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1. 发明专利

JP2014110793A Primer, probe and method for amplifying nucleic acid 有权
标题翻译：用于放大核酸的前体，探针和方法
公开(公告)号：JP2014110793A
公开(公告)日：2014-06-19
申请号：JP2014000518
申请日：2014-01-06
申请人： Univ Brandeis , ブランデイズユニバーシティー
发明人： WANGH LAWRENCE J , RICE JOHN , SANCHEZ AQUILES J , PIERCE KENNETH , SALK JESSE , REIS ARTHUR
IPC分类号： C12N15/09 , C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6844 , C12Q1/6851 , C12Q1/6876 , C12Q2600/156 , C12Q2600/16 , C12Q2545/114 , C12Q2531/107 , C12Q2527/107 , C12Q2561/113
摘要： PROBLEM TO BE SOLVED: To provide a nucleic acid amplification reaction including amplification using a polymerase chain reaction, and an assay method using the reaction and obtained by combining a sequence method and a hybridization probe detection method.SOLUTION: There is provided a method for producing both a double-stranded chain amplicon and a single-stranded chain amplicon by extending an oligonucleotide primer with a DNA polymerase, and analyzing at least one single-stranded chain amplification product in an asymmetry nucleic acid amplification step including at least one primer annealing temperature. The method includes: detecting the two-stranded chain amplicon by detecting homogeneous fluorescence; detecting the at least one single-stranded chain amplicon product by detecting the homogeneous fluorescence sequence-specific in a lower temperature than the at least one primer annealing temperature; and calculating a fluorescence ratio of the single-stranded chain product to fluorescence of the double-stranded chain amplicon.
摘要翻译：要解决的问题：提供包括使用聚合酶链式反应的扩增的核酸扩增反应和使用该反应并通过组合序列方法和杂交探针检测方法获得的测定方法。解决方案提供了一种生产方法通过用DNA聚合酶延伸寡核苷酸引物，双链链扩增子和单链链扩增子，并且在包括至少一个引物退火温度的不对称核酸扩增步骤中分析至少一种单链链扩增产物。该方法包括：通过检测均匀荧光检测双链链扩增子; 通过在比所述至少一个引物退火温度更低的温度下检测均相荧光序列特异性来检测所述至少一种单链链扩增子产物; 并计算双链链扩增子的单链链产物与荧光的荧光比。

2. 发明授权

US3929756A Synthetically produced tridecapeptide having the same activity as the hypothalamic substance, neurotensin 失效
标题翻译：具有与下丘脑物质，神经降压素相同活性的合成产生的十三肽
公开(公告)号：US3929756A
公开(公告)日：1975-12-30
申请号：US41781673
申请日：1973-11-21
申请人： UNIV BRANDEIS
发明人： LEEMAN SUSAN E , CARRAWAY ROBERT E
IPC分类号： A61K38/00 , C07K7/08 , C07C103/52 , A61K37/00
CPC分类号： C07K7/083 , A61K38/00
摘要： A hypotensive peptide, designated neurotensin, has been discovered and isolated in pure form from acid-acetone extracts of bovine hypothalami by column chromatography and paper electrophoresis. Based upon this discovery, a tridecapeptide has been chemically synthesized having the activity of this hypothalamic substance.
摘要翻译：已经通过柱层析和纸电泳，从牛下丘脑的酸 - 丙酮提取物中发现并分离出纯化形式的降血压肽，称为神经丝氨酸。基于这一发现，已经化学合成了具有该下丘脑物质活性的十三肽。

