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1. 发明授权

US07286277B2 Polarization light modulator 有权
标题翻译：极化光调制器
公开(公告)号：US07286277B2
公开(公告)日：2007-10-23
申请号：US11336277
申请日：2006-01-20
申请人： David M. Bloom , Mark C. Peterman
发明人： David M. Bloom , Mark C. Peterman
IPC分类号： G02F1/01
CPC分类号： G02B26/06 , G02B26/0808 , G02B26/0825 , G02B27/283
摘要： Polarization light modulators are based on an interferometric design in which a polarizing beam splitter serves as a polarizer and analyzer. A polarization displacement device shifts orthogonally polarized light beams parallel to the long axis of their elongated cross sections. Phase shifts are imparted to the orthogonally polarized beams by linear array MEMS optical phase shift devices. The output of the light modulator is a line image which may be scanned to form a two-dimensional image. Features to improve brightness, contrast and overall compactness of design are disclosed.
摘要翻译：偏振光调制器基于干涉测量设计，其中偏振分束器用作偏振器和分析器。偏振位移装置使平行于其细长截面的长轴的正交偏振光束移位。通过线性阵列MEMS光学相移装置将相移赋予正交偏振光束。光调制器的输出是可以被扫描以形成二维图像的线图像。公开了提高设计亮度，对比度和整体紧凑性的特征。

2. 发明申请

US20140034498A1 Localized Chemical Microgradients 审中-公开
标题翻译：本地化学微生物
公开(公告)号：US20140034498A1
公开(公告)日：2014-02-06
申请号：US14056183
申请日：2013-10-17
申请人： Mark C. Peterman , David M. Bloom
发明人： Mark C. Peterman , David M. Bloom
IPC分类号： B01D57/02
CPC分类号： B01D57/02 , G01N27/447
摘要： A device for creating microgradients in solution is disclosed. The device contains a microfluidic channel with openings at each end and two or more small apertures to a bath. Electrodes are placed in the openings at either end of the channel and an electrical power supply is connected to the electrodes. Several distinct current paths exist from one end of the channel to the other. For example current may flow from one electrode, through a portion of the channel, through an aperture into the bath, back through another aperture into the channel, and along another portion of the channel to the other electrode. Current flows along all possible connected paths when an electric field is applied along the channel and induces fluid flow into and out of the apertures in the channel. Fluid flow through the apertures results in the formation of microgradients in solution near the microfluidic channel device.
摘要翻译：公开了一种用于在溶液中产生微梯度的装置。该装置包含在每个端部具有开口并且具有两个或更多个小孔的微流体通道。电极放置在通道两端的开口处，电源连接到电极。从通道的一端到另一端存在若干不同的电流路径。例如，电流可以从一个电极流过通道的一部分，通过孔进入槽，通过另一个孔返回到通道中，并且沿通道的另一部分流向另一个电极。当沿着通道施加电场并且使流体流入和流出通道中的孔时，电流沿着所有可能的连接路径流动。通过孔的流体流动导致在微流体通道装置附近的溶液中形成微梯度。

3. 发明申请

US20080258036A1 SYSTEM FOR DIMENSIONAL STABILITY OF ELASTOMERIC MICRODEVICES 审中-公开
标题翻译：弹性微结构的尺寸稳定性系统
公开(公告)号：US20080258036A1
公开(公告)日：2008-10-23
申请号：US12058702
申请日：2008-03-29
申请人： Mark C. Peterman
发明人： Mark C. Peterman
IPC分类号： B29C39/40
CPC分类号： B29C39/40
摘要： Disclosed is a fixture device for maintaining fabrication of precise elastomeric microdevices. The fixture may be used to maintain dimensional stability of elastomeric devices during temperature cycling. Furthermore, the fixture may be used to control geometry during temperature cycling due to thermal curing. The fixture may be loaded into equipment for precise alignment and assembly of elastomeric devices. The fixture is particularly useful for building precise microdevices from polymeric or elastomeric materials.
摘要翻译：公开了一种用于维持精密弹性微型装置的制造的固定装置。固定装置可用于在温度循环期间维持弹性体装置的尺寸稳定性。此外，固定装置可用于控制由于热固化而在温度循环期间的几何形状。夹具可以装载到设备中，用于精确对准和组装弹性体装置。该固定装置特别适用于从聚合物或弹性体材料构建精密微型装置。

