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1. 发明专利

TW588169B 流體主系統中之電性可切換高分子液晶與高分子雙折射片及使用該高分子液晶與高分子雙折射片之光學裝置失效
简体标题：流体主系统中之电性可切换高分子液晶与高分子双折射片及使用该高分子液晶与高分子双折射片之光学设备
公开(公告)号：TW588169B
公开(公告)日：2004-05-21
申请号：TW090111618
申请日：2001-05-15
申请人：美國羅徹斯特大學 THE UNIVERSITY OF ROCHESTER
发明人：肯尼斯L 馬歇爾 KENNETH L. MARSHALL , 塔亞Z 科斯克 TANYA Z. KOSC , 史帝芬D 傑可伯斯 STEPHEN D. JACOBS , 賽奇M 費里斯 SADEG M. FARIS , 李萊 LE LI
IPC分类号： G02F
CPC分类号： G02F1/172 , G02F1/137
摘要：分散在液體主媒質中的片狀或板狀的高分子液晶(PLC)與其它雙折射高分子(BP)，當懸浮液是包含在一對具有透明導電塗佈層的硬質基板間時，或是當作分散在主體高分子主體內的微型封包時，便會構成具有電性可切換光學裝置之主動單元功能的系統。這些片狀物材料的光學特性包括較大的光學路徑長度，不同的偏極化狀態以及在選擇性反射或雙折射中較高的角度敏感性。這些片狀或板狀的裝置只需要3-20°垂直於單元表面的旋轉角度，便能達到習用裝置中使用顆粒旋轉或平移所得到的切換特性。
简体摘要：分散在液体主媒质中的片状或板状的高分子液晶(PLC)与其它双折射高分子(BP)，当悬浮液是包含在一对具有透明导电涂布层的硬质基板间时，或是当作分散在主体高分子主体内的微型封包时，便会构成具有电性可切换光学设备之主动单元功能的系统。这些片状物材料的光学特性包括较大的光学路径长度，不同的偏极化状态以及在选择性反射或双折射中较高的角度敏感性。这些片状或板状的设备只需要3-20°垂直於单元表面的旋转角度，便能达到习用设备中使用颗粒旋转或平移所得到的切换特性。

2. 发明专利

TW200510889A 使用懸浮於流體主體之複合層薄片系統以獲致與角度有關之光學效果之可電氣定址光學裝置 ELECTRICALLY ADDRESSABLE OPTICAL DEVICES USING A SYSTEM OF COMPOSITE LAYERED FLAKES SUSPENDED IN A FLUID HOST TO OBTAIN ANGULARLY DEPENDENT OPTICAL EFFECTS 审中-公开
简体标题：使用悬浮于流体主体之复合层薄片系统以获致与角度有关之光学效果之可电气寻址光学设备 ELECTRICALLY ADDRESSABLE OPTICAL DEVICES USING A SYSTEM OF COMPOSITE LAYERED FLAKES SUSPENDED IN A FLUID HOST TO OBTAIN ANGULARLY DEPENDENT OPTICAL EFFECTS
公开(公告)号：TW200510889A
公开(公告)日：2005-03-16
申请号：TW093114273
申请日：2004-05-20
申请人：美國羅徹斯特大學 THE UNIVERSITY OF ROCHESTER
发明人：塔亞Z 科斯克 KOSC, TANYA Z. , 肯尼斯L 馬歇爾 MARSHALL, KENNETH L. , 史帝芬D 傑可伯斯 JACOBS, STEPHEN D.
IPC分类号： G02F
CPC分类号： G02F1/172
摘要：具有懸浮在流體主體中，並受到電場作用之複數層不同材料之複合或分層薄片，在施加電場中根據薄片之角度或取向產生光學效果，其中該等複數層不同材料可以為介電材料、導電材料或液晶材料。光學效果取決於層之組分及厚度，產生反射、干涉、加色及／或減色效果。還可以選擇分層薄片之組分，以增強和／或改變薄片之介電性質，從而還增強和／或改變薄片在電場中之動作。該等裝置可以用作主動式電光顯示器、偏振片、濾波器、光調變器，以及希望控制偏振、反射和透射光學性質之任何場所。
简体摘要：具有悬浮在流体主体中，并受到电场作用之复数层不同材料之复合或分层薄片，在施加电场中根据薄片之角度或取向产生光学效果，其中该等复数层不同材料可以为介电材料、导电材料或液晶材料。光学效果取决于层之组分及厚度，产生反射、干涉、加色及／或减色效果。还可以选择分层薄片之组分，以增强和／或改变薄片之介电性质，从而还增强和／或改变薄片在电场中之动作。该等设备可以用作主动式电光显示器、偏振片、滤波器、光调制器，以及希望控制偏振、反射和透射光学性质之任何场所。

