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1. 发明专利

JP2014059304A Method for determining platelet-associated analytes 有权
标题翻译：用于确定平板相关分析仪的方法
公开(公告)号：JP2014059304A
公开(公告)日：2014-04-03
申请号：JP2013191710
申请日：2013-09-17
申请人： Siemens Healthcare Diagnostics Products Gmbh , シーメンスヘルスケアダイアグノスティクスプロダクツゲゼルシヤフトミツトベシユレンクテルハフツング
发明人： JUERGEN PATZKE
IPC分类号： G01N33/543 , C12Q1/68 , G01N33/53 , G01N33/545
CPC分类号： G01N33/86 , G01N33/5047 , G01N2333/75 , G01N2333/755
摘要： PROBLEM TO BE SOLVED: To provide a method suitable for routine processing in a clinical laboratory, particularly a method suitable for processing in an automated assay procedure which does not require complex sample preparation, particularly additional centrifugal separation and cleaning step.SOLUTION: A determination method of this invention includes: a step (a) of preparing a first assay volume containing platelet-rich plasma from an individual and a detergent; a step (b) of preparing a second assay volume which contains platelet-rich plasma and does not contain a detergent, or a second assay volume which contains platelet-poor plasma from an individual and does not contain a detergent, or a second assay volume which contains platelet-poor plasma from an individual and the detergent; a step (c) of measuring the amounts or activities of analytes in the first assay volume and the second assay volume; and a step (d) of comparing measurement results. A difference between the measurement results is equivalent to the amount or activity of platelet associated analyte.
摘要翻译：要解决的问题：提供适合临床实验室常规加工的方法，特别是适用于不需要复杂样品制备，特别是额外的离心分离和清洁步骤的自动测定程序中的加工方法。解决方案：确定方法本发明的方法包括：（a）从个体和洗涤剂制备含有富血小板血浆的第一测定体积; 制备含有富血小板血浆并且不含洗涤剂的第二测定体积的步骤（b），或包含来自个体的不含血小板血浆并且不含洗涤剂的第二测定体积或第二测定体积其含有来自个体的血小板血浆和洗涤剂; 测量第一测定体积和第二测定体积中分析物的量或活性的步骤（c）; 以及比较测量结果的步骤（d）。测量结果之间的差异等于血小板相关分析物的量或活性。

2. 发明专利

JP2014038094A Reaction vessel 有权
标题翻译：反应容器
公开(公告)号：JP2014038094A
公开(公告)日：2014-02-27
申请号：JP2013160351
申请日：2013-08-01
申请人： Siemens Healthcare Diagnostics Products Gmbh , シーメンスヘルスケアダイアグノスティクスプロダクツゲゼルシヤフトミツトベシユレンクテルハフツング
发明人： MELLER PAUL
IPC分类号： G01N35/02
CPC分类号： G01N35/00 , B01L3/5082 , B01L2200/025 , B01L2300/0851 , B01L2300/0858 , G01N21/03
摘要： PROBLEM TO BE SOLVED: To provide a reaction vessel that has an inclusion wall and an opening to store analysis object fluid and is capable of flexible and automatic processing and obtaining a high quality measurement result.SOLUTION: A inclusion wall 4 includes a first part 10 in which at least exterior surface is designed in circular symmetry and a second part 12 that is formed using translucent material and has at least two flat-surface areas 14 facing each other and placed in parallel, and a means 12 is provided to adjust the direction of a reaction vessel on an acceptance position.
摘要翻译：要解决的问题：提供一种具有包含壁和开口以存储分析对象流体的反应容器，并且能够灵活自动地加工并获得高质量的测量结果。包含壁4包括第一部分10 其中至少外表面被设计成圆形对称，以及第二部分12，其使用半透明材料形成并且具有至少两个彼此面对并平行放置的平坦表面区域14，并且提供装置12以调节方向的接收位置的反应容器。

