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1. 发明申请

WO2006015594A1 BEADED AND CROSS-LINKED POLY(AMINOALKYLENE) MATRIX AND USES THEREOF 审中-公开
标题翻译：珠光交联聚氨酯（AMINOALKYLENE）矩阵及其用途
公开(公告)号：WO2006015594A1
公开(公告)日：2006-02-16
申请号：PCT/DK2005/000384
申请日：2005-06-10
申请人： VERSAMATRIX A/S , GAVELIN, Patrik , REHNBERG, Pehr, Nicola , JOHANNSEN, Ib
发明人： GAVELIN, Patrik , REHNBERG, Pehr, Nicola , JOHANNSEN, Ib
IPC分类号： C08F8/00
CPC分类号： C08F226/02 , B01J20/267 , B01J20/285 , C08J3/12 , C08J3/246 , C08J2339/02 , C08J2371/02
摘要： The present invention relates to the synthesis of a beaded and cross-linked, high loading capacity polymer for solid phase synthesis, purification of reaction mixtures, chromatographic separation procedures, and the like. The invention can thus be used for the isolation of molecular entities having an affinity for the polymer beads or a chemical entity attached thereto. The beaded polymer matrix can be formed by cross-linking an optionally substituted poly(aminoalkylene), under inverse suspension or inverse emulsion polymerisation conditions, with a cross-linking unit of functionality ≥2.
摘要翻译：本发明涉及用于固相合成，反应混合物的纯化，色谱分离程序等的串联和交联的高负载能力聚合物的合成。因此，本发明可用于分离对聚合物珠或与其结合的化学实体具有亲和性的分子实体。串珠聚合物基质可以通过在反相悬浮或反相乳液聚合条件下与官能度= 2的交联单元交联任选取代的聚（氨基亚烷基）来形成。

2. 发明申请

WO2006021218A1 POLYETHER POLYMER MATRIX 审中-公开
标题翻译：聚酯聚合物基质
公开(公告)号：WO2006021218A1
公开(公告)日：2006-03-02
申请号：PCT/DK2005/000547
申请日：2005-08-26
申请人： VERSAMATRIX A/S , JOHANNSEN, Ib , GAVELIN, Patrik , GALLEGO, Monica, Ramos
发明人： JOHANNSEN, Ib , GAVELIN, Patrik , GALLEGO, Monica, Ramos
IPC分类号： C08G65/18
CPC分类号： C08G65/18 , C08G65/00 , Y10T428/254
摘要： The present invention relates to polyether resins, methods for their manufacture and uses thereof. In one aspect of the invention the polyether resin comprises a plurality of functional groups and is obtained by polymerisation of a mixture of alkoxylated reactive compounds selected from a) alkoxylated compounds having a functionality of more than one, and b) alkoxylated monofunctional reactive compounds, wherein the alkoxylated part of the alkoxylated compounds having a functionality of more than one has an average molecular weight which is different from the average molecular weight of the alkoxylated part of the alkoxylated monofunctional reactive compounds.
摘要翻译：本发明涉及聚醚树脂，其制造方法和用途。在本发明的一个方面，聚醚树脂包括多个官能团，并且通过选自以下的烷氧基化反应性化合物的混合物聚合得到：a）具有多于一个官能度的烷氧基化化合物，和b）烷氧基化单官能反应性化合物，其中具有多于一个官能度的烷氧基化化合物的烷氧基化部分具有与烷氧基化单官能反应性化合物的烷氧基化部分的平均分子量不同的平均分子量。

3. 发明公开

EP1778740A1 BEADED AND CROSS-LINKED POLY(AMINOALKYLENE) MATRIX AND USES THEREOF 审中-公开
标题翻译： PEARL形和聚（氨基亚烷基）矩阵和网络使用的THEREOF
公开(公告)号：EP1778740A1
公开(公告)日：2007-05-02
申请号：EP05748637.5
申请日：2005-06-10
申请人： VersaMatrix A/S
发明人： GAVELIN, Patrik , REHNBERG, Pehr, Nicola , JOHANNSEN, Ib
IPC分类号： C08F8/00 , C08F8/28 , C08F226/02
CPC分类号： C08F226/02 , B01J20/267 , B01J20/285 , C08J3/12 , C08J3/246 , C08J2339/02 , C08J2371/02
摘要： The present invention relates to the synthesis of a beaded and cross-linked, high loading capacity polymer for solid phase synthesis, purification of reaction mixtures, chromatographic separation procedures, and the like. The invention can thus be used for the isolation of molecular entities having an affinity for the polymer beads or a chemical entity attached thereto. The beaded polymer matrix can be formed by cross-linking an optionally substituted poly(aminoalkylene), under inverse suspension or inverse emulsion polymerisation conditions, with a cross-linking unit of functionality ≥2.

