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1. 发明申请

US20150226726A1 System and Method for Eluting and Testing Substance From Exhaled Aerosol Sample 有权
标题翻译：用于从呼出气溶胶样品洗脱和检测物质的系统和方法
公开(公告)号：US20150226726A1
公开(公告)日：2015-08-13
申请号：US14427229
申请日：2013-09-11
申请人： SENSA BUES AB
发明人： Olof Beck
IPC分类号： G01N33/497
CPC分类号： G01N33/497 , A61B5/082 , A61B5/097 , A61B5/4845 , H01J49/0427
摘要： A method recovering one or more nonvolatile compounds from an exhaled aerosol collected on an electrostatic filter membrane (205) comprises eluting the nonvolatile compounds from the filter with a polar solvent and collecting the eluate. The method is useful for processing samples collected from a portable breath analysis device comprising a sampling filter membrane for analysis.
摘要翻译：收集在静电过滤膜（205）上的呼出气溶胶中回收一种或多种非挥发性化合物的方法包括用极性溶剂从过滤器中洗脱不挥发性化合物并收集洗脱液。该方法对于处理从包含用于分析的取样滤膜的便携式呼吸分析装置收集的样品是有用的。

2. 发明授权

US09429564B2 System and method for eluting and testing substance from exhaled aerosol sample 有权
标题翻译：从呼出气溶胶样品中洗脱和检测物质的系统和方法
公开(公告)号：US09429564B2
公开(公告)日：2016-08-30
申请号：US14427229
申请日：2013-09-11
申请人： Sensa Bues AB
发明人： Olof Beck
IPC分类号： G01N33/48 , G01N33/497 , A61B5/08 , A61B5/097 , A61B5/00 , H01J49/04
CPC分类号： G01N33/497 , A61B5/082 , A61B5/097 , A61B5/4845 , H01J49/0427
摘要： A method recovering one or more nonvolatile compounds from an exhaled aerosol collected on an electrostatic filter membrane (205) comprises eluting the nonvolatile compounds from the filter with a polar solvent and collecting the eluate. The method is useful for processing samples collected from a portable breath analysis device comprising a sampling filter membrane for analysis.
摘要翻译：收集在静电过滤膜（205）上的呼出气溶胶中回收一种或多种非挥发性化合物的方法包括用极性溶剂从过滤器中洗脱不挥发性化合物并收集洗脱液。该方法对于处理从包含用于分析的取样滤膜的便携式呼吸分析装置收集的样品是有用的。

3. 发明申请

US20150033824A1 Portable Sampling Device and Method for Detection of Biomarkers in Exhaled Breath 审中-公开
标题翻译：便携式采样装置和呼气呼吸中生物标志物检测方法
公开(公告)号：US20150033824A1
公开(公告)日：2015-02-05
申请号：US14383846
申请日：2013-03-08
申请人： Sensa Bues AB
发明人： Bo Hammarlund , Olof Beck
IPC分类号： G01N33/497 , A61B5/08
CPC分类号： G01N33/497 , A61B5/082 , A61B5/097 , G01N2033/4975
摘要： A portable method and sampling device for collecting aerosols comprising biomarkers from exhaled breath of a subject for further sensor based analysis. The sampling device (41) comprising a housing (406) comprising at least one inlet (407) and at least one outlet (408) for the exhaled breath to exit through, and a sampling membrane arranged in the housing. The sampling membrane is arranged to collect the aerosols from said exhaled breath.
摘要翻译：一种用于收集气溶胶的便携式方法和采样装置，包括来自受试者的呼出气体的生物标志物，用于进一步的基于传感器的分析。采样装置（41）包括壳体（406），该壳体包括至少一个入口（407）和用于呼出的呼吸排出的至少一个出口（408），以及布置在壳体中的取样膜。取样膜布置成从呼出的呼吸中收集气溶胶。

4. 发明申请

US20230125894A1 System and Method for Drug Detection in Exhaled Breath 有权
公开(公告)号：US20230125894A1
公开(公告)日：2023-04-27
申请号：US18088439
申请日：2022-12-23
申请人： Sensa Bues AB
发明人： Göran Palmskog , Olof Beck
IPC分类号： G01N21/65 , A61B5/08 , A61B5/00 , G01N33/497 , F01D1/08 , F01D5/04 , A61B5/097 , G01J3/44
摘要： A portable system is disclosed for collecting a sample from exhaled breath of a subject. Drug substance in the exhaled breath are detected or determined. The sample is collected for further analysis using mass-spectroscopy. The system comprises a sampling unit and a housing arranged to hold the sampling unit, the sampling unit is adapted to collect non-volatile and volatile compounds of the at least one drug substance from the exhaled breath from the subject. The housing has at least one inlet for the subject to exhale into the housing to the sampling unit and at least one outlet for the exhaled breath to exit through.

