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1. 发明公开

EP0633793A1 ENDOTRACHEAL TUBE INTRODUCER 失效
标题翻译： EINFUEHRRORRICHTUNG EINEN LUFTROERENKANUELE。
公开(公告)号：EP0633793A1
公开(公告)日：1995-01-18
申请号：EP93907703.0
申请日：1993-03-26
申请人： FISHER, Joseph Arnold , BERDOWSKI, Alan
发明人： FISHER, Joseph Arnold , BERDOWSKI, Alan
IPC分类号： A61M25 , A61M16
CPC分类号： A61M16/0488
摘要： An endotracheal tube introducer (100) comprising a proximal end (12) and a distal end (14), the proximal end (12) comprising a mouth (30) of greater diameter than an endotracheal tube being inserted into it and an elongated portion connected to, and extending longitudinally away from, the mouth for insertion thereof past the epiglottis, between the vocal cords, into the trachea, the elongated portion comprising at least one guide (16) and reinforcing portion extending longitudinally along the length of the elongated portion away from the proximal end (12) and mouth (30), and relatively thin pliable side portions or wings (18A, 18B) extending laterally from the sides of the guide portion (16), one from each side and overlap one another at least proximate the distal end (14).
摘要翻译：包括近端和远端的气管插管导管器，所述近端包括比插入其中的气管插管更大的直径的嘴，以及连接到所述口并纵向远离所述口的细长部分，用于将其插入其中会话，在声带之间，进入气管，细长部分包括至少一个引导件和加强部分，该导向件和加强部分沿着细长部分的长度纵向延伸远离近端和口部，以及相对薄的柔软的侧部或翼部，引导部分的侧面，每侧各一个，至少靠近远端彼此重叠。

2. 发明授权

EP0633793B1 ENDOTRACHEAL TUBE INTRODUCER 失效
标题翻译： ENDOTRACHEAL导管介绍
公开(公告)号：EP0633793B1
公开(公告)日：1998-01-21
申请号：EP93907703.8
申请日：1993-03-26
申请人： FISHER, Joseph Arnold , BERDOWSKI, Alan
发明人： FISHER, Joseph Arnold , BERDOWSKI, Alan
IPC分类号： A61M16/00
CPC分类号： A61M16/0488
摘要： An endotracheal tube introducer (100) comprising a proximal end (12) and a distal end (14), the proximal end (12) comprising a mouth (30) of greater diameter than an endotracheal tube being inserted into it and an elongated portion connected to, and extending longitudinally away from, the mouth for insertion thereof past the epiglottis, between the vocal cords, into the trachea, the elongated portion comprising at least one guide (16) and reinforcing portion extending longitudinally along the length of the elongated portion away from the proximal end (12) and mouth (30), and relatively thin pliable side portions or wings (18A, 18B) extending laterally from the sides of the guide portion (16), one from each side and overlap one another at least proximate the distal end (14).
摘要翻译：一种包括近端（12）和远端（14）的气管内导管引入器（100），所述近端（12）包括直径大于插入其中的气管内插管的开口（30）并沿纵向远离嘴部延伸，以便将其插入通过会厌，在声带之间进入气管，所述细长部分包括至少一个导向件（16）和沿着细长部分的长度纵向延伸的加强部分（12）和嘴部（30）之间以及从引导部分（16）的侧面横向延伸的相对较薄的柔韧侧部或翼（18A，18B），每个侧面一个且彼此重叠至少接近远端（14）。

3. 发明授权

EP0973572B1 DEVICE FOR ELIMINATION OF VAPOUR ANAESTHETICS FROM PATIENTS AFTER SURGICAL PROCEDURES 失效
标题翻译： DEVICE FOR REMOVING麻醉蒸气从患者手术后
公开(公告)号：EP0973572B1
公开(公告)日：2003-10-22
申请号：EP97906959.8
申请日：1997-03-19
申请人： FISHER, Joseph Arnold
发明人： FISHER, Joseph Arnold
IPC分类号： A61M16/00 , A61M16/12
CPC分类号： A61M16/12 , A61M16/024 , A61M16/208 , A61M16/209 , A61M16/22 , A61M2202/0225 , A61M2202/0007

