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1. 发明申请

WO2020183232A1 METHOD FOR PICKLING MARINE PRODUCT, PICKLED MARINE PRODUCT AND PICKLING SOLUTION 审中-公开
公开(公告)号：WO2020183232A1
公开(公告)日：2020-09-17
申请号：PCT/IB2020/000068
申请日：2020-02-03
申请人： NIPPON SUISAN KAISHA, LTD.
发明人： MORI, Takashi , INOHARA, Kota , TAKAHASHI, Akiko , SUGIYAMA, Kiminori
IPC分类号： A23B4/023 , A23L17/40 , A23L17/50 , A23L17/00
摘要： Object: Provided is a pickling method that has little influence on the original taste and texture of marine products and suppresses drip during freezing and heating. Solution: A method for pickling a marine product under conditions satisfying the following a) to c): a) the total ionic strength during treatment is from 0.2 to 0.8 mol/kg; b) the total sodium chloride concentration is less than 1.5% by weight; and c) the pH of the pickled shrimp meat is from 6.5 to 8.6, where, the total ionic strength and total sodium chloride concentration mean the ionic strength and the sodium chloride concentration with respect to the sum of the weight of the marine products and the weight of the water of the pickling solution, assuming that the weight of the marine products is the weight of water.

2. 发明申请

WO1998027978A1 DERMATOLOGIC PREPARATION 审中-公开
标题翻译：精神准备
公开(公告)号：WO1998027978A1
公开(公告)日：1998-07-02
申请号：PCT/JP1997004680
申请日：1997-12-18
申请人： NIPPON SUISAN KAISHA, LTD. , IMAI, Yukie , DOISAKI, Nobushige , SHIMIZU, Nobuyoshi
发明人： NIPPON SUISAN KAISHA, LTD.
IPC分类号： A61K31/23
CPC分类号： A61K8/375 , A61K31/232 , A61Q19/00
摘要： A dermatologic preparation which is reduced in side effects, has excellent percutaneous absorbability, and contains as the active ingredient an unsaturated fatty acid, which is a triglyceride represented by general formula (1), wherein one or two R1, R2, and R3 each represents a residue of a long-chain unsaturated fatty acid and the remainder represent(s) residue(s) of a medium-chain fatty acid. The triglyceride is preferably represented by formula (1) wherein one of R1, R2, and R3 represents a residue of a long-chain unsaturated fatty acid and the remainder represent(s) residue(s) of a medium-chain fatty acid. The long-chain unsaturated fatty acid is selected from the group consisting of eicosapentaenoic acid, docosahexaenoic acid, docosapentaneoic acid, arachidonic acid, alpha -linolenic acid, gamma -linolenic acid, linoleic acid, and dihomo- gamma -linolenic acid. The most desirable is the eicosapentaenoic acid residue or docosahexaenoic acid residue. The triglyceride is one obtained from a long-chain unsaturated fatty acid and/or a derivative thereof each having a purity of preferably 90 % or higher, more preferably 95 % or higher.
摘要翻译：减少副作用的皮肤病学制剂具有优异的经皮吸收性，并且含有作为活性成分的不饱和脂肪酸，其是由通式（1）表示的甘油三酯，其中一个或两个R 1，R 2和R 3各自表示长链不饱和脂肪酸的残基，其余表示中链脂肪酸的残基。甘油三酸酯优选由式（1）表示，其中R 1，R 2和R 3中的一个表示长链不饱和脂肪酸的残基，其余表示中链脂肪酸的残基。长链不饱和脂肪酸选自二十碳五烯酸，二十二碳六烯酸，二十二碳烯酸，花生四烯酸，α-亚麻酸，γ-亚麻酸，亚油酸和二 - γ-亚麻酸。最需要的是二十碳五烯酸残基或二十二碳六烯酸残基。甘油三酯是从纯度优选为90％以上，更优选为95％以上的长链不饱和脂肪酸和/或其衍生物得到的甘油三酸酯。

