61F2/28 , A61F2/30734 , A61F2/30756 , A61F2/3872 , A61F2/4261 , A61F2/442 , A61L27/20 , A61L27/22 , A61L27/227 , A61L27/24 , A61L27/26 , A61L27/3641 , A61L27/46 , A61L27/48 , A61L27/54 , A61L27/56 , A61B17/0469 , A61F2/30907 , A61F2/3094 , A61F2/30965 , A61F2/38 , A61F2/461 , A61F2002/30062 , A61F2002/30113 , A61F2002/30131 , A61F2002/30205 , A61F2002/30225 , A61F2002/3023 , A61F2002/30677 , A61F2002/30736 , A61F2002/30766 , A61F2002/30808 , A61F2002/3082 , A61F2002/30822 , A61F2002/30827 , A61F2002/30879 , A61F2002/30881 , A61F2002/30891 , A61F2002/30904 , A61F2002/30957 , A61F2002/4276 , A61F2002/4279 , A61F2002/4282 , A61F2002/4284 , A61F2002/4289 , A61F2002/4292 , A61F2002/4294 , A61F2002/4297 , A61F2002/4495 , A61F2210/0004 , A61F2230/0006 , A61F2230/0013 , A61F2230/0067 , A61F2230/0069 , A61F2310/00365 , A61L2300/236 , A61L2300/252 , A61L2300/406 , A61L2300/414 , A61L2430/06 , A61L2430/38 , Y10S623/901
摘要： The present invention relates to a meniscal augmentation device of biocompatible and at least partially bioresorbable fibers for implantation into a segmental defect of a meniscus in a subject. Upon implantation, the composite of the device and the meniscus establishes a scaffold adapted for ingrowth of meniscal fibrochondrocytes. The invention further pertains to methods of fabricating and using the device.
摘要翻译：本发明涉及一种生物相容性和至少部分生物可再吸收纤维的半月板增强装置，用于植入受试者的半月板的节段性缺损。在植入后，装置和弯液面的复合物建立适合于向下生长的半月板纤维软骨细胞的支架。本发明还涉及制造和使用该装置的方法。

2. 发明授权

US5624463A Prosthetic articular cartilage 失效
标题翻译：假肢关节软骨
公开(公告)号：US5624463A
公开(公告)日：1997-04-29
申请号：US232743
申请日：1994-04-25
申请人： Kevin R. Stone , Shu-Tung Li
发明人： Kevin R. Stone , Shu-Tung Li
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/38 , A61F2/42 , A61F2/44 , A61L27/20 , A61L27/22 , A61L27/24 , A61L27/26 , A61L27/46 , A61L27/48 , A61L27/54 , A61L27/56 , A61L27/58 , A61F2/50
CPC分类号： A61L27/58 , A61F2/28 , A61F2/30756 , A61F2/3872 , A61F2/442 , A61L27/20 , A61L27/227 , A61L27/24 , A61L27/26 , A61L27/46 , A61L27/48 , A61L27/56 , A61F2/30907 , A61F2/3094 , A61F2/30965 , A61F2/38 , A61F2002/30006 , A61F2002/30062 , A61F2002/30113 , A61F2002/30131 , A61F2002/30205 , A61F2002/30225 , A61F2002/3023 , A61F2002/30677 , A61F2002/30736 , A61F2002/30766 , A61F2002/30808 , A61F2002/3082 , A61F2002/30822 , A61F2002/30827 , A61F2002/30879 , A61F2002/30881 , A61F2002/30891 , A61F2002/30904 , A61F2002/30957 , A61F2002/4276 , A61F2002/4279 , A61F2002/4282 , A61F2002/4284 , A61F2002/4289 , A61F2002/4292 , A61F2002/4294 , A61F2002/4297 , A61F2210/0004 , A61F2230/0006 , A61F2230/0013 , A61F2230/0067 , A61F2230/0069 , A61F2250/0015 , A61F2250/0057 , A61F2310/00365 , A61L2430/06 , A61L2430/38
摘要： A prosthetic, resorbable articular cartilage and methods of its fabrication and insertion are disclosed. The prosthetic articular cartilage, when implanted in a humanoid joint, acts as a resorbable scaffold for ingrowth of native articular chondrocytes and supports natural articulating joint forces. The prosthetic articular cartilage is a dry, porous, volume matrix of biocompatible and bioresorbable fibers. These fibers include a natural polymer or analogs thereof, at least a portion of which may be crosslinked. The matrix is adapted to have an in vivo outer surface contour substantially the same as that of natural articular cartilage in an articulating joint, and has a pore size in the approximate range of about 100 microns to about 400 microns.
摘要翻译：公开了一种假体，可再吸收的关节软骨及其制造和插入的方法。假体关节软骨植入人形关节时，作为天然关节软骨细胞向内生长的可吸收支架，并支持自然的关节联合力。假体关节软骨是生物相容性和生物可再吸收纤维的干燥，多孔的体积基质。这些纤维包括天然聚合物或其类似物，其至少一部分可以是交联的。该基质适于具有与铰接接头中的天然关节软骨基本上相同的体内外表面轮廓，并且具有在约100微米至约400微米的近似范围内的孔径。