3. 发明申请

WO2014116982A2 METHODS OF MODULATING GABAERGIC INHIBITORY SYNAPSE FORMATION AND FUNCTION 审中-公开
标题翻译：调节气体阻尼物质形成和功能的方法
公开(公告)号：WO2014116982A2
公开(公告)日：2014-07-31
申请号：PCT/US2014012997
申请日：2014-01-24
申请人： UNIV BRANDEIS , PARADIS SUZANNE , MOORE ANNA R , KUZIRIAN MARISSA S
发明人： PARADIS SUZANNE , MOORE ANNA R , KUZIRIAN MARISSA S
IPC分类号： A61K48/00 , A61K38/17
CPC分类号： C07K14/70596 , A61K38/17 , A61K38/177 , A61K48/00 , C07K2319/30 , C12N15/1138 , C12N2310/14 , C12N2320/30
摘要： The present technology relates to methods of modulating the number of GABAergic synapses between at least two neurons. These methods include contacting at least one of the neurons with a PlexinB agonist or a nucleic acid molecule encoding a PlexinB agonist, such as a composition including a Sema4D polypeptide or an extracellular fragment thereof, or a nucleic acid molecule encoding the Sema4D polypeptide or extracellular fragment thereof. The present technology also relates to methods of modulating neuronal activity in the central nervous system or peripheral nervous system of a subject in need thereof by modulating the number of GABAergic synapses between at least two neurons. The present technology further relates to methods of treating a neurological disorder that would benefit from modulating neuronal activity in the central nervous system or peripheral nervous system of a subject in need thereof.
摘要翻译：本技术涉及调节至少两个神经元之间的GABA能突触的数量的方法。这些方法包括使至少一个神经元与PlexinB激动剂或编码PlexinB激动剂的核酸分子接触，例如包含Sema4D多肽或其细胞外片段的组合物或编码Sema4D多肽或胞外片段的核酸分子它们。本技术还涉及通过调节至少两个神经元之间的GABA能突触的数目来调节有需要的受试者的中枢神经系统或周围神经系统的神经元活性的方法。本技术还涉及治疗有益于调节有需要的受试者的中枢神经系统或周围神经系统中的神经元活性的神经障碍的方法。

4. 发明申请

WO2014043526A3 COOLING SYSTEMS AND METHODS FOR CYRO SUPER-RESOLUTION FLUORESCENCE LIGHT MICROSCOPY AND OTHER APPLICATIONS 审中-公开
标题翻译：冷冻系统和方法用于CYRO超分辨荧光光微显微镜及其他应用
公开(公告)号：WO2014043526A3
公开(公告)日：2014-05-08
申请号：PCT/US2013059748
申请日：2013-09-13
申请人： UNIV BRANDEIS , INGERSOLL CHARLES G
发明人： INGERSOLL CHARLES G , DEROSIER DAVID J , TURRIGIANO GINA , NAHMANI MARC
IPC分类号： G02B21/28
CPC分类号： G02B21/28 , G02B21/26 , G02B21/32 , G02B21/33
摘要： New systems and methods are described for maintaining a desired steady state temperature differential between two objects that may otherwise undergo heat transfer to restore thermal steady state. In one application, a cooling microscope assembly and its use with conventional optical microscopes are described for achieving super-resolution imaging. The assembly allows for the high resolution imaging of samples at cryogenic temperatures while maintaining the temperature of the objective lens above freezing by employing circulation systems and a coupling fluid between the sample and objective Jens.
摘要翻译：描述了新的系统和方法，用于在两个物体之间保持期望的稳态温差，否则可能会经历热传递以恢复热稳定状态。在一个应用中，描述了用于实现超分辨率成像的冷却显微镜组件及其与常规光学显微镜的用途。该组件允许在低温下对样品进行高分辨率成像，同时通过采用循环系统和样品和物镜Jens之间的耦合流体将物镜的温度保持在高于冻结状态。