4. 发明授权

US07382449B2 Alignment tool for precise pattern transfer 失效
标题翻译：校准工具，用于精确的图案转移
公开(公告)号：US07382449B2
公开(公告)日：2008-06-03
申请号：US10905210
申请日：2004-12-21
申请人： Mark C. Peterman , David M. Bloom
发明人： Mark C. Peterman , David M. Bloom
IPC分类号： G01C1/06
CPC分类号： G03F9/7034 , G02B21/0024 , G02B21/26 , G03F9/7026 , G03F9/7042 , G03F9/7088
摘要： Multi-point confocal microscopy, bright field microscope imaging, computer-controlled positioning stages, and an algorithm for automated leveling are the basis for a powerful but simple tool for aligning stamps used in precise pattern transfer to substrates. The system is relatively inexpensive and brings a capability similar to that of a photolithographic mask aligner to the world of elastomeric-stamp-based lithography. Alignment of the stamp and substrate is possible without contact between the two before printing.
摘要翻译：多点共聚焦显微镜，明视野显微镜成像，计算机控制定位阶段和自动调平算法是用于将精确图案转印到基板上使用的标记对齐的强大而简单的工具的基础。该系统相对便宜，并且具有与光刻掩模对准器类似的功能，适用于基于弹性体印记的光刻领域。在打印之前，印模和基板的对准可以在两者之间没有接触。

5. 发明授权

US07147865B2 Artificial synapse chip 失效
标题翻译：人工突触芯片
公开(公告)号：US07147865B2
公开(公告)日：2006-12-12
申请号：US10713565
申请日：2003-11-13
申请人： Harvey A. Fishman , David Bloom , Stacey F. Bent , Mark C. Peterman , Jaan Noolandi , Neville Mehenti
发明人： Harvey A. Fishman , David Bloom , Stacey F. Bent , Mark C. Peterman , Jaan Noolandi , Neville Mehenti
IPC分类号： A61F2/14
CPC分类号： G06N3/061 , A61N1/0543 , A61N1/30 , A61N1/326 , A61N1/36046 , C12N5/0619 , C12N2503/00 , C12N2535/10
摘要： Devices and methods are provided for administering a fluid to a neuronal site. The device comprises a reservoir, an aperture in fluid connection to the reservoir, and electrical means for moving to the fluid to or through the aperture. The electrical means may take the form of electroosmotic force, piezoelectric movement of a diaphragm or electrolysis of a solution. The electrical means may be external to the host, implanted in the host or may be photodiodes activated by light, particularly where the neuronal site is associated with the retina.
摘要翻译：提供了用于向神经元部位施用流体的装置和方法。该装置包括储存器，与储存器流体连接的孔，以及用于将流体移动到或穿过孔的电气装置。电气装置可以采取电渗力的形式，隔膜的压电运动或溶液的电解。电气装置可以在宿主外部，植入宿主中，或者可以是由光激活的光电二极管，特别是在神经元部位与视网膜相关联的地方。

6. 发明授权

US07001608B2 Artificial synapse chip interface for electronic prosthetic retina 失效
公开(公告)号：US07001608B2
公开(公告)日：2006-02-21
申请号：US10184210
申请日：2002-06-27
申请人： Harvey A. Fishman , Mark Blumenkranz , Stacey F. Bent , David M. Bloom , Mark C. Peterman
发明人： Harvey A. Fishman , Mark Blumenkranz , Stacey F. Bent , David M. Bloom , Mark C. Peterman
IPC分类号： A61F2/14
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/326 , C12M35/00 , C12M35/02 , C12M35/08 , C12N5/0619 , C12N2503/00 , C12N2535/10
摘要： The invention provides microfabricated devices and methods for directing the growth of a cell process to form an artificial synapse. The devices are called artificial synapse chips. The artificial synapse comprises a nanofabricated aperture (about 50–100 nm in size) that connects the cell process to a chemical or electrical means of neuronal excitation. Such an aperture width mimics the length scales of a natural synapse and thus emphasizes the localized spatial relationship between a neuron and a stimulation source. The invention further provides devices and methods for regenerating a nerve fiber into an electrode. The invention thus provides a regeneration electrode that uses a novel neural interface for stimulation and that uses novel surface methods for directing neuronal growth making possible in vivo connection of the devices to neural circuitry in a retina and other anatomical locations.

7. 发明授权

US08585881B2 Localized chemical microgradients 有权
标题翻译：局部化学微生物
公开(公告)号：US08585881B2
公开(公告)日：2013-11-19
申请号：US10711327
申请日：2004-09-10
申请人： Mark C. Peterman , David M. Bloom
发明人： Mark C. Peterman , David M. Bloom
IPC分类号： B01D57/02
CPC分类号： B01D57/02 , G01N27/447
摘要： A device for creating microgradients in solution is disclosed. The device contains a microfluidic channel with openings at each end and two or more small apertures to a bath. Electrodes are placed in the openings at either end of the channel and an electrical power supply is connected to the electrodes. Several distinct current paths exist from one end of the channel to the other. For example current may flow from one electrode, through a portion of the channel, through an aperture into the bath, back through another aperture into the channel, and along another portion of the channel to the other electrode. Current flows along all possible connected paths when an electric field is applied along the channel and induces fluid flow into and out of the apertures in the channel. Fluid flow through the apertures results in the formation of microgradients in solution near the microfluidic channel device.
摘要翻译：公开了一种用于在溶液中产生微梯度的装置。该装置包含在每个端部具有开口并且具有两个或更多个小孔的微流体通道。电极放置在通道两端的开口处，电源连接到电极。从通道的一端到另一端存在若干不同的电流路径。例如，电流可以从一个电极流过通道的一部分，通过孔进入槽，通过另一个孔返回到通道中，并且沿通道的另一部分流向另一个电极。当沿着通道施加电场并且使流体流入和流出通道中的孔时，电流沿着所有可能的连接路径流动。通过孔的流体流动导致在微流体通道装置附近的溶液中形成微梯度。

