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1. 发明申请

WO2015017073A1 NUTRITIONAL COMPOSITIONS FOR ENHANCING BRAIN DEVELOPMENT 审中-公开
标题翻译：用于增强脑发育的营养组合物
公开(公告)号：WO2015017073A1
公开(公告)日：2015-02-05
申请号：PCT/US2014/045174
申请日：2014-07-02
申请人： MJN U.S. HOLDINGS LLC
发明人： BERG, Brian , JOUNI, Zeina , WITTKE, Anja , WAWORUNTU, Rosaline , CHICHLOWSKI, Maciej
IPC分类号： A23L1/30 , A23L1/305 , A23L1/308 , A23L1/29 , A61K38/40 , A61K31/702 , A61K35/20
CPC分类号： A23L33/26 , A23L33/115 , A23L33/12 , A23L33/17 , A23L33/21 , A23L33/40 , A61K31/202 , A61K31/685 , A61K31/702 , A61K31/7032 , A61K35/20 , A61K38/018 , A61K38/40 , A61K2300/00
摘要： A composition and method for enhancing brain development in a pediatric subject, the method including administering to the pediatric subject a nutritional composition having up to about 7 g/100 kcal of a fat or lipid source, wherein the fat or lipid source includes at least about 0.5 mg/100 kcal of milk or non-milk polar lipids; up to about 5 g/100 kcal of a protein source; at least about 15 mg/100 kcal of lactoferrin from a non-human source; about 0.015 g/100 kcal to about 0.15 g/100 kcal of a prebiotic composition including polydextrose and/or galactooligosaccharide; and at least about 5 mg/100 kcal of a source of long chain polyunsaturated fatty acids.
摘要翻译：一种用于增强儿科受试者的脑发育的组合物和方法，所述方法包括向小儿科受试者施用具有高达约7g / 100kcal脂肪或脂质来源的营养组合物，其中所述脂肪或脂质源包括至少约 0.5毫克/ 100千卡牛奶或非牛奶极性脂质; 高达约5g / 100kcal的蛋白质来源; 至少约15mg / 100kcal来自非人源的乳铁蛋白; 约0.015g / 100kcal至约0.15g / 100kcal的益生元组合物，包括聚葡萄糖和/或低聚半乳糖; 和至少约5mg / 100kcal的长链多不饱和脂肪酸源。

2. 发明申请

WO2016073132A1 NUTRITIONAL COMPOSITIONS CONTAINING A PREBIOTIC AND LACTOFERRIN AND USES THEREOF 审中-公开
标题翻译：含有预生产和拉唑替林的营养组合物及其用途
公开(公告)号：WO2016073132A1
公开(公告)日：2016-05-12
申请号：PCT/US2015/054628
申请日：2015-10-08
申请人： MJN U.S. HOLDINGS LLC
发明人： CHICHLOWSKI, Maciej , BERG, Brian , JOUNI, Zeina , WITTKE, Anja , WAWORUNTU, Rosaline
IPC分类号： A23L33/00 , A23L33/10 , A23L33/115 , A23L33/17
CPC分类号： A23L33/21 , A23L33/19 , A23L33/40 , A23V2002/00 , A23V2200/00 , A23V2200/32 , A23V2200/3202 , A23V2200/322 , A23V2250/284 , A23V2250/54248
摘要： Provided is a composition and method for modulating serotonergic receptor expression, reducing anxiety-like behavior and stress-induced inflammatory response in a pediatric subject, the method including administering to the pediatric subject a nutritional composition including lactoferrin from a non-human source and a prebiotic composition including polydextrose and/or galactooligosaccharides. Further provided is a method for reducing constipation in a pediatric subject by providing a nutritional composition including lactoferrin from a non-human source and a prebiotic composition including polydextrose and/or galactooligosaccharides.
摘要翻译：本发明提供了一种用于在儿科受试者中调节血清素受体表达，减少焦虑样行为和应激诱导的炎性反应的组合物和方法，所述方法包括向儿科受试者施用包括来自非人源的乳铁蛋白的营养组合物和益生元组合物包括聚右旋糖和/或低聚半乳糖。还提供了一种通过提供包含来自非人源的乳铁蛋白的营养组合物和包含聚葡萄糖和/或低聚半乳寡糖的益生元组合物来减轻儿科受试者便秘的方法。