3. 发明申请

WO1997035970A1 OLIGONUCLEOTIDES USED FOR DETECTING VIBRIO PARAHAEMOLYTICUS AND METHOD OF DETECTION THEREWITH 审中-公开
标题翻译：用于检测抗生素分析物的寡核苷酸及其检测方法
公开(公告)号：WO1997035970A1
公开(公告)日：1997-10-02
申请号：PCT/JP1997000991
申请日：1997-03-25
申请人： NIPPON SUISAN KAISHA, LTD. , KASTHURI, Venkateswaran , DOUMOTO, Nobuhiko
发明人： NIPPON SUISAN KAISHA, LTD.
IPC分类号： C12N15/11
CPC分类号： C12Q1/689 , C12N9/00 , C12N9/90 , Y02A50/451
摘要： An oligonucleotide having a nucleic acid sequence derived from SEQ ID NO:1 and at least one site capable of amplifying a nucleic acid sequence characteristic of Vibrio parahaemolyticus; the above oligonucleotide having a nucleic acid sequence unavailable from SEQ ID NO:3; the above oligonucleotide incapable of amplifying nucleic acid sequences originating in Vibrio alginolyticus and Vibrio harvei; the above oligonucleotide represented by the sequence of CGG CGT GGG TGT TTC GGT AGT or TCC GCT TCG CGC TCA TCA ATA; and a method of detecting Vibrio parahaemolyticus by preparing a primer set comprising two of the above oligonucleotides, selectively amplifying therewith a DNA gyrase subunit B gene sequence contained in a specimen as a target, and determining whether or not there is a gyrB unit specific for Vibrio parahaemolyticus in the specimen. This method has made it possible to provide a primer which specifically reacts with a gyrB gene of Vibrio parahaemolyticus to thereby differentiate and identify the same among other vibrios and strains other than the genus Vibrio. The primer specific for Vibrio parahaemolyticus serves to detect 285-bp gyrB gene fragments specific for this vibrio by the PCR method without the necessity for DNA extraction or like operations from bacterial cells.
摘要翻译：具有源自SEQ ID NO：1的核酸序列的寡核苷酸和能够扩增副溶血弧菌特征的核酸序列的至少一个位点; 上述寡核苷酸具有不可用于SEQ ID NO：3的核酸序列; 上述寡核苷酸不能扩增源自解酒弧菌和弧菌弧菌的核酸序列; 由CGG CGT GGG TGT TTC GGT AGT或TCC GCT TCG CGC TCA TCA ATA的序列表示的上述寡核苷酸; 以及通过制备包含两个上述寡核苷酸的引物组来检测副溶血性弧菌的方法，以包含在试样中的DNA促旋酶亚基B基因序列作为目标选择性地扩增，并确定是否存在对弧菌特异性的gyrB单位样本中的副溶血弧菌该方法使得可以提供与副溶血弧菌的gyrB基因特异性反应的引物，从而在弧菌弧菌以外的其他弧菌和菌株之间进行区分和鉴别。副溶血弧菌特异性的引物用于通过PCR方法检测对该弧菌特异性的285bp的gyrB基因片段，而不需要从细菌细胞进行DNA提取或类似操作。

4. 发明申请

WO1996010021A1 NOVEL ANTIOXIDANT TRICYCLIC FUSED HETEROCYCLIC COMPOUND 审中-公开
标题翻译：新型抗氧化剂三聚体熔融杂环化合物
公开(公告)号：WO1996010021A1
公开(公告)日：1996-04-04
申请号：PCT/JP1995001975
申请日：1995-09-28
申请人： NIPPON SUISAN KAISHA, LTD. , JINNO, Shuji , KOGURE, Yasuyo , ONUKI, Hiroyuki , OKITA, Takaaki
发明人： NIPPON SUISAN KAISHA, LTD.
IPC分类号： C07D313/14
CPC分类号： C07D493/04 , C07D313/14 , C07D337/14
摘要： A novel antioxidant tricyclic fused heterocyclic compound represented by general formula (2) and a salt thereof (wherein X-Y represents CH2-C=O, CH2-CH2 or CH=CH; Z represents O, S or S=O; and R1 to R8 represent each hydrogen, hydroxy, halogeno, lower alkyl, lower alkoxy, lower alkyl ketone or CF3, provided at least two groups among R1, R2, R3 and R4 represent each hydroxy). This compound has an antioxidant activity at least equivalent to that of alpha -tocopherol, and so is promising as a remedy for various diseases wherein in vivo lipid peroxides participate, such as cancer, arteriosclerotic diseases and liver diseases. It is also expected to be applicable to the preparation of cosmetics and chemicals.
摘要翻译：一种由通式（2）表示的新型抗氧化剂三环稠合杂环化合物及其盐（其中XY表示CH2-C = O，CH2-CH2或CH = CH; Z表示O，S或S = O; R1至R8 代表每个氢，羟基，卤代，低级烷基，低级烷氧基，低级烷基酮或CF 3，其中R1，R2，R3和R4中至少有两个代表每个羟基）。该化合物的抗氧化活性至少等于α-生育酚的抗氧化活性，因此作为对体内脂质过氧化物参与的各种疾病如癌症，动脉硬化疾病和肝脏疾病的治疗有希望。预计也适用于化妆品和化学品的制备。