4. 发明公开

EP0973572A1 ELIMINATION OF VAPOUR ANAESTHETICS FROM PATIENTS AFTER SURGICAL PROCEDURES 失效
标题翻译： NAKROSEMITTELDAMPF从患者手术去除后
公开(公告)号：EP0973572A1
公开(公告)日：2000-01-26
申请号：EP97906959.8
申请日：1997-03-19
申请人： FISHER, Joseph Arnold
发明人： FISHER, Joseph Arnold
IPC分类号： A61M16/00 , A61M16/12
CPC分类号： A61M16/12 , A61M16/024 , A61M16/208 , A61M16/209 , A61M16/22 , A61M2202/0225 , A61M2202/0007
摘要： A method of treatment of an animal to recover from vapour anaesthetics administration is provided, the method comprising delivering to a patient gases which do not contain CO2 at a specified rate, and gases containing CO2 to maintain the same PCO2 in the animal independent of the rate of ventilation, at the rate of ventilation of the animal which exceeds the rate of administration of the gases which do not contain CO2.
摘要翻译：呼吸回路系统，用于在麻醉患者通气。该系统包括一个标准的主要圆麻醉电路，其本身包括用于递送再呼吸的气体的单向吸气分支和用于接受呼出气体的单向呼气分支。因此，该呼吸回路系统包括一个辅助呼吸回路，而纯粹供给非再呼吸气体，并包括非再呼吸的，基本上不含二氧化碳的气体源，非再呼吸新鲜气体贮存器，用于存储新鲜气体，的非源再呼吸储备气体包含二氧化碳和气体输送管道。设置成与吸气分支通信是一种非再吸阀门，同时与两个吸气分支和输送导管连通设置为选择性地允许气体通过从吸气分支或从输送三通呼吸阀管道。

5. 发明申请

WO2022269497A1 A METHOD AND SYSTEM FOR DETERMINING A PERFUSION METRIC USING DEOXYHEMOGLOBIN AS A CONTRAST AGENT 审中-公开
公开(公告)号：WO2022269497A1
公开(公告)日：2022-12-29
申请号：PCT/IB2022/055769
申请日：2022-06-21
申请人： MIKULIS, David , POUBLANC, Julien , SOBCZYK, Olivia , DUFFIN, James , SAYIN, Ece Su , FISHER, Joseph Arnold , WOOD, John , VU, Chau
发明人： MIKULIS, David , POUBLANC, Julien , SOBCZYK, Olivia , DUFFIN, James , SAYIN, Ece Su , FISHER, Joseph Arnold , WOOD, John , VU, Chau
IPC分类号： A61B5/0205 , A61B5/00 , A61B5/083 , A61B5/1455 , A61M1/14
摘要： Hypoxia-induced deoxyhemoglobin concentration ([dOHb]) may be used as a susceptibility contrast agent in subjects. While the maximal rate of generating blood [dOHb] are limited by constraints in pulmonary gas mixing, decreasing dOHb with re-oxygenation of the lungs can be accomplished in one breath, resulting in a step reduction in arterial [dOHb] and thereby a step increase in cerebral BOLD signal recorded with MRI. The BOLD signal changes accompanying a step decrease in [dOHb] can be analyzed to calculate cerebral perfusion measures and compare their maps to those obtained using a bolus of a conventional contrast agent, gadolinium, and a conventional analysis requiring the identification of an arterial input function. The two methods provided comparable anatomically-distributed hemodynamic information.

