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2. 发明专利

JP2009143937A Pna monomer and precursor 有权
标题翻译： PNA单身和前辈
公开(公告)号：JP2009143937A
公开(公告)日：2009-07-02
申请号：JP2009006471
申请日：2009-01-15
申请人： Panagene Inc , パナジーン,インク
发明人： KIM SUNG KEE , LEE HYUNIL , LIM JONG CHAN , CHOI HOON , JUN JAE HUN , AHN SANG YEOL , LEE SUNG HEE , YOON WON JUN
IPC分类号： C07D405/12 , C12N15/09 , A61K31/513 , A61K31/52 , C07D277/80 , C07D417/04 , C07D417/12 , C07D417/14 , C07D473/02 , C07D473/18 , C07D473/32 , C07D473/34
CPC分类号： C07D417/04 , C07B2200/11 , C07D277/80 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： PROBLEM TO BE SOLVED: To provide a new monomer suitable for preparation of a PNA (Peptide Nucleic Acid) oligomer. SOLUTION: A cytosine derivative, an adenine derivative and a guanine derivative protected by a piperonyl oxy-carbonyl derivative are disclosed as the new monomers. The cytosine derivative is a compound having a structure represented by the formula α. The adenine derivative has a compound having a structure represented by the formula β. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供适合于制备PNA（肽核酸）低聚物的新单体。解决方案：公开了由胡椒基氧羰基衍生物保护的胞嘧啶衍生物，腺嘌呤衍生物和鸟嘌呤衍生物作为新单体。胞嘧啶衍生物是具有由式α表示的结构的化合物。腺嘌呤衍生物具有由式β表示的结构的化合物。版权所有（C）2009，JPO＆INPIT

4. 发明专利

AT440089T 未知
公开(公告)号：AT440089T
公开(公告)日：2009-09-15
申请号：AT03700408
申请日：2003-01-23
申请人： PANAGENE INC
发明人： KIM SUNG KEE , LEE HYUNIL , LIM JONG CHAN , CHOI HOON , JEON JAE HOON , AHN SANG YOUL , LEE SUNG HEE
IPC分类号： C07D241/08 , C07H19/00 , C07C303/40 , C07C311/18 , C07D239/47 , C07D239/54 , C07D403/06 , C07D473/18 , C07D473/30 , C07D473/34 , C07K14/00
摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein R1, R2, R3, R4, R5 is independently H, halogen, C 1 -C 4 alkyl, nitro, nitrile, C 1 -C 4 alkoxy, halogenated C 1 -C 4 alkyl, or halogenated C 1 -C 4 alkoxy, wherein at least one of R1, R3, and R5 is nitro; R6 is H or protected or unprotected side chain of natural or unnatural alpha-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases.

5. 发明专利

PH12017500798A1 PNA PROBES, KITS AND METHODS FOR DETECTING HUMAN PAPILLOMAVIRUS GENOTYPES OF HUMAN PAPILLOMAVIRUS 未知
公开(公告)号：PH12017500798A1
公开(公告)日：2017-10-02
申请号：PH12017500798
申请日：2017-04-27
申请人： PANAGENE INC
发明人： CHOI BO RA , KANG JAE HYUN , CHOI JAE JIN , KIM SUNG KEE , PARK DOO SAN
IPC分类号： C12Q1/68 , C12Q1/70
摘要： The present invention relates to a method for detecting a human papillomavirus (hereinafter, referred to as "HPV") genotype by using a PNA detection probe and, more specifically, to: a detection probe capable of genotype-specifically binding to HPV DNA; a detection kit containing the same; and a method for detecting a HPV genotype by using the same. The present invention can accurately detect 22 types of HPV genotype found in the uterin cervix, diagnose coinfections also by one or more HPV genotypes, detect whether other HPV genotypes, excluding the 22 types, are present, and detect HPV genotypes with high sensitivity and specificity.