4. 发明公开

EP1794209A1 POLYETHER POLYMER MATRIX 有权
标题翻译：聚醚树脂基
公开(公告)号：EP1794209A1
公开(公告)日：2007-06-13
申请号：EP05774799.0
申请日：2005-08-26
申请人： VersaMatrix A/S
发明人： JOHANNSEN, Ib , GAVELIN, Patrik , GALLEGO, Monica, Ramos
IPC分类号： C08G65/18
CPC分类号： C08G65/18 , C08G65/00 , Y10T428/254
摘要： The present invention relates to polyether resins, methods for their manufacture and uses thereof. In one aspect of the invention the polyether resin comprises a plurality of functional groups and is obtained by polymerisation of a mixture of alkoxylated reactive compounds selected from a) alkoxylated compounds having a functionality of more than one, and b) alkoxylated monofunctional reactive compounds, wherein the alkoxylated part of the alkoxylated compounds having a functionality of more than one has an average molecular weight which is different from the average molecular weight of the alkoxylated part of the alkoxylated monofunctional reactive compounds.

5. 发明公开

EP1699553A2 APPARATUS AND METHODS FOR ANALYSIS AND SORTING OF PARTICLES SUCH AS POLYMER BEADS 审中-公开
标题翻译：装置和方法进行分析和分选微粒AS聚合物微珠
公开(公告)号：EP1699553A2
公开(公告)日：2006-09-13
申请号：EP04803060.5
申请日：2004-12-22
申请人： VersaMatrix A/S
发明人： CHRISTENSEN, Soeren, Flygenring , JOHANNSEN, Ib
IPC分类号： B01J19/00
CPC分类号： G01N21/645 , B01J2219/00468 , B01J2219/005 , B01J2219/00551 , C40B70/00 , G01N2015/149 , G01N2021/6417 , G01N2035/00574
摘要： The present invention relates to an apparatus for analysing beads and particles, such as polymer beads used e.g. for solid phase synthesis. The apparatus in one embodiment comprises a rotatable, circular disc comprising a plurality of through-going, inlets, wherein an individual bead from a composition comprising different beads can be fixed to the disc at the end-position of a through-going inlet by applying a pressure drop over said disc comprising said through-going inlets. The pressure drop results in beads being sucked (i.e detachably fixed) onto the disc on top of the through-going inlets. When the disc is rotated the beads are transferred from the position where they initially became attached to the disc to fixed positions wherein suitable devices for measuring and/or analyzing and/or sorting the beads can be operated in order to e.g. measure and/or analyse and/or sort at least one bead of a plurality of beads. More specifically, the invention relates to an apparatus for measuring a plurality of optically detectable beads, such as polymer beads, said apparatus comprising a) a vacuum container comprising at least one planar capture body capable or rotating around a central axis, wherein said capture body comprises a plurality of through-going inlets, and wherein the diameter of each inlet is smaller than the average diameter of the beads to be measured and/or analysed and/or sorted, b) a pressure controlling device capable of controlling the pressure in the vacuum container, c) a device for rotating the vacuum container around the axis of the capture disc, and d) a device for measuring at least one property of at least one bead.

6. 发明申请

WO2006066598A2 ANTIBODY BINDING AFFINITY LIGANDS 审中-公开
标题翻译：抗体绑定亲属配偶
公开(公告)号：WO2006066598A2
公开(公告)日：2006-06-29
申请号：PCT/DK2005/000828
申请日：2005-12-23
申请人： VERSAMATRIX A/S , JOHANNSEN, Ib , GALLEGO, Monica, Ramos , MICHAEL, Roice , NOTHELFER, Franz , AMBROSIUS, Dorothee , JACOBI, Alexander
发明人： JOHANNSEN, Ib , GALLEGO, Monica, Ramos , MICHAEL, Roice , NOTHELFER, Franz , AMBROSIUS, Dorothee , JACOBI, Alexander
CPC分类号： C07K1/22 , B01J20/22 , B01J20/28016 , B01J20/286 , B01J20/29 , B01J20/3208 , B01J20/3219 , B01J20/3251 , C07K5/0808 , C07K5/0812 , C07K5/0815 , C07K5/0823 , C07K5/1016 , C07K5/1019 , C07K16/065 , C07K2317/52 , G01N33/54353
摘要： The present application discloses a solid support material having covalently immobilized thereon an affinity ligand, said ligand comprising one or more hydrophobic functional group(s) and one or more cationic functional group(s) or one or more heteroaromatic functional group(s), wherein at least one hydrophobic functional group is separated from at least one cationic/heteroaromatic functional group by a through bond distance of from 5 Å to 20 Å, wherein said ligand has a molecular weight of from 120 Da to 5,000 Da. Typically, the affinity resin has a binding capacity larger than 5 mg monoclonal antibody per mL of affinity resin. A method for the isolation of biomolecules, such as proteins, in particular antibodies, such as monoclonal antibodies, or derivatives thereof, is also disclosed.
摘要翻译：本申请公开了在其上共价固定有亲和配体的固体支持材料，所述配体包含一个或多个疏水官能团和一个或多个阳离子官能团或一个或多个杂芳族官能团，其中至少一个疏水性官能团与至少一个阳离子/杂芳族官能团通过距离为5至20的通过距离分离，其中所述配体的分子量为120Da至5,000Da。通常，亲和树脂的结合能力大于每毫升亲和树脂5毫克单克隆抗体。还公开了分离生物分子如蛋白质，特别是抗体如单克隆抗体或其衍生物的方法。

