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1. 发明专利

JP2012024092A Inhibition of pathogen by bacillus coagulans 审中-公开
标题翻译：通过BACILLUS COAGULANS抑制病原体
公开(公告)号：JP2012024092A
公开(公告)日：2012-02-09
申请号：JP2011180982
申请日：2011-08-22
申请人： Ganeden Biotech Inc , ガネデンバイオテック, インコーポレイテッド
发明人： FARMER SEAN
IPC分类号： C12N1/20 , A61K9/00 , A61K35/74 , A61P1/00 , A61P17/00 , A61P31/02 , A61P31/04 , C12N15/09 , C12R1/07
CPC分类号： A61K35/742 , A61K9/0034
摘要： PROBLEM TO BE SOLVED: To provide a highly efficacious, non-antibiotic-based therapeutic regimen which functions in acute treatment scenarios, as well as prophylactically to migrate antibiotic-resistant pathogens in both humans and animals.SOLUTION: The invention provides compositions, therapeutic systems, and methods of use which exploit the discovery that new lactic acid-producing bacterial strains, Bacillus coagulans, or extracellular products thereof, possess the ability to exhibit inhibitory activity in mitigating and preventing the growth and/or colonization rates of pathogenic bacteria, as well as mitigating the deleterious physiological effects of the infection by the pathogen(s).
摘要翻译：要解决的问题：提供在急性治疗方案中起作用的高效，非抗生素的治疗方案，以及预防性地在人和动物中迁移抗生素抗性病原体。解决方案：本发明提供组合物，治疗系统和使用方法，其利用发现新的产生乳酸的细菌菌株，凝结芽孢杆菌或其细胞外产物具有在减轻和预防中发挥抑制活性的能力致病细菌的生长和/或定植率，以及减轻病原体感染的有害生理作用。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2010095532A Method, system and composition to reduce cholesterol using bacillus coagulans spore 审中-公开
标题翻译：使用BACILLUS COAGULANS SPORE减少胆固醇的方法，系统和组合物
公开(公告)号：JP2010095532A
公开(公告)日：2010-04-30
申请号：JP2010011398
申请日：2010-01-21
申请人： Ganeden Biotech Inc , ガネデンバイオテック, インコーポレイテッド
发明人： FARMER SEAN , LEFKOWITZ ANDREW R
IPC分类号： A23L1/28 , A61K35/74 , A23L1/30 , A61K35/10 , A61K36/28 , A61K45/00 , A61K47/26 , A61P3/06 , A61P3/10 , A61P9/10 , C12N1/20
CPC分类号： A61K35/747 , A61K31/366 , A61K31/787 , A61K35/742 , A61K35/745 , A61K36/28 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide an application of symbiotic organisms in a therapeutic composition.
SOLUTION: The therapeutic composition includes a combination of lactic acid producing bacteria, for example isolated Bacillus coagulans, with a bifidogenic oligosaccharide or another cholesterol lowering agent used to reduce LDL cholesterol and a serum triglyceride. The therapeutic method using the composition and a system provided with the therapeutic composition are also disclosed.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供共生生物在治疗组合物中的应用。解决方案：治疗组合物包括乳酸生产细菌，例如分离的凝结芽孢杆菌与用于降低LDL胆固醇和血清甘油三酸酯的双歧杆菌寡糖或另一种降胆固醇剂的组合。还公开了使用该组合物的治疗方法和具有治疗组合物的系统。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2014001245A Block of pathogen by bacillus coagulans 审中-公开
标题翻译：巴布鲁斯杯的病毒块
公开(公告)号：JP2014001245A
公开(公告)日：2014-01-09
申请号：JP2013204376
申请日：2013-09-30
申请人： Ganeden Biotech Inc , ガネデンバイオテック, インコーポレイテッド
发明人： FARMER SEAN
IPC分类号： A61K35/74 , C12N1/20 , A61K9/00 , A61P1/00 , A61P17/00 , A61P31/02 , A61P31/04 , C12P1/04 , C12P7/56 , C12R1/07
CPC分类号： A61K35/742 , A61K9/0034
摘要： PROBLEM TO BE SOLVED: To provide a highly effective, non-antibiotic base treatment curing method functioning in the conditions of an acute treatment, and also prophylactically functioning in such a manner that an antibiotic resistant pathogen is moved in both of the human being and animals.SOLUTION: This invention provides a composition, a treatment system and a using method utilizing the discovery that, in the relaxation and obstruction of pathogenic bacterium propagation and/or colony formation velocity by new lactic acid production bacterial strain (such as Bacillus coagulans indicated in this specification) or its extracellular product, and in the relaxation of the toxic physiological effect of infection by these pathogens, they have the ability to offer block activity. This invention provides a composition including lactic acid production bacterial strain (such as Bacillus coagulans) for blocking pathogenic bacterial infection.
摘要翻译：要解决的问题：提供在急性治疗条件下起作用的高效，非抗生素碱治疗固化方法，并且还以预防功能方式使抗生素抗性病原体在人和动物中移动解决方案：本发明提供了一种组合物，治疗系统和使用方法，其利用以下发现：在通过新的乳酸生产细菌菌株（如凝结芽孢杆菌中所示的致病菌繁殖和/或集落形成速度的松弛和阻塞）本说明书）或其细胞外产物，并且在放松这些病原体的感染的毒性生理作用时，它们具有提供阻断活性的能力。本发明提供包含用于阻断病原菌感染的乳酸生产细菌菌株（如凝结芽孢杆菌）的组合物。