3. 发明专利

JP2014036663A Method for determining von willebrand factor activity in the absence of ristocetin and method for determining adamts-13 protease 有权
标题翻译：用于确定RISTOCETIN无效的Von WILLEBRAND因子活性的方法和用于测定ADAMTS-13蛋白的方法
公开(公告)号：JP2014036663A
公开(公告)日：2014-02-27
申请号：JP2013217981
申请日：2013-10-21
申请人： Siemens Healthcare Diagnostics Products Gmbh , シーメンス・ヘルスケア・ダイアグノスティックス・プロダクツ・ゲーエムベーハー
发明人： HARALD ALTHAUS , TOBIAS OBSER , PATZKE JUERGEN , SCHNEPPENHEIM REINHARD
IPC分类号： C12Q1/37 , C12N15/09 , G01N33/53 , G01N33/543 , G01N33/566
CPC分类号： G01N33/6893 , C12Q1/37 , G01N33/543 , G01N33/54313 , G01N33/553 , G01N33/566 , G01N33/68 , G01N33/86 , G01N2333/755 , G01N2333/96486 , G01N2800/222 , G01N2800/226
摘要： PROBLEM TO BE SOLVED: To provide an in vitro method for determining von Willebrand factor (VWF) activity in a sample in the absence of ristocetin and botrocetin, within the field of coagulation diagnosis.SOLUTION: There is provided a method for determining the von Willebrand factor (VWF)-cleaving activity of an ADAMTS-13 protease in a sample, comprising the steps of: a) mixing a sample which is suspected of containing the ADAMTS-13 protease with isolated VWF as a substrate to provide a reaction mix; b) incubating the reaction mix; and c) determining residual VWF activity in the reaction mix. The VWF substrate is a high molecular weight, multimeric VWF which includes VWF monomers having at least one amino acid sequence variation resulting in the VWF substrate being broken down by ADAMTS-13 in an accelerated manner compared to a VWF substrate that is high molecular weight, multimeric VWF composed of wild-type VWF monomers.
摘要翻译：要解决的问题：提供一种在凝血功能诊断领域内确定样品中血管性血友病因子（VWF）活性的体外方法。解决方案：提供了一种确定血管性血友病因子（VWF） - 样品中ADAMTS-13蛋白酶的活性，包括以下步骤：a）将怀疑含有ADAMTS-13蛋白酶的样品与分离的VWF作为底物混合以提供反应混合物; b）孵育反应混合物; 和c）确定反应混合物中的残余VWF活性。 VWF底物是高分子量多聚VWF，其包括具有至少一个氨基酸序列变异的VWF单体，其导致VWF底物以与高分子量的VWF底物相比加速地被ADAMTS-13分解，由野生型VWF单体组成的多聚VWF。

4. 发明专利

JP2013156256A Method for heating liquid of constant volume in heated pipette needle part 有权
标题翻译：用于加热加热针管部件中恒定液体液体的方法
公开(公告)号：JP2013156256A
公开(公告)日：2013-08-15
申请号：JP2013014609
申请日：2013-01-29
申请人： Siemens Healthcare Diagnostics Products Gmbh , シーメンスヘルスケアダイアグノスティクスプロダクツゲゼルシヤフトミツトベシユレンクテルハフツング
发明人： THORSTEN MICHELS , AYHAN SELVI , ALEXANDER WEDEKIND-KLEIN
IPC分类号： G01N35/00 , G01N35/10
CPC分类号： B01L3/021 , B01L3/02 , B01L7/00 , B01L2200/147 , B01L2300/0838 , B01L2300/18 , B01L2300/1888 , F16L53/00 , G01N35/10 , G01N2035/00425 , Y10T137/0318
摘要： PROBLEM TO BE SOLVED: To provide a method and device capable of equally heating liquid of various volume to a desired target temperature by using the conventional pipette device always having the same predetermined temperature.SOLUTION: A method for heating liquid of constant volume in a heated pipette needle part 1 having a closed loop controllable heater and an area with a temperature sensor 5 attached thereto includes a step a) for sucking liquid of desired volume, and a step b) for subsequently sucking air of constant volume. Selection is made such that the liquid of constant volume reaches the area with the temperature sensor of the heated pipette needle part attached thereto, and then passes through the area completely.
摘要翻译：要解决的问题：提供一种能够通过使用总是具有相同的预定温度的常规移液管装置将各种体积的液体均等地加热到所需目标温度的方法和装置。解决方案：一种用于加热恒定体积的液体的方法，具有闭环可控制加热器的移液管针头部分1和附着有温度传感器5的区域包括用于吸取所需体积的液体的步骤a）和步骤b），用于随后吸入恒定体积的空气。进行选择，使得恒定体积的液体到达加热的移液管针部分的温度传感器的区域，然后完全通过该区域。

