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2. 发明专利

JP5766604B2 検査信号特性の分析によるHIFU出力堆積の最適化およびフィードバック制御有权
标题翻译：通过测试信号的特性分析的输出HIFU沉积的优化和反馈控制
公开(公告)号：JP5766604B2
公开(公告)日：2015-08-19
申请号：JP2011522254
申请日：2009-08-06
申请人：ミラビリス・メディカ・インコーポレイテッド , MIRABILIS MEDICA, INC.
发明人：ダーリントン, グレゴリーピー. , エメリー, チャールズディー. , リード, ジャスティンエー. , フリーメル, バリー
IPC分类号： A61B18/00
CPC分类号： A61N7/02 , A61B17/225 , A61B8/08 , A61B17/22029 , A61B2017/00106 , A61B2017/00154 , A61B8/14

3. 发明申请

WO2014146005A9 ACOUSTIC-PULSER FEEDBACK AND POWER FACTOR CONTROL OF A HIFU DEVICE 审中-公开
公开(公告)号：WO2014146005A9
公开(公告)日：2014-09-18
申请号：PCT/US2014/030874
申请日：2014-03-17
申请人： MIRABILIS MEDICA, INC.
发明人： DARLINGTON, Gregory Paul , ETCHELLS, Tim
IPC分类号： H04R3/06 , H04R19/00
摘要： A method and system for adjusting a HIFU device compensates for shifts in transducer impedance so that the acoustic output from a HIFU transducer remains at a desired level. In accordance with a first aspect, the disclosure includes dynamically adjusting the tuning of a tuning network that causes the transducer/system to maintain an optimal power transfer to the acoustic output. In accordance with a second aspect, the disclosure monitors the acoustic output of the HIFU device and adjusts the electrical signal provided to the HIFU transducer to maintain a desired acoustic output.

4. 发明申请

WO2014014965A1 HUMAN INTERFACE AND DEVICE FOR ULTRASOUND GUIDED TREATMENT 审中-公开
标题翻译：人体接口和超声引导治疗装置
公开(公告)号：WO2014014965A1
公开(公告)日：2014-01-23
申请号：PCT/US2013/050767
申请日：2013-07-16
申请人： MIRABILIS MEDICA, INC.
发明人： DUNBAR, Lee, David , PARSONS, Jessica, E. , PEDERSEN, Robert, H. , ETCHELLS, Tim , DARLINGTON, Gregory, Paul , LAU, Michael, P.H. , QUISTGAARD, Jens, Urich
IPC分类号： A61B8/00 , G06T17/00
CPC分类号： A61N7/00 , A61B34/25 , A61B2090/378 , A61N7/02
摘要： A system and method for providing real-time, image-guided high intensity focused ultrasound (HIFU) targeting and treatment of tissue. In one embodiment, the system includes an HIFU applicator and a user interface with a touchscreen display for three-dimensional visualization of the tissue. Image frames displayed on the user interface depict real-time images of the tissue, including an image parallel to a feature of the applicator and an image orthogonal to the parallel image. Reference lines may be sketched using the touchscreen and displayed on the image frames. In one embodiment, tissue boundaries are detected and marked on the image frames, either by the user or automatically by the system. In another embodiment, the user interface includes a footswitch for the user to interact with the system. In another embodiment, the system includes an ultrasound imaging component configured to undock from the system for use as a stand-alone ultrasound imaging device.
摘要翻译：一种用于提供实时，图像引导的高强度聚焦超声（HIFU）靶向和治疗组织的系统和方法。在一个实施例中，系统包括HIFU施加器和具有触摸屏显示器的用户界面，用于组织的三维可视化。显示在用户界面上的图像帧描绘了组织的实时图像，包括平行于施用器的特征的图像和与该平行图像正交的图像。参考线可以使用触摸屏勾画并显示在图像帧上。在一个实施例中，组织边界被检测和标记在图像帧上，无论是由用户还是由系统自动地标记。在另一个实施例中，用户接口包括用于用户与系统交互的脚踏开关。在另一个实施例中，该系统包括被配置为从该系统脱离以用作独立的超声成像装置的超声成像部件。

