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1. 发明授权

US5106793A Process for the hot isostatic compression of silicon nitride bodies reinforced with carbide fibres and carbide whiskers 失效
标题翻译：用碳化硅纤维和碳化钨加固的硅氮化物体的热稳态压缩方法
公开(公告)号：US5106793A
公开(公告)日：1992-04-21
申请号：US399504
申请日：1989-09-11
申请人： Peter Greil , Klaus Nickel , Michael Hoffmann , Gunter Petzow
发明人： Peter Greil , Klaus Nickel , Michael Hoffmann , Gunter Petzow
IPC分类号： C04B35/584 , C04B35/593 , C04B35/645 , C04B35/80
CPC分类号： C04B35/806 , C04B35/6455
摘要： Carbide fiber- and carbide whisker-strengthened silicon nitride bodies are hot-isostatic pressed without encapsulation of the pressureless pre-sintered formed body at temperature between 1000.degree. and 3000.degree. C. in a nitrogen-protective gas atmosphere. At a low nitrogen partial pressure but high total gas pressure, a maximum consolidation can be achieved already at relatively low temperatures without destruction of the carbide fibers or carbide whiskers.
摘要翻译： PCT No.PCT / EP88 / 00205 Sec。 371日期1989年9月11日 102（e）日期1989年9月11日PCT提交1988年3月15日PCT公布。出版物WO88 / 07029 日期：1988年9月22日。碳氮化硅碳化硅碳化物体在氮保护气体气氛中在1000〜3000℃的温度下不经无压预烧结体体积而进行热等静压。在低氮分压但总气体压力高的情况下，可以在相对较低的温度下实现最大的固结，而不会破坏碳化物纤维或碳化物晶须。

2. 发明授权

US4908241A Process for the currentless deposition of electropositive metal layers on the surfaces of less electropositive metals 失效
标题翻译：在正电性较小的金属表面上无电沉积正电性金属层的方法
公开(公告)号：US4908241A
公开(公告)日：1990-03-13
申请号：US222386
申请日：1988-07-21
申请人： Helmut Quast , Johannes Raber , Walter Ott , Hans-Georg von Schnering , Karl Peters
发明人： Helmut Quast , Johannes Raber , Walter Ott , Hans-Georg von Schnering , Karl Peters
IPC分类号： C23C18/38 , C23C18/40 , C23C18/42 , C23C18/44
CPC分类号： C23C18/42 , C23C18/38
摘要： The present invention provides a process for the currentless deposition oflectropositive metal layers on to appropriate less electropositive metals by contacting an object to be coated with a coating bath, wherein a coating bath is used which contains a metal complex obtained by reacting a monovalent electropositive metal halide with a base, which is capable of complex formation with the electropositive metal, and a hydrohalic acid.The present invention also provides a coating bath for the currentless deposition of electropositive metal layers on to less electropositive metals, wherein said bath contains an electropositive metal complex obtained by reacting a monovalent electropositive metal halide with a base which is capable of complex formation with the electropositive metal and a hydrohalic acid.Furthermore, the present invention provides an electropositive metal complex, obtainable by the reaction of a monovalent electropositive metal halide with a base which is capable of complex formation with the electropositive metal and a hydrohalic acid, followed by precipitation from the reaction mixture.
摘要翻译：本发明提供了一种通过使待涂覆物体与涂层浴接触而使正电性金属层无电沉积到适当的少正电性金属的方法，其中使用包含通过使单价正电性金属具有能与正电性金属复合形成的碱的卤化物和氢卤酸。本发明还提供了一种用于将正电性金属层无电沉积至较少正电性金属的涂层浴，其中所述浴含有通过使正电性金属卤化物与能够与正电性复合形成的碱反应获得的正电性金属络合物金属和氢卤酸。此外，本发明提供一种正电性金属络合物，其可以通过使一价正电性金属卤化物与能与正电性金属和氢卤酸形成复合物的碱反应，然后从反应混合物中沉淀而得到。