5. 发明申请

WO2015027463A1 AGENTS FOR PREVENTING OR TREATING ALCOHOLIC FATTY LIVER 审中-公开
标题翻译：用于预防或治疗酒精性脂肪肝的药剂
公开(公告)号：WO2015027463A1
公开(公告)日：2015-03-05
申请号：PCT/CN2013/082664
申请日：2013-08-30
申请人： NIPPON SUISAN KAISHA, LTD.
发明人： HAN, Li , TSUJI, Tomoko , ZUO, Conglin , GUO, Maowu , WANG, Hongling , LIAO, Qin
IPC分类号： A61K31/22 , A61K31/201 , A61K31/202 , A61P1/16
CPC分类号： A61K31/201 , A61K31/202 , A61K31/685
摘要： Compositions that have efficacy for preventing and treating alcoholic fatty liver and which are highly safe to use are provided. The compositions can be used as agents for preventing or treating alcoholic fatty liver in which phospholipids that contain highly unsaturated fatty acids as constituent fatty acids, in particular krill oil, are contained as an active ingredient. The daily intake of krill oil is preferably in the range of 1 to 100 mg/kg body weight.
摘要翻译：提供了具有预防和治疗酒精性脂肪肝功效并且具有高度安全性的组合物。该组合物可用作预防或治疗含有高度不饱和脂肪酸作为构成脂肪酸的磷脂，特别是磷虾油的酒精性脂肪肝作为活性成分的药剂。磷虾油的每日摄入量优选为1〜100mg / kg体重。

6. 发明申请

WO2012043826A1 METHOD FOR TRANSFORMATION OF STRAMENOPILE 审中-公开
标题翻译： STRAMENOPILE转化方法
公开(公告)号：WO2012043826A1
公开(公告)日：2012-04-05
申请号：PCT/JP2011072650
申请日：2011-09-30
申请人： UNIV KYUSHU NAT UNIV CORP , UNIV MIYAZAKI , KONAN GAKUEN , NIPPON SUISAN KAISHA LTD , SAKAGUCHI KEISHI , HAMAGUCHI RIE , MATSUDA TAKANORI , ITO MAKOTO , NAGANO NAOKI , HAYASHI MASAHIRO , HONDA DAISUKE , OKITA YUJI , SUGIMOTO SHINICHI
发明人： SAKAGUCHI KEISHI , HAMAGUCHI RIE , MATSUDA TAKANORI , ITO MAKOTO , NAGANO NAOKI , HAYASHI MASAHIRO , HONDA DAISUKE , OKITA YUJI , SUGIMOTO SHINICHI
IPC分类号： C12N1/15 , C12N9/02 , C12N9/10 , C12N15/09 , C12P7/64
CPC分类号： C12N15/79 , C12N9/0071 , C12N9/0083 , C12N9/1029 , C12N15/113 , C12N15/52 , C12N15/895 , C12N2310/11 , C12N2310/14 , C12P7/6409 , C12P7/6427 , C12P7/6472 , C12Y114/19001 , C12Y114/19006 , C12Y203/01119
摘要： [Problem] To provide a transformation method for producing a stramenopile organism having an improved unsaturated fatty acid production capability by disrupting a gene of the stramenopile organism or inhibiting the expression of the gene in a genetically engineering manner. [Solution] A method for transforming a stramenopile organism, which comprises disrupting a gene of the stramenopile organism or inhibiting the expression of the gene in a genetically engineering manner, and which is characterized in that the stramenopile organism is selected from Thraustochytrium aureum, Parietichytrium sarkarianum, Thraustochytrium roseum and Parietichytrium sp. and the gene to be disrupted or of which the expression is to be inhibited is a gene associated with the biosynthesis of a fatty acid.
摘要翻译：本发明提供一种通过破坏嗜热原性杆菌生物的基因或以基因工程方式抑制基因表达而生产具有改善的不饱和脂肪酸生产能力的原生藻菌生物的转化方法。一种转化原生难菌生物体的方法，其包括以基因工程方式破坏原生难菌生物体的基因或抑制该基因的表达，并且其特征在于该原生藻体选自金黄色破囊壶菌（Thraustochytrium aureum），Parietichytrium sarkarianum ，破囊壶菌（Thraustochytrium roseum）和Parietichytrium sp。并且待破坏的基因或表达待抑制的基因是与脂肪酸的生物合成有关的基因。