5. 发明授权

US08705029B2 System and method for detection of analytes in exhaled breath 有权
标题翻译：用于检测呼气中分析物的系统和方法
公开(公告)号：US08705029B2
公开(公告)日：2014-04-22
申请号：US13739607
申请日：2013-01-11
申请人： Sensa Bues AB
发明人： Göran Palmskog , Olof Beck , Per Ola Andersson
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , A61B5/082 , A61B5/412 , G01J3/44 , G01N33/497
摘要： A device, system, and methods are disclosed for detecting the presence or determining a quantitative amount of at least one drug substance from exhaled breath of a subject in-situ. A collecting surface has a Surface Enhanced Raman Spectroscopy (SERS)-active layer that comprises at least one SERS-active material. The collecting surface is arranged as an outer surface of a waveguide for contact with exhaled breath, such that at least traces of said at least one drug substance in said exhaled breath can contact said SERS-active layer for read-out of a Raman shift spectrum that is detected in-situ for said detecting the presence or determining the quantitative amount of said at least one drug substance from said exhaled breath.
摘要翻译：公开了一种装置，系统和方法，用于从现场呼出的呼吸气体中检测存在或确定至少一种药物的定量。收集表面具有包含至少一种SERS活性材料的表面增强拉曼光谱（SERS）活性层。收集表面被布置为用于与呼出气体接触的波导的外表面，使得所述呼出的呼吸中的至少一种药物物质的至少痕迹可接触所述SERS活性层以读出拉曼位移谱其被现场检测，用于从所述呼出的呼吸中检测存在或确定所述至少一种药物的定量。

6. 发明申请

US20130128260A1 System and Method for Detection of Analytes in Exhaled Breath 有权
标题翻译：用于检测呼气中分析物的系统和方法
公开(公告)号：US20130128260A1
公开(公告)日：2013-05-23
申请号：US13739607
申请日：2013-01-11
申请人： Sensa Bues AB
发明人： Göran Palmskog , Olof Beck , Per Ola Andersson
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , A61B5/082 , A61B5/412 , G01J3/44 , G01N33/497
摘要： A device, system, and methods are disclosed for detecting the presence or determining a quantitative amount of at least one drug substance from exhaled breath of a subject in-situ. A collecting surface has a Surface Enhanced Raman Spectroscopy (SERS)-active layer that comprises at least one SERS-active material. The collecting surface is arranged as an outer surface of a waveguide for contact with exhaled breath, such that at least traces of said at least one drug substance in said exhaled breath can contact said SERS-active layer for read-out of a Raman shift spectrum that is detected in-situ for said detecting the presence or determining the quantitative amount of said at least one drug substance from said exhaled breath.
摘要翻译：公开了一种装置，系统和方法，用于从现场呼出的呼吸气体中检测存在或确定至少一种药物的定量。收集表面具有包含至少一种SERS活性材料的表面增强拉曼光谱（SERS）活性层。收集表面被布置为用于与呼出气体接触的波导的外表面，使得所述呼出的呼吸中的至少一种药物物质的至少痕迹可接触所述SERS活性层以读出拉曼位移谱其被现场检测，用于从所述呼出的呼吸中检测存在或确定所述至少一种药物的定量。

7. 发明授权

US11567011B2 System and method for drug detection in exhaled breath 有权
公开(公告)号：US11567011B2
公开(公告)日：2023-01-31
申请号：US16678761
申请日：2019-11-08
申请人： Sensa Bues AB
发明人： Göran Palmskog , Olof Beck
IPC分类号： A61B5/08 , A61B5/097 , G01N21/65 , A61B5/00 , G01N33/497 , F01D1/08 , F01D5/04 , G01J3/44
摘要： A portable system is disclosed for collecting a sample from exhaled breath of a subject. Drug substance in the exhaled breath are detected or determined. The sample is collected for further analysis using mass-spectroscopy. The system comprises a sampling unit and a housing arranged to hold the sampling unit, the sampling unit is adapted to collect non-volatile and volatile compounds of the at least one drug substance from the exhaled breath from the subject. The housing has at least one inlet for the subject to exhale into the housing to the sampling unit and at least one outlet for the exhaled breath to exit through.