3. 发明授权

US4798800A Process for isolating human globular domain NC1 of basal membrane collagen from human tissue 失效
标题翻译：从人体组织中分离基底膜胶原的人球状结构域NC1的方法
公开(公告)号：US4798800A
公开(公告)日：1989-01-17
申请号：US664538
申请日：1984-10-25
申请人： Rupert Timpl , Dietrich Brocks
发明人： Rupert Timpl , Dietrich Brocks
IPC分类号： G01N33/53 , A61K39/00 , A61K39/395 , C07K14/78 , C07K16/18 , C12Q1/00 , G01N33/532 , G01N33/564 , G01N33/577 , G01N33/68 , C07K3/02 , C07K3/22 , C07K15/20
CPC分类号： C07K16/18 , C07K14/78 , G01N33/564 , G01N33/577 , G01N33/6887 , Y10S530/835 , Y10S530/848 , Y10S530/849
摘要： The present invention provides human characterized by a molecular weight of about 170,000 Dalton, a hexameric structure with monomeric subunits with a molecular weight of about 28,000 Dalton and a carbohydrate content of about 2%.The present invention provides a process for obtaining and purifying globular domain NC1 of basal membrane collagen, wherein human or animal tissue is subjected to a first limiting treatment with bacterial collagenase, the degradation products obtained are separated from non-collagen proteins by chromatography on a weakly basic anion exchanger, the collagen degradation products are then subjected to a second collagenase digestion at an elevated temperature and the globular domain NC1 is purified by molecular sieve fractionation.Furthermore, the present invention is concerned with the use of this for the determination in body fluids in the case of the use of their antibodies, as well as far the detection of antibodies directed thereagainst in body fluids.
摘要翻译：本发明提供人类，其特征在于分子量为约170,000道尔顿，具有分子量为约28,000道尔顿和碳水化合物含量约2％的单体亚基的六聚体结构。本发明提供了获得和纯化基膜胶原蛋白的球状结构域NC1的方法，其中人或动物组织经受细菌胶原酶的第一限制性处理，所得到的降解产物通过弱的色谱从非胶原蛋白分离碱性阴离子交换剂，然后将胶原降解产物在升高的温度下进行第二次胶原酶消化，球状结构域NC1通过分子筛分级纯化。此外，本发明涉及在使用其抗体的情况下用于体液测定的用途，以及远在体液中定向的抗体的检测。

4. 发明授权

US08277802B2 Diagnosis and prevention of cancer cell invasion 有权
标题翻译：诊断和预防癌细胞侵袭
公开(公告)号：US08277802B2
公开(公告)日：2012-10-02
申请号：US10521410
申请日：2003-07-17
申请人： Axel Ullrich , Pjotr Knyazev , Tatjana Knyazeva , Yuri Cheburkin , Peter Vajkoczy
发明人： Axel Ullrich , Pjotr Knyazev , Tatjana Knyazeva , Yuri Cheburkin , Peter Vajkoczy
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： A61K39/3955 , A61K2039/505 , C07K16/2863 , C12Q1/6886 , C12Q2600/136
摘要： The present invention relates to diagnostic and therapeutic methods in the field of malignant disorders. Most particularly, the invention provides methods of determining the invasivity of malignant disorders and methods for reducing the invasivity of malignant disorders including the prevention or treatment of cancer cell invasion.
摘要翻译：本发明涉及恶性疾病领域的诊断和治疗方法。最特别地，本发明提供了确定恶性疾病的侵袭性的方法和降低恶性疾病的侵袭性的方法，包括预防或治疗癌细胞侵袭。

