专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

CN101225382A 生产克隆狗的方法无效
公开(公告)号：CN101225382A
公开(公告)日：2008-07-23
申请号：CN200710152251.1
申请日：2007-09-20
申请人：首尔大学校产学协力财团
发明人：李柄千 , 姜成根 , 金大暎 , 金敏奎 , 張龟 , 吴炫周 , M·萨敏·何塞因 , 费班托·羽达 , 金惠珍 , 洪少君 , 朴正恩 , 金正柱
IPC分类号： C12N15/06 , A61D19/04
CPC分类号： C12N15/873 , A01K67/027 , A01K2227/00 , A61D19/04
摘要：本发明提供一种克隆狗的方法，将卵母细胞去核生产去核卵母细胞，将狗的体细胞移植入去核卵母细胞中，在最优的条件下进行电融合生产核移植胚胎，然后将核移植胚胎移植入代孕母体。本发明克隆狗的方法具有高效率，而且对动物医学、人类学和医学有很大的贡献，如优良品种的繁殖、异种和带病动物模型。另外，本发明为首次成功克隆雌性狗，可以更加正确地研究克隆狗的生殖特点，而不是以往的雄性狗。

2. 发明授权

EP1389240B1 MDR1 VARIANTS AND METHODS FOR THEIR USE 有权
标题翻译： MDR1不同，使用方法
公开(公告)号：EP1389240B1
公开(公告)日：2009-11-18
申请号：EP02718831.7
申请日：2002-01-10
申请人： WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION
发明人： MEALEY, Katrina, L. , BENTJEN, Steven, A.
IPC分类号： C12Q1/68 , G01N33/68 , A01K67/027
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/00 , A01K2267/02 , A01K2267/03 , A61K49/0008 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/6893
摘要： This invention provides the identification of a truncation polym orphism of the mdr1 gene that is linked to ivermectin sen sitivity in subjects, such as collies. Also provided are methods for detecting drug transport sensibility in a subject, and animal models and in vitro cell systems using cells from animals having an mdr1 truncation.

3. 发明授权

US09546382B2 Hyperactive piggybac transposases 有权
标题翻译：多活性piggybac转座酶
公开(公告)号：US09546382B2
公开(公告)日：2017-01-17
申请号：US13774718
申请日：2013-02-22
申请人： Poseida Therapeutics, Inc.
发明人： Eric Ostertag , Blair Madison
IPC分类号： A01K67/00 , C12N15/85 , A61K48/00 , C12N9/22 , A61D19/04 , A01K67/033 , A01K67/027 , C12N15/90
CPC分类号： C12N9/1241 , A01K67/0275 , A01K67/0333 , A01K2217/052 , A01K2227/00 , A61D19/04 , A61K48/0008 , C12N9/22 , C12N15/8509 , C12N15/907 , C12N2799/027 , C12N2800/90 , C12Y207/07
摘要： The present invention provides PiggyBac transposase proteins, nucleic acids encoding the same, compositions comprising the same, kits comprising the same, non-human transgenic animals comprising the same, and methods of using the same.
摘要翻译：本发明提供了PiggyBac转座酶蛋白，编码它的核酸，包含该Pig的核酸的组合物，包含它们的组合物，包含它们的非人转基因动物的试剂及其使用方法。

4. 发明申请

US20080206144A1 MDR1 VARIANTS AND METHODS FOR THEIR USE 有权
标题翻译： MDR1变体及其使用方法
公开(公告)号：US20080206144A1
公开(公告)日：2008-08-28
申请号：US12110972
申请日：2008-04-28
申请人： Katrina L. Mealey
发明人： Katrina L. Mealey
IPC分类号： A61K49/00 , C12Q1/02
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/00 , A01K2267/02 , A01K2267/03 , A61K49/0008 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/6893
摘要： This invention provides the identification of a truncation polymorphism of the mdr1 gene that is linked to ivermectin sensitivity in subjects, such as collies. Also provided are methods for detecting drug transport sensitivity in a subject, and animal models and in vitro cell systems using cells from animals having an mdr1 truncation.
摘要翻译：本发明提供了与受试者（例如，乳制品）中的伊维菌素敏感性相关的mdr1基因的截短多态性的鉴定。还提供了用于检测受试者中药物转运敏感性的方法，以及使用具有mdr1截短的动物的细胞的动物模型和体外细胞系统。

