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1. 发明申请

WO2015069800A3 PROTECTIVE HELMETS WITH NON-LINEARLY DEFORMING ELEMENTS 审中-公开
标题翻译：具有非线性变形元件的保护头盔
公开(公告)号：WO2015069800A3
公开(公告)日：2015-11-05
申请号：PCT/US2014064173
申请日：2014-11-05
申请人： UNIV WASHINGTON CT COMMERCIALI
发明人： BROWD SAMUEL R , POSNER JONATHAN , REINHALL PER G , MARVER DAVID L , DARDIS II JOHN T
IPC分类号： A24B3/00 , A42B3/12
CPC分类号： A42B3/14 , A42B3/046 , A42B3/064 , A42B3/065 , A42B3/121 , A42B3/125 , A42B3/30
摘要： The present technology relates generally to protective helmets with non-linearly deforming members. Helmets configured in accordance with embodiments of the present technology can comprise, for example, an inner layer, an outer layer, a space between the inner layer and the outer layer, and an interface layer disposed in the space. The interface layer comprises a plurality of filaments, each having a height, a longitudinal axis along the height, a first end proximal to the inner layer, and a second end proximal to the outer layer. The filaments are sized and shaped to span the space between the inner layer and the outer layer. The filaments are configured to deform non-linearly in response to an external incident force on the helmet.
摘要翻译：本技术总体上涉及具有非线性变形构件的防护头盔。根据本技术的实施例配置的头盔可以包括例如内层，外层，内层和外层之间的空间以及设置在该空间中的界面层。界面层包括多个细丝，每个细丝具有高度，沿高度的纵向轴线，靠近内层的第一端和靠近外层的第二端。长丝的尺寸和形状设计成跨越内层和外层之间的空间。细丝构造成响应于头盔上的外部入射力而非线性地变形。

2. 发明申请

WO2014151630A2 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES 审中-公开
标题翻译：用于治疗寄生虫病的化合物和组合物
公开(公告)号：WO2014151630A2
公开(公告)日：2014-09-25
申请号：PCT/US2014026132
申请日：2014-03-13
申请人： IRM LLC , UNIV WASHINGTON CT COMMERCIALI , CHATTERJEE ARNAB KUMAR , LIANG FANG , MATHISON CASEY JACOB NELSON , MISHRA PRANAB KUMAR , MOLTENI VALENTINA , NAGLE ADVAIT SURESH , SUPEK FRANTISEK , TAN LIYING JOCELYN , VIDAL AGNES , GELB MICHAEL HERMAN , BUCKNER FREDERICK SIMMONS , TATIPAKA HARI BABU , NORCROSS RICHARD NEIL , GILLESPIE JOHN ROBERT , PENDEM NAGENDAR
发明人： CHATTERJEE ARNAB KUMAR , LIANG FANG , MATHISON CASEY JACOB NELSON , MISHRA PRANAB KUMAR , MOLTENI VALENTINA , NAGLE ADVAIT SURESH , SUPEK FRANTISEK , TAN LIYING JOCELYN , VIDAL AGNES , GELB MICHAEL HERMAN , BUCKNER FREDERICK SIMMONS , TATIPAKA HARI BABU , NORCROSS RICHARD NEIL , GILLESPIE JOHN ROBERT , PENDEM NAGENDAR
IPC分类号： C07D473/00
CPC分类号： C07D473/00 , C07D471/04 , C07D487/04 , C07D498/04
摘要： The present invention is related to compounds of Formula A or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further relates to pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.
摘要翻译：本发明涉及式A化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。本发明还涉及包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由寄生虫引起的疾病的病理和/或症状的方法，例如利什曼病，人非洲锥虫病和恰加斯病。

3. 发明申请

WO2014071211A3 MOLECULES, COMPOSITIONS AND METHODS TO TREAT ORGAN SCARRING 审中-公开
标题翻译：治疗器官瘢痕的分子，组合物和方法
公开(公告)号：WO2014071211A3
公开(公告)日：2014-06-26
申请号：PCT/US2013068107
申请日：2013-11-01
申请人： UNIV WASHINGTON CT COMMERCIALI , CHILDRENS HOSP MEDICAL CENTER
发明人： DUFFIELD JEREMY , REN SHUYU , HEGDE RASHMI
IPC分类号： A61K38/17
CPC分类号： C07K14/4703 , A61K38/1709
摘要： The present disclosure provides molecules, compositions and methods for treating scarring in organs. The molecules, compositions and methods treat scarring by modulating the WNT, platelet-derived growth factor receptor (PDGFR), transforming growth factor-beta (TGF3) and/or connective-tissue growth factor (CTGF) signaling pathways.
摘要翻译：本公开提供了用于治疗器官瘢痕形成的分子，组合物和方法。该分子，组合物和方法通过调节WNT，血小板衍生生长因子受体（PDGFR），转化生长因子-β（TGF3）和/或结缔组织生长因子（CTGF）信号传导途径来治疗瘢痕形成。