5. 发明申请

WO2011156690A3 METHODS FOR THE DEVELOPMENT OF VACCINES BASED ON OLIGOSACCHARIDE-OLIGONUCLEOTIDE CONJUGATES 审中-公开
标题翻译：基于寡糖 - 寡聚核苷酸偶联物开发疫苗的方法
公开(公告)号：WO2011156690A3
公开(公告)日：2012-05-24
申请号：PCT/US2011039949
申请日：2011-06-10
申请人： UNIV BRANDEIS , KRAUSS ISAAC J , HEDSTROM LIZBETH K , MACPHERSON IAIN S
发明人： KRAUSS ISAAC J , HEDSTROM LIZBETH K , MACPHERSON IAIN S
IPC分类号： C12N15/11 , A61K31/7088 , C07H21/00 , C12N15/10 , C12Q1/68
CPC分类号： A61K47/48092 , A61K39/21 , A61K47/4833 , A61K47/549 , A61K47/646 , A61K2039/55505 , A61K2039/55511 , A61K2039/6068 , A61K2039/6081 , A61K2039/627 , C07H15/22 , C07H21/04 , C12N7/00 , C12N15/1048 , C12N15/1058
摘要： Described herein are oligosaccharide-oligonucleotide conjugates useful as vaccines against one or more human or veterinary therapeutic indications, and methods of synthesizing and identifying them. The conjugates may be identified using non-human antibodies as binding targets, thereby expanding the power and scope of the invention. Efficacious conjugates may be identified through an iterative.
摘要翻译：本文描述了可用作针对一种或多种人或兽医治疗适应症的疫苗的寡糖 - 寡核苷酸缀合物，以及合成和鉴定它们的方法。可以使用非人抗体作为结合靶标鉴定缀合物，从而扩大本发明的功能和范围。有效的缀合物可以通过迭代来鉴定。

6. 发明申请

WO2009078931A9 IRF AS A TUMOR SUPPRESSOR AND USES THEREOF 审中-公开
标题翻译： IRF作为肿瘤抑制剂及其用途
公开(公告)号：WO2009078931A9
公开(公告)日：2009-10-15
申请号：PCT/US2008013541
申请日：2008-12-10
申请人： UNIV BRANDEIS , REN RUIBAO
发明人： REN RUIBAO
IPC分类号： A61K31/506 , A61K31/70 , A61K35/14 , A61K35/28 , A61K38/21 , A61K48/00 , A61P35/00 , A61P35/02
CPC分类号： A61K45/06

7. 发明申请

WO2006133221A3 APPARATUS AND METHOD FOR INTRODUCING MULTIWAVELENGTH LASER EXCITATION IN FLUORESCENCE MICROSCOPY 审中-公开
标题翻译：介绍荧光显微镜多波长激光激发的装置与方法
公开(公告)号：WO2006133221A3
公开(公告)日：2007-04-05
申请号：PCT/US2006021980
申请日：2006-06-06
申请人： UNIV BRANDEIS , FRIEDMAN LAWRENCE JAY , CHUNG JOHNSON CHENG-CHUN , GELLES JEFF DANIEL
发明人： FRIEDMAN LAWRENCE JAY , CHUNG JOHNSON CHENG-CHUN , GELLES JEFF DANIEL
IPC分类号： G01N21/64
CPC分类号： G02B21/16
摘要： Use of broadband mirrors to direct light into an objective enables the use of several wavelengths for imaging.
摘要翻译：使用宽带镜将光引入目标可以使用几种波长进行成像。