8. 发明授权

US08702976B2 Hand-held microfluidic testing device 有权
标题翻译：手持式微流体检测装置
公开(公告)号：US08702976B2
公开(公告)日：2014-04-22
申请号：US12589365
申请日：2009-10-21
申请人： Mark C. Peterman
发明人： Mark C. Peterman
IPC分类号： B01D35/30 , B01D43/00 , G01J3/44
CPC分类号： G01N27/44704 , B01L3/502761 , B01L2200/0652 , B01L2300/0636 , B01L2300/0654 , B01L2300/0681 , B01L2300/0867 , B01L2300/087 , B01L2400/0418 , B01L2400/0421 , B01L2400/0481 , B01L2400/0487 , G01N27/44791 , G01N30/6065 , G01N30/6095 , G01N2030/0095
摘要： A hand-held microfluidic testing device is provided. The testing device includes a housing having at least one cartridge receiving port and at least one cartridge for inputting to the cartridge receiving port, and an optical detection system in the housing, where the optical detection system is disposed to analyze at least one sample in the in at least one detection channel of the cartridge. The cartridge includes at least one sample inlet and sample outlet, at least one buffer inlet and buffer outlet, at least one detection material inlet and outlet, at least one calibration standard inlet and calibration standard outlet and a detection window disposed above a detection region of a channel, where the analysis cartridge is surrounded by a protective shell, that holds the analysis chip base, a chip lid, a sealing gasket, and protective film cover.
摘要翻译：提供手持式微流体测试装置。测试装置包括具有至少一个盒接收端口的壳体和用于输入到盒接收端口的至少一个盒，以及壳体中的光学检测系统，其中设置光学检测系统以分析至少一个样品在盒的至少一个检测通道中。所述筒包括至少一个样品入口和样品出口，至少一个缓冲入口和缓冲出口，至少一个检测材料入口和出口，至少一个校准标准入口和校准标准出口以及设置在分析盒被保护壳围绕的通道，其保持分析芯片基座，芯片盖，密封垫圈和保护膜盖。

9. 发明申请

US20100300883A1 Microfluidic separation device 失效
标题翻译：微流控分离装置
公开(公告)号：US20100300883A1
公开(公告)日：2010-12-02
申请号：US12455256
申请日：2009-05-29
申请人： Mark C. Peterman
发明人： Mark C. Peterman
IPC分类号： B01D57/02 , G01N33/00
CPC分类号： B01D61/427 , B01D57/02 , G01N21/658
摘要： A microfluidic separation device is provided that includes a sample channel having a first sample channel region and a second sample channel region, where a cross-section of the first sample channel region is smaller than a cross-section of the second sample channel region. The invention further includes a detection region having a first detection region and a second detection region, where a cross-section of the first detection region is larger than a cross-section of the second detection region and the second sample channel region is connected to the first detection region. Additionally, the invention includes a marker input channel disposed to input markers into the second sample channel region, where the markers are larger than the cross-section of the first sample channel region and the cross-section of the second detection region, where the markers collect in the first detection region.
摘要翻译：提供一种微流体分离装置，其包括具有第一样品通道区域和第二样品通道区域的样品通道，其中第一样品通道区域的横截面小于第二样品通道区域的横截面。本发明还包括具有第一检测区域和第二检测区域的检测区域，其中第一检测区域的横截面大于第二检测区域的横截面，并且第二样品通道区域连接到第二检测区域第一检测区域。另外，本发明包括标记输入通道，其设置成将标记输入到第二样品通道区域中，其中标记大于第一样品通道区域的横截面和第二检测区域的横截面，其中标记收集在第一个检测区域。

10. 外观设计

USD787560S1 Handheld solid-phase extraction vacuum pump 有权
公开(公告)号：USD787560S1
公开(公告)日：2017-05-23
申请号：US29534445
申请日：2015-07-28
申请人： Mark C. Peterman , Leo Lopez
设计人： Mark C. Peterman , Leo Lopez

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