5. 发明授权

US07981420B2 Therapeutic use of antibodies directed against repulsive guidance molecule (RGM) 有权
标题翻译：针对排斥指导分子（RGM）的抗体的治疗用途
公开(公告)号：US07981420B2
公开(公告)日：2011-07-19
申请号：US10451586
申请日：2001-12-21
申请人： Bernhard K. Mueller , Philippe P. Monnier , Paolo Macchi , Friedrich Bonhoeffer , Bernd Stahl , Matthias Mann , Jens S. Anderson
发明人： Bernhard K. Mueller , Philippe P. Monnier , Paolo Macchi , Friedrich Bonhoeffer , Bernd Stahl , Matthias Mann , Jens S. Anderson
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K14/47 , A61K38/1709 , A61K2039/505 , C07K14/465 , C07K14/4702 , C07K16/28
摘要： The present invention relates to the use of a modulator of a polypeptide having or comprising an amino acid sequence as disclosed herein or of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with seizures or associated with angiogenic disorders or disorders of the cardio-vascular system. Furthermore, the invention provides for the use of a modulator of a polypeptide having or comprising said amino acid sequence of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with angiogenic disorders or disorders of the cardio-vascular system. In addition the invention provides for the use of said polypeptide or said functional fragment or derivative thereof for the preparation of a pharmaceutical composition for preventing or treating tumor growth or formation of tumor metastases or as a marker of stem cells.
摘要翻译：本发明涉及具有或包含本文公开的氨基酸序列或其功能片段或衍生物或编码所述多肽或片段或衍生物的多核苷酸的调节剂用于制备药物组合物的用途预防，减轻或治疗与癫痫相关的脊椎动物神经组织的退化或损伤相关的疾病或病症或与心血管系统的血管生成障碍或病症有关。此外，本发明提供了具有或包含其功能片段或其衍生物的所述氨基酸序列或编码所述多肽或片段或衍生物的多核苷酸的多肽的调节剂用于制备用于预防，缓解的药物组合物或治疗与脊髓动物神经组织的变性或损伤相关的疾病或病症，与血管生成障碍或心血管系统的病症有关。此外，本发明提供了所述多肽或其功能片段或其衍生物用于制备用于预防或治疗肿瘤生长或肿瘤转移形成或作为干细胞标记的药物组合物的用途。

6. 发明授权

US4880782A Method of treating viral infections in humans and compositions therefor 失效
标题翻译：治疗人类病毒感染的方法及其组合物
公开(公告)号：US4880782A
公开(公告)日：1989-11-14
申请号：US41147
申请日：1987-04-22
申请人： Fritz Eckstein , Gerhard Hunsmann , Heinz Hartmann
发明人： Fritz Eckstein , Gerhard Hunsmann , Heinz Hartmann
IPC分类号： C07H19/16
CPC分类号： A61K31/70 , C07H19/16 , Y10S514/885
摘要： A method of treating viral diseases in a human subject is disclosed. The method involves applying effective amounts of the compound: ##STR1## wherein X is an azido group, a methoxy radical or a fluorine atom and B is thymine, uracil, guanine, cytosine, purine or hypoxanthine if X is methoxy or fluorine, and B is guanine, purine or hypoxanthine if X is azido or a pharmaceutically acceptable salt thereof. Also disclosed are compositions and compounds useful in the method.
摘要翻译：公开了治疗人类受试者病毒性疾病的方法。该方法包括施用有效量的化合物：其中X为叠氮基，甲氧基或氟原子，B为胸腺嘧啶，尿嘧啶，鸟嘌呤，胞嘧啶，嘌呤或次黄嘌呤，如果X为甲氧基或氟，B为如果X是叠氮基，则是鸟嘌呤，嘌呤或次黄嘌呤或其药学上可接受的盐。还公开了可用于该方法的组合物和化合物。

7. 发明授权

US4609629A Process for the immunological determination of proteins in body fluid which display a non-parallel inhibition curve to a reference inhibitor 失效
标题翻译：用于免疫测定体液中蛋白质的方法，其显示参考抑制剂的非平行抑制曲线
公开(公告)号：US4609629A
公开(公告)日：1986-09-02
申请号：US643815
申请日：1984-08-23
申请人： Rupert Timpl
发明人： Rupert Timpl
IPC分类号： G01N33/563 , G01N33/68 , G01N33/536 , G01N33/577
CPC分类号： G01N33/6887 , G01N33/6857 , Y10S436/815
摘要： The present invention provides a process for the immunological determinat of proteins in body fluids which display a non-parallel inhibition curve to a reference inhibitor, wherein specific monovalent antibody fragments are used as antiserum.
摘要翻译：本发明提供了一种免疫学测定体液中蛋白质的方法，该方法对参考抑制剂显示不平行的抑制曲线，其中特异性单价抗体片段用作抗血清。

