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1. 发明专利

TW200508247A SARS SARS 审中-公开
公开(公告)号：TW200508247A
公开(公告)日：2005-03-01
申请号：TW093109694
申请日：2004-04-08
申请人：維露諾華堤夫公司 VIRONOVATIVE B.V.
发明人：巴托洛莫斯里歐納杜斯哈格曼斯 HAAGMANS, BARTHOLOMEUS LEONARDUS , 堤伊斯庫伊肯 KUIKEN, THIJS , 羅納杜斯亞杜利努斯瑪利亞弗奇爾 FOUCHIER, RONALDUS ADRIANUS MARIA , 亞爾伯特斯多明尼庫斯瑪塞林努斯伊拉斯穆斯歐斯特豪斯 OSTERHAUS, ALBERTUS DOMINICUS MARCELLINUS ERASMUS
IPC分类号： C07K , C12N , A61K , G01N , C12Q , C07H
CPC分类号： C07K14/005 , A61K39/12 , A61K39/215 , C12N7/00 , C12N2770/20021 , C12N2770/20022 , C12N2770/20034 , C12Q1/701 , C12Q1/702
摘要：本發明係關於病毒學的領域。本發明提供一種經分離之本質上在冠狀病毒組群內之哺乳動物正意義單股的RNA病毒(SARS)及其成分。
简体摘要：本发明系关于病毒学的领域。本发明提供一种经分离之本质上在冠状病毒组群内之哺乳动物正意义单股的RNA病毒(SARS)及其成分。

2. 发明申请

WO2004096241A1 HMPV TREATMENT WITH RIBAVIRIN AND ANTI-HMPV ANTIBODY 审中-公开
标题翻译：用RIBAVIRIN和抗-HPV抗体进行HMPV治疗
公开(公告)号：WO2004096241A1
公开(公告)日：2004-11-11
申请号：PCT/NL2004/000293
申请日：2004-05-03
申请人： VIRONOVATIVE B.V. , MAERTZDORF, Jeroen , SIMON, James, Henry, Matthew
发明人： MAERTZDORF, Jeroen , SIMON, James, Henry, Matthew
IPC分类号： A61K31/7056
CPC分类号： A61K31/7056 , A61K38/21 , A61K2300/00
摘要： The invention relates to antimicrobial agents and antibodies and compositions comprising such agents and antibodies to treat and/or prevent respiratory and related diseases, in particular those caused by human metapneumovirus. Provided is a method for treating or preventing respiratory tract infections in a subject infected with a mammalian MPV, said method comprising administering a nucleoside analog, preferably Ribavirin or a derivative thereof, and an antimicrobial neutralising antibody, preferably an anti-hMPV antibody to said subject, and use of said nucleoside analog and antimicrobial neutralising antibody for the manufacture of a medicament for treating or preventing respiratory tract infections in a subject infected with a mammalian MPV.
摘要翻译：本发明涉及抗微生物剂和抗体以及包含此类试剂和抗体的组合物，其用于治疗和/或预防呼吸系统和相关疾病，特别是由人间质肺病毒引起的疾病。提供一种治疗或预防感染哺乳动物MPV的受试者的呼吸道感染的方法，所述方法包括向所述受试者施用核苷类似物，优选利巴韦林或其衍生物，抗微生物中和抗体，优选抗HMPV抗体以及所述核苷类似物和抗微生物中和抗体用于制备用于治疗或预防感染哺乳动物MPV的受试者的呼吸道感染的药物的用途。

3. 发明申请

WO2004089983A2 SARS 审中-公开
公开(公告)号：WO2004089983A2
公开(公告)日：2004-10-21
申请号：PCT/NL2004/000229
申请日：2004-04-08
申请人： VIRONOVATIVE B.V. , HAAGMANS, Bartholomeus, Leonardus , KUIKEN, Thijs , FOUCHIER, Ronaldus, Adrianus, Maria , OSTERHAUS, Albertus, Dominicus, Marcellinus, Erasmus
发明人： HAAGMANS, Bartholomeus, Leonardus , KUIKEN, Thijs , FOUCHIER, Ronaldus, Adrianus, Maria , OSTERHAUS, Albertus, Dominicus, Marcellinus, Erasmus
IPC分类号： C07K14/65
CPC分类号： C07K14/005 , A61K39/12 , A61K39/215 , C12N7/00 , C12N2770/20021 , C12N2770/20022 , C12N2770/20034 , C12Q1/701 , C12Q1/702
摘要： The invention relates to the field of virology. The invention provides an isolated essentially mammalian positive-sense single stranded RNA virus (SARS) within the group of coronaviuses and components thereof.
摘要翻译：本发明涉及病毒学领域。本发明提供了冠状病毒组及其组分内的分离的基本上哺乳动物的正义单链RNA病毒（SARS）。

