专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

2. 发明申请

WO2015020960A1 NOVEL LNCRNA POLYNUCLEOTIDES 审中-公开
标题翻译：新的LNCRNA多核苷酸
公开(公告)号：WO2015020960A1
公开(公告)日：2015-02-12
申请号：PCT/US2014/049611
申请日：2014-08-04
申请人： NOVARTIS AG , GLASS, David Jonathan , GONG, Chenguang , LI, Zhizhong
发明人： GLASS, David Jonathan , GONG, Chenguang , LI, Zhizhong
IPC分类号： C12N15/113 , A61K31/7088 , A61P35/00
CPC分类号： C12N15/113 , C12N15/11 , C12N2310/14
摘要： The present disclosure relates generally to LncMyoD, a LncRNA located in the human, about 22 kb upstream of (5' to) the MyoD gene, and located in the mouse about 30 kb upstream of the MyoD gene. The disclosure particularly pertains to compositions comprising the LncMyoD or a LncMyoD-derived polynucleotide, such as a pharmaceutical composition. LncMyoD-derived polynucleotides include polynucleotides comprising a portion of the LncMyoD sequence, such as one or more exons, one or more ORFs, one or more CAUH sequences, one or more fragments or portions, etc. The disclosure also pertains to methods of use of LncMyoD or a LncMyoD-derived polynucleotide in increasing muscle growth, treating sarcoma, treating other cancers in settings where IMP1 and/or IMP2 are upregulated, and/or in altering expression of other genes, such as c-Myc.
摘要翻译：本公开一般涉及位于人中的LncMyoD，位于MyoD基因（5'至上游）约22kb的LncRNA，位于MyoD基因上游约30kb的小鼠中。本公开特别涉及包含LncMyoD或LncMyoD衍生的多核苷酸（例如药物组合物）的组合物。 LncMyoD衍生的多核苷酸包括包含LncMyoD序列的一部分，例如一个或多个外显子，一个或多个ORF，一个或多个CAUH序列，一个或多个片段或部分等的多核苷酸。本公开还涉及使用 LncMyoD或LncMyoD衍生的多核苷酸，其中增加肌肉生长，治疗肉瘤，在IMP1和/或IMP2被上调的环境中治疗其它癌症，和/或改变其他基因如c-Myc的表达。

IPRDB

热门服务

关于我们

友情链接

联系方式