5. 发明申请

US20040226054A1 Method for identifying Alzheimer's disease therapeutics using transgenic animal models 有权
标题翻译：使用转基因动物模型鉴定阿尔茨海默病治疗剂的方法
公开(公告)号：US20040226054A1
公开(公告)日：2004-11-11
申请号：US10746473
申请日：2003-12-23
发明人： Kate Dora Games , Dale Bernard Schenk , Lisa Claire McConlogue , Peter Andrew Seubert , Russell E. Rydel
IPC分类号： A01K067/00
CPC分类号： C07K14/4711 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/00 , A01K2267/0312 , A01K2267/0356 , C07K2319/02 , C12N15/8509
摘要： The construction of transgenic animal models of human Alzheimer'disease, and methods of using the models to screen potential Alzheimer's disease therapeutics, are described. The models are characterized by pathologies similar to pathologies observed in Alzheimer's disease, based on expression of all three forms of the null-amyloid precursor protein (APP), APP695, APP751, and APP770, as well as various point mutations based on naturally occurring mutations, such as the London and Indiana familial Alzheimer's disease (FAD) mutations at amino acid 717, predicted mutations in the APP gene, and truncated forms of APP that contain the Anull region. Animal cells can be isolated from the transgenic animals or prepared using the same constructs with standard techniques such as lipofection or electroporation. The transgenic animals, or animal cells, are used to screen for compounds altering the pathological course of Alzheimer's disease as measured by their effect on the amount of APP, null-amyloid peptide, and numerous other Alzheimer's disease markers in the animals, the neuropathology of the animals, as well as by behavioral alterations in the animals.
摘要翻译：描述了人类阿尔茨海默病的转基因动物模型的构建以及使用该模型筛选潜在的阿尔茨海默病治疗剂的方法。基于所有三种形式的β-淀粉样蛋白前体蛋白（APP），APP695，APP751和APP770的表达以及基于天然存在的突变的各种点突变，模型的特征在于类似于在阿尔茨海默病中观察到的病理学的病理学，例如氨基酸717处的伦敦和印第安纳家族性阿尔茨海默病（FAD）突变，APP基因中预测的突变和含有Abeta区的APP的截短形式。可以从转基因动物中分离动物细胞，或者使用具有标准技术如脂质转染或电穿孔的相同构建体来制备动物细胞。转基因动物或动物细胞用于筛选改变阿尔茨海默氏病病理过程的化合物，如通过其对动物中APP，β-淀粉样蛋白肽和许多其他阿尔茨海默氏病标志物的量的影响所测量的，神经病理学动物，以及动物的行为改变。

6. 发明授权

US08134044B2 Transgenic reptiles 有权
标题翻译：转基因爬行动物
公开(公告)号：US08134044B2
公开(公告)日：2012-03-13
申请号：US12641847
申请日：2009-12-18
申请人： Paul E. Mozdziak , James N. Petitte
发明人： Paul E. Mozdziak , James N. Petitte
IPC分类号： A01K67/033 , C12N15/00 , G01N33/00 , C12P21/00
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/00 , A01K2267/03 , C12N15/8509 , C12N2799/027
摘要： A transgenic animal such as a transgenic snake or other reptile that expresses a heterologous expression product is described, along with methods of making the same. In general, the animal comprises cells containing a sequence encoding the heterologous expression product. The sequence encoding the heterologous expression product is integrated into the genome of the animal (e.g., in some or all cells thereof, and in some embodiments into germ cells thereof). The sequence encoding the heterologous expression product is, in general, operatively associated with an expression sequence or promoter. The animals are useful for, among other things, testing of repellents, testing of toxicological compounds, as teaching aids, for venom production, etc.
摘要翻译：描述了表达异源表达产物的转基因动物如转基因蛇或其他爬行动物及其制备方法。通常，动物包含含有编码异源表达产物的序列的细胞。编码异源表达产物的序列整合到动物的基因组中（例如，在其一些或所有细胞中，并且在一些实施方案中整合到其生殖细胞中）。编码异源表达产物的序列通常与表达序列或启动子可操作地相关联。这些动物除了别的以外，对于驱虫剂的测试，毒理化合物的测试，作为助剂，用于毒液的生产等是有用的。