3. 发明申请

WO2014179053A1 NUTRITIONAL COMPOSITION COMPRISING WHEY AND HYDROLYZED CASEIN AND USES THEREOF 审中-公开
标题翻译：包含乳清蛋白和水解酪蛋白的营养组合物及其用途
公开(公告)号：WO2014179053A1
公开(公告)日：2014-11-06
申请号：PCT/US2014/034190
申请日：2014-04-15
申请人： MJN U.S. HOLDINGS LLC
发明人： ALVEY, John, D. , BANAVARA, Dattatreya , BERG, Brian , WITTKE, Anja , BURRIN, Douglas
IPC分类号： A23L1/29 , A23L1/305
CPC分类号： A23L1/296 , A23L33/18 , A23L33/40 , A23V2002/00 , A23V2250/54246 , A23V2250/54252 , A23V2250/55
摘要： The present disclosure provides a nutritional composition, such as a preterm infant formula that includes a protein source comprising whey protein and hydrolyzed casein protein. The whey protein to hydrolyzed casein ratio may be from about 90:10 to about 50:50 by weight. The hydrolyzed casein may have a degree of hydrolysis of from about 20% to about 80%. Additionally, provided are methods for improved gastric emptying and improved digestibility in a target subject, such as a preterm infant. When administered, the nutritional compositions may promote intestinal transit and absorptive capacity. Consequently, better growth and development, especially neurological development of the target subject may be achieved.
摘要翻译：本公开提供营养组合物，例如包含含有乳清蛋白和水解酪蛋白的蛋白质来源的早产儿配方食品。乳清蛋白与水解酪蛋白的比例可以为约90:10至约50:50。水解酪蛋白可具有约20％至约80％的水解度。另外，提供了用于改善胃排空和改善目标对象（例如早产儿）消化率的方法。当施用时，营养组合物可以促进肠道运输和吸收能力。因此，可以实现更好的生长发育，尤其是目标受试者的神经发育。

4. 发明申请

WO2014143481A1 LOW-BUFFER NUTRITIONAL COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：低缓冲营养组合物及其用途
公开(公告)号：WO2014143481A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/016070
申请日：2014-02-12
申请人： MJN U.S. HOLDINGS LLC
发明人： WITTKE, Anja , BANAVARA, Dattatreya
IPC分类号： A23L1/30 , A23L1/304 , A23L1/308 , A23L1/03 , A23L1/29
CPC分类号： A23L1/296 , A23L29/015 , A23L29/035 , A23L33/16 , A23L33/19 , A23L33/26 , A23L33/40 , A23V2002/00 , A23V2200/32 , A23V2200/06 , A23V2200/3202 , A23V2200/3204 , A23V2250/1578
摘要： The present disclosure is directed to methods for supporting resistance to bacterial growth in the gastrointestinal tract of a subject, particularly in that of a human infant. In certain embodiments, the method comprises administering to a subject a nutritional composition that has a low buffer strength, wherein administration of said nutritional composition decreases the bacterial counts of bacteria selected from the group consisting of Enteropathogenic E. coli (EPEC), Enteroaggregative E. coli (EAEC), Cronobacter sakazakii, Salmonella enterica , and combinations thereof in the subject's gastrointestinal tract. This disclosure further relates to the manufacture and use of low-buffer nutritional compositions in methods for modulating gastric acidity and/or in methods for enhancing the rate of gastric emptying in a subject, each method comprising a step of administering at least one of said low-buffer nutritional compositions to the subject.
摘要翻译：本公开涉及用于支持对受试者的胃肠道中的细菌生长的抗性的方法，特别是对于婴儿。在某些实施方案中，所述方法包括对受试者施用具有低缓冲强度的营养组合物，其中所述营养组合物的施用降低了选自肠病毒性肠杆菌（Enterec病原性大肠杆菌）（Entercathogenic E.coli）（EPEC），肠聚集体E. 大肠杆菌（EAEC），阪崎肠埃布杆菌，肠炎沙门氏菌及其组合在受试者的胃肠道中。本公开还涉及在调节胃酸度的方法中和/或用于增强受试者胃排空速率的方法中制备和使用低缓冲营养组合物，每种方法包括施用至少一种所述低浓度缓冲营养组合物。

5. 发明申请

WO2014099134A1 MILK-BASED NUTRITIONAL COMPOSITIONS CONTAINING LACTOFERRIN AND USES THEREOF 审中-公开
标题翻译：含有LACTOFERRIN的基于乳汁的营养组合物及其用途
公开(公告)号：WO2014099134A1
公开(公告)日：2014-06-26
申请号：PCT/US2013/067223
申请日：2013-10-29
申请人： MJN U.S. HOLDINGS LLC
发明人： WITTKE, Anja
IPC分类号： A23L1/305 , A23L1/308 , A23J1/20 , A23L1/29 , C07K14/79
CPC分类号： A23J1/20 , A23L33/19 , A23L33/26 , A23L33/40 , A23V2002/00 , A23V2200/00 , C07K14/79 , A23V2250/54248
摘要： The present disclosure relates to milk-based nutritional compositions comprising lactoferrin and/or a prebiotic component, wherein, when combined, the lactoferrin and prebiotic component may exhibit additive or synergistic beneficial effects on the health and development of a pediatric subject. The disclosure further relates to methods comprising the administration of said milk-based nutritional compositions to pediatric subjects.
摘要翻译：本公开内容涉及包含乳铁蛋白和/或益生元组分的基于乳的营养组合物，其中当组合时，乳铁蛋白和益生元组分可以对儿科受试者的健康和发育显示出增加的或协同的有益效果。本公开还涉及包括向儿科受试者施用所述基于乳的营养组合物的方法。