7. 发明申请

WO1998016119A1 EDIBLE FATS CONTAINING ARACHIDONIC ACID AND FOODS CONTAINING THE SAME 审中-公开
标题翻译：含有芳香酸的食用脂肪和含有它的食物
公开(公告)号：WO1998016119A1
公开(公告)日：1998-04-23
申请号：PCT/JP1997003631
申请日：1997-10-09
申请人： SUNTORY LIMITED , NIPPON SUISAN KAISHA, LTD. , HIGASHIYAMA, Kenichi , AKIMOTO, Kengo , SHIMIZU, Sakayu , DOISAKI, Nobushige , FURIHATA, Kiyomi
发明人： SUNTORY LIMITED , NIPPON SUISAN KAISHA, LTD.
IPC分类号： A23D09/007
CPC分类号： A23D9/00 , A23L33/12 , A23L33/40 , A23V2002/00 , A23V2250/1862
摘要： Edible fats containing arachidonic acid obtained from microorganisms belonging to the subgenus Mortierella of the genus Mortierella and being capable of producing arachidonic acid, containing little unsaponified matters and, above all, the smallest possible amount of cyclopropane sterols which have never been eaten, and being suitable for the production of foods, in particular, modified milks for infants. The fats contain not more than 0.8 % by weight, preferably not more than 0.6 % by weight of unsaponified matters and 20 % by weight or more of arachidonic acid originating in microorganisms. Further, these fats contain not more than 0.3 % by weight, preferably not more than 0.15 % by weight of 24,25-methylenecholest-5-en-3 beta -ol. The microorganisms are those belonging to the subgenus Mortierella of the genus Mortierella and being capable of producing arachidonic acid. These microorganisms belong to the species alpina of the genus Mortierella. The foods include modified milks for premature infants, modified milks for infants, foods for infants, and foods for pregnant women and nursing mothers containing the above-mentioned edible fats.
摘要翻译：含有花生四烯酸的食用脂肪，其由属于被孢霉属的被孢霉属亚属的微生物获得，并且能够产生花生四烯酸，其含有很少未皂化的物质，并且最重要的是最少可能用量的未被食用的环丙烷甾醇，并且是合适的用于生产食品，特别是婴儿的改良乳。脂肪含有不超过0.8重量％，优选不超过0.6重量％的未皂化物质和20重量％以上来源于微生物的花生四烯酸。此外，这些脂肪含有不多于0.3重量％，优选不超过0.15重量％的24,25-亚甲基胆甾-5-烯-3β-醇。这些微生物属于被孢霉属的被孢霉属亚属属，并且能够产生花生四烯酸。这些微生物属于被孢霉属的alpina属。这些食物包括早产儿改良奶，婴幼儿改良乳，婴幼儿食品，孕妇食品和含有上述食用脂肪的哺乳母亲。

8. 发明申请

WO1997026239A1 VINYL MONOMERS HAVING POLYENIC SIDE CHAINS DERIVED FROM HIGHLY UNSATURATED FATTY ACIDS AND DERIVATIVES THEREOF, AND POLYMERS OF SAID MONOMERS 审中-公开
标题翻译：具有由高度不饱和脂肪酸及其衍生物衍生的多元醇链的乙烯基单体和同类单体的聚合物
公开(公告)号：WO1997026239A1
公开(公告)日：1997-07-24
申请号：PCT/JP1997000068
申请日：1997-01-16
申请人： NIPPON SUISAN KAISHA, LTD. , DOISAKI, Nobushige , JINNO, Shuji , HATA, Kazuhiko , ENDO, Takeshi
发明人： NIPPON SUISAN KAISHA, LTD.
IPC分类号： C07C69/587
CPC分类号： C08F20/40 , C07C69/54 , C07C69/587
摘要： Vinyl monomers having polyenic side chains derived from highly unsaturated fatty acids represented by general formula: R1COOH (wherein R1 is a C9-C25 hydrocarbyl having 3 to 6 unsaturated bonds) and derivatives thereof. Such a vinyl monomer can be prepared by, e.g., reducing docosahexaenoic acid (DHA) into an alcohol either directly or through several reaction steps and reacting the alcohol with acryloyl chloride. These vinyl monomers can be polymerized by the use of various polymerization initiators. Alternatively, they can also be copolymerized with other monomers. Thus the present invention provides vinyl monomers having polyenic side chains derived from highly unsaturated fatty acids and polymers thereof; polymers having, in the side chains, double bonds into which various functional groups can be introduced; and a useful method for utilizing the fatty acid esters remaining as the residue in the distillation of fish oils.
摘要翻译：具有由通式R 1 COOH（其中R 1是具有3〜6个不饱和键的C 9 -C 25烃基）表示的高度不饱和脂肪酸衍生的多烯侧链的乙烯基单体及其衍生物。这样的乙烯基单体可以通过例如直接或通过几个反应步骤将二十二碳六烯酸（DHA）还原成醇来制备，并使醇与丙烯酰氯反应。这些乙烯基单体可以通过使用各种聚合引发剂进行聚合。或者，它们也可以与其它单体共聚。因此，本发明提供了具有衍生自高度不饱和脂肪酸的多元侧链的乙烯基单体及其聚合物; 在侧链中可以引入各种官能团的双键; 以及在蒸馏鱼油中利用剩余的剩余脂肪酸酯的有用方法。