4. 发明专利

JP2012211176A Method and composition for dietary management of autoimmune disorders 审中-公开
标题翻译：自动排毒障碍膳食管理方法与组成
公开(公告)号：JP2012211176A
公开(公告)日：2012-11-01
申请号：JP2012150041
申请日：2012-07-04
申请人： Ganeden Biotech Inc , ガネデンバイオテックインコーポレイテッド
发明人： FARMER SEAN , LEFKOWITZ ANDREW R
IPC分类号： A61K35/74 , A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/4196 , A61K38/12 , A61K38/13 , A61K45/00 , A61P1/04 , A61P3/10 , A61P5/14 , A61P17/04 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/02 , A61P27/02 , A61P29/00 , A61P37/02
CPC分类号： A61K35/742 , A61K31/137 , A61K31/155 , A61K31/203 , A61K31/4174 , A61K31/424 , A61K31/43 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/545 , A61K31/655 , A61K31/7036 , A61K31/7048 , A61K38/13 , A61K45/06 , Y10S435/832 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide a method and a composition for dietary management of autoimmune disorders.SOLUTION: The composition containing lactic acid bacteria (particularly lactic acid producing members of the genus Bacillus) can be administered orally for treatment of digestive-related immune disorders by down-regulating of cytokines and controlling pathogenic or deleterious microorganisms in the gastrointestinal tract. The lactobacillus is provided, for instance, in form of the spore of the Bacillus coagulans hammer strain and/or in form of an nutritive cell. The composition can contain additionally an antifungal agent that is not derived from any microorganisms.
摘要翻译：要解决的问题：提供用于自身免疫性疾病的饮食管理的方法和组合物。解决方案：包含乳酸菌（特别是芽孢杆菌属的乳酸生成成员）的组合物可以口服给药以通过下调细胞因子并控制胃肠道中的致病或有害微生物来治疗消化相关的免疫疾病。乳杆菌例如以凝固芽孢杆菌锤菌株的孢子形式和/或营养细胞的形式提供。该组合物可另外含有不衍生自任何微生物的抗真菌剂。版权所有（C）2013，JPO＆INPIT