4. 发明申请

WO2013177581A2 WHOLE GENOME SEQUENCING OF A HUMAN FETUS 审中-公开
标题翻译：人类全身基因测序
公开(公告)号：WO2013177581A2
公开(公告)日：2013-11-28
申请号：PCT/US2013042774
申请日：2013-05-24
申请人： UNIV WASHINGTON CT COMMERCIALI
发明人： SHENDURE JAY ASHOK , KITZMAN JACOB OTTO , SNYDER MATTHEW
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6869 , C12Q2535/122 , C12Q2537/165
摘要： Methods of genome sequencing of a fetus are provided herein. In some embodiments, such methods include steps of predicting inheritance or transmission of an allele from one or more maternal-only heterozygous sites from a maternal genomic sequence to a fetal genome sequence; and predicting inheritance or transmission of an allele from one or more paternal-only heterozygous sites from a paternal genomic sequence to a fetal genome sequence. In some embodiments, the methods may also include predicting transmission of one or more genomic variants at one or more heterozygous sites that are present on both a maternal genomic sequence and a paternal genomic sequence. According to these embodiments, the paternal genomic sequence and the maternal genomic sequence are derived from a biological sample containing DNA. According to other embodiments, the sequencing methods may include a step of predicting de novo mutations in a fetal genomic sequence.
摘要翻译：本文提供胎儿的基因组测序方法。在一些实施方案中，这些方法包括预测从母体基因组序列到胎儿基因组序列的一个或多个仅母体杂合位点遗传或传播等位基因的步骤; 并预测从父系基因组序列到胎儿基因组序列的一个或多个仅有父本杂合位点的等位基因的遗传或传播。在一些实施方案中，所述方法还可以包括预测存在于母体基因组序列和父系基因组序列上的一个或多个杂合位点处的一种或多种基因组变体的传递。根据这些实施方案，父系基因组序列和母体基因组序列衍生自含有DNA的生物样品。根据其他实施方案，测序方法可以包括预测胎儿基因组序列中的从头突变的步骤。

5. 发明申请

WO2013052851A1 METHODS AND COMPOSITIONS FOR POLYPEPTIDE AND PROTEIN LABELING USING LIPOIC ACID LIGASES SPECIFIC TO RESORUFIN 审中-公开
标题翻译：使用特异性抑制剂的乳清酸多肽和蛋白质标记的方法和组合物
公开(公告)号：WO2013052851A1
公开(公告)日：2013-04-11
申请号：PCT/US2012059032
申请日：2012-10-05
申请人： MASSACHUSETTS INISTITUTE OF TECHNOLOGY , UNIV WASHINGTON CT COMMERCIALI
发明人： TING ALICE Y , BAKER DAVID , RICHTER FLORIAN , NIVON LUCAS , LIU DANIEL SHAO-CHEN
IPC分类号： C12N9/00
CPC分类号： C12N9/1241 , C12N9/93 , C12N15/102 , C12Y207/07063 , G01N33/532 , G01N33/533 , G01N2333/9015
摘要： The present disclosure provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants thereof, and lipoic acid analogs (e.g., lipoic acid analogs comprising a resorufin moiety) recognized by lipoic acid ligase and lipoic acid ligase mutants. Also provided herein is a method of imaging protein-protein interaction via a reaction mediated by lipoic acid ligase.
摘要翻译：本公开提供其用于在体外或体内标记肽和蛋白质的组合物和方法。本文描述的方法使用硫辛酸连接酶或其突变体，以及由硫辛酸连接酶和硫辛酸连接酶突变体识别的硫辛酸类似物（例如包含再溶血部分的硫辛酸类似物）。本文还提供了通过由硫辛酸连接酶介导的反应来成像蛋白质 - 蛋白质相互作用的方法。

