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    • 1. 发明申请
    • Localized Chemical Microgradients
    • 本地化学微生物
    • US20140034498A1
    • 2014-02-06
    • US14056183
    • 2013-10-17
    • Mark C. PetermanDavid M. Bloom
    • Mark C. PetermanDavid M. Bloom
    • B01D57/02
    • B01D57/02G01N27/447
    • A device for creating microgradients in solution is disclosed. The device contains a microfluidic channel with openings at each end and two or more small apertures to a bath. Electrodes are placed in the openings at either end of the channel and an electrical power supply is connected to the electrodes. Several distinct current paths exist from one end of the channel to the other. For example current may flow from one electrode, through a portion of the channel, through an aperture into the bath, back through another aperture into the channel, and along another portion of the channel to the other electrode. Current flows along all possible connected paths when an electric field is applied along the channel and induces fluid flow into and out of the apertures in the channel. Fluid flow through the apertures results in the formation of microgradients in solution near the microfluidic channel device.
    • 公开了一种用于在溶液中产生微梯度的装置。 该装置包含在每个端部具有开口并且具有两个或更多个小孔的微流体通道。 电极放置在通道两端的开口处,电源连接到电极。 从通道的一端到另一端存在若干不同的电流路径。 例如,电流可以从一个电极流过通道的一部分,通过孔进入槽,通过另一个孔返回到通道中,并且沿通道的另一部分流向另一个电极。 当沿着通道施加电场并且使流体流入和流出通道中的孔时,电流沿着所有可能的连接路径流动。 通过孔的流体流动导致在微流体通道装置附近的溶液中形成微梯度。
    • 2. 发明授权
    • Localized chemical microgradients
    • 局部化学微生物
    • US08585881B2
    • 2013-11-19
    • US10711327
    • 2004-09-10
    • Mark C. PetermanDavid M. Bloom
    • Mark C. PetermanDavid M. Bloom
    • B01D57/02
    • B01D57/02G01N27/447
    • A device for creating microgradients in solution is disclosed. The device contains a microfluidic channel with openings at each end and two or more small apertures to a bath. Electrodes are placed in the openings at either end of the channel and an electrical power supply is connected to the electrodes. Several distinct current paths exist from one end of the channel to the other. For example current may flow from one electrode, through a portion of the channel, through an aperture into the bath, back through another aperture into the channel, and along another portion of the channel to the other electrode. Current flows along all possible connected paths when an electric field is applied along the channel and induces fluid flow into and out of the apertures in the channel. Fluid flow through the apertures results in the formation of microgradients in solution near the microfluidic channel device.
    • 公开了一种用于在溶液中产生微梯度的装置。 该装置包含在每个端部具有开口并且具有两个或更多个小孔的微流体通道。 电极放置在通道两端的开口处,电源连接到电极。 从通道的一端到另一端存在若干不同的电流路径。 例如,电流可以从一个电极流过通道的一部分,通过孔进入槽,通过另一个孔返回到通道中,并且沿通道的另一部分流向另一个电极。 当沿着通道施加电场并且使流体流入和流出通道中的孔时,电流沿着所有可能的连接路径流动。 通过孔的流体流动导致在微流体通道装置附近的溶液中形成微梯度。