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1. 发明申请

US20090025489A1 Apparatus and methods for analysis and sorting of particles such as polymer beads 有权
标题翻译：用于分析和分选诸如聚合物珠粒子的装置和方法
公开(公告)号：US20090025489A1
公开(公告)日：2009-01-29
申请号：US10583997
申请日：2004-12-22
申请人： Soeren Flygenring Christensen , Ib Johannsen
发明人： Soeren Flygenring Christensen , Ib Johannsen
IPC分类号： G01N1/00
CPC分类号： G01N21/645 , B01J2219/00468 , B01J2219/005 , B01J2219/00551 , C40B70/00 , G01N2015/149 , G01N2021/6417 , G01N2035/00574
摘要： The present invention relates to an apparatus for analysing beads and particles, such as polymer beads used e.g. for solid phase synthesis. The apparatus in one embodiment comprises a rotatable, circular disc comprising a plurality of through-going inlets, wherein an individual bead from a composition comprising different beads can be fixed to the disc at the end-position of a through-going inlet by applying a pressure drop over said disc comprising said through-going inlets. The pressure drop results in beads being sucked (i.e. detachably fixed) onto the disc on top of the through-going inlets. When the disc is rotated the beads are transferred from the position where they initially became attached to the disc to fixed positions wherein suitable devices for measuring and/or analysing and/or sorting the beads can be operated in order to e.g. measure and/or analyse and/or sort at least one bead of a plurality of beads. More specifically, the invention relates to an apparatus for measuring a plurality of optically detectable beads, such as polymer beads, said apparatus comprising a) a vacuum container comprising at least one planar capture body capable of rotating around a central axis, wherein said capture body comprises a plurality of through-going inlets, and wherein the diameter of each inlet is smaller than the average diameter of the beads to be measured and/or analysed and/or sorted, b) a pressure controlling device capable of controlling the pressure in the vacuum container, c) a device for rotating the vacuum container around the axis of the capture disc, and d) a device for measuring at least one property of at least one bead.
摘要翻译：本发明涉及一种用于分析珠粒和颗粒的装置，例如聚合物珠，例如聚合物珠。用于固相合成。在一个实施例中的装置包括可旋转的圆盘，其包括多个贯穿入口，其中来自包含不同珠粒的组合物的单个珠粒可以在通入入口的终端位置处固定到盘上，所述盘上的压降包括所述贯穿入口。压力下降导致珠被吸入（即可拆卸地固定）到贯穿入口的顶部上的盘上。当盘旋转时，珠粒从它们最初附着到盘的位置转移到固定位置，其中用于测量和/或分析和/或分选珠粒的合适的装置可以操作以便例如测量和/或分析和/或排列多个珠粒的至少一个珠粒。更具体地，本发明涉及一种用于测量多个可光学检测的珠粒（例如聚合物珠粒）的装置，所述装置包括：a）真空容器，其包括能够围绕中心轴线旋转的至少一个平面捕获体，其中所述捕获体包括多个贯通入口，并且其中每个入口的直径小于待测量和/或分析和/或分选的珠粒的平均直径; b）压力控制装置，其能够控制在真空容器，c）用于围绕捕获盘的轴线旋转真空容器的装置，以及d）用于测量至少一个珠粒的至少一个性质的装置。