4. 发明授权

US08722341B2 Metapneumovirus strains and their use in vaccine formulations and sequences 有权
标题翻译：肺炎病毒菌株及其在疫苗制剂中的用途以及用于表达抗原序列的载体
公开(公告)号：US08722341B2
公开(公告)日：2014-05-13
申请号：US12319152
申请日：2008-12-31
申请人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Aurelia Haller , Roderick Tang
发明人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Aurelia Haller , Roderick Tang
IPC分类号： C07K16/00 , C07K16/10 , G01N33/53
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18622 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/56983
摘要： Provided is an isolated mammalian negative strand RNA virus, metapneumovirus (MPV). Described are isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. Also described is mammalian MPV, subgroups and variants thereof, and genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods is provided. Nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus are described. Also provided are chimeric or recombinant viruses encoded by said nucleotide sequences and chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences.
摘要翻译：提供了分离的哺乳动物负链RNA病毒，偏肺病毒（MPV）。描述的是分离的哺乳动物负链RNA病毒，其被鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。还描述了哺乳动物MPV，亚组及其变体，以及哺乳动物偏肺病毒，特别是人类偏肺病毒的不同分离物的基因组核苷酸序列。提供了用于诊断和治疗方法的哺乳动物偏肺炎病毒的不同分离株的序列信息的使用。描述了编码偏肺病毒或其部分基因组的核苷酸序列，包括哺乳动物和禽类间质肺病毒。还提供了由所述核苷酸序列编码的嵌合或重组病毒以及包含一个或多个非天然或异源序列的嵌合和重组哺乳动物MPV。

5. 发明申请

WO2002057302A3 A VIRUS CAUSING RESPIRATORY TRACT ILLNESS IN SUSCEPTIBLE MAMMALS 审中-公开
公开(公告)号：WO2002057302A3
公开(公告)日：2002-07-25
申请号：PCT/NL2002/000040
申请日：2002-01-18
申请人： VIRONOVATIVE B.V. , DE JONG, Jan, Cornelius , FOUCHIER, Ronaldus, Adrianus, Maria , VAN DEN HOOGEN, Bernadetta, Gerarda , OSTERHAUS, Albertus, Dominicus, Marcellinus, Erasmus , GROEN, Jan
发明人： DE JONG, Jan, Cornelius , FOUCHIER, Ronaldus, Adrianus, Maria , VAN DEN HOOGEN, Bernadetta, Gerarda , OSTERHAUS, Albertus, Dominicus, Marcellinus, Erasmus , GROEN, Jan
IPC分类号： C07K14/135
摘要： The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single stranded RNA virus (MPV) within the sub-family Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus and components thereof.

6. 发明申请

WO2005049814A2 NOVEL ATYPICAL PNEUMONIA-CAUSING VIRUS 审中-公开
标题翻译：新型原发性肺炎病毒引起的病毒
公开(公告)号：WO2005049814A2
公开(公告)日：2005-06-02
申请号：PCT/NL2004/000805
申请日：2004-11-18
申请人： VIRONOVATIVE B.V. , DE JONG, Jan, Cornelis , BESTEBROER, Theodorus, Marinus , SIMON, James, Henry, Matthew , FOUCHIER, Ronaldus, Adrianus, Maria , OSTERHAUS, Albertus, Dominicus, Marcellinus, Erasmus
发明人： DE JONG, Jan, Cornelis , BESTEBROER, Theodorus, Marinus , SIMON, James, Henry, Matthew , FOUCHIER, Ronaldus, Adrianus, Maria , OSTERHAUS, Albertus, Dominicus, Marcellinus, Erasmus
IPC分类号： C12N7/00
CPC分类号： G01N15/1468 , A61K39/00 , A61K2039/525 , C12N7/00 , C12N2770/20021 , G01N33/56983 , G01N2333/165
摘要： The invention relates to the field of virology. The invention provides a new isolated essentially mammalian positive-sense single stranded RNA virus (EMCR-CoV) within the group of coronaviuses and components thereof.
摘要翻译：本发明涉及病毒学领域。本发明提供了一种新的分离的基本上哺乳动物正义单链RNA病毒（EMCR-CoV）在冠状病毒组及其组分内。