5. 发明申请

WO2010102302A3 ULTRASOUND TREATMENT AND IMAGING APPLICATOR 审中-公开
标题翻译：超声处理和成像应用
公开(公告)号：WO2010102302A3
公开(公告)日：2011-01-13
申请号：PCT/US2010026565
申请日：2010-03-08
申请人： MIRABILIS MEDICA INC , EMERY CHARLES D , FRIEMEL BARRY
发明人： EMERY CHARLES D , FRIEMEL BARRY
IPC分类号： A61N7/00 , A61H23/00
CPC分类号： A61B8/14 , A61B8/08 , A61B8/485 , A61B8/56
摘要： An ultrasound treatment system includes an applicator in which a therapeutic ultrasound transducer is surrounded by an annular imaging transducer. Illumination signals generated by the therapy or imaging transducer are sequentially or simultaneously delivered to tissue in a viewing space to create corresponding echo signals that are received by the elements of the annular imaging transducer. These echo signals are analyzed with a processor to produce an image of tissue in the viewing space.
摘要翻译：超声处理系统包括施用器，其中治疗性超声换能器被环形成像换能器包围。由治疗或成像传感器产生的照明信号被顺序地或同时地传送到观察空间中的组织，以产生由环形成像换能器的元件接收的相应的回波信号。这些回波信号用处理器进行分析，以在观看空间中产生组织的图像。

6. 发明申请

WO2010102302A2 ULTRASOUND TREATMENT AND IMAGING APPLICATOR 审中-公开
标题翻译：超声处理和成像应用
公开(公告)号：WO2010102302A2
公开(公告)日：2010-09-10
申请号：PCT/US2010/026565
申请日：2010-03-08
申请人： MIRABILIS MEDICA, INC. , EMERY, Charles, D. , FRIEMEL, Barry
发明人： EMERY, Charles, D. , FRIEMEL, Barry
IPC分类号： A61N7/00 , A61H23/00
CPC分类号： A61B8/14 , A61B8/08 , A61B8/485 , A61B8/56
摘要： An ultrasound treatment system includes an applicator in which a therapeutic ultrasound transducer is surrounded by an annular imaging transducer. Illumination signals generated by the therapy or imaging transducer are sequentially or simultaneously delivered to tissue in a viewing space to create corresponding echo signals that are received by the elements of the annular imaging transducer. These echo signals are analyzed with a processor to produce an image of tissue in the viewing space.
摘要翻译：超声处理系统包括施用器，其中治疗性超声换能器被环形成像换能器包围。由治疗或成像传感器产生的照明信号被顺序地或同时地传送到观察空间中的组织，以产生由环形成像换能器的元件接收的相应的回波信号。这些回波信号用处理器进行分析，以在观看空间中产生组织的图像。