6. 发明专利

AT453631T 未知
公开(公告)号：AT453631T
公开(公告)日：2010-01-15
申请号：AT03718981
申请日：2003-04-28
申请人： PANAGENE INC
发明人： KIM SUNG KEE , LEE HYUNIL , LIM JONG CHAN , CHOI HOON , JEON JAE HOON , AHN SANG YOUL , LEE SUNG HEE , YOON WON JUN
IPC分类号： C07D277/76 , C12N15/09 , A61K31/513 , A61K31/52 , C07D263/58 , C07D277/80 , C07D405/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D473/02 , C07D473/18 , C07D473/26 , C07D473/32 , C07D473/34
摘要： This application relates to monomers of the general formula (I) for the preparation PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: (I) wherein E is nitrogen or C-R'; J is sulfur or oxygen; R', R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural a-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

7. 发明专利

DE602004023951D1 未知
公开(公告)号：DE602004023951D1
公开(公告)日：2009-12-17
申请号：DE602004023951
申请日：2004-04-07
申请人： PANAGENE INC
发明人： KIM SUNG KEE , LEE HYUNIL , LIM JONG CHAN , LEE SUNG HEE
IPC分类号： C07D413/12 , A61K31/496 , C07D263/46 , C07D271/10 , C07D271/113 , C07D417/02 , C07D417/12
摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is sulfur or oxygen; J is nitrogen or C-R'; R1, R' is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy or a functional group having one of following general formulae: wherein A 1 , A 2 , A 3 , A 4 , A 5 , is independently selected from H, halogen such as F, Cl, Br or I, CF 3 , alkyl, preferably C 1 -C 4 alkyl, nitro, nitrile, alkoxy, preferably C 1 -C 4 alkoxy, halogenated (such as F, Cl, Br and I) alkyl, preferably halogenated C 1 -C 4 alkyl, halogenated (such as F, Cl, Br and I) alkoxy, preferably halogenated C 1 -C 4 alkoxy, phenyl, and halogenated (such as F, Cl, Br and I phenyl; R2 is H or protected or unprotected side chain of natural or unnatural alpha-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

8. 发明专利

AU2003223014A1 PNA MONOMER AND PRECURSOR 未知
公开(公告)号：AU2003223014A1
公开(公告)日：2003-11-10
申请号：AU2003223014
申请日：2003-04-28
申请人： PANAGENE INC
发明人： KIM SUNG KEE , LEE HYUNIL , LIM JONG CHAN , CHOI HOON , JEON JAE HOON , AHN SANG YOUL , LEE SUNG HEE , YOON WON JUN
IPC分类号： C12N15/09 , A61K31/513 , A61K31/52 , C07D277/80 , C07D405/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D473/02 , C07D473/18 , C07D473/32 , C07D473/34 , C07D277/76 , C07D413/12 , C07D473/26
摘要： This application relates to monomers of the general formula (I) for the preparation PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: (I) wherein E is nitrogen or C-R'; J is sulfur or oxygen; R', R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural a-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

9. 发明专利

DK2174936T3 PNA-MONOMER OG PRÆKURSOR 未知
公开(公告)号：DK2174936T3
公开(公告)日：2013-11-04
申请号：DK09015826
申请日：2003-04-28
申请人： PANAGENE INC
发明人： KIM SUNG KEE , LEE HYUNIL , LIM JONG CHAN , CHOI HOON , JEON JAE HOON , LEE SUNG HEE , YOON WON JUN , AHN SANG YOUL
IPC分类号： C07D277/76 , C12N15/09 , A61K31/513 , A61K31/52 , A61K31/522 , A61P35/00 , C07D263/58 , C07D277/80 , C07D405/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D473/02 , C07D473/18 , C07D473/26 , C07D473/32 , C07D473/34

10. 发明专利

DE60330766D1 未知
公开(公告)号：DE60330766D1
公开(公告)日：2010-02-11
申请号：DE60330766
申请日：2003-04-28
申请人： PANAGENE INC
发明人： KIM SUNG KEE , LEE HYUNIL , LIM JONG CHAN , CHOI HOON , JEON JAE HOON , AHN SANG YOUL , LEE SUNG HEE , YOON WON JUN
IPC分类号： C07D277/76 , C12N15/09 , A61K31/513 , A61K31/52 , A61K31/522 , A61P35/00 , C07D263/58 , C07D277/80 , C07D405/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D473/02 , C07D473/18 , C07D473/26 , C07D473/32 , C07D473/34
摘要： This application relates to monomers of the general formula (I) for the preparation PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: (I) wherein E is nitrogen or C-R'; J is sulfur or oxygen; R', R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural a-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

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