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1. 发明专利

JP5904688B2 共生乳酸産生細菌およびその使用有权
标题翻译：共生乳酸产生菌和它们的用途
公开(公告)号：JP5904688B2
公开(公告)日：2016-05-18
申请号：JP2000565902
申请日：1999-08-06
申请人：ガネデンバイオテック, インコーポレイテッド
发明人：ファーマー, シーン
IPC分类号： A61K9/08 , A61K47/26 , A61P1/00 , A61P31/04 , A61K35/74
CPC分类号： A61K35/742 , A61K31/43 , A61K31/496 , A61K31/545 , A61K31/65 , A61K31/704 , A61K31/7048 , A61K35/745 , A61K35/747 , A61K38/14 , A61K45/06 , C12R1/07

2. 发明专利

JP2012024092A Inhibition of pathogen by bacillus coagulans 审中-公开
标题翻译：通过BACILLUS COAGULANS抑制病原体
公开(公告)号：JP2012024092A
公开(公告)日：2012-02-09
申请号：JP2011180982
申请日：2011-08-22
申请人： Ganeden Biotech Inc , ガネデンバイオテック, インコーポレイテッド
发明人： FARMER SEAN
IPC分类号： C12N1/20 , A61K9/00 , A61K35/74 , A61P1/00 , A61P17/00 , A61P31/02 , A61P31/04 , C12N15/09 , C12R1/07
CPC分类号： A61K35/742 , A61K9/0034
摘要： PROBLEM TO BE SOLVED: To provide a highly efficacious, non-antibiotic-based therapeutic regimen which functions in acute treatment scenarios, as well as prophylactically to migrate antibiotic-resistant pathogens in both humans and animals.SOLUTION: The invention provides compositions, therapeutic systems, and methods of use which exploit the discovery that new lactic acid-producing bacterial strains, Bacillus coagulans, or extracellular products thereof, possess the ability to exhibit inhibitory activity in mitigating and preventing the growth and/or colonization rates of pathogenic bacteria, as well as mitigating the deleterious physiological effects of the infection by the pathogen(s).
摘要翻译：要解决的问题：提供在急性治疗方案中起作用的高效，非抗生素的治疗方案，以及预防性地在人和动物中迁移抗生素抗性病原体。解决方案：本发明提供组合物，治疗系统和使用方法，其利用发现新的产生乳酸的细菌菌株，凝结芽孢杆菌或其细胞外产物具有在减轻和预防中发挥抑制活性的能力致病细菌的生长和/或定植率，以及减轻病原体感染的有害生理作用。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2010095532A Method, system and composition to reduce cholesterol using bacillus coagulans spore 审中-公开
标题翻译：使用BACILLUS COAGULANS SPORE减少胆固醇的方法，系统和组合物
公开(公告)号：JP2010095532A
公开(公告)日：2010-04-30
申请号：JP2010011398
申请日：2010-01-21
申请人： Ganeden Biotech Inc , ガネデンバイオテック, インコーポレイテッド
发明人： FARMER SEAN , LEFKOWITZ ANDREW R
IPC分类号： A23L1/28 , A61K35/74 , A23L1/30 , A61K35/10 , A61K36/28 , A61K45/00 , A61K47/26 , A61P3/06 , A61P3/10 , A61P9/10 , C12N1/20
CPC分类号： A61K35/747 , A61K31/366 , A61K31/787 , A61K35/742 , A61K35/745 , A61K36/28 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide an application of symbiotic organisms in a therapeutic composition.
SOLUTION: The therapeutic composition includes a combination of lactic acid producing bacteria, for example isolated Bacillus coagulans, with a bifidogenic oligosaccharide or another cholesterol lowering agent used to reduce LDL cholesterol and a serum triglyceride. The therapeutic method using the composition and a system provided with the therapeutic composition are also disclosed.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供共生生物在治疗组合物中的应用。解决方案：治疗组合物包括乳酸生产细菌，例如分离的凝结芽孢杆菌与用于降低LDL胆固醇和血清甘油三酸酯的双歧杆菌寡糖或另一种降胆固醇剂的组合。还公开了使用该组合物的治疗方法和具有治疗组合物的系统。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2007537270A Methods and compositions for the dietary management of autoimmune disorders 有权
公开(公告)号：JP2007537270A
公开(公告)日：2007-12-20
申请号：JP2007513310
申请日：2005-05-11
申请人：ガネデンバイオテックインコーポレイテッド
发明人：ショーンファーマー , アンドリューアール．レフコウィッツ
IPC分类号： A61K35/74 , A61K38/12 , A61K38/13 , A61K47/04 , A61K47/22 , A61P1/04 , A61P17/06 , A61P19/02 , A61P29/00 , A61P37/06 , A61P43/00
CPC分类号： A61K35/742 , A61K31/137 , A61K31/155 , A61K31/203 , A61K31/4174 , A61K31/424 , A61K31/43 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/545 , A61K31/655 , A61K31/7036 , A61K31/7048 , A61K38/13 , A61K45/06 , Y10S435/832 , A61K2300/00
摘要： The present invention describes the use of lactic acid bacteria, particularly lactic acid producing members of the genus Bacillus, in treating digestive-related immune disorders by downregulating of cytokines and by inhibiting pathogenic or deleterious microorganisms in the gastrointestinal tract. Specific formulations of Bacillus coagulans for various immune disorders are elaborated.