5. 发明专利

JP2012141310A Method of determining inhibitors of coagulation 有权
标题翻译：测定凝血酶抑制剂的方法
公开(公告)号：JP2012141310A
公开(公告)日：2012-07-26
申请号：JP2011285680
申请日：2011-12-27
申请人： Siemens Healthcare Diagnostics Products Gmbh , シーメンス・ヘルスケア・ダイアグノスティックス・プロダクツ・ゲーエムベーハー
发明人： KAPPEL ANDREAS , ANDREAS RECHNER , SINA STEPHAN , THOMAS WISSEL
IPC分类号： G01N33/53 , G01N21/76 , G01N33/542 , G01N33/566
CPC分类号： G01N33/86 , C12Q1/56
摘要： PROBLEM TO BE SOLVED: To provide improved methods for determining anticoagulants, which use two components interacting owing to close spatial proximity and generating a detectable signal, in such a way that low molecular weight ligands which is not required to have two or more artificial residue for association with any of signaling components can be used.SOLUTION: A method for determining anticoagulants includes: admixing an aliquot of a sample which is suspected of containing an anticoagulant with a defined amount of a proteolytically active coagulation factor and with a ligand which binds to the active site of the proteolytically active coagulation factor but is not cleaved by the factor at a peptide bond; and measuring a signal generated by a signal-producing system as a result of binding of the ligand to the activated coagulation factor.
摘要翻译：要解决的问题：提供用于确定抗凝剂的改进方法，其使用两个组分相互作用，由于紧密的空间邻近性并产生可检测的信号，使得低分子量配体不需要具有两个或更多个可以使用与任何信号成分缔合的人造残留物。解决方案：用于测定抗凝血剂的方法包括：将怀疑含有抗凝血剂的样品的等分试样与限定量的蛋白水解活性凝血因子和与蛋白水解活性凝血酶活性位点结合的配体混合因子，但不被肽键上的因子切割; 并且由于配体与活化凝血因子结合而测量由信号产生系统产生的信号。版权所有（C）2012，JPO＆INPIT

6. 发明专利

JP2011227102A Complexes, and use of the same in detection method 审中-公开
标题翻译：复合物及其在检测方法中的应用
公开(公告)号：JP2011227102A
公开(公告)日：2011-11-10
申请号：JP2011179276
申请日：2011-08-19
申请人： Siemens Healthcare Diagnostics Products Gmbh , シーメンス・ヘルスケア・ダイアグノスティックス・プロダクツ・ゲーエムベーハー
发明人： MICHAEL TRIER , KARSTEN SHELP , HARALD ACKERMAN , LEE HORU , PRATAP SINGH , SUSAN SWONG
IPC分类号： G01N33/543 , G01N33/53 , G01N33/533 , G01N33/536 , G01N33/542 , G01N33/548 , G01N33/58
CPC分类号： G01N33/533 , G01N33/536 , G01N33/542 , G01N33/582
摘要： PROBLEM TO BE SOLVED: To improve a measurement signal in detecting an analyte, especially in detecting an analyte using a homogeneous test.SOLUTION: A complexes has a first carrier molecule and a second carrier molecule. The first carrier molecule is associated with one or more specific binding partners R1 to an analyte, and it has an additional binding part for a specific binding partner X. The second carrier molecule is associated with one or more specific binding partners R2 to the analyte, and it has an additional binding part for a specific binding partner Y.
摘要翻译：要解决的问题：改进检测分析物的测量信号，特别是在使用均匀试验检测分析物时。解决方案：配合物具有第一载体分子和第二载体分子。第一载体分子与一种或多种特异性结合配偶体R1与分析物相关联，并且其具有用于特异性结合配偶体X的另外的结合部分。第二载体分子与一种或多种与分析物的特异性结合配偶体R2相关联，并且具有特定结合配偶体Y的附加结合部分。版权所有（C）2012，JPO＆INPIT