9. 发明申请

WO1996025926A1 GLUTAMIC ACID RECEPTOR AGONIST 审中-公开
标题翻译：谷氨酸受体激动剂
公开(公告)号：WO1996025926A1
公开(公告)日：1996-08-29
申请号：PCT/JP1996000379
申请日：1996-02-20
申请人： NIPPON SUISAN KAISHA, LTD. , TAKEO, Jiro , YAMASHITA, Shinya , WADA, Keiji , CHIBA, Yoshiyuki
发明人： NIPPON SUISAN KAISHA, LTD.
IPC分类号： A61K31/18
CPC分类号： C07C323/62 , A61K31/00 , A61K31/18 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/4035 , A61K31/4406 , C07C317/28 , C07C323/49 , C07C323/56
摘要： A glutamic acid receptor agonist which comprises as the active ingredient sulfonamide derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof wherein A represents naphthyl, pyridyl, phenyl optionally having 1 to 5 substituents selected from the group consisting of halogeno, C1-4 alkyl, C1-4 alkoxy, nitro and acetamido, or C1-20 alkyl; B represents C1-3 alkylene, -OCH2- or -CH=CH-; X and Y are the same or different and each represents hydrogen or fluoro; R represents carboxy, C2-5 alkoxycarbonyl, hydroxymethyl or (a) (wherein R represents hydrogen or C1-3 alkyl; and R2 represents hydrogen, hydroxy, C1-3 alkyl, carboxymethyl or C3-6 alkoxycarbonyl); m represents an integer of 0 to 2 and n represents an integer of 0 to 3. The agonist is efficatious in the prevention and treatment of nerve degeneration in morbid conditions.
摘要翻译：一种谷氨酸受体激动剂，其包含作为活性成分的通式（I）表示的磺酰胺衍生物或其药学上可接受的盐，其中A表示萘基，吡啶基，任选具有1至5个选自卤代，C 1-4 烷基，C 1-4烷氧基，硝基和乙酰氨基，或C 1-20烷基; B表示C 1-3亚烷基，-OCH 2 - 或-CH = CH-; X和Y相同或不同，各自表示氢或氟; R表示羧基，C 2-5烷氧基羰基，羟甲基或（a）（其中R 1表示氢或C 1-3烷基; R 2表示氢，羟基，C 1-3烷基，羧甲基或C 3-6烷氧基羰基）。 m表示0〜2的整数，n表示0〜3的整数。激动剂在预防和治疗病态中的神经变性方面是有效的。

10. 发明申请

WO2012103692A1 SEXUAL FUNCTION IMPROVING AGENT 审中-公开
标题翻译：性能改善剂
公开(公告)号：WO2012103692A1
公开(公告)日：2012-08-09
申请号：PCT/CN2011/073528
申请日：2011-04-29
申请人： NIPPON SUISAN KAISHA, LTD. , HAN, Li , TSUJI, Tomoko , LI, Pengtao , WANG, Jun , LEI, Hongtao
发明人： HAN, Li , TSUJI, Tomoko , LI, Pengtao , WANG, Jun , LEI, Hongtao
IPC分类号： A61K31/683 , A61K31/685 , A61K31/202 , A61K35/56 , A61P15/00
CPC分类号： A61K31/685 , A23J7/00 , A23L33/115 , A61K31/202 , A61K31/661 , A61K31/683 , A61K35/612
摘要： A sexual function improving agent contains a lipid as an active ingredient, which includes a highly unsaturated fatty acid as a constituent fatty acid.
摘要翻译：性功能改善剂含有脂质作为活性成分，其包括高度不饱和脂肪酸作为构成脂肪酸。

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