6. 发明申请

WO2012054262A1 METHODS AND DEVICE TO REDUCE SLOSH ENERGY ABSORPTION EFFECTS BY REDUCING BLOOD FLOW FROM THE CRANIUM 审中-公开
标题翻译：通过减少血液中的血液流量来减少能量吸收效应的方法和装置
公开(公告)号：WO2012054262A1
公开(公告)日：2012-04-26
申请号：PCT/US2011/055783
申请日：2011-10-11
申请人： WEST VIRGINIA UNIVERSITY , SMITH, David , FISHER, Joseph, Arnold
发明人： SMITH, David , FISHER, Joseph, Arnold
IPC分类号： B64D10/00
CPC分类号： A41D13/0512 , A61B17/1325 , A61B17/135 , A63B71/081 , A63B71/10 , A63B71/1291 , A63B2225/62
摘要： Venous compression in the neck reduced the extent of axonal injury in a standardized mild TBI model in rodents. The mechanism restricted brain venous drainage and increased the central nervous system blood volume and pressure, thus shifting intracranial physiology to the steep part of the volume-compliance curve. The lack of compliance inside the confines of the skull and spinal canal prevented slosh energy absorption and the resultant axonal injury by causing them to approach a more elastic collision when the skull was struck during the weight drop method. A first embodiment can be a device comprising a means to reduce SLOSH energy absorption in a fluid containing organism by reducing the flow of one or more outflow vessels of the cranium by compressing said vessels.
摘要翻译：颈部静脉压缩减少了啮齿动物标准化轻度TBI模型中轴突损伤的程度。该机制限制脑静脉引流，增加中枢神经系统血容量和压力，从而将颅内生理转化为体积依从性曲线的陡峭部分。在颅骨和椎管内限制缺乏依从性，通过在减肥方法中颅骨被撞击时，通过使他们接近更具弹性的碰撞，从而防止了身体的能量吸收和所产生的轴突损伤。第一实施例可以是包括通过压缩所述血管来减少颅骨的一个或多个流出血管的流动来减少含有流体的生物体中的SLOSH能量吸收的装置的装置。

7. 发明申请

WO1993019798A1 ENDOTRACHEAL TUBE INTRODUCER 审中-公开
标题翻译：内管导入器
公开(公告)号：WO1993019798A1
公开(公告)日：1993-10-14
申请号：PCT/CA1993000128
申请日：1993-03-26
申请人： FISHER, Joseph, Arnold , BERDOWSKI, Alan
IPC分类号： A61M16/00
CPC分类号： A61M16/0488
摘要： An endotracheal tube introducer (100) comprising a proximal end (12) and a distal end (14), the proximal end (12) comprising a mouth (30) of greater diameter than an endotracheal tube being inserted into it and an elongated portion connected to, and extending longitudinally away from, the mouth for insertion thereof past the epiglottis, between the vocal cords, into the trachea, the elongated portion comprising at least one guide (16) and reinforcing portion extending longitudinally along the length of the elongated portion away from the proximal end (12) and mouth (30), and relatively thin pliable side portions or wings (18A, 18B) extending laterally from the sides of the guide portion (16), one from each side and overlap one another at least proximate the distal end (14).
摘要翻译：包括近端（12）和远端（14）的气管内插管器（100），所述近端（12）包括比插入其中的气管插管更大的直径的嘴（30）和连接的细长部分从而将其插入到口中以便将其插入到会话之间，在声带之间进入气管，细长部分包括至少一个引导件（16）和沿着细长部分的长度纵向延伸的加强部分从近端（12）和口（30）以及从引导部分（16）的侧面横向延伸的相对薄的柔软的侧部或翼（18A，18B），一个从每侧至少彼此重叠远端（14）。

