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1. 发明专利

JP2010158510A Photothermal structure for biomedical application, and method therefor 有权
标题翻译：用于生物医学应用的光热结构及其方法
公开(公告)号：JP2010158510A
公开(公告)日：2010-07-22
申请号：JP2009252491
申请日：2009-11-02
申请人： Altea Therapeutics Corp , Spectrx Inc , アルテアセラピューティクスコーポレイション , スペクトリクス,インコーポレイテッド
发明人： EPPSTEIN JONATHAN A , HATCH MICHAEL R , YANG DIFEI
IPC分类号： A61B10/02 , A61M37/00 , A61B5/00 , A61B10/00 , A61B17/00 , A61K41/00 , A61K45/00
CPC分类号： A61B5/15134 , A61B5/14514 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150068 , A61B5/150083 , A61B5/150099 , A61B5/150229 , A61B5/150358 , A61B5/15136 , A61B5/157 , A61B2010/008 , A61B2017/00172 , A61B2562/12 , A61K41/0047
摘要： PROBLEM TO BE SOLVED: To provide a photothermal structure for biomedical applications. SOLUTION: A photothermal structure is designed for the uniform application of a photothermal material (for example, a dye or a pigment) to a tissue (for example, the stratum corneum). In one embodiment, the photothermal structure includes a photothermal material combined with a carrier (for example, an adhesive or an ink), and the resulting combination is applied to a substrate (for example, an inert polymeric substrate) to form a photothermal structure. In another embodiment, the photothermal structure comprises a photothermal material incorporated into a film-forming polymeric material. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供用于生物医学应用的光热结构。解决方案：光热结构被设计用于将光热材料（例如，染料或颜料）均匀地施加到组织（例如角质层）上。在一个实施方案中，光热结构包括与载体（例如粘合剂或油墨）组合的光热材料，并将所得组合物施加到基底（例如惰性聚合物基底）上以形成光热结构。在另一个实施方案中，光热结构包括掺入成膜聚合物材料中的光热材料。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2006192285A Microporation of human skin for drug delivery and monitoring 审中-公开
标题翻译：人类皮肤用于药物递送和监测的微波
公开(公告)号：JP2006192285A
公开(公告)日：2006-07-27
申请号：JP2006038655
申请日：2006-02-15
申请人： Altea Therapeutics Corp , Spectrx Inc , アルテアセラピューティクスコーポレイション , スペクトルクス, インコーポレイテッド
发明人： EPPSTEIN JONATHAN A , HATCH MICHAEL R , YANG DIFEI
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1459 , A61B5/1473 , A61B5/1477 , A61B5/1491 , A61B5/15 , A61B5/151 , A61B5/155 , A61B5/157 , A61B10/00 , A61B17/00 , A61B17/32 , A61B17/34 , A61B18/20 , A61K41/00 , A61M37/00
CPC分类号： A61B5/14514 , A61B5/1486 , A61B10/0045 , A61B17/3203 , A61B18/20 , A61B18/203 , A61B2017/00172 , A61B2017/00761 , A61B2017/00765 , A61B2018/00452 , A61B2018/0047 , A61K41/0047 , A61M37/0092 , A61M2037/0007
摘要： PROBLEM TO BE SOLVED: To provide a monitoring system of analyte in human body in non-invasive model at low cost. SOLUTION: A system for monitoring the concentration of analyte in individual body includes enhancing the permeability of the corneum in the selected region in individual body The enhancement is performed by (a) forming a micro-pore in the corneum without the serious damage being caused in the underlying tissue, decreasing barrier characteristics of that stratum corneum for flax of that active infiltrated items, and puncturing that stratum corneum in the selected area. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：以低成本在非侵入性模型中提供人体中分析物的监测系统。解决方案：用于监测单个体内分析物浓度的系统包括增强个体体内所选区域中角质层的渗透性。增强是通过（a）在角质层中形成微孔而没有严重损伤在下面的组织中引起，减少该活性渗透物品的亚麻角质层的屏障特征，以及刺穿所选区域中的角质层。版权所有（C）2006，JPO＆NCIPI