3. 发明专利

DE3106674C2 未知
公开(公告)号：DE3106674C2
公开(公告)日：1992-06-11
申请号：DE3106674
申请日：1981-02-23
申请人： THE UNIVERSITY OF ROCHESTER, ROCHESTER, N.Y., US
发明人： KENDE, ANDREW S., PITTSFORD, N.Y., US , CURRAN, DENNIS P., MADISON, WIS., US , KING, MARGARET LOGAN, ROCHESTER, N.Y., US , FELDSTEIN, NEIL A., WESTBURY, N.Y., US
IPC分类号： C07C69/003 , A61K31/357 , A61K31/36 , A61P35/00 , C07C41/00 , C07C41/06 , C07C43/18 , C07C43/20 , C07C43/225 , C07C43/23 , C07C45/00 , C07C49/755 , C07C67/00 , C07C69/63 , C07D317/44 , C07D317/50 , C07D317/54 , C07D317/62 , C07D317/70 , C07D493/04
摘要： The present invention provides compounds having the structure: VI wherein R1 represents alkoxy or aralkoxy, R2 represents hydrogen, alkoxy, aralkoxy, alkyl, aralkyl, or R1 and R2 taken together represent the group -O-CH2-O-, R3 represents hydrogen, alkyl, aralkyl, acyl or a protecting group, Y represents Cl, Br, I or a leaving group; and X represents Cl, Br or I. The present invention also provides a process for preparation of compounds VI in a single step wherein X and Y are the same and represent Cl, Br, or I, and R3 is as previously defined except that in this instance, it does not represent a protecting group. According to another aspect of the present invention there are provided compounds VII-a and VII-b having the structure: wherein R1, R2 and R3 are as previously defined, j is an integer having a value of 0 or 1, Z1 represents a non-reacting electron withdrawing group, and Z2 represents a non-reacting electron withdrawing group or hydrogen, R8 and R9 are the same or different and represent hydrogen, alkyl, aralkyl, alkoxy, or aralkoxy, and R7 represents hydrogen, alkyl, aralkyl or acyl. Compounds VII-a may be prepared from compounds VI through the use of the process of "insertion-cyclization" which is provided by another aspect of the present invention. According to a further aspect of the present invention, compounds VII-a are converted into tetralone III-a shown below: III-a wherein R1, R2, R3, Z1, Z2, R7, R8 and R9 are as previously defined. Certain of these compounds can, in turn, be readily converted into picropodophyllin and picrosikkimotoxin. The latter can be converted into known antineoplastic agents by known procedures.

4. 发明专利

AT11429T 未知
公开(公告)号：AT11429T
公开(公告)日：1985-02-15
申请号：AT80106041
申请日：1980-10-06
申请人： THE UNIVERSITY OF ROCHESTER
发明人： YOUNG, FRANK E. , WILSON, GARY A. , MOTTICE, SUSAN L.
IPC分类号： C12N15/09 , C12N1/20 , C12N15/00 , C12N15/75
摘要： Asporogenous mutant B. subtilis RUB 331 (ATCC 31578) and a process for using such mutant are disclosed. The asporogenous mutant desirably reverts to sporeformers with a frequency not greater than 10-7 reversions per bacterium per generation and meets the requirements of the NIH "Guidelines for Research Involving Recombinant DNA Molecules" for a B. subtilis host component of a Host-Vector 1 system.