8. 发明申请

WO2023286040A1 IMPLEMENTING A PERIODIC DEOXYHEMOGLOBIN SIGNAL 审中-公开
公开(公告)号：WO2023286040A1
公开(公告)日：2023-01-19
申请号：PCT/IB2022/056604
申请日：2022-07-18
申请人： FISHER, Joseph Arnold , DUFFIN, James , POUBLANC, Julien , SOBCZYK, Olivia , MIKULIS, David , SAYIN, Ece Su
发明人： FISHER, Joseph Arnold , DUFFIN, James , POUBLANC, Julien , SOBCZYK, Olivia , MIKULIS, David , SAYIN, Ece Su
IPC分类号： A61B5/145 , A61B5/055 , A61B5/0205
摘要： A method of implementing changes in deoxyhemoglobin concentration, the method comprising: targeting a sequence of partial pressures of oxygen in arterial blood (PaCh) values in a subject using a sequential gas delivery device in a periodic input pattern; measuring a blood- oxygen level dependent (BOLD) signal in a voxel of the subject's brain using a magnetic resonance imaging device while targeting the sequence of values; comparing the pattern to the signal; and determining a vascular tissue characteristic (vessel type, vessel orientation, or pathological condition) for the voxel based on the comparison.

9. 发明申请

WO2023286039A1 INDUCING DEOXYHEMOGLOBIN AS A CONTRAST AGENT IN A SUBJECT FOR MRI 审中-公开
公开(公告)号：WO2023286039A1
公开(公告)日：2023-01-19
申请号：PCT/IB2022/056603
申请日：2022-07-18
申请人： FISHER, Joseph Arnold , DUFFIN, James , SOBCZYK, Olivia , SAYIN, Ece Su , MIKULIS, David , POUBLANC, Julien , SCHULMAN, Jacob B.
发明人： FISHER, Joseph Arnold , DUFFIN, James , SOBCZYK, Olivia , SAYIN, Ece Su , MIKULIS, David , POUBLANC, Julien , SCHULMAN, Jacob B.
IPC分类号： A61M16/10
摘要： The speed and range of the transition to low lung PO2 can be optimized such that it approaches the PO2 and timing profile of reoxygenation from a hypoxic profile. However, such hypoxic "spikes" are much more difficult to implement than re-oxygenation. A solution is to control the independent variables which contribute to hypoxia in the lung. These variables may be controlled in alone or in aggregate to minimize the time required to generate a target profile of transient lung hypoxia. In particular, a rapid decrease in [dOHb] can be implemented by breathing deeply, exhaling at least a portion of the functional residual capacity, lowering the PO2 at baseline, increasing the breathing rate, and increasing the PCO2 to shift the oxygen-hemoglobin dissociation curve to the right.

10. 发明授权

US5323771A Endotracheal tube introducer 失效
标题翻译：气管导管
公开(公告)号：US5323771A
公开(公告)日：1994-06-28
申请号：US863112
申请日：1992-04-03
申请人： Joseph A. Fisher , Alan Berdowski
发明人： Joseph A. Fisher , Alan Berdowski
IPC分类号： A61M25/08 , A61M16/00 , A61M16/04
CPC分类号： A61M16/0488
摘要： An endotracheal tube introducer comprising a proximal end and a distal end, the proximal end comprising a mouth of greater diameter than an endotracheal tube being inserted into it and an elongated portion connected to, and extending longitudinally away from, the mouth for insertion thereof past the epiglottis, between the vocal cords, into the trachea, the elongated portion comprising at least one guide and reinforcing portion extending longitudinally along the length of the elongated portion away from the proximal end and mouth, and relatively thin pliable side portions or wings extending laterally from the sides of the guide portion, one from each side and overlap one another at least proximate the distal end.
摘要翻译：包括近端和远端的气管内导管器，所述近端包括比插入其中的气管插管更大的直径的口，以及连接到所述口并纵向远离所述口的细长部分，用于将其插入所述嘴会话，在声带之间，进入气管，细长部分包括沿着细长部分的远离近端和嘴部的长度纵向延伸的至少一个引导件和加强部分，以及相对薄的柔软的侧部或翼部，引导部分的侧面，每个侧面一个并且至少在远端附近彼此重叠。

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