6. 发明申请

WO2012027631A3 METHODS FOR DETECTING ANTI-HE4 ANTIBODIES AND METHODS OF DIAGNOSIS AND/OR PROGNOSIS OF CONDITIONS ASSOCIATED WITH HE4-EXPRESSING CELLS 审中-公开
标题翻译：用于检测抗HE4抗体的方法和与HE4表达细胞相关的病症的诊断和/或预处理方法
公开(公告)号：WO2012027631A3
公开(公告)日：2012-07-19
申请号：PCT/US2011049274
申请日：2011-08-26
申请人： UNIV WASHINGTON CT COMMERCIALI , HELLSTROM KARL ERIK , HELLSTROM INGEGERD , LIU PU , JAFFAR JADE , SWISHER ELIZABETH
发明人： HELLSTROM KARL ERIK , HELLSTROM INGEGERD , LIU PU , JAFFAR JADE , SWISHER ELIZABETH
IPC分类号： G01N33/53 , G01N33/48
CPC分类号： G01N33/6854 , G01N33/57449 , G01N2800/52
摘要： The present invention features, inter alia, compositions and methods related to the detection of HE4-expressing tumor cells in a subject. The methods include detection of anti-HE4 antibodies in a biological sample obtained from the subject. The methods are useful for diagnosis and monitoring the efficacy of treatments for cancers in which HE4 is expressed, for example, ovarian cancer.
摘要翻译：本发明尤其涉及与受试者中表达HE4的肿瘤细胞的检测相关的组合物和方法。所述方法包括从受试者获得的生物样品中检测抗HE4抗体。该方法可用于诊断和监测治疗对HE4表达的癌症的疗效，例如卵巢癌。

7. 发明申请

WO2011133922A3 ULTRASOUND BASED METHOD AND APPARATUS FOR STONE DETECTION AND TO FACILITATE CLEARANCE THEREOF 审中-公开
标题翻译：基于超声波的方法和设备，用于石材检测和便于其清除
公开(公告)号：WO2011133922A3
公开(公告)日：2012-02-16
申请号：PCT/US2011033652
申请日：2011-04-22
申请人： UNIV WASHINGTON CT COMMERCIALI , BAILEY MICHAEL , KUCEWICZ JOHN , LU WEI , SAPOZHNIKOV OLEG , ILLIAN PAUL , SHAH ANUP , DUNMIRE BARBRINA , OWEN NEIL , CUNITZ BRYAN , KACZKOWSKI PETER , PAUN MARLA
发明人： BAILEY MICHAEL , KUCEWICZ JOHN , LU WEI , SAPOZHNIKOV OLEG , ILLIAN PAUL , SHAH ANUP , DUNMIRE BARBRINA , OWEN NEIL , CUNITZ BRYAN , KACZKOWSKI PETER , PAUN MARLA
IPC分类号： A61B8/08 , A61B17/22 , A61B19/00 , G01S15/89 , G06T7/00 , G06T7/60
CPC分类号： A61B17/225 , A61B5/055 , A61B5/7232 , A61B6/03 , A61B6/485 , A61B8/085 , A61B8/488 , A61B17/2256 , A61B2017/22005 , A61B2090/378 , A61N7/00 , A61N2007/0004 , A61N2007/0052 , A61N2007/0082 , G01S7/52071 , G01S15/899
摘要： Described herein are methods and apparatus for detecting stones by ultrasound, in which the ultrasound reflections from a stone are preferentially selected and accentuated relative to the ultrasound reflections from blood or tissue. Also described herein are methods and apparatus for applying pushing ultrasound to in vivo stones or other objects, to facilitate the removal of such in vivo objects.
摘要翻译：这里描述了用于通过超声检测石块的方法和装置，其中相对于来自血液或组织的超声波反射优先选择和加强来自石头的超声反射。本文还描述了将推进超声应用于体内石块或其它物体的方法和装置，以便于去除这样的体内物体。