3. 发明申请

WO02058994A9 VACUUM DEVICE FOR SUBSTANCE EXTRACTION 审中-公开
标题翻译：用于物质萃取的真空装置
公开(公告)号：WO02058994A9
公开(公告)日：2004-01-08
申请号：PCT/US0202233
申请日：2002-01-24
申请人： SPECTRX INC , LINCOLN DANNY F , KUMAR KRISHNA , SAMUELS MARKS A
发明人： LINCOLN DANNY F , KUMAR KRISHNA , SAMUELS MARKS A
IPC分类号： F04B17/00 , F04B43/00 , F04B43/04 , F04B45/047 , B65B1/04
CPC分类号： F04B45/047 , F04B17/00 , F04B43/0009 , F04B43/043
摘要： A vacuum device and method for extraction of a substance from a fluid source the vacuum device including an upper member (20) that may be selectively, and operably, connected to a lower membrane. The upper member (20) defines a bottom opening (24) and has a vacuum pump (40) in fluid communication with the bottom opening (24). The vacuum pump (40) is selectively coupled to an energy source. The lower member defines an inner cavity, a first opening, and a second opening. An elastic membrane defining an interior cavity is disposed in the inner cavity and is coupled to the first opening of the lower member.
摘要翻译：一种用于从流体源提取物质的真空装置和方法，所述真空装置包括可以选择性地且可操作地连接到下膜的上部构件（20）。上部构件（20）限定底部开口（24）并且具有与底部开口（24）流体连通的真空泵（40）。真空泵（40）选择性地耦合到能量源。下部构件限定内腔，第一开口和第二开口。限定内腔的弹性膜设置在内腔中并且联接到下构件的第一开口。

4. 发明申请

WO0059373A9 ASSAY DEVICE FOR MEASURING CHARACTERISTICS OF A FLUID ON A CONTINUAL BASIS 审中-公开
标题翻译：用于测量流体在连续基础上的特性的测定装置
公开(公告)号：WO0059373A9
公开(公告)日：2002-02-07
申请号：PCT/US0009393
申请日：2000-04-07
申请人： SPECTRX INC , KUMAR KRISHNA S , PAPP JOSEPH , FARQUHAR J DAVID , TAYLOR LANCE , SMITH ALAN M , VREEKE MARK S , HATCH MICHAEL R , SCHIFFER JARAD , FAUPEL MARK L , CONNOLLY JAMES
发明人： KUMAR KRISHNA S , PAPP JOSEPH , FARQUHAR J DAVID , TAYLOR LANCE , SMITH ALAN M , VREEKE MARK S , HATCH MICHAEL R , SCHIFFER JARAD , FAUPEL MARK L , CONNOLLY JAMES
IPC分类号： G01N33/66 , A61B5/00 , G01N27/28 , G01N27/416
CPC分类号： A61B5/1486 , A61B5/1495
摘要： The present invention is directed at an assay device for detecting and enabling measurement of an analyte in a fluid. The assay device contains: a) an inlet port to receive fluid; b) a well in fluid communication with the inlet port; c) an outlet port in fluid communication with the well, wherein the outlet port is designed to allow discharge of the fluid; d) at least one first working electrode and at least one reference electrode disposed within the well; e) a quantity of reactant that reacts with the analyte to form a reaction product, wherein the reaction product is in fluid communication with the at least one first working electrode; and f) at least one membrane disposed over or around the reactant to regulate contact of the analyte in the fluid with the reactant.
摘要翻译：本发明涉及用于检测和测量流体中分析物的测定装置。测定装置包含：a）用于接收流体的入口; b）与入口流体连通的井; c）与所述井流体连通的出口，其中所述出口被设计成允许流体排放; d）至少一个第一工作电极和设置在所述阱内的至少一个参考电极; e）一定量的与分析物反应以形成反应产物的反应物，其中反应产物与至少一个第一工作电极流体连通; 和f）设置在反应物上方或周围的至少一个膜，以调节流体中分析物与反应物的接触。

5. 发明申请

WO0076575A3 ALIGNMENT DEVICES AND METHODS FOR FLUID EXTRACTION FROM TISSUE AND SUBSTANCE DELIVERY 审中-公开
标题翻译：用于从组织和物质输送中流体提取的排列装置和方法
公开(公告)号：WO0076575A3
公开(公告)日：2001-07-05
申请号：PCT/US0016064
申请日：2000-06-12
申请人： SPECTRX INC , SAMUELS MARK A , KUMAR KRISHNA S , ROBINSON GARRETT T , FARQUHAR J DAVID , CALAWAY ALLISON , WILLIAMS DEIDRE , HATCH MICHAEL R , SMITH ALAN , WOODS TERESA
发明人： SAMUELS MARK A , KUMAR KRISHNA S , ROBINSON GARRETT T , FARQUHAR J DAVID , CALAWAY ALLISON , WILLIAMS DEIDRE , HATCH MICHAEL R , SMITH ALAN , WOODS TERESA
IPC分类号： G01N1/10 , A61B5/00 , A61B5/145 , A61B5/1468 , A61B10/00 , A61B17/00 , A61B17/34 , A61B18/04 , A61B18/20 , A61B19/00 , A61K41/00
CPC分类号： A61B5/6833 , A61B5/064 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150076 , A61B5/150748 , A61B5/150969 , A61B5/15136 , A61B5/157 , A61B10/0045 , A61B17/3403 , A61B17/3468 , A61B2017/00477 , A61B2017/00482 , A61B2017/348 , A61B2017/3492
摘要： An alignment device and related systems and methods for aligning at least one apparatus with respect to a surface of a tissue. The alignment device comprises a tissue interface member suitable for positioning on the surface of the tissue and mating with the apparatus to maintain alignment of the apparatus during an operation of the apparatus. The alignment device is useful to align various apparatus that are part of a continuous analyte monitoring system.
摘要翻译：一种对准装置以及相关系统和方法，用于使至少一个装置相对于组织表面对准。对齐装置包括适于定位在组织的表面上并且与装置配合以在装置的操作期间维持装置的对齐的组织接口构件。对齐装置可用于对齐作为连续分析物监测系统的一部分的各种设备。