7. 发明申请

US20100297730A1 Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus 审中-公开
标题翻译：重组副流感病毒表达系统和包含源自偏肺病毒的异源抗原的疫苗
公开(公告)号：US20100297730A1
公开(公告)日：2010-11-25
申请号：US12317496
申请日：2008-12-22
申请人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Aurelia Haller , Roderick Tang
发明人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Aurelia Haller , Roderick Tang
IPC分类号： C12N7/01
CPC分类号： G01N33/502 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , A61K2039/70 , A61K2123/00 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2760/18322 , C12N2760/18334 , C12N2760/18522 , C12N2760/18534 , C12N2760/18621 , C12N2760/18622 , C12N2760/18634 , C12N2760/18643 , C12N2840/203 , G01N33/5008 , G01N33/56983
摘要： The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. In particular, the heterologous gene products include gene product of another species of PIV or from another negative strand RNA virus, including but not limited to, influenza virus, respiratory syncytial virus, human metapneumovirus and avian pneumovirus. The chimeric viruses and expression products may advantageously be used in vaccine formulations including vaccines against a broad range of pathogens and antigens.
摘要翻译：本发明涉及可用于在合适的宿主细胞系统中表达异源基因产物的重组牛副流感病毒（bPIV）cDNA或RNA，和/或挽救表达，包装和/或呈递异源的负链RNA重组病毒基因产物。特别地，异源基因产物包括另一种PIV或另一种负链RNA病毒的基因产物，包括但不限于流感病毒，呼吸道合胞病毒，人偏肺病毒和禽肺病毒。嵌合病毒和表达产物可有利地用于疫苗制剂中，包括针对各种病原体和抗原的疫苗。

8. 发明申请

US20070134255A1 Hmpv treatment with ribavirin and anti-hmpv antibody 审中-公开
标题翻译：使用利巴韦林和抗hmpv抗体进行Hmpv治疗
公开(公告)号：US20070134255A1
公开(公告)日：2007-06-14
申请号：US10555329
申请日：2004-05-03
申请人： Jeroen Maertzdorf , James Simon
发明人： Jeroen Maertzdorf , James Simon
IPC分类号： A61K39/42 , A61K31/7056
CPC分类号： A61K31/7056 , A61K38/21 , A61K2300/00
摘要： The invention relates to antimicrobial agents and antibodies and compositions comprising such agents and antibodies to treat and/or prevent respiratory and related diseases, in particular those caused by human metapneumovirus. Provided is a method for treating or preventing respiratory tract infections in a subject infected with a mammalian MPV, said method comprising administering a nucleoside analog, preferably Ribavirin or a derivative thereof, and an antimicrobial neutralising antibody, preferably an anti-hMPV antibody to said subject, and use of said nucleoside analog and antimicrobial neutralising antibody for the manufacture of a medicament for treating or preventing respiratory tract infections in a subject infected with a mammalian MPV.
摘要翻译：本发明涉及抗微生物剂和抗体以及包含此类试剂和抗体的组合物，其用于治疗和/或预防呼吸系统和相关疾病，特别是由人类偏肺病毒引起的疾病。提供一种治疗或预防感染哺乳动物MPV的受试者的呼吸道感染的方法，所述方法包括向所述受试者施用核苷类似物，优选利巴韦林或其衍生物，抗微生物中和抗体，优选抗HMPV抗体以及所述核苷类似物和抗微生物中和抗体用于制备用于治疗或预防感染哺乳动物MPV的受试者的呼吸道感染的药物的用途。