2. 发明申请

WO2006015594A1 BEADED AND CROSS-LINKED POLY(AMINOALKYLENE) MATRIX AND USES THEREOF 审中-公开
标题翻译：珠光交联聚氨酯（AMINOALKYLENE）矩阵及其用途
公开(公告)号：WO2006015594A1
公开(公告)日：2006-02-16
申请号：PCT/DK2005/000384
申请日：2005-06-10
申请人： VERSAMATRIX A/S , GAVELIN, Patrik , REHNBERG, Pehr, Nicola , JOHANNSEN, Ib
发明人： GAVELIN, Patrik , REHNBERG, Pehr, Nicola , JOHANNSEN, Ib
IPC分类号： C08F8/00
CPC分类号： C08F226/02 , B01J20/267 , B01J20/285 , C08J3/12 , C08J3/246 , C08J2339/02 , C08J2371/02
摘要： The present invention relates to the synthesis of a beaded and cross-linked, high loading capacity polymer for solid phase synthesis, purification of reaction mixtures, chromatographic separation procedures, and the like. The invention can thus be used for the isolation of molecular entities having an affinity for the polymer beads or a chemical entity attached thereto. The beaded polymer matrix can be formed by cross-linking an optionally substituted poly(aminoalkylene), under inverse suspension or inverse emulsion polymerisation conditions, with a cross-linking unit of functionality ≥2.
摘要翻译：本发明涉及用于固相合成，反应混合物的纯化，色谱分离程序等的串联和交联的高负载能力聚合物的合成。因此，本发明可用于分离对聚合物珠或与其结合的化学实体具有亲和性的分子实体。串珠聚合物基质可以通过在反相悬浮或反相乳液聚合条件下与官能度= 2的交联单元交联任选取代的聚（氨基亚烷基）来形成。

3. 发明申请

WO2006021218A1 POLYETHER POLYMER MATRIX 审中-公开
标题翻译：聚酯聚合物基质
公开(公告)号：WO2006021218A1
公开(公告)日：2006-03-02
申请号：PCT/DK2005/000547
申请日：2005-08-26
申请人： VERSAMATRIX A/S , JOHANNSEN, Ib , GAVELIN, Patrik , GALLEGO, Monica, Ramos
发明人： JOHANNSEN, Ib , GAVELIN, Patrik , GALLEGO, Monica, Ramos
IPC分类号： C08G65/18
CPC分类号： C08G65/18 , C08G65/00 , Y10T428/254
摘要： The present invention relates to polyether resins, methods for their manufacture and uses thereof. In one aspect of the invention the polyether resin comprises a plurality of functional groups and is obtained by polymerisation of a mixture of alkoxylated reactive compounds selected from a) alkoxylated compounds having a functionality of more than one, and b) alkoxylated monofunctional reactive compounds, wherein the alkoxylated part of the alkoxylated compounds having a functionality of more than one has an average molecular weight which is different from the average molecular weight of the alkoxylated part of the alkoxylated monofunctional reactive compounds.
摘要翻译：本发明涉及聚醚树脂，其制造方法和用途。在本发明的一个方面，聚醚树脂包括多个官能团，并且通过选自以下的烷氧基化反应性化合物的混合物聚合得到：a）具有多于一个官能度的烷氧基化化合物，和b）烷氧基化单官能反应性化合物，其中具有多于一个官能度的烷氧基化化合物的烷氧基化部分具有与烷氧基化单官能反应性化合物的烷氧基化部分的平均分子量不同的平均分子量。

4. 发明申请

US20080319097A1 Polyether Polymer Matrix 审中-公开
标题翻译：聚醚聚合物基质
公开(公告)号：US20080319097A1
公开(公告)日：2008-12-25
申请号：US11661513
申请日：2005-08-26
申请人： Ib Johannsen , Patrik Gavelin
发明人： Ib Johannsen , Patrik Gavelin
IPC分类号： C08F2/46 , C08G65/00 , C08G73/02 , C08G69/26
CPC分类号： C08F8/32 , C08L71/02 , C08L2666/04
摘要： The present invention relates to polymer resins, methods for their generation and uses thereof. In one aspect the present invention is directed to a resin obtainable by aminolysis of a precursor resin, wherein the precursor resin is obtainable by polymerisation of i) polydisperse di- or oligofunctional vinyl or cyclic ether compounds and ii) aminolytically sensitive, mono-functional vinyl or cyclic ether compounds.
摘要翻译：本发明涉及聚合物树脂，其生产方法及其应用。一方面，本发明涉及通过前体树脂的氨解可获得的树脂，其中所述前体树脂可通过i）多分散二官能或低官能乙烯基或环醚化合物的聚合获得，和ii）氨基水解敏感的单官能乙烯基或环醚化合物。