3. 发明授权

US4259752A Endoprosthetic wrist joint 失效
标题翻译：内孕腕关节
公开(公告)号：US4259752A
公开(公告)日：1981-04-07
申请号：US110483
申请日：1980-01-04
申请人： Julio Taleisnik
发明人： Julio Taleisnik
IPC分类号： A61F2/00 , A61F2/42 , A61F1/03
CPC分类号： A61F2/4261 , A61F2002/30253 , A61F2002/4264 , A61F2002/4282 , A61F2002/4292 , A61F2230/0076
摘要： This disclosure is of a surgically implantable prosthesis which is particularly intended for use as a replacement for a dysfunctional wrist joint.
摘要翻译：本公开是一种手术可植入的假体，其特别旨在用作功能障碍性腕关节的替代物。

4. 发明申请

WO1998056318A1 BIAXIAL LIGAMENTOUS-RESTRAINED PROSTHESES FOR UPPER AND LOWER EXTREMITY ARTHROPLASTIES 审中-公开
标题翻译：双重限制性的上升和下降极限的前景
公开(公告)号：WO1998056318A1
公开(公告)日：1998-12-17
申请号：PCT/US1997014517
申请日：1997-08-19
申请人： GOLDBERG, Robert
IPC分类号： A61F02/42
CPC分类号： A61F2/4225 , A61B17/06166 , A61B17/86 , A61F2/08 , A61F2/0811 , A61F2/28 , A61F2/30767 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/40 , A61F2/4202 , A61F2/4241 , A61F2/4261 , A61F2002/2835 , A61F2002/30133 , A61F2002/30252 , A61F2002/30253 , A61F2002/30448 , A61F2002/30461 , A61F2002/30462 , A61F2002/30604 , A61F2002/30777 , A61F2002/30787 , A61F2002/30789 , A61F2002/30807 , A61F2002/30878 , A61F2002/4235 , A61F2002/4248 , A61F2002/4251 , A61F2002/4258 , A61F2002/4274 , A61F2002/4276 , A61F2002/4279 , A61F2002/4282 , A61F2002/4284 , A61F2002/4289 , A61F2002/4292 , A61F2002/4631 , A61F2220/005 , A61F2220/0075 , A61F2230/0015 , A61F2230/0073 , A61F2230/0076 , A61F2310/00017 , A61F2310/00023 , A61F2310/00179 , A61F2310/00592
摘要： Prostheses (52) for restoring damaged upper and lower extremity bones which are tethered, suspended and restrained along at least two crisscrossing axes.
摘要翻译：用于恢复损伤的上肢和下肢骨骼的假肢（52），其被沿着至少两个十字交叉的轴线束缚，悬挂和限制。

5. 发明申请

WO1991016867A1 PROSTHETIC INTERVERTEBRAL DISC 审中-公开
公开(公告)号：WO1991016867A1
公开(公告)日：1991-11-14
申请号：PCT/US1991003106
申请日：1991-05-06
申请人： REGEN CORPORATION
发明人： REGEN CORPORATION , STONE, Kevin, R.
IPC分类号： A61F02/44
CPC分类号： A61F2/442 , A61F2/28 , A61F2/30756 , A61F2/30907 , A61F2/3094 , A61F2/30965 , A61F2/38 , A61F2/3872 , A61F2002/30062 , A61F2002/30131 , A61F2002/30205 , A61F2002/3023 , A61F2002/30677 , A61F2002/30736 , A61F2002/30766 , A61F2002/3082 , A61F2002/30879 , A61F2002/30904 , A61F2002/30957 , A61F2002/4276 , A61F2002/4279 , A61F2002/4282 , A61F2002/4284 , A61F2002/4289 , A61F2002/4292 , A61F2002/4294 , A61F2002/4297 , A61F2210/0004 , A61F2230/0013 , A61F2230/0067 , A61F2230/0069 , A61F2310/00365
摘要： A prosthetic intervertebral disc (200) is disclosed which can be implanted in the human skeleton, and which can act as a scaffold for regrowth of intervertebral disc material. The disc (200) includes a dry, porous, volume matrix of biocompatible and bioresorbable fibers which may be interspersed with glycosaminoglycan molecules. The matrix is adapted to have in vivo an outer surface contour substantially the same as that of a natural intervertebral disc, whereby said matrix establishes an at least partially bioresorbable scaffold adapted for ingrowth of intervertebral fibrochondrocytes. Cross-links may be provided by a portion of the GAG molecules.
摘要翻译：公开了一种假体椎间盘（200），其可以植入人骨架中，并且其可以用作椎间盘材料再生长的支架。盘（200）包括干燥，多孔的生物相容性和生物可再吸收纤维的体积基质，其可以与糖胺聚糖分子分散。该基质适于在体内具有与天然椎间盘基本上相同的外表面轮廓，由此所述基质建立适于椎间盘软骨细胞向内生长的至少部分生物可再吸收的支架。交联可由GAG分子的一部分提供。