8. 发明授权

US4131534A Preparation of carrier ampholyte mixtures 失效
标题翻译：载体两性电解质混合物的制备
公开(公告)号：US4131534A
公开(公告)日：1978-12-26
申请号：US860615
申请日：1977-12-14
申请人： Wilhelm Just
发明人： Wilhelm Just
IPC分类号： B01D57/02 , G01N27/447 , G01N27/26
CPC分类号： G01N27/44795 , B01D57/02 , G01N27/44747
摘要： Carrier ampholyte mixtures are prepared by reaction between organic amino imino compounds and unsaturated carboxylic acid esters followed by hydrolysis.
摘要翻译：载体两性电解质混合物通过有机氨基或亚氨基化合物与不饱和羧酸酯的反应，随后进行水解而制备。

9. 发明授权

US06991714B1 Apparatus and method for taking samples from polymer support material 失效
标题翻译：从聚合物支撑材料取样的装置和方法
公开(公告)号：US06991714B1
公开(公告)日：2006-01-31
申请号：US09647910
申请日：1999-03-26
申请人： Christine Gauss , Martin Horn , Markus Kalkum , Holger Eickhoff
发明人： Christine Gauss , Martin Horn , Markus Kalkum , Holger Eickhoff
IPC分类号： G01N27/26 , G01N1/00 , B01L3/00
CPC分类号： B26F1/04 , G01N27/44739 , G01N2035/1076
摘要： A sample taking apparatus comprises a plurality of separation tools (10) (for example, punching capillaries) on a holding device (20), wherein the separation tools (10) are each provided with actuating means (30) for separate control thereof. In a sample taking method (for example, for punching samples from separation gels), successively removed samples are deposited in parallel onto a target substrate.
摘要翻译：样品采集装置包括在保持装置（20）上的多个分离工具（10）（例如，冲压毛细管），其中分离工具（10）各自设置有用于单独控制的致动装置（30）。在采样方法（例如，用于冲压分离凝胶的样品）中，将连续去除的样品平行沉积到目标基底上。

10. 发明授权

US4910296A Medicaments containing alpha 1 thymosin fragments and having an immunostimulant action, and fragments of alpha 1 thymosin 失效
标题翻译：含有α1胸腺素片段并具有免疫刺激作用的药物和α1胸腺素的片段
公开(公告)号：US4910296A
公开(公告)日：1990-03-20
申请号：US879086
申请日：1986-06-26
申请人： Christian Birr , Ilona Werner , Ulrich Stollenwerk, deceased , by Paul Stollenwerk, heir , by Margot Stollenwerk, heir
发明人： Christian Birr , Ilona Werner , Ulrich Stollenwerk, deceased , by Paul Stollenwerk, heir , by Margot Stollenwerk, heir
IPC分类号： A61K38/00 , C07K5/068 , C07K5/072 , C07K5/083 , C07K5/09 , C07K5/093 , C07K5/103 , C07K5/11 , C07K5/113 , C07K14/575
CPC分类号： C07K14/57581 , C07K5/06086 , C07K5/06104 , C07K5/0806 , C07K5/0808 , C07K5/0815 , C07K5/0819 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1019 , C07K5/1021 , A61K38/00
摘要： Fragments of Alpha-1 thymosin ranging from two to twelve peptides in lengthnd pharmaceutically acceptable salts thereof. These fragments possess immunostimulatory and immunoregulatory properties similar to the alpha thymosin molecule and are useful in the same fashion as in this molecule.
摘要翻译：长度为2至12个肽的α-1胸腺素片段及其药学上可接受的盐。这些片段具有类似于α胸腺素分子的免疫刺激和免疫调节特性，并且以与该分子中相同的方式是有用的。

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