7. 发明专利

JP2014182148A Closure system for reagent vessel receiving position in automatic analysis apparatus 有权
标题翻译：用于自动分析装置的试剂容器接收位置的闭合系统
公开(公告)号：JP2014182148A
公开(公告)日：2014-09-29
申请号：JP2014054995
申请日：2014-03-18
申请人： Siemens Healthcare Diagnostics Products Gmbh , シーメンスヘルスケアダイアグノスティクスプロダクツゲゼルシヤフトミツトベシユレンクテルハフツング
发明人： WILLMES HUGO
IPC分类号： G01N35/02 , G01N35/04
CPC分类号： B65D43/265 , B01L3/50825 , B01L3/523 , B01L9/06 , G01N35/025 , G01N2035/00287 , G01N2035/0405
摘要： PROBLEM TO BE SOLVED: To provide a closure system for a reaction vessel receiving position in an automatic analysis apparatus.SOLUTION: The invention relates to a closure system (1) for a holder (2) for a reaction vessel (4) in an automatic analysis apparatus. The closure system (1) comprises a lid (16) secured movably on a retainer element (18), where the lid closes an opening (6) of the holder (2) in a closed attitude and opens it in an open attitude. The closure system (1) further comprises an energizing element (26), which is designed in such a way that, depending on the attitude of the lid (16), it exerts energizing force in the direction of the closed attitude or of the open attitude.
摘要翻译：要解决的问题：提供一种用于在自动分析装置中的反应容器接收位置的封闭系统。解决方案：本发明涉及一种用于在自动分析装置中用于反应容器（4）的保持器（2）的封闭系统（1）分析仪器。闭合系统（1）包括可移动地固定在保持器元件（18）上的盖子（16），其中盖子以闭合的姿态封闭保持器（2）的开口（6）并以打开的姿态打开。闭合系统（1）还包括通电元件（26），其被设计成使得根据盖子（16）的姿态，其在闭合姿态或打开的方向上施加激励力态度。

8. 发明专利

JP2014178315A Pipetting needle holding device 有权
标题翻译：管接头设备
公开(公告)号：JP2014178315A
公开(公告)日：2014-09-25
申请号：JP2014045160
申请日：2014-03-07
申请人： Siemens Healthcare Diagnostics Products Gmbh , シーメンスヘルスケアダイアグノスティクスプロダクツゲゼルシヤフトミツトベシユレンクテルハフツング
发明人： WILLMES HUGO
IPC分类号： G01N35/10
CPC分类号： G01N35/1079 , B01L3/50825
摘要： PROBLEM TO BE SOLVED: To provide a holding device for a hollow needle for piecing a cap of a sample tube, the holding device being capable of particularly stably holding the hollow needle and simply replacing the hollow needle when the hollow needle is worn.SOLUTION: A holding device (1) for a hollow needle (12) to pierce a cap of a blood sampling tube in an automated analyzer, the holding device (1) comprising a first holding element (2) capable of being detachably fixed to a base plate (42) that automatically moves, and a second holding element (4) connected to the first holding element (2). The holding device (1) is provided with at least one bearing bushing (14) fixed between the holding elements (2, 4), into which the hollow needle (12) is embedded.
摘要翻译：要解决的问题：为了提供用于接合样品管盖的中空针的保持装置，该保持装置能够特别稳定地保持中空针，并且当中空针穿着时简单地更换中空针。解决方案：一种用于在自动分析仪中刺穿采血管的帽的空心针（12）的保持装置（1），所述保持装置（1）包括：第一保持元件（2），其能够可拆卸地固定到基板（42）和与第一保持元件（2）连接的第二保持元件（4）。保持装置（1）设置有固定在保持元件（2,4）之间的至少一个轴承套（14），中空针（12）嵌入该保持元件。