5. 发明专利

JP2009269925A Probiotic lactic acid bacteria for treating microbial infection associated with sids 审中-公开
标题翻译：用于治疗与小孩相关的微生物感染的生物酸性细菌
公开(公告)号：JP2009269925A
公开(公告)日：2009-11-19
申请号：JP2009186168
申请日：2009-08-10
申请人： Ganeden Biotech Inc , ガネデンバイオテック, インコーポレイテッド
发明人： FARMER SEAN , MIKHAIL ROBERT J
IPC分类号： A61K35/74 , C12N1/20 , A23C9/12 , A23L1/03 , A23L1/30 , A61K9/14 , A61K9/20 , A61K31/702 , A61K31/715 , A61K47/04 , A61K47/12 , A61K47/26 , A61P1/00 , A61P31/04 , A61P43/00
CPC分类号： A23C9/1203 , A23L29/065 , A23Y2220/00 , A23Y2300/00 , A61K35/742 , A61K35/745 , A61K35/747
摘要： PROBLEM TO BE SOLVED: To provide a therapeutic composition and a therapeutic system, using a spore-forming Bacillus species, especially B. coagulans, and a method of uses for treating and/or preventing infections related to various bacterial gastrointestinal infections, especially SIDS-associated infection. SOLUTION: This composition containing non-pathogenic lactic acid bacteria such as the Bacillus species, and the spore or extracellular products of B. coagulans, formulated so as to be orally administered into a gastrointestinal duct for inhibiting the bacterial infection in the stomach and intestine is described. Also, a method and a system for using the composition to treat the stomach and intestinal infection, especially sudden infant death syndrome (SIDS) are disclosed. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种治疗组合物和治疗系统，其使用孢子形成芽孢杆菌属物种，特别是凝固芽孢杆菌，以及用于治疗和/或预防与各种细菌性胃肠道感染有关的感染的方法，特别是SIDS相关感染。解决方案：该组合物含有非致病性乳酸菌如芽孢杆菌属物种，以及凝固芽孢杆菌的孢子或细胞外产物，其被配制成口服施用于胃肠道以抑制胃中的细菌感染并描述肠。另外，公开了一种使用该组合物治疗胃肠道感染，特别是婴儿猝死综合征（SIDS）的方法和系统。版权所有（C）2010，JPO＆INPIT

6. 发明专利

JP2009261389A Probiotic composition 审中-公开
标题翻译：生物组成
公开(公告)号：JP2009261389A
公开(公告)日：2009-11-12
申请号：JP2009075677
申请日：2009-03-26
申请人： Ganeden Biotech Inc , ガネデンバイオテックインコーポレイテッド
发明人： FARMER SEAN
IPC分类号： C12N1/20 , A23K1/00 , A23K1/18 , A23L1/30 , A61K9/50 , A61K35/74 , A61K47/02 , A61K47/26 , A61P1/10 , A61P1/12 , A61P1/14 , A61P3/02 , C12N1/21
CPC分类号： A23K50/75 , A23K10/18 , A23L33/135 , A61K35/742
摘要： PROBLEM TO BE SOLVED: To provide a Bacillus bacterium which forms a spore that is a germination-competent in the presence of a bile acid, wherein gastrointestinal microbial flora plays a number of vital roles in maintaining functions of gastrointestinal tract and overall physiological health and probiotics are a term, which refers to the use of microorganisms in a positive way to benefit health. SOLUTION: The intestinal tissue of an animal is colonized by administering bacteria forming spores having germination competency and the bacterial cells or spores of the bacteria to the animal in the presence of a bile acid. The intestinal tissue is colonized by efficiently approaching of a viable vegetative cell to small intestine and rapidly multiplying there. The spores germinate in an inhibitory environment to conventional spores to become a vegetative cell and thereby colony is certainly formed in intestinal tissue to confer clinical benefits. Unlike known probiotic bacterial preparations, the colonization of the small and large intestine is reliably led. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种芽孢杆菌属细菌，其在胆汁酸存在下形成具有发芽能力的孢子，其中胃肠微生物菌群在维持胃肠道功能和整体生理学方面起许多重要作用健康和益生菌是一个术语，它是指以积极的方式使用微生物来使健康受益。解决方案：通过在胆汁酸的存在下向细菌施用形成具有发芽能力的孢子的细菌和细菌的细菌细胞或孢子将动物的肠组织定殖。肠组织通过有效地接近可行的营养细胞定殖到小肠并迅速繁殖。孢子在对常规孢子的抑制环境中发芽，成为营养细胞，从而在肠组织中肯定形成菌落以产生临床益处。与已知的益生菌细菌制剂不同，小肠和大肠的定植是可靠的。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2013172746A Beverage composition 有权
标题翻译：饮料组合物
公开(公告)号：JP2013172746A
公开(公告)日：2013-09-05
申请号：JP2013103654
申请日：2013-05-16
申请人： Ganeden Biotech Inc , ガネーデンバイオテックインコーポレイテッド
发明人： FARMER SEAN
IPC分类号： A23L2/52 , A23L1/30 , A23L2/38
CPC分类号： A23F3/14
摘要： PROBLEM TO BE SOLVED: To provide beverage compositions containing lactic acid-producing bacteria.SOLUTION: Beverage compositions are prepared so that lactic acid-producing bacteria, particularly Bacillus species remain viable and retain their beneficial probiotic properties in boiling water by combining dry matter and a liquid, and heating the combination by heat, flame, or a microwave.
摘要翻译：要解决的问题：提供含有产生乳酸的细菌的饮料组合物。溶液：制备饮料组合物，使得产生乳酸的细菌，特别是芽孢杆菌属物种保持存活并通过将干物质和液体，并通过加热，火焰或微波加热组合。