9. 发明授权

US08927206B2 Virus causing respiratory tract illness in susceptible mammals 有权
标题翻译：易感染哺乳动物引起呼吸道疾病的病毒
公开(公告)号：US08927206B2
公开(公告)日：2015-01-06
申请号：US10466811
申请日：2002-01-18
申请人： Jan Cornelius De Jong , Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Jan Groen
发明人： Jan Cornelius De Jong , Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Jan Groen
IPC分类号： C12Q1/70 , C12N15/86 , C07K14/005 , C12N7/00 , A61K39/00
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18622 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/56983
摘要： The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single stranded RNA virus (MPV) within the sub-family Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus and components thereof.
摘要翻译：本发明涉及病毒学领域。本发明提供了一种分离的基本上哺乳动物的负义义单链RNA病毒（MPV），其在副粘病毒亚科家族肺炎链球菌中，并且可以鉴定为与亚属肺炎病毒属及其组分的系统发育相关。

10. 发明申请

US20100278813A1 Methods of treating and preventing RSV, hMPV, and PIV using anti-RSV, anti-hMPV, and anti-PIV antibodies 审中-公开
标题翻译：使用抗RSV，抗hMPV和抗PIV抗体治疗和预防RSV，hMPV和PIV的方法
公开(公告)号：US20100278813A1
公开(公告)日：2010-11-04
申请号：US12001458
申请日：2007-12-11
申请人： James F. Young , Peter Kiener , Albertus Dominicus Erasmus Osterhaus , Ronaldus Adrianus Maria Fouchier
发明人： James F. Young , Peter Kiener , Albertus Dominicus Erasmus Osterhaus , Ronaldus Adrianus Maria Fouchier
IPC分类号： A61K39/42 , A61P31/12
CPC分类号： C07K16/1027 , A61K2039/505
摘要： The present invention relates to methods for broad spectrum prevention and treatment of viral respiratory infection. In particular, the present invention relates to methods for preventing, treating or ameliorating symptoms associated with respiratory syncytial virus (RSV), parainfluenza virus (PIV), and/or human metapneumovirus (hMPV) infection, the methods comprising administering to a subject an effective amount of one or more anti-RSV-antigen antibodies or antigen-binding fragments thereof, one or more anti-hMPV-antigen antibodies or antigen-binding fragments thereof, and/or one or more anti-PIV-antigen antibodies or antigen-binding fragments thereof. In certain embodiments, a certain serum titer of the anti-RSV-antigen antibodies, anti-PIV-antigen antibodies, and/or anti-hMPV-antigen antibodies or antigen-binding fragments thereof is achieved in said subject. In certain specific embodiments, the subject is human and, preferably, the anti-RSV-antigen antibody, anti-PIV-antigen antibody, and/or anti-hMPV-antigen antibodies are human or humanized. The present invention relates further to compositions comprising the anti-RSV-antigen is antibodies, anti-PIV-antigen antibodies, and/or anti-hMPV-antigen antibodies or antigen-binding fragments thereof. The present invention also relates to detectable or diagnostic compositions comprising the one or more anti-RSV-antigen antibodies, anti-PIV-antigen antibodies, and/or anti-hMPV-antigen antibodies or antigen-binding fragments thereof and methods for detecting or diagnosing RSV, PIV and/or hMPV infection utilizing the compositions.
摘要翻译：本发明涉及广谱预防和治疗病毒性呼吸道感染的方法。特别地，本发明涉及用于预防，治疗或改善与呼吸道合胞病毒（RSV），副流感病毒（PIV）和/或人类偏肺病毒（hMPV）感染相关的症状的方法，所述方法包括向受试者施用有效的一种或多种抗RSV抗原抗体或其抗原结合片段，一种或多种抗hMPV抗原抗体或其抗原结合片段，和/或一种或多种抗PIV-抗原抗体或抗原结合片段。在某些实施方案中，在所述受试者中实现抗RSV抗原抗体，抗PIV抗原抗体和/或抗hMPV抗原抗体或其抗原结合片段的某一血清滴度。在某些具体实施方案中，受试者是人，优选抗RSV抗原抗体，抗PIV抗原抗体和/或抗hMPV-抗原抗体是人或人源化的。本发明进一步涉及包含抗RSV抗原的组合物是抗体，抗PIV抗原抗体和/或抗hMPV-抗原抗体或其抗原结合片段。本发明还涉及包含一种或多种抗RSV抗原抗体，抗-PIV-抗原抗体和/或抗-hMPV-抗原抗体或其抗原结合片段的可检测或诊断组合物和用于检测或诊断的方法使用组合物的RSV，PIV和/或hMPV感染。

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