6. 发明申请

WO2003099123A1 SYSTEM AND METHOD FOR THE EXTRACTION AND MONITORING OF A BIOLOGICAL FLUID 审中-公开
标题翻译：用于提取和监测生物流体的系统和方法
公开(公告)号：WO2003099123A1
公开(公告)日：2003-12-04
申请号：PCT/US2003/016315
申请日：2003-05-22
申请人： SPECTRX, INC. , FAUPEL, Mark , LINCOLN, Danny
发明人： FAUPEL, Mark , LINCOLN, Danny
IPC分类号： A61B5/15
CPC分类号： A61B5/155 , A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150213 , A61B5/150229 , A61B5/150343 , A61B5/150358 , A61B5/150969 , A61B10/0045 , A61B2010/008
摘要： Systems and methods use extraction devices for extracting and monitoring biological fluids of patients. The systems and methods involve creating an opening in the biological tissue of the patient and placing a sampling aperture of the extraction device over the opening. The sampling aperture is defined in a contact surface of the extraction device that is placed into contact with the tissue of the patient. A pump of the extraction device such as a depressible bulb sealed to the body is charged to create a vacuum between the pump through a sampling channel to the sampling aperture, and the vacuum draws the biological fluid from the tissue opening into the sampling channel. An access point is exposed to the sampling channel, and the sample of fluid may be accessed from the access point. The access point may be an extraction opening covered by an access door, and the access door is opened to access the sample. Alternatively, the access point may be electrodes extending into the sampling channel where the electrodes are connectable to a fluid analyzer device.
摘要翻译：系统和方法使用提取装置来提取和监测患者的生物液体。所述系统和方法涉及在患者的生物组织中产生开口并将提取装置的采样孔放置在开口上。取样孔限定在提取装置的与患者组织接触的接触表面中。对诸如密封到身体的可压迫的灯泡的提取装置的泵进行充电以在泵通过采样通道到采样孔之间产生真空，并且真空将生物流体从组织开口吸入采样通道。接入点暴露于采样通道，可以从接入点访问流体样本。接入点可以是由进入门覆盖的提取开口，并且访问门被打开以访问样本。或者，接入点可以是延伸到采样通道中的电极，其中电极可连接到流体分析器装置。

7. 发明申请

WO2003072164A3 INSERTION DEVICE FOR AN INSERTION SET AND METHOD OF USING THE SAME 审中-公开
公开(公告)号：WO2003072164A3
公开(公告)日：2003-09-04
申请号：PCT/US2003/006219
申请日：2003-02-26
申请人： SPECTRX, INC. , DOUGLAS, Joel, S.
发明人： DOUGLAS, Joel, S.
IPC分类号： A61M5/20
摘要： A system for inserting at least a portion of an insertion set through the surface of a tissue, having: an inserter (10) with a moveable plunger (30) disposed within a cavity therein; an insertion set holder (15) received into the distal end of the cavity; and an insertion set (20) received into the insertion set holder (15), wherein the insertion set (20) is moveable within the insertion set holder (15) such that when the plunger is advanced into contact with the insertion set (20), the insertion set (20) advances through the insertion set holder (15) to a position at which at least a portion of the insertion set (20) extends out of the distal end of the cavity.