5. 发明申请

US20090023606A1 Beaded and Cross-Linked Poly(Aminoalkylene)Matrix and Uses Thereof 审中-公开
标题翻译：串联和交联聚（氨基亚烷基）基体及其用途
公开(公告)号：US20090023606A1
公开(公告)日：2009-01-22
申请号：US11659863
申请日：2005-06-10
申请人： Patrik Gavelin , Nicola Pehr-Rehnberg , Ib Johannsen
发明人： Patrik Gavelin , Nicola Pehr-Rehnberg , Ib Johannsen
IPC分类号： C08F226/02 , C40B50/14 , C07K1/00 , C07K1/04 , C07H21/02 , C07H21/04
CPC分类号： C08F226/02 , B01J20/267 , B01J20/285 , C08J3/12 , C08J3/246 , C08J2339/02 , C08J2371/02
摘要： The present invention relates to the synthesis of a beaded and cross-linked, high loading capacity polymer for solid phase synthesis, purification of reaction mixtures, chromatographic separation procedures, and the like. The invention can thus be used for the isolation of molecular entities having an affinity for the polymer beads or a chemical entity attached thereto. The beaded polymer matrix can be formed by cross-linking an optionally substituted poly(aminoalkylene), under inverse suspension or inverse emulsion polymerisation conditions, with a cross-linking unit of functionality ≧2.
摘要翻译：本发明涉及用于固相合成，反应混合物纯化，色谱分离步骤等的串联和交联的高负载能力聚合物的合成。因此，本发明可用于分离对聚合物珠粒或与其连接的化学实体具有亲和力的分子实体。串珠聚合物基质可以通过在反相悬浮或反相乳液聚合条件下与官能度> = 2的交联单元交联任选取代的聚（氨基亚烷基）而形成。

6. 发明申请

US20120041111A1 Spherical radiofrequency-encoded beads 审中-公开
标题翻译：球形射频编码珠
公开(公告)号：US20120041111A1
公开(公告)日：2012-02-16
申请号：US11631181
申请日：2005-07-01
申请人： Soren Christensen , Ole Jensen
发明人： Soren Christensen , Ole Jensen
IPC分类号： C08L33/26 , C08K5/1535
CPC分类号： B01J19/0046 , B01J2219/00416 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00565 , B01J2219/00567
摘要： The invention relates to a method for the production of a composition comprising a plurality of spherical radiofrequency-identifiable (RF-tagged) polymeric beads as well the composition as such. The invention also relates to an apparatus for analyzing, identifying or sorting as well as treating a plurality of spherical radiofrequency-identifiable beads, and further to a method for recording individual reaction steps involved in the step-wise synthesis of a chemical compound on a radiofrequency-detectable bead. The beads of the composition are substantial spherical and preferably comprises a hydrophilic polymer material so as to prevent fouling.
摘要翻译：本发明涉及一种制备组合物的方法，所述组合物包含多个球形射频识别（RF标记）聚合物珠粒以及组合物。本发明还涉及一种用于分析，识别或分选以及处理多个球形射频识别珠的装置，还涉及用于记录在射频上逐步合成化合物的各个反应步骤的方法可检测珠。组合物的珠粒是基本上球形的，并且优选包含亲水性聚合物材料，以防止结垢。