8. 发明申请

WO2011091041A2 PILE TO MINIMIZE NOISE TRANSMISSION AND METHOD OF PILE DRIVING 审中-公开
标题翻译：减少噪声传播的桩和桩驱动方法
公开(公告)号：WO2011091041A2
公开(公告)日：2011-07-28
申请号：PCT/US2011021723
申请日：2011-01-19
申请人： UNIV WASHINGTON CT COMMERCIALI , REINHALL P G , DAHL PETER H
发明人： REINHALL PER G , DAHL PETER H
IPC分类号： E02D5/72 , E02D5/24
CPC分类号： E02D13/00 , E02D5/24 , E02D5/52 , E02D5/72
摘要： A pile and method for driving a pile includes a pile having a structural outer tube, and an inner member disposed generally concentrically with the outer tube. The outer tube and inner member are fixed to a driving shoe. The pile is constructed and driven such that the pile driver impacts only the inner member. The impact loads are transmitted to the driving shoe to drive the pile into the sediment, such that the outer tube is thereby pulled into the sediment. In a particular embodiment the outer tube is formed of steel, and the inner member also comprises a steel tube. In an alternative embodiment one or both of the inner member and the outer tube are formed of an alternative material, for example, concrete. In an embodiment, the outer tube has a recess that captures a flange on the inner member. In an embodiment the outer tube is attached to the inner member with an elastic spring.
摘要翻译：用于驱动桩的桩和方法包括具有结构外管的桩和与外管大致同心布置的内部构件。外管和内部构件固定到驱动滑脚。桩的构造和驱动使得打桩机仅撞击内部构件。冲击载荷传递到驱动滑板上，以将桩驱动到沉积物中，从而将外管拉入沉积物中。在特定实施例中，外管由钢形成，并且内部构件还包括钢管。在替代实施例中，内部构件和外部管中的一个或两个由替代材料例如混凝土形成。在一个实施例中，外管具有捕获内部构件上的凸缘的凹部。在一个实施例中，外管用弹性弹簧连接到内部构件。

9. 发明申请

WO2015017670A3 METHODS AND SYSTEMS FOR MANAGING MULTI-DEVICE INTERACTION USING THE DOPPLER EFFECT 审中-公开
标题翻译：使用多普勒效应管理多设备交互的方法和系统
公开(公告)号：WO2015017670A3
公开(公告)日：2015-04-23
申请号：PCT/US2014049175
申请日：2014-07-31
申请人： UNIV WASHINGTON CT COMMERCIALI
发明人： GUPTA SIDHANT , PATEL SHWETAK N , AUMI TANVIR ISLAM , GOEL MAYANK , LARSON ERIC COOPER
IPC分类号： G06F3/033 , G06F3/0488
CPC分类号： G06F3/017 , G01S5/18
摘要： The present technology relates generally to systems and methods for managing multi-device interactions using the Doppler effect. In some embodiments, for example, a method for managing multiple device interactions in accordance with the technology comprises receiving an indication of a first Doppler shift detected by a first receiving device of an audio signal from a transmitting device, receiving an indication of a second Doppler shift detected by a second receiving device of the audio signal from the transmitting device, comparing the first and second Doppler shifts and, based at least in part on comparing the first and second Doppler shifts, determining a gesture made with the transmitting device.
摘要翻译：本技术总体上涉及使用多普勒效应管理多设备交互的系统和方法。在一些实施例中，例如，根据本技术的用于管理多个设备交互的方法包括：接收第一接收设备检测到的来自发送设备的音频信号的第一多普勒频移的指示;接收第二多普勒指示符由第二接收设备检测来自发射设备的音频信号的移位，比较第一和第二多普勒频移，并且至少部分地基于比较第一和第二多普勒频移来确定由发射设备做出的手势。

10. 发明申请

WO2013106460A3 COMPOSITIONS AND METHODS FOR TREATING MALIGNANT ASTROCYTOMAS 审中-公开
标题翻译：用于治疗恶性胶质瘤的组合物和方法
公开(公告)号：WO2013106460A3
公开(公告)日：2014-09-18
申请号：PCT/US2013020871
申请日：2013-01-09
申请人： UNIV WASHINGTON CT COMMERCIALI
发明人： STELLA NEPHI , DIAZ PHILIPPE
IPC分类号： C07D471/04 , A61K31/435 , C07D209/88
CPC分类号： C07D209/86 , C07D209/88 , C07D401/06 , C07D471/04
摘要： The disclosure provides methods of treating glioblastoma, methods of screening for compounds that treat glioblastoma, and pharmaceutical compositions useful in the treatment of glioblastoma.
摘要翻译：本公开提供了治疗胶质母细胞瘤的方法，筛选治疗胶质母细胞瘤的化合物的方法，以及可用于治疗胶质母细胞瘤的药物组合物。

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