8. 发明专利

JP2010215665A Symbiosis lactic acid production bacteria and use thereof 审中-公开
标题翻译：酸乳酸生产细菌及其用途
公开(公告)号：JP2010215665A
公开(公告)日：2010-09-30
申请号：JP2010153465
申请日：2010-07-05
申请人： Ganeden Biotech Inc , ガネデンバイオテック, インコーポレイテッド
发明人： FARMER SEAN
IPC分类号： A61K35/74 , C12N15/09 , A61K9/06 , A61K31/4164 , A61K31/43 , A61K31/4375 , A61K31/47 , A61K31/496 , A61K31/545 , A61K31/7048 , A61K38/00 , A61K45/00 , A61K45/06 , A61K47/02 , A61K47/22 , A61K47/26 , A61P1/00 , A61P1/04 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , C12N1/20 , C12N1/21 , C12R1/07
CPC分类号： A61K35/742 , A61K31/43 , A61K31/496 , A61K31/545 , A61K31/65 , A61K31/704 , A61K31/7048 , A61K35/745 , A61K35/747 , A61K38/14 , A61K45/06 , C12R1/07
摘要： PROBLEM TO BE SOLVED: To provide a methodology for selective breeding and isolation of lactic acid-producing bacterial strains which possess resistance to anti-microbial agents for application in various type of therapeutic uses. SOLUTION: The invention discloses therapeutic compositions for treating or preventing gastrointestinal infection induced by a pathogenic bacterium, wherein the composition includes, in a pharmacologically acceptable carrier suitable for administration to gastrointestinal tract of vertebrate, one or more species or strains of lactic acid-producing bacteria with a therapeutically effective concentration, and the lactic acid-producing bacteria has a potential of both a reduction in the rate of colonization and the latent severity of the deleterious physiological effects of the colonization. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供选择性育种和分离具有抗微生物剂抗性的乳酸生产菌株的方法，用于各种治疗用途。解决方案：本发明公开了用于治疗或预防致病性细菌引起的胃肠道感染的治疗组合物，其中该组合物在适于给予脊椎动物胃肠道的药理学上可接受的载体中包含一种或多种乳酸菌种或菌株产生具有治疗有效浓度的细菌，并且产生乳酸的细菌具有降低定植率和定植的有害生理效应的潜在严重性的潜力。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2009269922A Topical use of probiotic bacillus spore for preventing or controlling microbe infection 审中-公开
标题翻译：用于预防或控制微生物感染的生物细菌培养基的局限性使用
公开(公告)号：JP2009269922A
公开(公告)日：2009-11-19
申请号：JP2009185292
申请日：2009-08-07
申请人： Ganeden Biotech Inc , ガネデンバイオテック, インコーポレイテッド
发明人： FARMER SEAN , MIKHAIL ROBERT J
IPC分类号： A61F13/15 , A61K35/74 , A01N63/00 , A61F13/20 , A61F13/472 , A61F13/49 , A61K9/00 , A61K9/06 , A61K9/08 , A61K9/10 , A61K9/107 , A61K9/12 , A61K9/14 , A61K47/10 , A61K47/14 , A61K47/36 , A61K47/38 , A61L15/58 , A61P17/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/22