5. 发明专利

DE3153681C2 未知
公开(公告)号：DE3153681C2
公开(公告)日：1992-07-09
申请号：DE3153681
申请日：1981-02-23
申请人： THE UNIVERSITY OF ROCHESTER, ROCHESTER, N.Y., US
发明人： KENDE, ANDREW S., PITTSFORD, N.Y., US , CURRAN, DENNIS P., MADISON, WIS., US , KING, MARGARET LOGAN, ROCHESTER, N.Y., US , FELDSTEIN, NEIL A., WESTBURY, N.Y., US
IPC分类号： C07C69/003 , A61K31/357 , A61K31/36 , A61P35/00 , C07C41/00 , C07C41/06 , C07C43/18 , C07C43/20 , C07C43/225 , C07C43/23 , C07C45/00 , C07C49/755 , C07C67/00 , C07C69/63 , C07D317/44 , C07D317/50 , C07D317/54 , C07D317/62 , C07D317/70 , C07D493/04
摘要： The present invention provides compounds having the structure: VI wherein R1 represents alkoxy or aralkoxy, R2 represents hydrogen, alkoxy, aralkoxy, alkyl, aralkyl, or R1 and R2 taken together represent the group -O-CH2-O-, R3 represents hydrogen, alkyl, aralkyl, acyl or a protecting group, Y represents Cl, Br, I or a leaving group; and X represents Cl, Br or I. The present invention also provides a process for preparation of compounds VI in a single step wherein X and Y are the same and represent Cl, Br, or I, and R3 is as previously defined except that in this instance, it does not represent a protecting group. According to another aspect of the present invention there are provided compounds VII-a and VII-b having the structure: wherein R1, R2 and R3 are as previously defined, j is an integer having a value of 0 or 1, Z1 represents a non-reacting electron withdrawing group, and Z2 represents a non-reacting electron withdrawing group or hydrogen, R8 and R9 are the same or different and represent hydrogen, alkyl, aralkyl, alkoxy, or aralkoxy, and R7 represents hydrogen, alkyl, aralkyl or acyl. Compounds VII-a may be prepared from compounds VI through the use of the process of "insertion-cyclization" which is provided by another aspect of the present invention. According to a further aspect of the present invention, compounds VII-a are converted into tetralone III-a shown below: III-a wherein R1, R2, R3, Z1, Z2, R7, R8 and R9 are as previously defined. Certain of these compounds can, in turn, be readily converted into picropodophyllin and picrosikkimotoxin. The latter can be converted into known antineoplastic agents by known procedures.

6. 发明专利

DE2837033C2 未知
公开(公告)号：DE2837033C2
公开(公告)日：1988-04-21
申请号：DE2837033
申请日：1978-08-24
申请人： THE UNIVERSITY OF ROCHESTER, ROCHESTER, N.Y., US
发明人： RUTLEDGE, PETER S., PROF. DR., REMUERA, AUCKLAND, NZ , KENDE, ANDREW S., DR., PITTSFORD, N.Y., US
IPC分类号： C07D317/60 , C07D317/70 , C07D493/04
摘要： Efficient total syntheses of (+/-)-picropodophyllone and (+/-)-4'-demethylpicropodophyllone are described. These compounds are intermediates in the preparation of known antineoplastic agents.

7. 发明申请

WO2012109476A2 METHODS AND COMPOSITIONS RELATED TO STAUFEN 1 BINDING SITES FORMED BY DUPLEXING ALU ELEMENTS 审中-公开
标题翻译：与双链体ALU元件形成的结合位点1相关的方法和组合物
公开(公告)号：WO2012109476A2
公开(公告)日：2012-08-16
申请号：PCT/US2012/024534
申请日：2012-02-09
申请人： THE UNIVERSITY OF ROCHESTER , MAQUAT, Lynne, E. , GONG, Chenguang
发明人： MAQUAT, Lynne, E. , GONG, Chenguang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C07K14/47 , C12Q1/6881 , C12Q2600/178
摘要： Disclosed are compositions and methods for identifying binding sites of targets of Staul-mediated mRNA decay; methods and compositions for treating subjects with conditions resulting from Staul -mediated mRNA decay, and method of screening for therapeutic agents. Also disclosed is the new pathway as a means for cells to down-regulate the expression of Staul-binding mRNAs.
摘要翻译：公开了用于鉴定Staul介导的mRNA衰变的靶标的结合位点的组合物和方法; 用于治疗由Staul介导的mRNA衰变引起的病症的受试者的方法和组合物，以及筛选治疗剂的方法。还公开了作为细胞下调Staul结合mRNA表达的手段的新途径。