7. 发明公开

EP1778740A1 BEADED AND CROSS-LINKED POLY(AMINOALKYLENE) MATRIX AND USES THEREOF 审中-公开
标题翻译： PEARL形和聚（氨基亚烷基）矩阵和网络使用的THEREOF
公开(公告)号：EP1778740A1
公开(公告)日：2007-05-02
申请号：EP05748637.5
申请日：2005-06-10
申请人： VersaMatrix A/S
发明人： GAVELIN, Patrik , REHNBERG, Pehr, Nicola , JOHANNSEN, Ib
IPC分类号： C08F8/00 , C08F8/28 , C08F226/02
CPC分类号： C08F226/02 , B01J20/267 , B01J20/285 , C08J3/12 , C08J3/246 , C08J2339/02 , C08J2371/02
摘要： The present invention relates to the synthesis of a beaded and cross-linked, high loading capacity polymer for solid phase synthesis, purification of reaction mixtures, chromatographic separation procedures, and the like. The invention can thus be used for the isolation of molecular entities having an affinity for the polymer beads or a chemical entity attached thereto. The beaded polymer matrix can be formed by cross-linking an optionally substituted poly(aminoalkylene), under inverse suspension or inverse emulsion polymerisation conditions, with a cross-linking unit of functionality ≥2.

8. 发明公开

EP1654326A1 TRIANGULENIUM FLUORESCENT DYES AND POLYMERS COMPRISING SUCH DYES 审中-公开
标题翻译：三聚氰胺共聚物
公开(公告)号：EP1654326A1
公开(公告)日：2006-05-10
申请号：EP04739015.8
申请日：2004-07-30
申请人： VersaMatrix A/S
发明人： LAURSEN, Bo, Wegge , MICHAEL, Roice , CHRISTENSEN, Soeren, Flygenning
IPC分类号： C09B11/12 , C09B11/24 , C08K5/1545 , B01J19/00
CPC分类号： C08K5/0041 , C07D491/16 , C07D493/16 , C09B11/12 , C09B11/24 , C09B57/00
摘要： The invention relates to fluorescent dyes comprising a triangulene structure in the form of a ring system of six, six-membered rings fused in a triangular fashion. The dyes are useful for visualisation of chemical compounds including polymer matrices for e.g. chromatographic separation and isolation of desirable chemical moieties, and for chemical library synthesis.
摘要翻译：本发明涉及荧光染料，其包含以三角形方式融合的六个六元环的环系形式的三环结构。染料可用于化学化合物的可视化，包括例如聚合物基质。色谱分离和分离所需的化学部分，以及化学文库合成。

9. 发明公开

EP1784441A1 A HIGH LOADING FUNCTIONAL RESIN 有权
标题翻译：具有高承载功能性树脂
公开(公告)号：EP1784441A1
公开(公告)日：2007-05-16
申请号：EP05774800.6
申请日：2005-08-26
申请人： VersaMatrix A/S
发明人： JOHANNSEN, Ib , GAVELIN, Patrik
IPC分类号： C08G65/333 , C08G65/322 , C08L71/02 , C08F8/30
CPC分类号： C08F8/32 , C08L71/02 , C08L2666/04
摘要： The present invention relates to polymer resins, methods for their generation and uses thereof. In one aspect the present invention is directed to a resin obtainable by aminolysis of a precursor resin, wherein the precursor resin is obtainable by polymerisation of i) polydisperse di-or oligofunctional vinyl or cyclic ether compounds and ii) aminolytically sensitive, mono-functional vinyl or cyclic ether compounds.

10. 发明公开

EP1701784A1 IDENTIFICATION OF ENCODED BEADS 审中-公开
标题翻译：识别编码的珠粒的
公开(公告)号：EP1701784A1
公开(公告)日：2006-09-20
申请号：EP04803061.3
申请日：2004-12-22
申请人： VersaMatrix A/S
发明人： CHRISTENSEN, Soeren, Flygenring , JOHANNSEN, Ib , CARSTENSEN, Jens, Michael , KUHLMANN, Lionel
IPC分类号： B01J19/00 , G06K9/64 , G01N15/14
CPC分类号： G01N21/6428 , B01J19/0046 , B01J2219/00468 , B01J2219/00576 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , C40B20/04 , C40B50/14 , C40B60/10 , G01N21/645 , G01N21/6458 , G06K9/6211
摘要： The present invention is relates to methods for the identification of spatially encoded beaded or granulated matrices comprising a plurality of immobilised particles. The identification is based on a distance matrix determination or based on a set of geometrical figures, such a triangles, on the basis of which individual matrices can be determined.

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