8. 发明申请

WO2003072164A2 INSERTION DEVICE FOR AN INSERTION SET AND METHOD OF USING THE SAME 审中-公开
标题翻译：插入装置的插入装置及其使用方法
公开(公告)号：WO2003072164A2
公开(公告)日：2003-09-04
申请号：PCT/US2003/006219
申请日：2003-02-26
申请人： SPECTRX, INC. , DOUGLAS, Joel, S.
发明人： DOUGLAS, Joel, S.
IPC分类号： A61M
CPC分类号： A61M5/158 , A61M5/3287 , A61M2005/1581 , A61M2005/1585
摘要： A system for inserting at least a portion of an insertion set through the surface of a tissue, having: an inserter with a moveable plunger disposed within a cavity therein; an insertion set holder received into the distal end of the cavity; and an insertion set received into the insertion set holder, wherein the insertion set is moveable within the insertion set holder such that when the plunger is advanced into contact with the insertion set, the insertion set advances through the insertion set holder to a position at which at least a portion of the insertion set extends out of the distal end of the cavity.
摘要翻译：一种用于插入穿过组织表面的插入组件的至少一部分的系统，其具有：具有设置在其中的空腔内的可移动柱塞的插入器; 容纳在腔的远端的插入组支架; 以及插入组件，其插入组件夹持器中，其中所述插入组件可在所述插入组件保持器内移动，使得当所述柱塞前进到所述插入组件时，所述插入组件通过所述插入组件保持器前进到其中插入组的至少一部分延伸出空腔的远端。

9. 发明申请

WO02076527A2 ADAPTER FOR MEDICATION CARTRIDGES 审中-公开
标题翻译：适应症药盒
公开(公告)号：WO02076527A2
公开(公告)日：2002-10-03
申请号：PCT/US0208993
申请日：2002-03-22
申请人： SPECTRX INC
发明人： DOUGLAS JOEL S
IPC分类号： A61M5/162 , A61M
CPC分类号： A61M5/162
摘要： An adapter assembly for connecting a cartridge of medication (or any other substance) to a catheter and for securely housing the cartridge within a base or housing, comprising: a body having a bore dimensioned to receive a head of a cartridge therein; a retaining mechanism disposed within the bore in the body, the retaining mechanism dimensioned to hold onto the head of the cartridge; and a double ended hollow needle passing through the first body, the needle having a first end projecting into the bore in the first body; or alternatively; a bottom portion having a bore dimensioned to receive a head of a cartridge therein; a top portion coupled to the bottom portion; a needle hub coupled to the top portion; and a double ended hollow needle passing through the needle hub; wherein an outer surface of the cap is dimensioned to be received into a base.
摘要翻译：一种用于将药物（或任何其他物质）药筒连接到导管并用于将药筒牢固地容纳在基部或外壳内的适配器组件，包括：具有尺寸设计成容纳其中的药筒头部的孔的本体; 保持机构，其设置在所述主体的所述孔内，所述保持机构的尺寸设置成保持在所述盒的头部上; 以及穿过所述第一主体的双端中空针，所述针具有突出到所述第一主体中的所述孔中的第一端; 或者替代地底部部分具有尺寸适于容纳其中的墨盒的头部的孔; 耦合到所述底部的顶部; 联接到顶部的针毂; 和穿过针座的双端中空针; 其特征在于，所述盖的外表面的尺寸设计成被接收到基座中。

10. 发明申请

WO0015102A9 ATTRIBUTE COMPENSATION FOR ANALYTE DETECTION AND/OR CONTINUOUS MONITORING 审中-公开
标题翻译：属性补偿用于分析检测和/或连续监测
公开(公告)号：WO0015102A9
公开(公告)日：2000-10-05
申请号：PCT/US9920796
申请日：1999-09-10
申请人： SPECTRX INC , HATCH MICHAEL R , EPPSTEIN JONATHAN A , MCRAE STUART
发明人： HATCH MICHAEL R , EPPSTEIN JONATHAN A , MCRAE STUART
IPC分类号： A61B5/00 , A61B5/145
CPC分类号： A61B5/14514 , A61B5/00 , A61B5/14532
摘要： A system and method for detecting a measuring an analyte in a biological fluid of an animal. A harvesting device (10) is provided suitable for positioning on the surface of tissue of an animal to harvest biological fluid therefrom. The harvesting device (10) comprises an analyte sensor (50) positioned to be contacted by the harvested biological fluid and which generates a measurement signal representative of the analyte. At least one attribute sensor (40) is provided to measure an attribute associated with the biological fluid harvesting operation of the harvesting device (10) or the assay of the biological fluid, and which generates an attribute signal representative of the attribute. Adjustments are made to operational parameters of the harvesting device (10) based on the one or more attributes.
摘要翻译：用于检测测量动物的生物流体中的分析物的系统和方法。提供了一种收获装置（10），其适于定位在动物组织的表面上以从中收集生物流体。收获装置（10）包括分析物传感器（50），所述分析物传感器（50）定位成与收获的生物流体接触并且生成代表分析物的测量信号。提供至少一个属性传感器（40）以测量与收获装置（10）的生物流体收集操作或生物流体分析相关的属性，并且生成表示属性的属性信号。基于一个或多个属性对收割装置（10）的操作参数进行调整。

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