6. 发明申请

WO2014092861A1 NUTRITIONAL COMPOSITION FOR PROMOTING SATIETY 审中-公开
标题翻译：营养满意的营养成分
公开(公告)号：WO2014092861A1
公开(公告)日：2014-06-19
申请号：PCT/US2013/065555
申请日：2013-10-18
申请人： MJN U.S. HOLDINGS LLC
发明人： POELS, Eduard K. , RUDOLPH, Colin , VAN DAEL, Peter , WITTKE, Anja , MCMAHON, Robert J.
IPC分类号： A23L1/29
CPC分类号： A23L1/296 , A23L33/17 , A23L33/40 , A23V2002/00 , A23V2200/332
摘要： Provided herein are nutritional compositions comprising a protein source, a fat source, a carbohydrate source, and at least one nucleotide, wherein the protein source comprises at least one free amino acid, wherein the at least one free amino acid comprises a glutamate salt, glutamic acid, taurine, glutamine, alanine, or any combination thereof. Also provided herein are methods of promoting satiety, preventing or reducing the incidence of overweight or obesity, or preventing or reducing the incidence of diabetes in a subject comprising administering to a subject a nutritional composition comprising a protein source, a fat source, a carbohydrate source, and at least one nucleotide, wherein the protein source comprises at least one free amino acid, wherein the at least one free amino acid comprises a glutamate salt, glutamic acid, taurine, glutamine, alanine, or any combination thereof.
摘要翻译：本文提供了包含蛋白质源，脂肪源，碳水化合物源和至少一个核苷酸的营养组合物，其中所述蛋白质来源包含至少一种游离氨基酸，其中所述至少一种游离氨基酸包含谷氨酸盐，谷氨酸酸，牛磺酸，谷氨酰胺，丙氨酸或其任何组合。本文还提供了促进饱腹感，预防或减少超重或肥胖的发生率或预防或减少受试者中糖尿病发病率的方法，包括向受试者施用包含蛋白质来源，脂肪来源，碳水化合物来源的营养组合物和至少一个核苷酸，其中所述蛋白源包含至少一种游离氨基酸，其中所述至少一种游离氨基酸包含谷氨酸盐，谷氨酸，牛磺酸，谷氨酰胺，丙氨酸或其任何组合。

7. 发明公开

EP2996491A1 NUTRITIONAL COMPOSITION COMPRISING WHEY AND HYDROLYZED CASEIN AND USES THEREOF 审中-公开
标题翻译：乳清营养成分及其用途和水解酪蛋白
公开(公告)号：EP2996491A1
公开(公告)日：2016-03-23
申请号：EP14724950.2
申请日：2014-04-15
申请人： MJN U.S. Holdings, LLC
发明人： ALVEY, John, D. , BANAVARA, Dattatreya , BERG, Brian , WITTKE, Anja , BURRIN, Douglas
IPC分类号： A23L3/00
CPC分类号： A23L1/296 , A23L33/18 , A23L33/40 , A23V2002/00 , A23V2250/54246 , A23V2250/54252 , A23V2250/55
摘要： The present disclosure provides a nutritional composition, such as a preterm infant formula that includes a protein source comprising whey protein and hydrolyzed casein protein. The whey protein to hydrolyzed casein ratio may be from about 90:10 to about 50:50 by weight. The hydrolyzed casein may have a degree of hydrolysis of from about 20% to about 80%. Additionally, provided are methods for improved gastric emptying and improved digestibility in a target subject, such as a preterm infant. When administered, the nutritional compositions may promote intestinal transit and absorptive capacity. Consequently, better growth and development, especially neurological development of the target subject may be achieved.