8. 发明申请

WO2007106351A2 POROUS SILICON MATERIALS AND DEVICES 审中-公开
标题翻译：多孔硅材料和器件
公开(公告)号：WO2007106351A2
公开(公告)日：2007-09-20
申请号：PCT/US2007/005768
申请日：2007-03-07
申请人： THE UNIVERSITY OF ROCHESTER , SUN, Wei , FAUCHET, Philippe, M. , PUZAS, J., Edward
发明人： SUN, Wei , FAUCHET, Philippe, M. , PUZAS, J., Edward
IPC分类号： A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10351
摘要： Provided are materials and devices comprising physiologically acceptable silicon. The materials and devices can comprise a vector, including a viral vector.
摘要翻译：提供了包括生理上可接受的硅的材料和器件。材料和装置可以包括载体，包括病毒载体。

9. 发明申请

WO2005122712A2 SOLUBLE LOW-DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN BINDS DIRECTLY TO ALZHEIMER’S AMYLOID-BETA PEPTIDE 审中-公开
标题翻译：可溶性低密度脂蛋白受体相关蛋白质直接与阿尔茨海默氏淀粉样蛋白肽
公开(公告)号：WO2005122712A2
公开(公告)日：2005-12-29
申请号：PCT/US2004/019034
申请日：2004-06-14
申请人： SOCRATECH L.L.C. , THE UNIVERSITY OF ROCHESTER , BERISLAV, Zlokovic, V. , DEANE, Rashid
发明人： BERISLAV, Zlokovic, V. , DEANE, Rashid
IPC分类号： C07K14/705 , G01N33/68 , G01N33/92
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/4711 , C07K14/705 , G01N33/92 , G01N2800/2821
摘要： A soluble derivative of low-density lipoprotein receptor related protein-1 (sLRP-1) binds directly to Alzheimer's amyloid-β peptide (Aβ). This binding may be used to detect Aβ or to separate Aβ from the rest of a subject's body. In Alzheimer's disease, it may be used to provide diagnostic results by detecting Aβ, treatment by removing Aβ, or both.
摘要翻译：低密度脂蛋白受体相关蛋白-1（sLRP-1）的可溶性衍生物直接与阿尔茨海默氏淀粉样蛋白-β肽（Abeta）结合。这种结合可用于检测Abeta或将Abeta与受试者身体的其余部分分开。在阿尔茨海默病中，可以通过检测Abeta，通过除去Abeta或两者来治疗来提供诊断结果。

10. 发明申请

WO2004104685A1 ELECTRICALLY ADDRESSABLE OPTICAL DEVICES USING A SYSTEM OF COMPOSITE LAYERED FLAKES SUSPENDED IN A FLUID HOST TO OBTAIN ANGULARLY DEPENDENT OPTICAL EFFECTS 审中-公开
标题翻译：使用在液体宿主中悬挂的复合层状体系的系统获得可靠的光学效果的电动寻址光学装置
公开(公告)号：WO2004104685A1
公开(公告)日：2004-12-02
申请号：PCT/US2004/015618
申请日：2004-05-19
申请人： THE UNIVERSITY OF ROCHESTER
发明人： KOSC, Tanya, Z. , MARSHALL, Kenneth, L. , JACOBS, Stephen, D.
IPC分类号： G02F1/17
CPC分类号： G02F1/172
摘要： Composite or layered flakes (12) having a plurality of layers of different materials, which may be dielectric materials, conductive materials, or liquid crystalline materials suspended in a fluid host (14) and subjected to an electric field, provide optical effects dependent upon the angle or orientation of the flakes (12) in the applied electric field. The optical effects depend upon the composition and thickness of the layers, producing reflectance, interference, additive and/or subtractive color effects. The composition of layered flakes (12) may also be selected to enhance and/or alter the dielectric properties of flakes, whereby flake motion in an electric field is also enhanced and/or altered. Devices having a system of flakes (12) in a fluid host (14) are useful as active electro-optical displays, polarizers, filters, light modulators, and wherever controllable polarizing, reflecting and transmissive optical properties are desired.
摘要翻译：具有多层不同材料的复合或层状薄片（12），其可以是悬浮在流体主体（14）中并经受电场的电介质材料，导电材料或液晶材料，提供依赖于在所施加的电场中的薄片（12）的角度或取向。光学效果取决于层的组成和厚度，产生反射率，干涉，添加和/或减色效果。也可以选择层状薄片（12）的组成以增强和/或改变薄片的介电性能，由此电场中的薄片运动也被增强和/或改变。具有流体主体（14）中的薄片（12）系统的装置可用作有源电光显示器，偏振器，滤光器，光调制器，并且需要可控的偏振，反射和透射光学性质。

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