5. 发明专利

JP2010215665A Symbiosis lactic acid production bacteria and use thereof 审中-公开
标题翻译：酸乳酸生产细菌及其用途
公开(公告)号：JP2010215665A
公开(公告)日：2010-09-30
申请号：JP2010153465
申请日：2010-07-05
申请人： Ganeden Biotech Inc , ガネデンバイオテック, インコーポレイテッド
发明人： FARMER SEAN
IPC分类号： A61K35/74 , C12N15/09 , A61K9/06 , A61K31/4164 , A61K31/43 , A61K31/4375 , A61K31/47 , A61K31/496 , A61K31/545 , A61K31/7048 , A61K38/00 , A61K45/00 , A61K45/06 , A61K47/02 , A61K47/22 , A61K47/26 , A61P1/00 , A61P1/04 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , C12N1/20 , C12N1/21 , C12R1/07
CPC分类号： A61K35/742 , A61K31/43 , A61K31/496 , A61K31/545 , A61K31/65 , A61K31/704 , A61K31/7048 , A61K35/745 , A61K35/747 , A61K38/14 , A61K45/06 , C12R1/07
摘要： PROBLEM TO BE SOLVED: To provide a methodology for selective breeding and isolation of lactic acid-producing bacterial strains which possess resistance to anti-microbial agents for application in various type of therapeutic uses. SOLUTION: The invention discloses therapeutic compositions for treating or preventing gastrointestinal infection induced by a pathogenic bacterium, wherein the composition includes, in a pharmacologically acceptable carrier suitable for administration to gastrointestinal tract of vertebrate, one or more species or strains of lactic acid-producing bacteria with a therapeutically effective concentration, and the lactic acid-producing bacteria has a potential of both a reduction in the rate of colonization and the latent severity of the deleterious physiological effects of the colonization. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供选择性育种和分离具有抗微生物剂抗性的乳酸生产菌株的方法，用于各种治疗用途。解决方案：本发明公开了用于治疗或预防致病性细菌引起的胃肠道感染的治疗组合物，其中该组合物在适于给予脊椎动物胃肠道的药理学上可接受的载体中包含一种或多种乳酸菌种或菌株产生具有治疗有效浓度的细菌，并且产生乳酸的细菌具有降低定植率和定植的有害生理效应的潜在严重性的潜力。版权所有（C）2010，JPO＆INPIT