8. 发明公开

EP2934188A1 MILK-BASED NUTRITIONAL COMPOSITIONS CONTAINING LACTOFERRIN AND USES THEREOF 有权转让
标题翻译： NAHRUNGSZUSAMMENSETZUNGEN AUF MILCHBASIS MIT LACTOFERRIN UND ANWENDUNGEN DAVON
公开(公告)号：EP2934188A1
公开(公告)日：2015-10-28
申请号：EP13786870.9
申请日：2013-10-29
申请人： MJN U.S. Holdings, LLC
发明人： WITTKE, Anja
IPC分类号： A23L1/305 , A23L1/308 , A23J1/20 , A23L1/29 , C07K14/79
CPC分类号： A23J1/20 , A23L33/19 , A23L33/26 , A23L33/40 , A23V2002/00 , A23V2200/00 , C07K14/79 , A23V2250/54248
摘要： The present disclosure relates to milk-based nutritional compositions comprising lactoferrin and/or a prebiotic component, wherein, when combined, the lactoferrin and prebiotic component may exhibit additive or synergistic beneficial effects on the health and development of a pediatric subject. The disclosure further relates to methods comprising the administration of said milk-based nutritional compositions to pediatric subjects.
摘要翻译：本公开内容涉及包含乳铁蛋白和/或益生元组分的基于乳的营养组合物，其中当组合时，乳铁蛋白和益生元组分可以对儿科受试者的健康和发育显示出增加或协同的有益效果。本公开还涉及包括向儿科受试者施用所述基于乳的营养组合物的方法。

9. 发明授权

EP2934188B1 MILK-BASED NUTRITIONAL COMPOSITIONS CONTAINING LACTOFERRIN AND USES THEREOF 有权转让
标题翻译：含有乳铁蛋白的基于乳制品的营养组合物及其用途
公开(公告)号：EP2934188B1
公开(公告)日：2018-04-11
申请号：EP13786870.9
申请日：2013-10-29
申请人： MJN U.S. Holdings LLC
发明人： WITTKE, Anja
IPC分类号： A23L33/17 , A23L33/21 , A23J1/20 , A23L33/00
CPC分类号： A23J1/20 , A23L33/19 , A23L33/26 , A23L33/40 , A23V2002/00 , A23V2200/00 , C07K14/79 , A23V2250/54248
摘要： The present disclosure relates to milk-based nutritional compositions comprising lactoferrin and/or a prebiotic component, wherein, when combined, the lactoferrin and prebiotic component may exhibit additive or synergistic beneficial effects on the health and development of a pediatric subject. The disclosure further relates to methods comprising the administration of said milk-based nutritional compositions to pediatric subjects.

10. 发明公开

EP3154376A1 PEDIATRIC NUTRITIONAL COMPOSITION WITH HUMAN MILK OLIGOSACCHARIDES, PREBIOTICS AND PROBIOTICS 无效转让
标题翻译： PÄDIATRISCHENÄHRSTOFFZUSAMMENSETZUNGMIT MENSCHLICHEN MILCHOLIGOSACCHARIDEN，PRÄBIOTIKAUND PROBIOTIKA
公开(公告)号：EP3154376A1
公开(公告)日：2017-04-19
申请号：EP15715926.0
申请日：2015-03-25
申请人： MJN U.S. Holdings, LLC
发明人： CHICHLOWSKI, Maciej , JOUNI, Zeina , BERG, Brian , WITTKE, Anja , WAWORUNTU, Rosaline
IPC分类号： A23L33/10 , A23L33/00 , A61K35/747 , C12N1/00
CPC分类号： A23L33/40 , A23L33/10 , A23L33/115 , A23L33/12 , A23L33/135 , A23L33/18 , A23L33/26 , A23V2002/00 , A23Y2220/73 , A61K35/747 , A61K38/018 , A61K2300/00
摘要： The present disclosure generally relates to pediatric nutritional compositions including a prebiotic mixture of galacto-oligosaccharide and/or polydextrose, a probiotic, such as Lactobacillus rhamnosus GG, and human milk oligosaccharides. More particularly, the present disclosure relates to a nutritional composition having: (i) a protein source, (ii) a lipid source, (iii) a carbohydrate source, (iv) a human milk oligosaccharide or a precursor thereof, (v) polydextrose and/or galacto-oligosaccharides, and (vi) a probiotic. The disclosed nutritional compositions advantageously promote the gut-brain axis.
摘要翻译：本公开内容一般涉及儿科营养组合物，其包括半乳寡聚糖和/或聚右旋糖的益生元混合物，益生菌如鼠李糖乳杆菌GG和人乳低聚糖。更具体地说，本公开内容涉及具有以下功能的营养组合物：（i）蛋白源，（ii）脂质源，（iii）碳水化合物源，（iv）人乳寡糖或其前体，（v）聚右旋糖和/或半乳寡聚糖，和（vi）益生菌。所公开的营养组合物有利地促进肠 - 脑轴。

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