9. 发明专利

JP2014137372A Closing device 审中-公开
标题翻译：封闭装置
公开(公告)号：JP2014137372A
公开(公告)日：2014-07-28
申请号：JP2013271912
申请日：2013-12-27
申请人： Siemens Healthcare Diagnostics Products Gmbh , シーメンスヘルスケアダイアグノスティクスプロダクツゲゼルシヤフトミツトベシユレンクテルハフツング
发明人： THOMAS BUTZ
IPC分类号： G01N35/00 , B65G47/90
CPC分类号： B65D43/02 , B01L3/523 , G01N35/1002 , G01N2035/0405
摘要： PROBLEM TO BE SOLVED: To provide a closing device of an opening of a container lid having the opening reduced in heat exchange with the inside of a container and the periphery of the container.SOLUTION: A device 1 for closing an opening of a container lid includes: a fixing element 2 for fixing the device on the container lid; a closing element 20 movably connected to the fixing element and for covering the opening of the container lid at a closing position and for not covering the opening of the container lid at an opening position; and a guide rail 26 movably connected to the fixing element and the closing element and applied with a horizontal force with a result that the closing element is movable from the closing position to the opening position. The fixing element and the closing element are connected by a pair of mutually parallel levers 14 which are rotatably mounted on a fixing element side bearing 18 and a closing element side bearing 16, respectively. The guide rail is rotatably mounted on each lever via each bearing, and each bearing includes a rotation axis vertical to the closing element.
摘要翻译：要解决的问题：提供一种容器盖的开口的关闭装置，其具有与容器的内部和容器的周边热交换的开口减小的容器盖。解决方案：用于封闭容器盖的开口的装置1 包括：用于将装置固定在容器盖上的固定元件2; 闭合元件20，其可移动地连接到所述固定元件，并且在关闭位置处覆盖所述容器盖的开口，并且在打开位置处不覆盖所述容器盖的开口; 以及可移动地连接到固定元件和闭合元件并且施加水平力的导轨26，导致关闭元件可以从关闭位置移动到打开位置。固定元件和闭合元件通过一对相互平行的杠杆14连接，杠杆14可旋转地安装在固定元件侧轴承18和关闭元件侧轴承16上。导轨通过每个轴承可旋转地安装在每个杠杆上，并且每个轴承包括垂直于关闭元件的旋转轴。

10. 发明专利

JP2014052376A Adjustment system for transfer system in in-vitro diagnostic system 有权
标题翻译：体内诊断系统转移系统调整系统
公开(公告)号：JP2014052376A
公开(公告)日：2014-03-20
申请号：JP2013185145
申请日：2013-09-06
申请人： Siemens Healthcare Diagnostics Products Gmbh , シーメンスヘルスケアダイアグノスティクスプロダクツゲゼルシヤフトミツトベシユレンクテルハフツング
发明人： HERZ ACHIM , ALEXANDER WEDEKIND-KLEIN
IPC分类号： G01N35/04 , G01N35/10
CPC分类号： G01B21/16 , G01N35/10 , G01N35/109
摘要： PROBLEM TO BE SOLVED: To provide an adjustment system that enables a quick automated adjustment of a transfer system in an in-vitro diagnostic system.SOLUTION: The adjustment system comprises a contact element 4, which is arranged on a movable element 2 of a transfer system 1 by means of a joint element 5. The joint element 5 has a self-resetting design. Distance measuring sensors 7, 8 are associated with a distance between the contact element 4 and the movable element 2.
摘要翻译：要解决的问题：提供一种能够快速自动调整体外诊断系统中的传送系统的调节系统。解决方案：调节系统包括接触元件4，其设置在可移动元件2上的传送系统1通过接头元件5.接头元件5具有自复位设计。距离测量传感器7,8与接触元件4和可移动元件2之间的距离相关联。

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