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1. 发明申请

WO2010048633A3 METHOD AND APPARATUS FOR FEEDBACK CONTROL OF HIFU TREATMENTS 审中-公开
标题翻译：用于HIFU治疗的反馈控制的方法和设备
公开(公告)号：WO2010048633A3
公开(公告)日：2010-08-05
申请号：PCT/US2009062127
申请日：2009-10-26
申请人： MIRABILIS MEDICA INC , FRIEMEL BARRY , PARSONS JESSICA E , EMERY CHARLES D , DARLINGTON GREGORY P , REED JUSTIN A , ETCHELLS TIM
发明人： FRIEMEL BARRY , PARSONS JESSICA E , EMERY CHARLES D , DARLINGTON GREGORY P , REED JUSTIN A , ETCHELLS TIM
IPC分类号： A61N7/00 , A61N7/02
CPC分类号： A61B8/08 , A61B17/42 , A61B2017/00119 , A61B2090/378 , A61N7/02
摘要： HIFU therapy to a desired tissue site is controlled based on detected changes in one or more characteristics of a received backscatter signal resulting from exposure of the tissue to HIFU or other interrogation signals. In one embodiment, the bloom of backscatter signals outward from a treatment region (e.g., towards the HIFU transducer) is detected and monitored. Once the bloom reaches a predetermined location, treatment is stopped. Other signal characteristics such as angular distribution of frequency components in the backscatter signal, changes in reflection, power required to saturate a tissue characteristic, changes in attenuation and changes in a cumulative energy distribution function of the backscatter signal that change as a result of the application of HIFU power are also used to control the delivery of HIFU signals in accordance with other embodiments of the disclosed technology.
摘要翻译：基于由组织暴露于HIFU或其他询问信号所导致的接收后向散射信号的一个或多个特征中的检测到的变化来控制HIFU治疗至期望的组织部位。在一个实施例中，检测并监测从治疗区域（例如朝向HIFU换能器）向外散射的背散射信号。一旦花朵达到预定位置，治疗就停止。其他信号特性，例如反向散射信号中频率分量的角度分布，反射的变化，饱和组织特性所需的功率，衰减的变化以及作为应用的结果而变化的反向散射信号的累积能量分布函数的变化根据所公开的技术的其他实施例，HIFU功率也被用于控制HIFU信号的传送。

2. 发明专利

HK1160048A1 用於治療回饋控制的儀器未知
公开(公告)号：HK1160048A1
公开(公告)日：2012-08-10
申请号：HK12100453
申请日：2012-01-13
申请人： MIRABILIS MEDICA INC
发明人： FRIEMEL BARRY , PARSONS JESSICA E , EMERY CHARLES D , DARLINGTON GREGORY P , REED JUSTIN A , ETCHELLS TIM
IPC分类号： A61N20060101 , A61B20060101

3. 发明公开

EP2349482A4 METHOD AND APPARATUS FOR FEEDBACK CONTROL OF HIFU TREATMENTS 有权
标题翻译：方法和设备控制HIFU治疗方法
公开(公告)号：EP2349482A4
公开(公告)日：2013-01-16
申请号：EP09822853
申请日：2009-10-26
申请人： MIRABILIS MEDICA INC
发明人： FRIEMEL BARRY , PARSONS JESSICA E , EMERY CHARLES D , DARLINGTON GREGORY P , REED JUSTIN A , ETCHELLS TIM
IPC分类号： A61N7/00
CPC分类号： A61B8/08 , A61B17/42 , A61B2017/00119 , A61B2090/378 , A61N7/02

4. 发明专利

CA2741723A1 METHOD AND APPARATUS FOR FEEDBACK CONTROL OF HIFU TREATMENTS 未知
公开(公告)号：CA2741723A1
公开(公告)日：2010-04-29
申请号：CA2741723
申请日：2009-10-26
申请人： MIRABILIS MEDICA INC
发明人： FRIEMEL BARRY , PARSONS JESSICA E , EMERY CHARLES D , DARLINGTON GREGORY P , REED JUSTIN A , ETCHELLS TIM
IPC分类号： A61N7/00 , A61N7/02
摘要： HIFU therapy to a desired tissue site is controlled based on detected changes in one or more characteristics of a received backscatter signal resulting from exposure of the tissue to HIFU or other interrogation signals. In one embodiment, the bloom of backscatter signals outward from a treatment region (e.g., towards the HIFU transducer) is detected and monitored. Once the bloom reaches a predetermined location, treatment is stopped. Other signal characteristics such as angular distribution of frequency components in the backscatter signal, changes in reflection, power required to saturate a tissue characteristic, changes in attenuation and changes in a cumulative energy distribution function of the backscatter signal that change as a result of the application of HIFU power are also used to control the delivery of HIFU signals in accordance with other embodiments of the disclosed technology.