7. 发明申请

WO2004113389A3 HIGH CAPACITY POLY(ALKYLENE)GLYCOL BASED AMINO POLYMERS 审中-公开
公开(公告)号：WO2004113389A3
公开(公告)日：2004-12-29
申请号：PCT/DK2004/000461
申请日：2004-06-28
申请人： VERSAMATRIX A/S , MICHAEL, Roice , JOHANNSEN, Ib , MELDAL, Morten
发明人： MICHAEL, Roice , JOHANNSEN, Ib , MELDAL, Morten
IPC分类号： C08F8/04
摘要： The present invention relates to a cross-linked and beaded, stable and high loading capacity polymer matrix for affinity chromatography applications and for solid phase synthesis. The polymer matrix can be obtained by a method comprising the steps of providing a plurality of macromonomers each comprising a poly(oxalkylene) chain terminated with an acylamide functional group, polymerising said macromonomers using a free radical initiator or an ionic initiator, optionally with the addition of copolymerizing agents, and converting in the beaded polymer matrix at least 50% of the amide groups to amine functional groups by reduction of the amide groups with a suitable reducing agent.

8. 发明公开

EP1784441A1 A HIGH LOADING FUNCTIONAL RESIN 有权
标题翻译：具有高承载功能性树脂
公开(公告)号：EP1784441A1
公开(公告)日：2007-05-16
申请号：EP05774800.6
申请日：2005-08-26
申请人： VersaMatrix A/S
发明人： JOHANNSEN, Ib , GAVELIN, Patrik
IPC分类号： C08G65/333 , C08G65/322 , C08L71/02 , C08F8/30
CPC分类号： C08F8/32 , C08L71/02 , C08L2666/04
摘要： The present invention relates to polymer resins, methods for their generation and uses thereof. In one aspect the present invention is directed to a resin obtainable by aminolysis of a precursor resin, wherein the precursor resin is obtainable by polymerisation of i) polydisperse di-or oligofunctional vinyl or cyclic ether compounds and ii) aminolytically sensitive, mono-functional vinyl or cyclic ether compounds.

9. 发明公开

EP1701784A1 IDENTIFICATION OF ENCODED BEADS 审中-公开
标题翻译：识别编码的珠粒的
公开(公告)号：EP1701784A1
公开(公告)日：2006-09-20
申请号：EP04803061.3
申请日：2004-12-22
申请人： VersaMatrix A/S
发明人： CHRISTENSEN, Soeren, Flygenring , JOHANNSEN, Ib , CARSTENSEN, Jens, Michael , KUHLMANN, Lionel
IPC分类号： B01J19/00 , G06K9/64 , G01N15/14
CPC分类号： G01N21/6428 , B01J19/0046 , B01J2219/00468 , B01J2219/00576 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , C40B20/04 , C40B50/14 , C40B60/10 , G01N21/645 , G01N21/6458 , G06K9/6211
摘要： The present invention is relates to methods for the identification of spatially encoded beaded or granulated matrices comprising a plurality of immobilised particles. The identification is based on a distance matrix determination or based on a set of geometrical figures, such a triangles, on the basis of which individual matrices can be determined.

10. 发明申请

WO2007022780A1 A METHOD OF MODIFYING A MACROMOLECULAR SYSTEM 审中-公开
标题翻译：一种修饰大分子系统的方法
公开(公告)号：WO2007022780A1
公开(公告)日：2007-03-01
申请号：PCT/DK2006/000461
申请日：2006-08-25
申请人： VERSAMATRIX A/S , JOHANNSEN, Ib , MICHAEL, Roice
发明人： JOHANNSEN, Ib , MICHAEL, Roice
IPC分类号： C08G85/00 , C08G65/10 , C08G81/02 , C08G81/00 , C08J7/12 , C08G65/32 , C08J7/04 , C08H1/00
CPC分类号： C08G65/2618 , C08G65/331
摘要： The present application discloses a method of modifying a macromolecule, the method comprising the steps of (i) providing the macromolecule; (ii) providing a compound of the general formula (I): wherein N is a primary amino group protected with the protecting group P, wherein the protecting group involves both free valences of the primary amino group; m is an integer of 1-12 and n is an integer of 1-2000; R1 and R2 are independently selected from the group consisting of hydrogen and Ci-4-alkyl; and X is a reactive group; and (iii) allowing the compound of the general formula (I) to react with the macromolecule so as to form grafts on the macromolecule. Compounds of the general formula (i) and a method for the preparation thereof are also disclosed.
摘要翻译：本申请公开了一种修饰大分子的方法，该方法包括以下步骤：（i）提供高分子; （ii）提供通式（I）的化合物：其中N是被保护基P保护的伯氨基，其中保护基包括伯氨基的游离价; m为1-12的整数，n为1-2000的整数; R 1和R 2独立地选自氢和C 1-4 - 烷基; X为反应性基团; 和（iii）使通式（I）的化合物与大分子反应，以便在大分子上形成移植物。还公开了通式（i）的化合物及其制备方法。

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