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1. 发明专利

JP2015057607A 発散された息における薬物検出审中-公开
标题翻译：呼吸道中的药物检测
公开(公告)号：JP2015057607A
公开(公告)日：2015-03-26
申请号：JP2014226506
申请日：2014-11-06
申请人：センサビューズエービー , Sensa Bues Ab , センサビューズエービー
发明人： PALMSKOG GOERAN , OLOF BECK
IPC分类号： G01N1/02 , G01N1/10 , G01N1/22 , G01N27/62
CPC分类号： G01N21/658 , A61B5/082 , A61B5/412 , G01J3/44 , G01N33/497
摘要：【課題】被験者の発散した息から、質量分析による製剤原料の検出または測定を行うサンプルを収集する携帯型サンプリング装置を提供する。【解決手段】装置10は、サンプリングユニット14と、サンプリングユニット14を保持するためのハウジング12とを備え、サンプリングユニット14は、被験者の発散した息から製剤原料の非揮発性物質及び揮発性物質を収集するために適合されている。ハウジング12は、被験者がハウジング12内のサンプリングユニット14へ息を発散するための入口15と、出口16を有している。【選択図】図1
摘要翻译：要解决的问题：提供一种便携式取样装置，其收集样品以通过质谱法从被检体呼出的呼吸中检测或测量制剂材料。解决方案：装置10包括取样单元14和用于保持取样单元14.采样单元14适于从受试者呼出的呼吸中收集制剂材料的非挥发性物质和挥发性物质。壳体12包括用于允许受试者向壳体12中的取样单元14呼出呼吸的入口15和出口16。

2. 发明申请

WO2012120140A1 A PORTABLE SAMPLING DEVICE AND METHOD FOR SAMPLING DRUG SUBSTANCES FROM EXHALED BREATH 审中-公开
标题翻译：一种便携式采样装置和从排气口抽取药物的方法
公开(公告)号：WO2012120140A1
公开(公告)日：2012-09-13
申请号：PCT/EP2012/054180
申请日：2012-03-09
申请人： SENSA BUES AB , BECK, Olof , HAMMARLUND, Bo
发明人： BECK, Olof , HAMMARLUND, Bo
IPC分类号： G01N33/497 , A61B5/097
CPC分类号： G01N33/497 , A61B5/082 , A61B5/091 , A61B5/097 , A61B5/4845 , B29C65/46 , B29C65/665 , B29K2023/10 , B29K2033/04 , B29K2105/256 , B29K2105/258 , G01N2033/4975
摘要： A portable drug sampling device for handheldly collecting a sample from exhaled breath of a subject for further sensor based analysis. The device comprising: a housing (406) comprising at least one inlet (407) and at least one outlet (408) for the exhaled breath to exit through, and a sampling membrane (302) arranged in the housing. A tubular element (40) having a mouthpiece section (401) for the subject to exhale into, and a saliva trap section comprising baffles (103) to create a non-straight gas flow path for letting aerosols pass through the tubular element. The sampling membrane (302) is arranged to collect the aerosols from the exhaled breath. The portable drug testing device further comprises a volume collecting element (208).
摘要翻译：一种便携式药物采样装置，用于从用于进一步基于传感器的分析的呼吸呼吸中手持收集样品。该装置包括：壳体（406），包括至少一个入口（407）和用于呼出的呼吸排出的至少一个出口（408）和布置在壳体中的取样膜（302）。管状元件（40）具有用于受试者呼出的吸口部分（401）和包括挡板（103）的唾液陷阱部分，以产生用于使气溶胶通过管状元件的非直线气流通道。取样膜（302）布置成从呼出的呼吸中收集气溶胶。便携式药物检测装置还包括容积收集元件（208）。

3. 发明申请

WO2011029889A1 DRUG DETECTION IN EXHALED BREATH 审中-公开
标题翻译：呼吸道中的药物检测
公开(公告)号：WO2011029889A1
公开(公告)日：2011-03-17
申请号：PCT/EP2010/063266
申请日：2010-09-09
申请人： SENSA BUES AB , PALMSKOG, Göran , BECK, Olof
发明人： PALMSKOG, Göran , BECK, Olof
IPC分类号： G01N33/497 , A61B5/097 , H01J49/04
CPC分类号： G01N21/658 , A61B5/082 , A61B5/412 , G01J3/44 , G01N33/497
摘要： A portable system (10) is disclosed for collecting a sample from exhaled breath of a subject. Drug substance in the exhaled breath are detected or determined. The sample is collected for further analysis using mass-spectroscopy. The system comprises a sampling unit (14) and a housing (12) arranged to hold the sampling unit (14), the sampling unit (14) is adapted to collect non-volatile and volatile compounds of the at least one drug substance from the exhaled breath from the subject. The housing (12) has at least one inlet (15) for the subject to exhale into the housing (12) to the sampling unit (14) and at least one outlet (16) for the exhaled breath to exit through.
摘要翻译：公开了一种便携式系统（10），用于从受试者的呼出气中收集样品。检测或确定呼出气中的药物。收集样品以进行质谱分析。该系统包括一个采样单元（14）和一个布置成保持采样单元（14）的壳体（12），采样单元（14）适用于从该采样单元（14）收集至少一种药物的非挥发性和挥发性化合物从主题呼出呼吸。壳体（12）具有至少一个入口（15），用于受试者呼出到采样单元（14）的壳体（12）和用于呼出的呼吸的至少一个出口（16）通过。