5. 发明公开

EP2872044A4 HUMAN INTERFACE AND DEVICE FOR ULTRASOUND GUIDED TREATMENT 审中-公开
标题翻译： MENSCHLICHE SCHNITTSTELLE UND VORRICHTUNGFÜRULTRASCHALLGEFÜHRTEBEHANDLUNG
公开(公告)号：EP2872044A4
公开(公告)日：2016-04-06
申请号：EP13819568
申请日：2013-07-16
申请人： MIRABILIS MEDICA INC
发明人： DUNBAR LEE DAVID , PARSONS JESSICA E , PEDERSEN ROBERT H , ETCHELLS TIM , DARLINGTON GREGORY PAUL , LAU MICHAEL P H , QUISTGAARD JENS URICH
IPC分类号： A61B8/00 , A61B34/00 , A61B90/00 , A61N7/02 , G06T17/00
CPC分类号： A61N7/00 , A61B34/25 , A61B2090/378 , A61N7/02
摘要： A system and method for providing real-time, image-guided high intensity focused ultrasound (HIFU) targeting and treatment of tissue. In one embodiment, the system includes an HIFU applicator and a user interface with a touchscreen display for three-dimensional visualization of the tissue. Image frames displayed on the user interface depict real-time images of the tissue, including an image parallel to a feature of the applicator and an image orthogonal to the parallel image. Reference lines may be sketched using the touchscreen and displayed on the image frames. In one embodiment, tissue boundaries are detected and marked on the image frames, either by the user or automatically by the system. In another embodiment, the user interface includes a footswitch for the user to interact with the system. In another embodiment, the system includes an ultrasound imaging component configured to undock from the system for use as a stand-alone ultrasound imaging device.
摘要翻译：一种用于提供实时，图像引导的高强度聚焦超声（HIFU）靶向和治疗组织的系统和方法。在一个实施例中，系统包括HIFU施加器和具有触摸屏显示器的用户界面，用于组织的三维可视化。显示在用户界面上的图像帧描绘了组织的实时图像，包括平行于涂抹器特征的图像和与该平行图像正交的图像。参考线可以使用触摸屏勾画并显示在图像帧上。在一个实施例中，组织边界被检测和标记在图像帧上，无论是由用户还是由系统自动地标记。在另一个实施例中，用户界面包括用于使用者与系统交互的脚踏开关。在另一个实施例中，该系统包括被配置为从系统中脱离以用作独立的超声成像装置的超声成像部件。

6. 发明申请

WO2005065407A3 POSITION TRACKING DEVICE 审中-公开
标题翻译：位置跟踪装置
公开(公告)号：WO2005065407A3
公开(公告)日：2007-07-05
申请号：PCT/US2004044044
申请日：2004-12-29
申请人： LIPOSONIX INC , QUISTGAARD JENS U , DESILETS CHARLES S , ETCHELLS TIM , DARLINGTON GREGORY PAUL
发明人： QUISTGAARD JENS U , DESILETS CHARLES S , ETCHELLS TIM , DARLINGTON GREGORY PAUL
IPC分类号： A61B5/05 , A61B8/00 , A61B8/08
CPC分类号： A61B8/08 , A61B8/0841 , A61B8/4438
摘要： A position tracking device is disclosed combining one or more optical sensors in a housing with a medical device. The medical device may be an insertion device or one that produces radiant energy. The device may utilize an on-board processor or an external processor to track position data generated by the optical sensors and correlate the treatment regime of the medical device. Alternative embodiments and methods of use are also described.
摘要翻译：公开了将壳体中的一个或多个光学传感器与医疗装置组合的位置跟踪装置。医疗装置可以是产生辐射能的插入装置或者插入装置。该装置可以利用车载处理器或外部处理器来跟踪由光学传感器产生的位置数据并使医疗装置的处理方式相关联。还描述了替代实施例和使用方法。