6. 发明授权

US5702468A Carpal bone biaxially restrained prosthesis 失效
标题翻译：腕骨双轴限制假体
公开(公告)号：US5702468A
公开(公告)日：1997-12-30
申请号：US401448
申请日：1995-03-09
申请人： Robert Goldberg
发明人： Robert Goldberg
IPC分类号： A61B17/06 , A61B17/86 , A61F2/00 , A61F2/08 , A61F2/28 , A61F2/30 , A61F2/32 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2/46
CPC分类号： A61F2/4225 , A61F2/4241 , A61F2/4261 , A61B17/06166 , A61B17/86 , A61F2/08 , A61F2/0811 , A61F2/28 , A61F2/30767 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/40 , A61F2/4202 , A61F2002/2835 , A61F2002/30133 , A61F2002/30252 , A61F2002/30253 , A61F2002/30448 , A61F2002/30461 , A61F2002/30462 , A61F2002/30604 , A61F2002/30777 , A61F2002/30787 , A61F2002/30789 , A61F2002/30807 , A61F2002/30878 , A61F2002/4235 , A61F2002/4248 , A61F2002/4251 , A61F2002/4258 , A61F2002/4274 , A61F2002/4276 , A61F2002/4279 , A61F2002/4282 , A61F2002/4284 , A61F2002/4289 , A61F2002/4292 , A61F2002/4631 , A61F2220/005 , A61F2220/0075 , A61F2230/0015 , A61F2230/0073 , A61F2230/0076 , A61F2310/00017 , A61F2310/00023 , A61F2310/00179 , A61F2310/00592
摘要： A carpal bone prothesis comprising a body member made of a biocompatible, medically inert material which is designed to be restrained along at least two independent axes. In one important embodiment, the body member includes at least two independent channels and ingrowth receptive ligaments which extend through the channels and are attached to adjacent carpal bones along the first axis and to the dorsal and palmar capsules along the second axis.
摘要翻译：包括由生物相容的医药惰性材料制成的身体构件的腕骨修复体，其被设计成沿着至少两个独立的轴线被约束。在一个重要的实施例中，身体构件包括至少两个独立的通道和向内生长的接受韧带，其延伸穿过通道并且沿着第一轴线附接到相邻的腕骨，并沿着第二轴线附接到背侧和手掌胶囊。