7. 发明申请

US20080295191A1 METHOD FOR PRODUCING CLONED DOG 有权
标题翻译：生产克隆狗的方法
公开(公告)号：US20080295191A1
公开(公告)日：2008-11-27
申请号：US11762077
申请日：2007-06-13
申请人： Byeong Chun Lee , Sung Keun Kang , Dae Yong Kim , Min Kyu Kim , Goo Jang , Hyun Ju Oh , M. Shamim Hossein , Fibrianto Yuda , Hye Jin Kim , So Gun Hong , Jung Eun Park , Joung Joo Kim
发明人： Byeong Chun Lee , Sung Keun Kang , Dae Yong Kim , Min Kyu Kim , Goo Jang , Hyun Ju Oh , M. Shamim Hossein , Fibrianto Yuda , Hye Jin Kim , So Gun Hong , Jung Eun Park , Joung Joo Kim
IPC分类号： A01K67/027 , C12N15/89
CPC分类号： C12N15/873 , A01K67/027 , A01K2227/00 , A61D19/04
摘要： Provided is a method for producing a cloned dog by enucleating an oocyte of a dog to produce an enucleated oocyte, transferring a somatic cell of the dog into the enucleated oocyte, carrying out electrofusion under optimized conditions to produce a nuclear transfer embryo, and transferring the nuclear transfer embryo into its surrogate mother.The method has the effect of producing a cloned dog with high efficiency, and thus can contribute to the development of studies in veterinary medicine, anthropology and medical science, such as the propagation of superior species, xenotransplantation and diseased animal models. In addition, the present invention has the effect of exactly researching production properties of the cloned dog by producing a female cloned dog for the first time, rather than the conventional male cloned dog.
摘要翻译：本发明提供了通过将狗的卵母细胞去核以产生去核卵母细胞，将狗的体细胞转移到去核卵母细胞中，在优化条件下进行电融合以产生核转移胚，并转移核转移胚胎成为其代孕母亲。该方法具有高效生产克隆狗的作用，有助于兽医，人类学，医学等研究的发展，如优良种的繁殖，异种移植和病态动物模型。此外，本发明具有通过首次生产雌性克隆狗而不是常规的雄性克隆狗来正确研究克隆狗的生产性质的效果。

8. 发明授权

US06790621B2 Method of detecting ivermectin sensitivity in a canine subject by identifying a mutation in a mdr1-encoding sequence 有权
标题翻译：通过鉴定mdr1编码序列中的突变来检测犬受试者中伊维菌蛋白敏感性的方法
公开(公告)号：US06790621B2
公开(公告)日：2004-09-14
申请号：US10044671
申请日：2002-01-10
申请人： Katrina L. Mealey , Steven A. Bentjen
发明人： Katrina L. Mealey , Steven A. Bentjen
IPC分类号： C12Q168
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/00 , A01K2267/02 , A01K2267/03 , A61K49/0008 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/6893
摘要： This invention provides the identification of a truncation polymorphism of the mdr1 gene that is linked to ivermectin sensitivity in subjects, such as collies. Also provided are methods for detecting drug transport sensitivity in a subject, and animal models and in vitro cell systems using cells from animals having an mdr1 truncation.
摘要翻译：本发明提供了与受试者（例如，乳制品）中的伊维菌素敏感性相关的mdr1基因的截短多态性的鉴定。还提供了用于检测受试者中药物转运敏感性的方法，以及使用具有mdr1截短的动物的细胞的动物模型和体外细胞系统。

9. 发明申请

WO02057499A2 MDR1 VARIANTS AND METHODS FOR THEIR USE 审中-公开
标题翻译： MDR1变体及其使用方法
公开(公告)号：WO02057499A2
公开(公告)日：2002-07-25
申请号：PCT/US0200868
申请日：2002-01-10
申请人： UNIV WASHINGTON , MEALEY KATRINA L , BENTJEN STEVEN A
发明人： MEALEY KATRINA L , BENTJEN STEVEN A
IPC分类号： A61K49/00 , C12N15/85 , C12Q1/68 , G01N33/68 , A01K67/027
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/00 , A01K2267/02 , A01K2267/03 , A61K49/0008 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/6893
摘要： This invention provides the identification of a truncation polym orphism of the mdr1 gene that is linked to ivermectin sen sitivity in subjects, such as collies. Also provided are methods for detecting drug transport sensibility in a subject, and animal models and in vitro cell systems using cells from animals having an mdr1 truncation.
摘要翻译：本发明提供了在受试者（例如，乳制品）中与伊维菌素敏感性相关的mdr1基因的截短多态性的鉴定。还提供了使用来自具有mdr1截断的动物的细胞来检测受试者，动物模型和体外细胞系统中的药物转运敏感性的方法。

10. 发明申请

WO2010099296A1 HYPERACTIVE PIGGYBAC TRANSPOSASES 审中-公开
公开(公告)号：WO2010099296A1
公开(公告)日：2010-09-02
申请号：PCT/US2010/025380
申请日：2010-02-25
申请人： TRANSPOSAGEN BIOPHARMACEUTICALS, INC. , OSTERTAG, Eric , MADISON, Blair
发明人： OSTERTAG, Eric , MADISON, Blair
IPC分类号： C12N9/22
CPC分类号： C12N9/1241 , A01K67/0275 , A01K67/0333 , A01K2217/052 , A01K2227/00 , A61D19/04 , A61K48/0008 , C12N9/22 , C12N15/8509 , C12N15/907 , C12N2799/027 , C12N2800/90 , C12Y207/07
摘要： The present invention provides PiggyBac transposase proteins, nucleic acids encoding the same, compositions comprising the same, kits comprising the same, non-human transgenic animals comprising the same, and methods of using the same.
摘要翻译：本发明提供了PiggyBac转座酶蛋白，编码它的核酸，包含该Pig的核酸的组合物，包含它们的组合物，包含它们的非人转基因动物的试剂及其使用方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式