6. 发明专利

JP2009269922A Topical use of probiotic bacillus spore for preventing or controlling microbe infection 审中-公开
标题翻译：用于预防或控制微生物感染的生物细菌培养基的局限性使用
公开(公告)号：JP2009269922A
公开(公告)日：2009-11-19
申请号：JP2009185292
申请日：2009-08-07
申请人： Ganeden Biotech Inc , ガネデンバイオテック, インコーポレイテッド
发明人： FARMER SEAN , MIKHAIL ROBERT J
IPC分类号： A61F13/15 , A61K35/74 , A01N63/00 , A61F13/20 , A61F13/472 , A61F13/49 , A61K9/00 , A61K9/06 , A61K9/08 , A61K9/10 , A61K9/107 , A61K9/12 , A61K9/14 , A61K47/10 , A61K47/14 , A61K47/36 , A61K47/38 , A61L15/58 , A61P17/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/22
CPC分类号： A01N63/00 , A61K9/0014 , A61K9/0034 , A61K9/0046 , A61K35/742 , A61K47/10 , A61K47/14 , A61K47/38
摘要： PROBLEM TO BE SOLVED: To provide a therapeutic composition, a product and a method of use, by utilizing an isolated Bacillus species for inhibiting various microbial infections caused by bacteria, yeasts, fungi or viruses. SOLUTION: This composition containing the isolated Bacillus species and the spores or extracellular products of B. coagulans, suitable for topical application to inhibit the proliferation of yeasts, fungi, bacteria or simple herpes viruses is disclosed. By topically applying the composition containing the isolated Bacillus species, spores or extracellular products of the B. coagulans, a method for inhibiting the proliferation of the yeasts, fungi, bacteria or a simplex herpes virus is also disclosed. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：为了提供治疗组合物，产品和使用方法，通过利用分离的芽孢杆菌属物种来抑制由细菌，酵母，真菌或病毒引起的各种微生物感染。解决方案：本发明公开了含有分离芽孢杆菌属物种和凝固芽孢杆菌孢子或细胞外产物的组合物，其适用于局部应用以抑制酵母，真菌，细菌或简单疱疹病毒的增殖。通过局部施用包含分离的芽孢杆菌属物种，凝结芽孢杆菌的孢子或细胞外产物的组合物，还公开了抑制酵母，真菌，细菌或单纯疱疹病毒增殖的方法。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2014001245A Block of pathogen by bacillus coagulans 审中-公开
标题翻译：巴布鲁斯杯的病毒块
公开(公告)号：JP2014001245A
公开(公告)日：2014-01-09
申请号：JP2013204376
申请日：2013-09-30
申请人： Ganeden Biotech Inc , ガネデンバイオテック, インコーポレイテッド
发明人： FARMER SEAN
IPC分类号： A61K35/74 , C12N1/20 , A61K9/00 , A61P1/00 , A61P17/00 , A61P31/02 , A61P31/04 , C12P1/04 , C12P7/56 , C12R1/07
CPC分类号： A61K35/742 , A61K9/0034
摘要： PROBLEM TO BE SOLVED: To provide a highly effective, non-antibiotic base treatment curing method functioning in the conditions of an acute treatment, and also prophylactically functioning in such a manner that an antibiotic resistant pathogen is moved in both of the human being and animals.SOLUTION: This invention provides a composition, a treatment system and a using method utilizing the discovery that, in the relaxation and obstruction of pathogenic bacterium propagation and/or colony formation velocity by new lactic acid production bacterial strain (such as Bacillus coagulans indicated in this specification) or its extracellular product, and in the relaxation of the toxic physiological effect of infection by these pathogens, they have the ability to offer block activity. This invention provides a composition including lactic acid production bacterial strain (such as Bacillus coagulans) for blocking pathogenic bacterial infection.
摘要翻译：要解决的问题：提供在急性治疗条件下起作用的高效，非抗生素碱治疗固化方法，并且还以预防功能方式使抗生素抗性病原体在人和动物中移动解决方案：本发明提供了一种组合物，治疗系统和使用方法，其利用以下发现：在通过新的乳酸生产细菌菌株（如凝结芽孢杆菌中所示的致病菌繁殖和/或集落形成速度的松弛和阻塞）本说明书）或其细胞外产物，并且在放松这些病原体的感染的毒性生理作用时，它们具有提供阻断活性的能力。本发明提供包含用于阻断病原菌感染的乳酸生产细菌菌株（如凝结芽孢杆菌）的组合物。