7. 发明申请

WO2009018351A1 METHODS AND APPARATUS FOR ENGAGEMENT AND COUPLING OF AN INTRACAVITORY IMAGING AND HIGH INTENSITY FOCUSED ULTRASOUND PROBE 审中-公开
标题翻译：入侵和联合成像和高强度聚焦超声探头的方法和装置
公开(公告)号：WO2009018351A1
公开(公告)日：2009-02-05
申请号：PCT/US2008/071607
申请日：2008-07-30
申请人： MIRABILIS MEDICA INC. , LAU, Michael P.H. , DARLINGTON, Gregory Paul , CONNELLY, Michael J. , GUO, Zihong
发明人： LAU, Michael P.H. , DARLINGTON, Gregory Paul , CONNELLY, Michael J. , GUO, Zihong
IPC分类号： A61B8/12 , A61N7/02 , A61B17/22 , A61B17/42 , A61B19/00
CPC分类号： A61B8/12 , A61B8/4209 , A61B8/4272 , A61B8/4281 , A61B8/445 , A61B17/2202 , A61B17/2256 , A61B17/4241 , A61B2017/2253 , A61B2017/4216 , A61B2018/00029 , A61B2090/3782 , A61B2090/3784 , A61N7/022
摘要： A combined imaging/HIFU probe (10) includes an imaging scan head (12), a HIFU transducer (16), and an outlet port (20) that delivers a flow of fluid across the HIFU transducer. At least a portion of the body cavity is filled with fluid in which the probe is- immersed. The fluid provides a coupling for transmission of ultrasound energy between the probe and the patient. A flow of fluid may also be used to flush obstructions from an area of tissue near the HIFU transducer. Further described herein is a cuff (60) to help retain fluid in the body cavity, a regulator (64) to regulate fluid flow with respect to the body cavity according to a desired fluid pressure, and a cover (180) for the HIFU transducer that has at least one perforation defined therethrough to allow fluid to flow through the cover. Further disclosed herein are methods of deploying a combined imaging/HIFU probe in a body cavity.
摘要翻译：组合成像/ HIFU探针（10）包括成像扫描头（12），HIFU换能器（16）和输出流体流过HIFU换能器的出口（20）。体腔的至少一部分填充有探针浸入其中的流体。流体提供用于在探针和患者之间传输超声能量的耦合。流体流也可用于冲洗HIFU换能器附近的组织区域的障碍物。本文进一步描述的是用于帮助保持体腔中的流体的袖带（60），根据期望的流体压力调节流体相对于体腔的流体的调节器（64），以及用于HIFU换能器的盖（180）其具有穿过其中限定的至少一个穿孔，以允许流体流过盖。本文进一步公开的是将组合成像/ HIFU探针部署在体腔中的方法。

8. 发明申请

WO2010048633A3 METHOD AND APPARATUS FOR FEEDBACK CONTROL OF HIFU TREATMENTS 审中-公开
标题翻译：用于HIFU治疗的反馈控制的方法和设备
公开(公告)号：WO2010048633A3
公开(公告)日：2010-08-05
申请号：PCT/US2009062127
申请日：2009-10-26
申请人： MIRABILIS MEDICA INC , FRIEMEL BARRY , PARSONS JESSICA E , EMERY CHARLES D , DARLINGTON GREGORY P , REED JUSTIN A , ETCHELLS TIM
发明人： FRIEMEL BARRY , PARSONS JESSICA E , EMERY CHARLES D , DARLINGTON GREGORY P , REED JUSTIN A , ETCHELLS TIM
IPC分类号： A61N7/00 , A61N7/02
CPC分类号： A61B8/08 , A61B17/42 , A61B2017/00119 , A61B2090/378 , A61N7/02
摘要： HIFU therapy to a desired tissue site is controlled based on detected changes in one or more characteristics of a received backscatter signal resulting from exposure of the tissue to HIFU or other interrogation signals. In one embodiment, the bloom of backscatter signals outward from a treatment region (e.g., towards the HIFU transducer) is detected and monitored. Once the bloom reaches a predetermined location, treatment is stopped. Other signal characteristics such as angular distribution of frequency components in the backscatter signal, changes in reflection, power required to saturate a tissue characteristic, changes in attenuation and changes in a cumulative energy distribution function of the backscatter signal that change as a result of the application of HIFU power are also used to control the delivery of HIFU signals in accordance with other embodiments of the disclosed technology.
摘要翻译：基于由组织暴露于HIFU或其他询问信号所导致的接收后向散射信号的一个或多个特征中的检测到的变化来控制HIFU治疗至期望的组织部位。在一个实施例中，检测并监测从治疗区域（例如朝向HIFU换能器）向外散射的背散射信号。一旦花朵达到预定位置，治疗就停止。其他信号特性，例如反向散射信号中频率分量的角度分布，反射的变化，饱和组织特性所需的功率，衰减的变化以及作为应用的结果而变化的反向散射信号的累积能量分布函数的变化根据所公开的技术的其他实施例，HIFU功率也被用于控制HIFU信号的传送。