CPC分类号： A01N63/00 , A61K9/0014 , A61K9/0034 , A61K9/0046 , A61K35/742 , A61K47/10 , A61K47/14 , A61K47/38
摘要： PROBLEM TO BE SOLVED: To provide a therapeutic composition, a product and a method of use, by utilizing an isolated Bacillus species for inhibiting various microbial infections caused by bacteria, yeasts, fungi or viruses. SOLUTION: This composition containing the isolated Bacillus species and the spores or extracellular products of B. coagulans, suitable for topical application to inhibit the proliferation of yeasts, fungi, bacteria or simple herpes viruses is disclosed. By topically applying the composition containing the isolated Bacillus species, spores or extracellular products of the B. coagulans, a method for inhibiting the proliferation of the yeasts, fungi, bacteria or a simplex herpes virus is also disclosed. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：为了提供治疗组合物，产品和使用方法，通过利用分离的芽孢杆菌属物种来抑制由细菌，酵母，真菌或病毒引起的各种微生物感染。解决方案：本发明公开了含有分离芽孢杆菌属物种和凝固芽孢杆菌孢子或细胞外产物的组合物，其适用于局部应用以抑制酵母，真菌，细菌或简单疱疹病毒的增殖。通过局部施用包含分离的芽孢杆菌属物种，凝结芽孢杆菌的孢子或细胞外产物的组合物，还公开了抑制酵母，真菌，细菌或单纯疱疹病毒增殖的方法。版权所有（C）2010，JPO＆INPIT

10. 发明申请

WO2005110445A2 METHODS AND COMPOSITIONS FOR THE DIETARY MANAGEMENT OF AUTOIMMUNE DISORDERS 审中-公开
标题翻译：自发性疾病饮食管理的方法和组成
公开(公告)号：WO2005110445A2
公开(公告)日：2005-11-24
申请号：PCT/US2005/016469
申请日：2005-05-11
申请人： GANEDEN BIOTECH, INC. , FARMER, Sean , LEFKOWITZ, Andrew, R.
发明人： FARMER, Sean , LEFKOWITZ, Andrew, R.
IPC分类号： A61K35/74
CPC分类号： A61K35/742 , A61K31/137 , A61K31/155 , A61K31/203 , A61K31/4174 , A61K31/424 , A61K31/43 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/545 , A61K31/655 , A61K31/7036 , A61K31/7048 , A61K38/13 , A61K45/06 , Y10S435/832 , A61K2300/00
摘要： The present invention describes the use of lactic acid bacteria, particularly lactic acid producing members of the genus Bacillus, in treating digestive-related immune disorders by downregulating of cytokines and by inhibiting pathogenic or deleterious microorganisms in the gastrointestinal tract. Specific formulations of Bacillus coagulans for various immune disorders are elaborated.
摘要翻译：本发明描述了通过下调细胞因子和通过抑制胃肠道中的病原性或有害微生物来使用乳酸菌，特别是芽孢杆菌属的乳酸生产成分来治疗消化相关的免疫病症。阐述了用于各种免疫疾病的凝结芽孢杆菌的具体制剂。

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