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    • 10. 发明申请
    • LOW-BUFFER NUTRITIONAL COMPOSITIONS AND USES THEREOF
    • 低缓冲营养组合物及其用途
    • WO2014143481A1
    • 2014-09-18
    • PCT/US2014/016070
    • 2014-02-12
    • MJN U.S. HOLDINGS LLC
    • WITTKE, AnjaBANAVARA, Dattatreya
    • A23L1/30A23L1/304A23L1/308A23L1/03A23L1/29
    • A23L1/296A23L29/015A23L29/035A23L33/16A23L33/19A23L33/26A23L33/40A23V2002/00A23V2200/32A23V2200/06A23V2200/3202A23V2200/3204A23V2250/1578
    • The present disclosure is directed to methods for supporting resistance to bacterial growth in the gastrointestinal tract of a subject, particularly in that of a human infant. In certain embodiments, the method comprises administering to a subject a nutritional composition that has a low buffer strength, wherein administration of said nutritional composition decreases the bacterial counts of bacteria selected from the group consisting of Enteropathogenic E. coli (EPEC), Enteroaggregative E. coli (EAEC), Cronobacter sakazakii, Salmonella enterica , and combinations thereof in the subject's gastrointestinal tract. This disclosure further relates to the manufacture and use of low-buffer nutritional compositions in methods for modulating gastric acidity and/or in methods for enhancing the rate of gastric emptying in a subject, each method comprising a step of administering at least one of said low-buffer nutritional compositions to the subject.
    • 本公开涉及用于支持对受试者的胃肠道中的细菌生长的抗性的方法,特别是对于婴儿。 在某些实施方案中,所述方法包括对受试者施用具有低缓冲强度的营养组合物,其中所述营养组合物的施用降低了选自肠病毒性肠杆菌(Enterec病原性大肠杆菌)(Entercathogenic E.coli)(EPEC),肠聚集体E. 大肠杆菌(EAEC),阪崎肠埃布杆菌,肠炎沙门氏菌及其组合在受试者的胃肠道中。 本公开还涉及在调节胃酸度的方法中和/或用于增强受试者胃排空速率的方法中制备和使用低缓冲营养组合物,每种方法包括施用至少一种所述低浓度 缓冲营养组合物。