8. 发明申请

WO2013166420A3 LIQUID CRYSTALLINE PHYTOSTEROL-GLYCERINE COMPLEX FOR ENHANCED BIOAVAILABILITY AND WATER DISPERSAL 审中-公开
标题翻译：液体生物降解药水复合物用于增强生物利用度和水分散
公开(公告)号：WO2013166420A3
公开(公告)日：2014-03-13
申请号：PCT/US2013039517
申请日：2013-05-03
申请人： UNIV BRANDEIS
发明人： PERLMAN DANIEL
IPC分类号： A23D9/007
CPC分类号： A61K31/575 , A23D7/0053 , A23D9/007 , A23L33/11
摘要： Edible phytosterol-containing compositions include molecular complexes of non- esterified phytosterols (P) and glycerine (G) in the form of liquid crystalline microparticles. Addition of an emulsifier (M) such as a monoglyceride or a modified lecithin, and optionally an ionic surfactant, to the complex facilitates its dispersal in an aqueous medium. A composition containing either the binary PG or ternary PGM molecular complexes can be formulated as a beverage, food product, or nutritional supplement. When administered to a human subject, the complexes sequester cholesterol in the gastrointestinal tract and reduce LDL cholesterol and total plasma cholesterol levels.
摘要翻译：含食用植物甾醇的组合物包括液晶微粒形式的非酯化植物甾醇（P）和甘油（G）的分子复合物。向复合物中加入乳化剂（M）如单酸甘油酯或改性卵磷脂和任选的离子表面活性剂有利于其在水性介质中的分散。含有二元PG或三元PGM分子复合物的组合物可以配制成饮料，食品或营养补充剂。当施用于人受试者时，复合物螯合胃肠道中的胆固醇并降低LDL胆固醇和总血浆胆固醇水平。

9. 发明申请

WO2011163512A3 CANCER THERAPY 审中-公开
标题翻译：癌症治疗
公开(公告)号：WO2011163512A3
公开(公告)日：2013-04-25
申请号：PCT/US2011041682
申请日：2011-06-23
申请人： UNIV BRANDEIS , REN RUIBAO , CUIFFO BENJAMIN
发明人： REN RUIBAO , CUIFFO BENJAMIN
IPC分类号： A61K38/00 , A61P35/00 , C12N15/11
CPC分类号： A61K31/713 , A61K31/336 , C12N15/1137 , C12N2310/14 , C12Y203/01085
摘要： Methods of blocking or modulating the palmitoylation of NRAS or other RAS proteins useful in the treatment of cancer are provided, as are methods for identifying and/or characterizing such agents. In addition, methods for identifying and/or characterizing patient populations responsive to the particular agents are provided.
摘要翻译：提供了可用于治疗癌症的NRAS或其他RAS蛋白质的棕榈酰化的阻断或调节方法，以及用于鉴定和/或表征这些药剂的方法。此外，提供了用于鉴定和/或表征响应于特定药剂的患者群体的方法。

10. 发明申请

WO2012166706A2 SUPRAMOLECULAR NANOFIBERS AND HYDROGELS BASED ON OLIGOPEPTIDES FUNCTIONALIZED WITH NUCLEOBASES 审中-公开
标题翻译：基于功能化的寡核苷酸的分子纳米粒子和羟基化合物
公开(公告)号：WO2012166706A2
公开(公告)日：2012-12-06
申请号：PCT/US2012039822
申请日：2012-05-29
申请人： UNIV BRANDEIS , XU BING
发明人： XU BING
IPC分类号： C07D239/46 , A61K31/513 , A61K31/52 , C07D473/04
CPC分类号： C07D239/54 , A61K9/06 , A61K9/70 , A61K47/183 , A61K47/22 , A61K47/26 , B82Y5/00 , C07D239/47 , C07D473/18 , C07D473/34 , C07K5/06078 , C07K5/0812
摘要： Described herein are nucleopeptide compounds that include a nucleobase and an oligopeptide. The compounds may self-assemble to form supramolecular hydrogels. Also, the compounds may be used as a platform to examine specific biological functions (e.g., binding to DNA and RNA) of a dynamic supramolecular system that is able to interact with both proteins and nucleic acids. Other uses include: methods of growing cells and methods of delivering a substance to a cell.
摘要翻译：本文描述的是包括核碱基和寡肽的核肽化合物。化合物可以自组装形成超分子水凝胶。此外，化合物可以用作平台以检查能够与蛋白质和核酸相互作用的动态超分子系统的特异性生物学功能（例如，结合DNA和RNA）。其他用途包括：生长细胞的方法和向细胞递送物质的方法。

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