9. 发明申请

WO2010048633A2 METHOD AND APPARATUS FOR FEEDBACK CONTROL OF HIFU TREATMENTS 审中-公开
标题翻译： HIFU治疗反馈控制的方法与装置
公开(公告)号：WO2010048633A2
公开(公告)日：2010-04-29
申请号：PCT/US2009/062127
申请日：2009-10-26
申请人： MIRABILIS MEDICA INC. , FRIEMEL, Barry , PARSONS, Jessica, E. , EMERY, Charles, D. , DARLINGTON, Gregory, P. , REED, Justin, A. , ETCHELLS, Tim
发明人： FRIEMEL, Barry , PARSONS, Jessica, E. , EMERY, Charles, D. , DARLINGTON, Gregory, P. , REED, Justin, A. , ETCHELLS, Tim
IPC分类号： A61N7/00 , A61N7/02
CPC分类号： A61B8/08 , A61B17/42 , A61B2017/00119 , A61B2090/378 , A61N7/02
摘要： HIFU therapy to a desired tissue site is controlled based on detected changes in one or more characteristics of a received backscatter signal resulting from exposure of the tissue to HIFU or other interrogation signals. In one embodiment, the bloom of backscatter signals outward from a treatment region (e.g., towards the HIFU transducer) is detected and monitored. Once the bloom reaches a predetermined location, treatment is stopped. Other signal characteristics such as angular distribution of frequency components in the backscatter signal, changes in reflection, power required to saturate a tissue characteristic, changes in attenuation and changes in a cumulative energy distribution function of the backscatter signal that change as a result of the application of HIFU power are also used to control the delivery of HIFU signals in accordance with other embodiments of the disclosed technology.
摘要翻译：基于通过将组织暴露于HIFU或其他询问信号而导致的接收的反向散射信号的一个或多个特性的检测变化来控制对所需组织部位的HIFU治疗。在一个实施例中，检测和监视来自处理区域（例如，朝向HIFU换能器）向外的反向散射信号的绽放。一旦绽放到达预定位置，治疗就停止。其他信号特性，例如反向散射信号中的频率分量的角度分布，反射变化，饱和组织特征所需的功率，衰减的变化以及作为应用的结果而改变的反向散射信号的累积能量分布函数的变化的HIFU功率也用于根据所公开的技术的其他实施例来控制HIFU信号的传送。

10. 发明申请

WO2009134998A3 HEMOSTATIC TISSUE TUNNEL GENERATOR FOR INSERTING TREATMENT APPARATUS INTO TISSUE OF A PATIENT 审中-公开
标题翻译：用于将治疗装置插入患者组织的HEMOSTATIC TISSUE TUNNEL GENERATOR
公开(公告)号：WO2009134998A3
公开(公告)日：2010-03-04
申请号：PCT/US2009042303
申请日：2009-04-30
申请人： MIRABILIS MEDICA INC , AUTH DAVID C , LEBEDEV ALEXANDER , CONNOLLY MICHAEL J
发明人： AUTH DAVID C , LEBEDEV ALEXANDER , CONNOLLY MICHAEL J
IPC分类号： A61B18/12 , A61B18/18 , A61N7/00
CPC分类号： A61B18/1492 , A61B8/12 , A61B18/1815 , A61B2018/00791 , A61B2018/1213 , A61B2018/1472 , A61B2018/1475 , A61B2090/3784 , A61B2218/002 , A61B2218/007
摘要： A catheter for insertion into and treatment of tissue in a patient comprises a radio frequency (RF) electrode having an elongated body that conducts electrical RF energy to a conductive tip. An insulating sleeve surrounds the elongated body. In a first mode of operation, the conductive tip is exposed outside the insulating sleeve and the RF electrode delivers RF energy that erodes the tissue of the patient and creates a tunnel through which the catheter can advance into the tissue of the patient. In a second mode of operation, the insulating sleeve and/or the RF electrode is retracted and a second treatment apparatus treats the tissue.
摘要翻译：用于插入和治疗患者组织的导管包括射频（RF）电极，其具有将电RF能量传导到导电尖端的细长主体。绝缘套管围绕细长体。在第一操作模式中，导电尖端暴露在绝缘套管的外部，RF电极提供RF能量，其侵蚀患者的组织并产生导管可以前进到患者组织中的隧道。在第二操作模式中，绝缘套管和/或RF电极缩回，第二处理装置处理组织。

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