4. 发明申请

WO2011029888A1 SURFACE-ENHANCED RAMAN SCATTERING FOR DRUG DETECTION IN EXHALED BREATH 审中-公开
标题翻译：表面增强吸入式呼吸器中药物检测的拉曼散射
公开(公告)号：WO2011029888A1
公开(公告)日：2011-03-17
申请号：PCT/EP2010/063265
申请日：2010-09-09
申请人： SENSA BUES AB , PALMSKOG, Göran , BECK, Olof , ANDERSSON, Per Ola
发明人： PALMSKOG, Göran , BECK, Olof , ANDERSSON, Per Ola
IPC分类号： G01N21/65 , G01N33/497
CPC分类号： G01N21/658 , A61B5/082 , A61B5/412 , G01J3/44 , G01N33/497
摘要： A sensor for detecting a drug substance (15) from exhaled breath of a subject in-situ. Its collecting surface has a Surface Enhanced Raman Spectroscopy (SERS)-active layer (14) of a SERS-active material. The collecting surface is arranged as an outer surface of a waveguide (12) for contact with exhaled breath, such that at least traces of said drug substance (15) in said exhaled breath can contact said SERS-active layer for read-out of a Raman shift spectrum.
摘要翻译：一种用于从现场呼出的呼吸气体检测药物（15）的传感器。其收集表面具有SERS活性材料的表面增强拉曼光谱（SERS）活性层（14）。收集表面被布置为用于与呼出的呼吸接触的波导（12）的外表面，使得所述呼出的呼吸中的至少痕量的所述药物（15）可以接触所述SERS活性层以读出拉曼位移谱。

5. 发明申请

WO2014041045A1 SYSTEM AND METHOD FOR ELUTING AND TESTING SUBSTANCE FROM EXHALED AEROSOL SAMPLE 审中-公开
标题翻译：用于从外部气溶胶样品中测量和测试物质的系统和方法
公开(公告)号：WO2014041045A1
公开(公告)日：2014-03-20
申请号：PCT/EP2013/068860
申请日：2013-09-11
申请人： SENSA BUES AB
发明人： BECK, Olof
IPC分类号： G01N33/497 , A61B5/097 , A61B5/08
CPC分类号： G01N33/497 , A61B5/082 , A61B5/097 , A61B5/4845 , H01J49/0427
摘要： A method recovering one or more nonvolatile compounds from an exhaled aerosol collected on an electrostatic filter membrane (205) comprises eluting the nonvolatile compounds from the filter with a polar solvent and collecting the eluate. The method is useful for processing samples collected from a portable breath analysis device comprising a sampling filter membrane for analysis.
摘要翻译：收集在静电过滤膜（205）上的呼出气溶胶中回收一种或多种非挥发性化合物的方法包括用极性溶剂从过滤器中洗脱不挥发性化合物并收集洗脱液。该方法对于处理从包含用于分析的取样滤膜的便携式呼吸分析装置收集的样品是有用的。

6. 发明申请

WO2013132085A1 A PORTABLE SAMPLING DEVICE AND METHOD FOR DETECTION OF BIOMARKERS IN EXHALED BREATH 审中-公开
标题翻译：便携式采样装置和检测呼吸道中生物标志物的方法
公开(公告)号：WO2013132085A1
公开(公告)日：2013-09-12
申请号：PCT/EP2013/054789
申请日：2013-03-08
申请人： SENSA BUES AB
发明人： HAMMARLUND, Bo , BECK, Olof
IPC分类号： G01N33/497 , A61B5/08
CPC分类号： G01N33/497 , A61B5/082
摘要： A portable method and sampling device for collecting aerosols comprising biomarkers from exhaled breath of a subject for further sensor based analysis. The sampling device (41) comprising a housing (406) comprising at least one inlet (407) and at least one outlet (408) for the exhaled breath to exit through, and a sampling membrane arranged in the housing. The sampling membrane is arranged to collect the aerosols from said exhaled breath.
摘要翻译：一种用于收集气溶胶的便携式方法和采样装置，包括来自受试者的呼出气体的生物标志物，用于进一步的基于传感器的分析。采样装置（41）包括壳体（406），该壳体包括至少一个入口（407）和用于呼出的呼吸排出的至少一个出口（408），以及布置在壳体中的取样膜。取样膜布置成从呼出的呼吸中收集气溶胶。