7. 发明授权

US5681353A Meniscal augmentation device 失效
标题翻译： Meniscal增加装置
公开(公告)号：US5681353A
公开(公告)日：1997-10-28
申请号：US250008
申请日：1994-05-27
申请人： Shu-Tung Li , Kevin R. Stone
发明人： Shu-Tung Li , Kevin R. Stone
IPC分类号： A61L27/00 , A01N1/02 , A61B17/04 , A61B19/00 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/38 , A61F2/42 , A61F2/44 , A61F2/46 , A61L27/20 , A61L27/22 , A61L27/24 , A61L27/26 , A61L27/36 , A61L27/46 , A61L27/48 , A61L27/54 , A61L27/56 , A61L27/58 , A61P19/02
CPC分类号： A61L27/58 , A61F2/28 , A61F2/30734 , A61F2/30756 , A61F2/3872 , A61F2/4261 , A61F2/442 , A61L27/20 , A61L27/22 , A61L27/227 , A61L27/24 , A61L27/26 , A61L27/3641 , A61L27/46 , A61L27/48 , A61L27/54 , A61L27/56 , A61B17/0469 , A61F2/30907 , A61F2/3094 , A61F2/30965 , A61F2/38 , A61F2/461 , A61F2002/30062 , A61F2002/30113 , A61F2002/30131 , A61F2002/30205 , A61F2002/30225 , A61F2002/3023 , A61F2002/30677 , A61F2002/30736 , A61F2002/30766 , A61F2002/30808 , A61F2002/3082 , A61F2002/30822 , A61F2002/30827 , A61F2002/30879 , A61F2002/30881 , A61F2002/30891 , A61F2002/30904 , A61F2002/30957 , A61F2002/4276 , A61F2002/4279 , A61F2002/4282 , A61F2002/4284 , A61F2002/4289 , A61F2002/4292 , A61F2002/4294 , A61F2002/4297 , A61F2002/4495 , A61F2210/0004 , A61F2230/0006 , A61F2230/0013 , A61F2230/0067 , A61F2230/0069 , A61F2310/00365 , A61L2300/236 , A61L2300/252 , A61L2300/406 , A61L2300/414 , A61L2430/06 , A61L2430/38 , Y10S623/901
摘要： The present invention relates to a meniscal augmentation device of biocompatible and at least partially bioresorbable fibers for implantation into a segmental defect of a meniscus in a subject. Upon implantation, the composite of the device and the meniscus establishes a scaffold adapted for ingrowth of meniscal fibrochondrocytes. The invention further pertains to methods of fabricating and using the device.
摘要翻译：本发明涉及一种生物相容性和至少部分生物可再吸收纤维的半月板增强装置，用于植入受试者的半月板的节段性缺损。在植入后，装置和弯液面的复合物建立适合于向下生长的半月板纤维软骨细胞的支架。本发明还涉及制造和使用该装置的方法。

8. 发明授权

US5314485A Total prosthesis of the wrist 失效
标题翻译：手腕总假体
公开(公告)号：US5314485A
公开(公告)日：1994-05-24
申请号：US943565
申请日：1992-09-11
申请人： Thierry Judet
发明人： Thierry Judet
IPC分类号： A61F2/00 , A61F2/30 , A61F2/42
CPC分类号： A61F2/4261 , A61F2002/30207 , A61F2002/30286 , A61F2002/30602 , A61F2002/308 , A61F2002/30841 , A61F2002/30894 , A61F2002/4264 , A61F2002/4279 , A61F2002/4282 , A61F2002/4284 , A61F2002/4289 , A61F2002/4292 , A61F2230/0063 , A61F2230/0067 , A61F2310/00011
摘要： A total wrist prosthesis with a radio-carpal articular level having a first radio-ulnar center of rotation located in a frontal plane and a medio-carpal articular level having a second radio-ulnar center of rotation located also in the frontal plane but being distinct from the first radio-ulnar center of rotation. The prosthesis including a radial element having an anchoring shank insertable into the distal portion of a radius bone, and a shoulder resting against the distal face of the said radius bone. A plate is connected to the radial element having a concave bearing surface having a radio-ulnar deviation radius of curvature in the frontal plane and a flexion-extension radius of curvature in a sagittal plane smaller than the radio-ulnar deviation radius of curvature. An intermediate element is also provided rotatable in radio-ulnar deviation and in flexion-extension with respect to the concave bearing surface and having a shape so as to cooperate with the concave bearing surface, and including a recess offset dorsally and in an ulnar direction. A metacarpal element is provided for anchoring into metacarpal bones and is free to rotate solely in a radio-ulnar deviation movement with respect to the intermediate element.
摘要翻译：具有放射性腕关节水平的全腕式假体具有位于前平面中的第一放射性尺度中心和具有位于前平面中的第二放射尺度中心的中腕关节水平，但是不同从第一个无线电尺度旋转中心。所述假体包括径向元件，所述径向元件具有可插入到半径骨的远侧部分中的锚定柄，以及抵靠所述桡骨骨远端面的肩部。板与径向元件连接，该径向元件具有在前平面中具有放射性尺度偏差曲率半径的凹形支承表面，以及在径向平面中的弯曲延伸半径小于放射性尺度偏差曲率半径。中间元件还可以以放射性尺度偏差旋转并且相对于凹形支承表面弯曲延伸，并且具有与凹形支承表面配合的形状，并且包括在背侧和尺寸方向上偏移的凹部。提供掌骨元件用于锚定到掌骨中，并且仅在相对于中间元件的无线电尺度偏移运动中自由旋转。