8. 发明专利

JP5137571B2 Methods and compositions for the dietary management of autoimmune disorders 有权
公开(公告)号：JP5137571B2
公开(公告)日：2013-02-06
申请号：JP2007513310
申请日：2005-05-11
申请人：ガネデンバイオテックインコーポレイテッド
发明人：ショーンファーマー , アンドリューアール．レフコウィッツ
IPC分类号： A61K35/74 , A61K38/12 , A61K38/13 , A61P43/00
CPC分类号： A61K35/742 , A61K31/137 , A61K31/155 , A61K31/203 , A61K31/4174 , A61K31/424 , A61K31/43 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/545 , A61K31/655 , A61K31/7036 , A61K31/7048 , A61K38/13 , A61K45/06 , Y10S435/832 , A61K2300/00
摘要： The present invention describes the use of lactic acid bacteria, particularly lactic acid producing members of the genus Bacillus, in treating digestive-related immune disorders by downregulating of cytokines and by inhibiting pathogenic or deleterious microorganisms in the gastrointestinal tract. Specific formulations of Bacillus coagulans for various immune disorders are elaborated.

9. 发明专利

JP5108174B2 Method for reducing cholesterol using Bacilluscoagulans spores, systems, and compositions 有权
公开(公告)号：JP5108174B2
公开(公告)日：2012-12-26
申请号：JP2000540840
申请日：1999-04-01
申请人：ガネデンバイオテック, インコーポレイテッド
发明人：シーンファーマー， , アンドリューアール．レフコウィッツ，
IPC分类号： A23L1/28 , A61K35/74 , A23L1/30 , A61K31/192 , A61K31/194 , A61K31/216 , A61K31/22 , A61K31/366 , A61K31/404 , A61K31/436 , A61K31/4402 , A61K31/616 , A61K31/702 , A61K31/736 , A61K35/10 , A61K36/18 , A61K36/28 , A61K36/899 , A61K45/00 , A61P3/06 , A61P3/10 , A61P9/10 , C12N1/20
CPC分类号： A61K35/747 , A61K31/366 , A61K31/787 , A61K35/742 , A61K35/745 , A61K36/28 , A61K2300/00
摘要： The invention describes therapeutic compositions including a lactic acid-producing bacteria, such as isolated Bacillus coagulans, in combination with a bifidogenic oligosaccharides or other cholesterol-reducing agents for use in reducing LDL cholesterol and serum triglycerides. Also described are therapeutic methods using the compositions and systems containing the therapeutic compositions.

10. 发明专利

JP2012211176A Method and composition for dietary management of autoimmune disorders 审中-公开
标题翻译：自动排毒障碍膳食管理方法与组成
公开(公告)号：JP2012211176A
公开(公告)日：2012-11-01
申请号：JP2012150041
申请日：2012-07-04
申请人： Ganeden Biotech Inc , ガネデンバイオテックインコーポレイテッド
发明人： FARMER SEAN , LEFKOWITZ ANDREW R
IPC分类号： A61K35/74 , A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/4196 , A61K38/12 , A61K38/13 , A61K45/00 , A61P1/04 , A61P3/10 , A61P5/14 , A61P17/04 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/02 , A61P27/02 , A61P29/00 , A61P37/02
CPC分类号： A61K35/742 , A61K31/137 , A61K31/155 , A61K31/203 , A61K31/4174 , A61K31/424 , A61K31/43 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/545 , A61K31/655 , A61K31/7036 , A61K31/7048 , A61K38/13 , A61K45/06 , Y10S435/832 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide a method and a composition for dietary management of autoimmune disorders.SOLUTION: The composition containing lactic acid bacteria (particularly lactic acid producing members of the genus Bacillus) can be administered orally for treatment of digestive-related immune disorders by down-regulating of cytokines and controlling pathogenic or deleterious microorganisms in the gastrointestinal tract. The lactobacillus is provided, for instance, in form of the spore of the Bacillus coagulans hammer strain and/or in form of an nutritive cell. The composition can contain additionally an antifungal agent that is not derived from any microorganisms.

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