7. 发明申请

US20120212735A1 System and Method for Detection of Analytes in Exhaled Breath 有权
公开(公告)号：US20120212735A1
公开(公告)日：2012-08-23
申请号：US13394979
申请日：2010-09-09
申请人： Göran Palmskog , Olof Beck , Per Ola Andersson
发明人： Göran Palmskog , Olof Beck , Per Ola Andersson
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , A61B5/082 , A61B5/412 , G01J3/44 , G01N33/497
摘要： A sensor for detecting a drug substance (15) from exhaled breath of a subject in-situ. Its collecting surface has a Surface Enhanced Raman Spectroscopy (SERS)-active layer (14) of a SERS-active material. The collecting surface is arranged as an outer surface of a waveguide (12) for contact with exhaled breath, such that at least traces of said drug substance (15) in said exhaled breath can contact said SERS-active layer for read-out of a Raman shift spectrum.

8. 发明授权

US11567011B2 System and method for drug detection in exhaled breath 有权
公开(公告)号：US11567011B2
公开(公告)日：2023-01-31
申请号：US16678761
申请日：2019-11-08
申请人： Sensa Bues AB
发明人： Göran Palmskog , Olof Beck
IPC分类号： A61B5/08 , A61B5/097 , G01N21/65 , A61B5/00 , G01N33/497 , F01D1/08 , F01D5/04 , G01J3/44
摘要： A portable system is disclosed for collecting a sample from exhaled breath of a subject. Drug substance in the exhaled breath are detected or determined. The sample is collected for further analysis using mass-spectroscopy. The system comprises a sampling unit and a housing arranged to hold the sampling unit, the sampling unit is adapted to collect non-volatile and volatile compounds of the at least one drug substance from the exhaled breath from the subject. The housing has at least one inlet for the subject to exhale into the housing to the sampling unit and at least one outlet for the exhaled breath to exit through.

9. 发明授权

US10359417B2 Portable sampling device and method for detection of biomarkers in exhaled breath 有权
公开(公告)号：US10359417B2
公开(公告)日：2019-07-23
申请号：US14383846
申请日：2013-03-08
申请人： Sensa Bues AB
发明人： Bo Hammarlund , Olof Beck
IPC分类号： A61B5/097 , A61B5/08 , G01N33/497
摘要： A portable method and sampling device for collecting aerosols comprising biomarkers from exhaled breath of a subject for further sensor based analysis. The sampling device (41) comprising a housing (406) comprising at least one inlet (407) and at least one outlet (408) for the exhaled breath to exit through, and a sampling membrane arranged in the housing. The sampling membrane is arranged to collect the aerosols from said exhaled breath.

10. 发明申请

US20140204374A1 System and Method for Detection of Analytes in Exhaled Breath 审中-公开
标题翻译：用于检测呼气中分析物的系统和方法
公开(公告)号：US20140204374A1
公开(公告)日：2014-07-24
申请号：US14222696
申请日：2014-03-24
申请人： Sensa Bues AB
发明人： Göran Palmskog , Olof Beck , Per Ola Andersson
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , A61B5/082 , A61B5/412 , G01J3/44 , G01N33/497
摘要： A device, system, and methods are disclosed for detecting the presence or determining a quantitative amount of at least one drug substance from exhaled breath of a subject in-situ. A collecting surface has a Surface Enhanced Raman Spectroscopy (SERS)-active layer that comprises at least one SERS-active material. The collecting surface is arranged as an outer surface of a waveguide for contact with exhaled breath, such that at least traces of said at least one drug substance in said exhaled breath can contact said SERS-active layer for read-out of a Raman shift spectrum that is detected in-situ for said detecting the presence or determining the quantitative amount of said at least one drug substance from said exhaled breath.
摘要翻译：公开了一种装置，系统和方法，用于从现场呼出的呼吸气体中检测存在或确定至少一种药物的定量。收集表面具有包含至少一种SERS活性材料的表面增强拉曼光谱（SERS）活性层。收集表面被布置为用于与呼出气体接触的波导的外表面，使得所述呼出的呼吸中的至少一种药物物质的至少痕迹可接触所述SERS活性层以读出拉曼位移谱其被现场检测，用于从所述呼出的呼吸中检测存在或确定所述至少一种药物的定量。

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