9. 发明授权

US5258043A Method for making a prosthetic intervertebral disc 失效
标题翻译：制造假肢椎间盘的方法
公开(公告)号：US5258043A
公开(公告)日：1993-11-02
申请号：US813984
申请日：1991-12-26
申请人： Kevin R. Stone
发明人： Kevin R. Stone
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/38 , A61F2/42 , A61F2/44 , A61L27/20 , A61L27/22 , A61L27/24 , A61L27/26 , A61L27/46 , A61L27/48 , A61L27/54 , A61L27/56 , A61L27/58
CPC分类号： A61F2/442 , A61F2/28 , A61F2/3872 , A61F2/30756 , A61F2/30907 , A61F2/3094 , A61F2/30965 , A61F2/38 , A61F2002/30062 , A61F2002/30131 , A61F2002/30205 , A61F2002/3023 , A61F2002/30677 , A61F2002/30736 , A61F2002/30766 , A61F2002/3082 , A61F2002/30879 , A61F2002/30904 , A61F2002/30957 , A61F2002/4276 , A61F2002/4279 , A61F2002/4282 , A61F2002/4284 , A61F2002/4289 , A61F2002/4292 , A61F2002/4294 , A61F2002/4297 , A61F2002/4495 , A61F2210/0004 , A61F2230/0013 , A61F2230/0067 , A61F2230/0069 , A61F2310/00365 , Y10S623/901 , Y10S623/911
摘要： A prosthetic intervertebral disc is disclosed which can be implanted in the human skeleton, and which can act as a scaffold for regrowth of intervertebral disc material. The disc includes a dry, porous, volume matrix of biocompatible and bioresorbable fibers which may be interspersed with glyscosaminoglycan molecules. The matrix is adapted to have in vivo an outer surface contour substantially the same as that of a natural intervertebral disc, whereby the matrix establishes an at least partially bioresorbable scaffold adapted for ingrowth of intervertebral fibrochondrocytes. Cross-links may be provided by a portion of the GAG molecules.
摘要翻译：公开了一种假体椎间盘，其可以植入人骨架中，并且其可以用作椎间盘材料再生长的支架。圆盘包括干燥，多孔的生物相容性和生物可再吸收纤维的体积基质，其可以散布于糖胺聚糖分子中。基质适于在体内具有与天然椎间盘基本上相同的外表面轮廓，由此基质建立适于椎间盘软骨细胞向内生长的至少部分生物可再吸收支架。交联可由GAG分子的一部分提供。

10. 发明授权

US06371985B1 Prostheses restrained by immediate attachment while ingrowth proceeds naturally over time 失效
标题翻译：假装在随着时间的推移自然而然而自然而然地受到紧迫的约束
公开(公告)号：US06371985B1
公开(公告)日：2002-04-16
申请号：US09459283
申请日：1999-12-17
申请人： Robert S. Goldberg
发明人： Robert S. Goldberg
IPC分类号： A61F228
CPC分类号： A61F2/4241 , A61B17/06166 , A61B17/86 , A61F2/08 , A61F2/0811 , A61F2/28 , A61F2/30767 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/40 , A61F2/4202 , A61F2/4225 , A61F2/4261 , A61F2002/2835 , A61F2002/30133 , A61F2002/30252 , A61F2002/30253 , A61F2002/30448 , A61F2002/30461 , A61F2002/30462 , A61F2002/30604 , A61F2002/30777 , A61F2002/30787 , A61F2002/30789 , A61F2002/30807 , A61F2002/30878 , A61F2002/4235 , A61F2002/4248 , A61F2002/4251 , A61F2002/4258 , A61F2002/4274 , A61F2002/4276 , A61F2002/4279 , A61F2002/4282 , A61F2002/4284 , A61F2002/4289 , A61F2002/4292 , A61F2002/4631 , A61F2220/005 , A61F2220/0075 , A61F2230/0015 , A61F2230/0073 , A61F2230/0076 , A61F2310/00017 , A61F2310/00023 , A61F2310/00179 , A61F2310/00592
摘要： The invention is a surgically implantable bone and bone joint prosthesis which is designed to be directly attached during surgery and which includes ingrowth receptive zones or stationing sites for delayed ingrowth adhesion naturally over time. The ingrowth receptive zones preferably emulate cancellous bone and are at locations on the body member corresponding generally to the area where connective tissue naturally attaches in vivo.
摘要翻译：本发明是可手术植入的骨和骨关节假体，其被设计为在手术期间直接连接，并且包括向内生长接受区或驻扎位点，以随着时间的推移自然地延迟向内生长粘连。向内生长受体区域优选地模拟松质骨并且位于主体部件上的位置，其通常对应于结缔组织在体内自然附着的区域。

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