8. 发明授权

US10359417B2 Portable sampling device and method for detection of biomarkers in exhaled breath 有权
公开(公告)号：US10359417B2
公开(公告)日：2019-07-23
申请号：US14383846
申请日：2013-03-08
申请人： Sensa Bues AB
发明人： Bo Hammarlund , Olof Beck
IPC分类号： A61B5/097 , A61B5/08 , G01N33/497
摘要： A portable method and sampling device for collecting aerosols comprising biomarkers from exhaled breath of a subject for further sensor based analysis. The sampling device (41) comprising a housing (406) comprising at least one inlet (407) and at least one outlet (408) for the exhaled breath to exit through, and a sampling membrane arranged in the housing. The sampling membrane is arranged to collect the aerosols from said exhaled breath.

9. 发明申请

US20180306775A1 Portable Sampling Device and Method for Sampling Drug Substances From Exhaled Breath 审中-公开
公开(公告)号：US20180306775A1
公开(公告)日：2018-10-25
申请号：US15956368
申请日：2018-04-18
申请人： Sensa Bues AB
发明人： Olof Beck , Bo Hammarlund
IPC分类号： G01N33/497 , B29C65/66 , A61B5/091 , A61B5/097 , A61B5/00 , B29C65/46 , A61B5/08 , B29K23/00 , B29K33/04 , B29K105/00
CPC分类号： G01N33/497 , A61B5/082 , A61B5/091 , A61B5/097 , A61B5/4845 , B29C65/46 , B29C65/665 , B29K2023/10 , B29K2033/04 , B29K2105/256 , B29K2105/258 , G01N2033/4975
摘要： A portable drug testing device for handheldly collecting a sample from exhaled breath of a subject for further sensor based analysis. The portable drug testing device comprising a housing comprising at least one inlet and at least one outlet for the exhaled breath to exit through, and a sampling membrane arranged in the housing. a tubular element having a mouthpiece section for the subject to exhale into, and a selective trap section in fluid communication with the mouthpiece and the inlet of the housing having a non-straight gas flow path for letting aerosols pass through the tubular element. The sampling membrane is arranged to collect the aerosols from the exhaled breath. The portable drug testing device further comprises a volume measure unit for determining that a pre-defined volume of the exhaled breath has passed through the sampling membrane.

10. 发明申请

US20140204374A1 System and Method for Detection of Analytes in Exhaled Breath 审中-公开
标题翻译：用于检测呼气中分析物的系统和方法
公开(公告)号：US20140204374A1
公开(公告)日：2014-07-24
申请号：US14222696
申请日：2014-03-24
申请人： Sensa Bues AB
发明人： Göran Palmskog , Olof Beck , Per Ola Andersson
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , A61B5/082 , A61B5/412 , G01J3/44 , G01N33/497
摘要： A device, system, and methods are disclosed for detecting the presence or determining a quantitative amount of at least one drug substance from exhaled breath of a subject in-situ. A collecting surface has a Surface Enhanced Raman Spectroscopy (SERS)-active layer that comprises at least one SERS-active material. The collecting surface is arranged as an outer surface of a waveguide for contact with exhaled breath, such that at least traces of said at least one drug substance in said exhaled breath can contact said SERS-active layer for read-out of a Raman shift spectrum that is detected in-situ for said detecting the presence or determining the quantitative amount of said at least one drug substance from said exhaled breath.
摘要翻译：公开了一种装置，系统和方法，用于从现场呼出的呼吸气体中检测存在或确定至少一种药物的定量。收集表面具有包含至少一种SERS活性材料的表面增强拉曼光谱（SERS）活性层。收集表面被布置为用于与呼出气体接触的波导的外表面，使得所述呼出的呼吸中的至少一种药物物质的至少痕迹可接触所述SERS活性层以读出拉曼位移谱其被现场检测，用于从所述呼出的呼吸中检测存在或确定所述至少一种药物的定量。

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