7. 发明申请

WO2005065371A3 SYSTEMS AND METHODS FOR THE DESTRUCTION OF ADIPOSE TISSUE 审中-公开
标题翻译：用于破坏ADIPOSE组织的系统和方法
公开(公告)号：WO2005065371A3
公开(公告)日：2006-07-06
申请号：PCT/US2004043920
申请日：2004-12-29
申请人： LIPOSONIX INC , QUISTGAARD JENS U , ETCHELLS TIM , DARLINGTON GREGORY PAUL , DESILETS CHARLES S
发明人： QUISTGAARD JENS U , ETCHELLS TIM , DARLINGTON GREGORY PAUL , DESILETS CHARLES S
IPC分类号： A61B5/05 , A61B8/00 , A61B19/00 , A61F7/00 , A61N7/02
CPC分类号： A61B8/00 , A61B5/6843 , A61B8/4218 , A61B34/20 , A61B34/32 , A61B90/361 , A61B90/50 , A61B2034/105 , A61B2034/107 , A61B2034/2065 , A61B2090/064 , A61B2090/365 , A61B2090/378 , A61B2090/395 , A61B2090/5025 , A61B2090/504 , A61N7/02 , A61N2007/0008
摘要： Described is a system and method for the destruction of adipose tissue using an energy applicator (600) such as a HIFU transducer. The system has a scan head (500) containing an energy applicator, a mechanical arm (200) for carrying the weight of the scan head, and a therapy controlle (250) such as a computer for controlling the operation of the scan head. The therapy controller (250) may be part of a general purpose (400), and may be used as a robotic controller to automate the procedure. Methods are included for destroying adipose tissue in a quick, non-invasive manner.
摘要翻译：描述了使用诸如HIFU换能器的能量施加器（600）来破坏脂肪组织的系统和方法。该系统具有包含能量施加器的扫描头（500），用于承载扫描头的重量的机械臂（200）以及用于控制扫描头的操作的诸如计算机的治疗控制器（250）。治疗控制器（250）可以是通用目的（400）的一部分，并且可以用作自动化程序的机器人控制器。包括以快速，无创的方式破坏脂肪组织的方法。

8. 发明申请

WO2005065409A3 ULTRASOUND THERAPY HEAD WITH MOVEMENT CONTROL 审中-公开
标题翻译：超声波治疗头与运动控制
公开(公告)号：WO2005065409A3
公开(公告)日：2006-04-20
申请号：PCT/US2004044046
申请日：2004-12-29
申请人： LIPOSONIX INC , QUISTGAARD JENS U , ETCHELLS TIM , DARLINGTON GREGORY PAUL , DESILETS CHARLES S
发明人： QUISTGAARD JENS U , ETCHELLS TIM , DARLINGTON GREGORY PAUL , DESILETS CHARLES S
IPC分类号： A61B19/00 , A61H1/02 , A61N7/02 , A61H1/00 , A61H5/00
CPC分类号： A61N7/02 , A61B8/4461 , A61B34/70 , A61N2007/0082
摘要： A therapy head for use in HIFU procedures is described. The therapy head has an enclosure with a window, an energy applicator and a means of moving the energy applicator within the enclosure. The therapy head uses motors and actuators to move the energy applicator, usually an ultrasound transducer, inside the enclosure. A controller is provided either internally or externally that allows the therapy head to identify and distinguish locations where the therapy head should be to radiate energy into a patient. The controller uses the motors and actuators to move the energy applicator into the desired locations.
摘要翻译：描述了用于HIFU程序的治疗头。治疗头具有带有窗口的外壳，能量施加器以及将能量施加器移动到外壳内的装置。治疗头使用电动机和致动器将能量施加器（通常是超声换能器）移动到外壳内部。在内部或外部提供控制器，其允许治疗头识别并区分治疗头应将能量辐射到患者体内的位置。控制器使用电动机和执行器将能量施加器移动到所需的位置。

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